Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology

ea0029p1170 | Obesity | ICEECE2012

Association of 3111t/c polymorphism of the clock gene with binge eating disorder in obese children and adolescents

Arthur T. , Deram S. , Frazzatto E. , Guazzelli I. , Villares S.

Introduction: The etiopathogenesis of obesity is represented by the endogenous circadian clock system, which has been shown to have a part in the regulation of body weight and energy homeostasis. The gene Circadian locomotor output cycles kaput (CLOCK) is part of the positive regulatory branch of the system. Polymorphism in CLOCK genes in human disorders characterized by alterations of endogenous circadian rhythms. Moreover, since in up to 30% of obese subjects seeking treatme...

ea0029p1171 | Obesity | ICEECE2012

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

Martinez de Morentin P. , Whittle A. , Martinez-Sanchez N. , Martins L. , Ferno J. , Nogueiras R. , Dieguez C. , Vidal-Puig A. , Lopez M.

Introduction: Smokers around the globe commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. In addition, numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. Nicotine’s effects on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood...

ea0029p1172 | Obesity | ICEECE2012

Ac 2-26, an annexin A1-derived peptide, reduces inflammation in human SGBS adipocytes after hypoxia treatment

Kosicka-Knox A. , Cunliffe A. , Mackenzie R. , Zariwala M. , Renshaw D.

Previous studies demonstrated that the N-terminal peptide of annexin A1 (AnxA1) (peptide Ac2-26) can mimic the anti-inflammatory actions of the full-length protein in various systems. In the current study, we report the effectiveness of the peptide Ac2-26 as an anti-inflammatory agent in a model of human SGBS adipocytes. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with BMI, body fat level and waist to hip ratio. We have also ...

ea0029p1173 | Obesity | ICEECE2012

Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects

Schulte D. , Muller N. , Neumann K. , Oberhauser F. , Faust M. , Gudelhofer H. , Krone W. , Laudes M.

Background: Obesity is associated with macrophage infiltration of adipose tissue. These inflammatory cells affect adipocytes not only by classical cytokines but also by the secreted glycopeptide wnt5a. Healthy adipocytes on the other site are able to release the specific wnt5a inhibitor sFRP5. This protective effect, however, was found to be diminished in obesity. The aim of the present study was to examine i) whether obese human subjects exhibit increased serum concentrations...

ea0029p1174 | Obesity | ICEECE2012

Zinc-α2-glycoprotein in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients

Garrido-Sanchez L , Escote X , Fernandez-Garcia D , Vendrell J , Tinahones F J , Garcia-Fuentes E

Objective: Zinc-α2 glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. We analyze ZAG expression levels in adipose tissue from a group of morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).Design: mRNA expression levels of PPARgamma, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VA...

ea0029p1175 | Obesity | ICEECE2012

Longitudinal changes in body mass index and body composition among 417 adult survivors of childhood cancer

Blijdorp K. , van den Heuvel M. , Pieters R. , Boot A. , van der Lelij A. , Neggers S.

Introduction: Obesity, represented by high body mass index (BMI), is a major complication after treatment for childhood cancer. High amount of total and visceral fat and low lean body mass are described as more reliable determinants, predicting the development of cardiovascular disease. In this study longitudinal changes of BMI and body composition in adult childhood cancer survivors were evaluated.Methods: Data of 417 adult childhood cancer survivors, w...

ea0029p1176 | Obesity | ICEECE2012

Brown rice and its component, γ-oryzanol, attenuate the preference for dietary fat by decreasing hypothalamic endoplasmic reticulum stress in mice

Kozuka C. , Yabiku K. , Sunagawa S. , Ueda R. , Taira S. , Ikema T. , Yamakawa K. , Higa M. , Shimabukuro M. , Masuzaki H.

It is known that brown rice (BR) prevents obesity and type 2 diabetes in humans. Previous studies have shown that exaggerated endoplasmic reticulum (ER) stress in the hypothalamus of obese mice is linked to hyperphagia. Here we tested the hypothesis that BR might decrease ER stress in hypothalamus, leading to the attenuation the preference for dietary fat.Eight-week-old mice were randomly divided into three groups: the control, BR-containing diet, and th...

ea0029p1177 | Obesity | ICEECE2012

Weight-perception in male career US firefighters and its association with cardiovascular risk factors

Baur D. , Christophi C. , Kales S.

Objective: To evaluate the associations among body mass index, weight perception and cardiovascular risk factors in male career US firefighters.Design: The present cross-sectional study was nested within a federally-funded multicenter, prospective cohort investigation of cardio-respiratory fitness (CRF), health and employment outcomes among career firefighters.Subjects: Seven hundred and sixty-eight male career firefighters from tw...

ea0029p1178 | Obesity | ICEECE2012

GH secretagogue receptor gene 171 C/T polymorphism association with metabolic features in obese children and adolescents

Arthur T. , Deram S. , Guazzelli I. , Frazzatto E. , Villares S.

Introduction: Ghrelin, enhances appetite and increases food intake in healthy humans. The endogenous ligand ghrelin is the GH secretagogue receptor (GHSR), and effects of ghrelin are mediated via GHSR. The GHSR system plays a significant role in regulating the process of obesity and type 2 diabetes that are linked to metabolic syndrome (MS). Therefore, the GHSR gene 171C/T (rs495225) polymorphism is a good candidate for susceptibility to obesity and excellent MS.<p class="...

ea0029p1179 | Obesity | ICEECE2012

Using 1H-nuclear magnetic resonance spectroscopy to identify changes in the plasma metabolome of rats fed low-carbohydrate/high fat diets

Bielohuby M. , Friedrich N. , Meurer S. , Budde K. , Wallaschofksi H. , Bidlingmaier M.

We previously reported the impact of low-carbohydrate/high-fat (LC–HF) diets on different endocrine systems in rats. To unravel metabolic pathways involved, we now studied if pair-feeding isoenergetic amounts of three different diets – all composed of macronutrient from the same sources but at different relative abundance, – leads to specific changes of the plasma metabolic profile.Methods: Plasma was collected from male Wistar rats (n<...

ea0029p1180 | Obesity | ICEECE2012

Metabolic syndrome after liver transplantation: pre- and post-operative risk factors

Lunati M. , Grancini V. , Agnelli F. , Masserini B. , Zimbalatti D. , Rossi G. , Beck-Peccoz P. , Orsi E.

Background: Metabolic syndrome (MS) is a common condition among liver transplanted patients and it contributes to late morbidity and mortality by favoring the development of cardiovascular disease (CVD).The aim of this study was to assess the prevalence of MS in the first 6 months after orthotopic liver transplantation (OLT) and the associated pre-operative and post-operative risk factors.Methods: Seventy-one cirrhotic patients wer...

ea0029p1181 | Obesity | ICEECE2012

Metformin in normoglycemic obesity: a systematic review

Li S. , Guo J. , Lv X. , Liu Y. , Chen T. , Tian H.

Objective: Metformin was considered as a weight lowering agent in diabetes patients, while it remained unclear in simple obesity patients. We aimed to investigate if metformin is effective and safe in the therapy of normoglycemic obesity.Methods: We systematically searched MEDLINE (1950–2011), EMBase (1950–2011), and CCTR (4th Issue 2011), and collected and screened all randomized controlled trials compared metformin and placebo in obese partic...

ea0029p1182 | Obesity | ICEECE2012

Growth differentiation factor-15 and transforming growth factor-β1 in healthy adults with and without obesity

Sasse C. , Look M. , Albers E. , Zur B. , Stoffel-Wagner B.

Introduction: GDF-15 and TGF-β1 are growth factors involved in immune modulation and development of arteriosclerosis. Aim of this study was to assess whether GDF-15 and TGF-β1 concentrations are higher in adipose vs non-adipose individuals and whether this indicates early immune modulation with higher risk of arteriosclerosis.Description of methods: We examined 84 healthy individuals: 38 non-obese (average age 24.9 years) with mean BMI of 20.5+...

ea0029p1183 | Obesity | ICEECE2012

Abstract withdrawn....

ea0029p1184 | Obesity | ICEECE2012

The effect of ‘The Programme of weight loss’ in women, Arkhangelsk, Russia

Postoeva A. , Uutela A.

Background: Different programmes are offered to help people to reduce weight. ‘The Programme of Weight Loss’ is working in the outpatient clinic in the Arkhangelsk, Russia, but its effectiveness was not assessed before.Aim of the study was to assess the effect of the complex course ‘The Programme of Weight Loss’.Methods: The panel study was conducted and included women participated in the two-week Programme from...

ea0029p1185 | Obesity | ICEECE2012

Efficacy of orlistat vs placebo in the improvement of lipid profile among overweight and obese patients: a meta-analysis

Malong C. , Delgado J. , Cunanan E.

Background: According to the 6th National Nutrition Health Survey, the Filipino is generally unfit, with increasing incidences of major risk factors for cardiovascular disease like hypertension, abnormal lipid profile, obesity and diabetes over the last 5 years. Orlistat, a lipase inhibitor is one of the medications used to facilitate weight loss in obese patients. Given that weight loss is known to be associated with an improvement in the serum lipid profile, concurrent impro...

ea0029p1186 | Obesity | ICEECE2012

Insulin resistance and acne: a new risk factor for men?

Del Prete M. , Faggiano A. , Mauriello M. , Di Somma C. , Monfrecola G. , Fabbrocini G. , Colao A.

Introduction: Acne is a common skin disease that occasionally can be influenced by endocrine abnormalities. In females, a clear relationship has been highlight between acne onset and peripheral insulin resistance and hyperinsulinemia, whereas few data are available in male. The aim of this study was to investigate the relationship between acne and insulin resistance as well as other metabolic impairment in male subjects with acne.Methods/design: Twenty-t...

ea0029p1187 | Obesity | ICEECE2012

Metabolic syndrome in benign and malignant nodular thyroid diseases

Can S. , Anil C. , Nar A. , Gursoy A. , Tutuncu N Bascil

Introduction: Metabolic syndrome (MetS) is a group of metabolic abnormalities where insulin resistance (IR) plays a major role. Previous studies have shown that thyroid volume and nodule prevalence were increased in patients with IR. The aim of our study is to evaluate MetS and its components in patients with benign and malignant nodular thyroid disease (NTD).Methods: A total of 800 patients (430 euthyroid benign and 370 euthyroid malignant NTD) followed...

ea0029p1188 | Obesity | ICEECE2012

Abstract withdrawn...

ea0029p1189 | Obesity | ICEECE2012

A pilot study in obese patients who refer to plastic surgery: temperamental-personality traits

Azzi M. , Vindigni V. , Lancerotto L. , Bassetto F. , Marini M. , Grasso G. , Pavan C.

Literature evidenced correlation between psychiatric disorders and overweight/obese (BMI>25) conditions, management and treatment. There are involved psychiatric diseases and temperamental traits. Our study, born from collaboration between Psychiatric and Plastic Surgery Clinic of Padua University, wants to detect psychiatric disorders, temperamental traits and body image perception in overweight-obese patients who seek surgical liposuction or abdominoplastic. We studied (...

ea0029p1190 | Obesity | ICEECE2012

Evaluation of success of an obesity consultation (2004–2010)

Domingues A. , Sequeira I. , Chambel P. , Lopes M Santana , Marcelino M. , Passos D. , Lopes L Oliveira , Goncalves N. , Jacome de Castro J.

Introduction: Moderate weight loss (5–10%) translates into health benefits, including improvement in cardiovascular risk. It is essential to assess the results and indicators of success in treating obesity, which is the objective of this work.Methods: A retrospective study of patients with overweight and obesity, followed in Nutrition consultation between 2004 and 2010. We analyzed biodemographic and anthropometric variables, consultation reason and...

ea0029p1191 | Obesity | ICEECE2012

Regulation of lipid droplet function in adipocytes: role of RAB18

Malagon M. , Rabanal Y. , Pulido M. , Almabouada F. , Garcia-Navarro S. , Gracia-Navarro F. , Vazquez-Martinez R.

Adipocytes are cells highly specialized in storing excess energy as neutral lipids in lipid droplets (LDs). These organelles act not only as mere fat reservoirs, but also as active modulators of lipid storage and mobilization in response to hormonal signals. This role is accomplished through a plethora of proteins associated with the LD surface that spatially and temporally coordinate lipid metabolism and traffic on demand. Recently, we have shown that the LD-associated protei...

ea0029p1192 | Obesity | ICEECE2012

Frequency of obesity, insulin resistance, cardio-metabolic risk factors and genetic variation in the genes encoding ADIPOQ and PPAR-γ in urban adults

Dzgoeva F. , Ilyin A. , Prokofjev S.

The aims of the study were to analyze the relationship among insulin resistance, obesity, dysglycemia, dyslipidemia and to evaluate the role of common variants in candidate genes for their ability to predict the metabolic syndrome and cardio-metabolic risk factors.Subjects and methods: 752 non-diabetic individuals (190 males and 562 females; age 35.05+4.47 years, BMI 26.72+5.92 kg/m2) participating in the study were genotyped for variants in p...

ea0029p1193 | Obesity | ICEECE2012

Melanocortin 4 receptor genetics in defining the morbid obesity in general population: common polymorphisms vs mutations

Klovins J. , Ignatovica V. , Schioth H. , Pirags V.

Since the discovery of melanocortin 4 receptor (MC4R) as an important regulator of food intake it has been recognised as one of the major monogenic factors of obesity. However the mutations identified are usually very rare, not found in control subjects from the background population and can explain only a minor part of heritability (2–3%). Here we explore the role of non-synonymous mutations identified by MC4R sequencing in cohort of 380 severely obese individuals (BMI 3...

ea0029p1194 | Obesity | ICEECE2012

Effects of bezafibrate treatment on pancreatic remodeling and insulin resistance in ovariectomized C57BL/6 mice fed high-fat diet

Faria T. , Ludgero-Correia A. , Aguilla M. , Mandarim-de-Lacerda C.

Introduction: Ovariectomized C57BL/6 mice are a good model to study the postmenopausal stage. It has been reported that high-fat diet (HFD) augments the body fat mass and insulin resistance (IR) in animal models. Goal of this study was to investigate the combined effects of ovariectomy (OVX) and HFD on insulin sensitivity and pancreatic remodeling in C57BL/6 mice treated with bezafibrate.Methods: Female C57BL/6 mice were subjected to surgical OVX and sur...

ea0029p1195 | Obesity | ICEECE2012

See OC5.1...

ea0029p1196 | Obesity | ICEECE2012

Prediabetes in adult GH deficiency is associated with a substantial reduction in serum and adipose tissue expression levels of zinc-α2-glycoprotein

Balaz M. , Ukropcova B. , Kurdiova T. , Penesova A. , Skyba P. , Vlcek M. , Belan V. , Klimes I. , Payer J. , Imrich R. , Smith S. , Tkacova R. , Gasperikova D. , Ukropec J.

Adult GH deficiency (GHD) is associated with prediabetes and low levels of GH are found in obesity. We hypothesized that zinc-α2-glycoprotein (ZAG), a novel adipokine reduced in obesity, is regulated by GH. ZAG serum and adipose tissue expression were measured in three study populations: i) cachectic (BMI=19.3±0.5 kg/m2), lean/overweight (BMI=26.0±0.5 kg/m2) and obese (BMI=36.0±1.6 kg/m2) patients with chronic obstructive pu...

ea0029p1197 | Obesity | ICEECE2012

Signalling properties of the melanocortin 3 receptor are modified by interaction with different ghrelin receptor variants in heterodimers

Piechowski C. , Krude H. , Gruters A. , Kleinau G. , Biebermann H.

It is a widely accepted concept that G-protein-coupled receptors (GPCRs) are able to form homo- and heterodimers. The physiological relevance of these interactions is of utmost importance.Recently, we demonstrated that due to co-expression of two key players of hypothalamic body weight regulation, the melanocortin 3 receptor (MC3R) and ghrelin receptor (GHSR), signalling of the MC3R is enhanced (hyperstimulation) as compared to activation of MC3R alone. ...

ea0029p1198 | Obesity | ICEECE2012

Metabolic signature of visceral and subcutaneous obese adipose tissue secretomes reveal altered tissular amino acid metabolism

Hanzu F. , Vinaixa M. , Papageorgiu K. , Delgado S. , Carmona F. , Correig X. , Goms R. , Vidal J.

Introduction: Obesity and its associated chronic comorbidities represent a worldwide health problem in epidemic increase. Recent researches have reported notable differences in the amino acids metabolism signatures between obese, mild insulin resistant but non-diabetic, and lean individuals. Moreover, amino acids metabolites are emerging as strong predictors in the development of diabetes in obesity. The contribution of the obese adipose tissue from various depots to the syste...

ea0029p1199 | Obesity | ICEECE2012

Time-course of changes of GLUT4 expression in insulin-sensitive tissues in an animal model of metabolic syndrome

Lehnen A. , Leguisamo N. , Borges J. , Machado U. , Okamoto M. , Markoski M. , Pinto G. , Meurer L. , Schaan B.

Background: Reduced GLUT4 expression in insulin-sensitive tissues, insulin resistance, inflammation, nonalcoholic steatohepatitis (NASH) and hypertension are pathophysiologic changes expected in metabolic syndrome animal models.Aims: To fully characterize the development and maintenance of metabolic syndrome features over time (GLUT4 in insulin-sensitive tissues, insulin resistance, inflammation, blood pressure and liver changes) in spontaneously hyperte...

ea0029p1200 | Obesity | ICEECE2012

Acute ghrelin effects on depressive-like behavior in bulbectomyced mice: a possible mechanism of action

Carlini V. , Martini A. , Kumar P. , Sawant R. , Rask-Andersen M. , Fredriksson R. , Rubiales de Barioglio S. , Schioth H. , Fiol de Cuneo M.

Ghrelin (Ghr) is an orexigenic peptide investigated by Lutter and col. 2008 for its potential role in the development of depressive symptoms induced by chronic stress, suggesting that Ghr defends against depressive-like symptoms. Rodent bilateral olfactory bulbectomy (OB) is an animal model that appears to fulfill many of the criteria required for the study of depression; hence, Ghr could be an alternative therapeutic tool for depression therapy. We study the possibility that ...

ea0029p1201 | Obesity | ICEECE2012

Association of the obesity/type 2 diabetes-related genetic variants with visceral fat acccumulation in obese, overweight and lean subjects

Wawrusiewicz-Kurylonek N. , Citko A. , Goscik J. , Maliszewska K. , Adamska E. , Gorska M. , Kretowski A.

Introduction: It has been recently suggested the genetic predisposition to obesity leads to increased risk of type 2 diabetes by its obesity predisposing effect. Surprisingly genetic loci that contribute to the development of obesity identified by genome-wide association studies (GWAS) account for only 2% of the variance in BMI. Visceral fat accumulation has an important role in increasing the risk of developing metabolic disorders, such as type 2 diabetes, dyslipidemia and CV...

ea0029p1202 | Obesity | ICEECE2012

See S70.5...

ea0029p1203 | Obesity | ICEECE2012

Loss of hypothalamic-pituitary-adrenal axis improves obese phenotype and restores hypothalamic agouti-related protein mRNA in leptin-deficient ob/ob mice

Nishiyama M. , Nakayama S. , Okazaki M. , Tsugita M. , Taguchi T. , Makino S. , Okada Y. , Tsuda M. , Iwasaki Y. , Terada Y.

Purpose: Glucocorticoid excess causes obesity and hyperphagia (e.g. Cushing syndrome), but the molecular mechanism of glucocorticoid-induced hyperphagia is not fully understood. To clarify this point, we investigated here the phenotype of leptin and Corticotropin-releasing hormone (CRH) double knockout mice (DKO).Methods: Leptin-deficient ob/ob mice were bred with CRH-deficient mice for generation of DKO mice. We examined body weight, food consumption an...

ea0029p1204 | Obesity | ICEECE2012

Different metabolic response to intagastric balloon treatment between non-morbid and morbid type of obesity

Nikolic M. , Mirosevic G. , Kruljac I. , Vrkljan M. , Supanc V. , Ljubicic N. , Duvnjak M. , Budimir I. , Pezo Nikolic B. , Sabol M. , Nikolac I. , Bekavac Beslin M.

BioEnterics Intragastric Balloon (BIB) is a non-invasive procedure which proved to be effective in short-term treatment of obesity. It’s effect on alterations in metabolic parameters is poorly understood. Since our previous study showed different ghrelin and leptin response between groups of morbidly (M) and non-morbidly (NM) patients after BIB placement, we aimed to investigate the alteration dynamics in metabolic parameters between these two groups.<p class="abstext...

ea0029p1205 | Obesity | ICEECE2012

Metabolic and hormonal consequences of circadian rhythm disruption in Bmal1 null mice

Kennaway D. , Boden M. , Varcoe T.

There is compelling evidence that shiftworkers are at risk of developing metabolic disturbances, diabetes and obesity as a result of disruption to circadian rhythms, but the mechanisms by which this may occur are not clear. The Bmal1 null mouse, which lacks both central and peripheral tissue rhythms, was used in this study to address the role of circadian rhythmicity in metabolic homeostasis.Male Bmal1 null mice and wild-type litter mates (2 month...

ea0029p1206 | Obesity | ICEECE2012

Aldosterone increases oxidative stress in differentiated, but not in undifferentiated 3T3-L1 adipocytes via activation of mineralocorticoid receptors

Limor R. , Uda M. , Knoll E. , Stern N.

In the cardiovascular system, aldosterone promotes inflammation, tissue remodeling and endothelial dysfunction. In diet-induced obesity, lipid accumulation involves acceleration of preadipocyte differentiation into mature adipocytes. Mutually exerted control mechanisms may exist between aldosterone secretion and fat: circulating aldosterone is increased in proportion to fat mass in humans and fat tissue expresses mineralocorticoid receptors (MR). Here we tested whether or not ...

ea0029p1207 | Obesity | ICEECE2012

Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit

Vignozzi L. , Morelli A. , Sarchielli E. , Comeglio P. , Filippi S. , Cellai I. , Maneschi E. , Serni S. , Gacci M. , Carini M. , Piccinni M. , Saad F. , Adorini L. , Vannelli G. , Maggi M.

Metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) are often associated. One of their common denominators is hypogonadism. However, testosterone supplementation is limited by concerns for potential prostatic side effects. The objective was to determine whether MetS-associated prostate alterations are prevented by testosterone supplementation. We used a previously described animal model of MetS, obtained by feeding male rabbits ...

ea0029p1208 | Obesity | ICEECE2012

GPR83 in interaction with GHSR and MC3R: lessons from in vitro studies

Muller A. , Muller T. , Kleinau G. , Gruters-Kieslich A. , Krude H. , Tschop M. , Biebermann H.

GPR83 is an orphan G-protein coupled receptor (GPCR) and is expressed in thymus and brain. Within the brain GPR83 mRNA is identified at high levels in the hypothalamic arcuate nucleus that is known to control for body weight regulation.Expression of GPR83 in the arcuate nucleus and the protection of GPR83 knock-out mice against diet induced obesity prompted us to investigate GPR83 signaling properties as well as potential interaction with the melanocorti...

ea0029p1209 | Obesity | ICEECE2012

Metabolic effects of 3-iodothyronamine in hepatocytes

Ghelardoni S. , Chiellini G. , Frascarelli S. , Zucchi R.

3-iodothyronamine (T1AM) is an endogenous thyroid hormone derivative which produces profound metabolic effects such as a shift in fuel substrate utilization from carbohydrates to lipid. Thus, in the present work we investigated the effects of T1AM on hepatic glucose metabolism.To assess metabolite release, human hepatocellular carcinoma cells (HepG2) were exposed for 4 h to different concentrations of exogenous T1AM (0.1, 1 and 10 μM) in glucose pro...

ea0029p1210 | Obesity | ICEECE2012

The adipokines TNF-α and IL6 predicted incident cancer development in a Chinese community-based cohort

Yeung C. , Tso A. , Xu A. , Lam T. , Lo S. , Fong C. , Wat N. , Woo J. , Cheung B. , Lam K.

Adipose tissue is recognized as an active endocrine organ. Cytokines released from adipocytes induce chronic low-grade inflammation, which is linked to the development of cardiovascular diseases and malignancy.In this study, we examined the relationship between baseline adipokines level and incident cancer risk in a community-based cohort of Chinese subjects. Subjects were recruited from the Hong Kong Cardiovascular Risk Factors Prevalence Study 2(CRISPS 2) cohort. Those with ...

ea0029p1211 | Obesity | ICEECE2012

ASP injection promotes macrophage infiltration and M1 polarization in obese adipose tissue

Fisette A. , Oikonomopoulou K. , Munkonda M. , Lambris J. , Cianflone K.

Recent integrative approaches showed that adipose tissue play a major endocrine role. Molecules secreted by the expanding adipose tissue modulate systemic inflammation and contribute heavily to the pathology of obesity co-morbidities. Acylation stimulating protein (ASP) is an adipokine that has been linked with energy metabolism and lipid metabolism. The ASP receptor, C5L2, is widespread within tissues in the organism, yet ASP effects outside the adipose tissue remain explored...

ea0029p1212 | Obesity | ICEECE2012

Regulation of adiponectin by free fatty acids in lean and obese subjects

Kim K. , Nam S. , Ahn C. , Yu J. , Kim K. , Cha B. , Lee H. , Richelsen B.

Objective: To evaluate the effects of free fatty acids (FFAs) on the regulation of plasma and adipose tissue mRNA adiponectin expression in lean and obese subjects.Methods: Seven obese men (31.3±1.1 kg/m2) and eight lean men (21.3±0.4 kg/m2) were studied. Subjects received an Intralipid 20% infusion over 180-min with sodium heparin. Blood sampling and abdominal subcutaneous adipose tissue biopsy were taken before and after...

ea0029p1213 | Obesity | ICEECE2012

SUR2a gene is upregulated in skeletal muscle insulin resistance of obese rats: correlation with GLUT4 gene

Felipe dos Santos Ferreira Marques M. , Cristina Tieko Mori R. , Mitiko Okamoto M. , Fabres Machado U.

Objective: The aim of this study was to investigate whether SUR2A (sulfonylurea receptor type 2A, ABCC9) MEF2a (myocyte enhancer factor-2a) and HIF1a (Hypoxia-inducible factor-1) can influence glucose uptake in oxidative muscle soleus by regulating GLUT4 expression.Methods: Insulin resistance was induced in male Wistar rats by inducing obesity with monosodium glutamate (MSG). At the age 3 months, half control and MSG-treated animals started receiving 0.1...

ea0029p1214 | Obesity | ICEECE2012

Circulating oxidized LDL in patients with visceral obesity

Giestas A. , Palma I. , Oliveira J. , Ferreira M. , Ramos H.

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL ...

ea0029p1215 | Obesity | ICEECE2012

Leptin modulates brain neural activity associated with feeding behavior in patients with lipodystrophy

Aotani D. , Ebihara K. , Sawamoto N. , Kusakabe T. , Aizawa-Abe M. , Kataoka S. , Sakai T. , Ebihara C. , Fujikura J. , Hosoda K. , Fukuyama H. , Nakao K.

Introduction: Markedly decreased plasma leptin concentrations in patients with lipodystrophy commonly lead to overeating. Leptin-replacement therapy improves feeding behavior in these patients. The aim of the present study is to clarify neural networks influenced by leptin signals for appetite regulation in the patients with lipodystrophy.Methods: We measured neural responses to visual food stimuli by use of functional magnetic resonance imaging (fMRI) a...

ea0029p1216 | Obesity | ICEECE2012

Age variations in adiposity and body fat composition among spanish women

Pedrera-Zamorano J. , Roncero-Martin R. , Calderon-Garcia J. , Rodriguez-Dominguez T. , Rey-Sanchez P. , Canal-Macias M.

Objective: To characterize the age variations of fatness pattern in Spanish womenResearch methods and procedures:: A cross-sectional study of 2226 Spanish women (16 to 74 years old) women was undertaken to study age variations in adiposity, body composition, obesity and central fat distribution. The women were divided into seven groups: Group I (G I, 15–24 years), Group II (G II, 25–34 years), Group III (G III, 35–44 years), Group IV (G IV...

ea0029p1217 | Obesity | ICEECE2012

Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in chinese young adults

Shi J. , Hong J. , Gu W. , Zhang Y. , Cui B. , Yan Q. , Wang W. , Ning G.

Clear evidence on the specific impact of fatty acid binding proteins (FABPs) on cell biology and lipid metabolism in complex systems had been lacking until FABP-deficient mice models were created. Surprisingly, no change in appearance, gross morphology or viability was observed in FABP1-deficient mice. However, metabolic parameters in mice upon exposure to high-fat/cholesterol diet differed between studies. Therefore, liver fatty acid-binding protein (also called FABP1) plays ...

ea0029p1218 | Obesity | ICEECE2012

Gender differences in measurements of total and regional body composition in preschool children

Dahlgren J. , Karlsson A. , Kullberg J.

Background: Generally, abdominal adipose tissue correlates stronger to decreased insulin sensitivity than what BMI does. In adults, males have more visceral adipose tissue (VAT) and less subcutaneous adipose tissue (SAT) than females. Comparisons between measures of body composition from magnetic resonance imaging (MRI), dual x-ray absorptiometry (DXA) and anthropometry have been studied previously; however not in preschool children.Aim: This study compa...

ea0029p1219 | Obesity | ICEECE2012

Comparison of serum high-molecular-weight (HMW) adiponectin and homeostasis model assessment of insulin resistance (HOMA-IR) as markers for metabolic syndrome (MS) in estonian adult population

Eglit T. , Rajasalu T. , Ringmets I. , Lember M.

Introduction: The MS is a cluster of metabolic risk factors which are closely associated with insulin resistance and hypoadiponectinemia. The HMW adiponectin has been acknowledged as a predictive marker for MS. The prevalence of MS increases worldwide. Recently, the prevalence of MS among Estonian adults was estimated to be 26%. In the current study, we aimed to compare the utility of HMW adiponectin and HOMA-IR for the identification of MS.Methods: Our ...

ea0029p1220 | Obesity | ICEECE2012

Local inflammatory response in adipose tissue dysfunction

Cantini G. , Francalanci M. , Di Franco A. , Baglioni S. , Poli G. , Samavat J. , Querci V. , Liotta F. , Perigli G. , Lucchese M. , Forti G. , Luconi M.

Chronic low-grade inflammatory condition is associated with metabolic pathologies such as obesity. However, the role exerted by local inflammation occurring in different fat depots, such as subcutaneous (SAT) versus visceral (VAT) adipose tissue (AT), is still under evaluation. Aim of the present study was to characterize the inflammatory state in adipose tissue of obese (OB: n=58, mean±S.D. BMI=47±9) vs normoweight (NOR: n=28, mean±...

ea0029p1221 | Obesity | ICEECE2012

Effect of two different types of bariatric surgery on metabolic profile in obese type 2 diabetic women

Bradnova O. , Halkova T. , Vcelak J. , Vankova M. , Dvorakova K. , Grimmichova T. , Stanicka S. , Sramkova P. , Dolezalova K. , Fried M. , Kyrou I. , Hill M. , Hainer V. , Bendlova B. , McTernan P. , Kumar S. , Vrbikova J.

Introduction: Bariatric surgery has been proved to be the most effective treatment for type 2 diabetes mellitus (T2D). Post-operative improvement in insulin sensitivity seems to be partly independent of weight loss and may be affected by changes in incretin secretion. Previous studies reported that the glucose-dependent insulinotropic polypeptide (GIP)-induced enhancement of fat stores may lead to increased insulin resistance. We determinated the effect of laparoscopic adjusta...

ea0029p1222 | Obesity | ICEECE2012

Visceral-to-subcutaneous fat ratio using fat measurement CT is essential for the assessment of risk for diabetes, hypertension and early atherosclerosis

Kim H. , Bae S. , Kim E. , Kim C.

Background and aims: Obesity is an important risk factor for metabolic and cardiovascular disease. Although body mass index (BMI) and waist circumference are convenient and economic methods for assessment of obesity, those could not fully reflect risk for diabetes, hypertension and early atherosclerosis.Materials and methods: We cross-sectionally analyzed anthropometric and laboratory data of 868 Korean adults (age 53.2±11.2 years) which were record...

ea0029p1223 | Obesity | ICEECE2012

Effect of obesity on vitamin d and parathormone levels

Baser H. , Tuzun D. , Saglam F. , Caner S. , Ersoy R. , Cakir B.

Aim: In this study our aim was to investigate the relationship between obesity and vitamin D and hyperparathyroidism.Material and Method: 127 healthy persons included in this study. Study group were divided into four groups according to body mass index (BMI). Group 1 (n=35) BMI 18.5–24.9 kg/m2, Group 2 (n=35) BMI 25–29.9 kg/m2, Group 3 (n=35) BMI 3.0–34.9 kg/m2, Group 4 (n=22) BM...

ea0029p1224 | Obesity | ICEECE2012

Limited effects of leptin and adiponectin on proliferation and protein metabolism of porcine myoblasts under serum-free culture conditions

Will K. , Kalbe C. , Kuzinski J. , Losel D. , Viergutz T. , Palin M. , Rehfeldt C.

Cross-talk between adipose tissue and skeletal muscle via endocrine and paracrine mechanisms may be important in determining nutrient partitioning and lean-to-fat ratio. Such interactions could be mediated in part by adipokines secreted from adipose tissue. Little is known, however, about the role of adipokines in influencing growth and development of skeletal muscle.The aim of this study was to determine the direct effects of leptin and adiponectin on t...

ea0029p1225 | Obesity | ICEECE2012

Effect of secreted frizzled-related protein 2 (sFRP2) from adipose tissue on pancreatic cell function

Bujalska I. , Rabbitt E. , Gathercole L. , Stewart P.

The detrimental effect of excessive obesity on insulin resistance is well established. The expansion of adipose tissue is dependent on two processes: adipogenesis and angiogenesis and the Wnt signalling pathway has been reported to affect both. In adipose tissue the Wnt signalling pathway functions in a converse manner: increasing commitment of mesenchymal stem cells to preadipocytes and inhibiting differentiation of preadipocytes to mature adipocytes by decreasing expression ...

ea0029p1226 | Obesity | ICEECE2012

Curcumin inhibits the upregulation of cathepsin L by palmitate in fat

Yoo J. , Lee Y. , Kim J. , Kang S. , Nam J. , Park J. , Ahn C. , Song Y. , Kim K.

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

ea0029p1227 | Obesity | ICEECE2012

Preventing childhood obesity by community based intervention approaches

Borys J. , du Plessis H. , Walter L. , Harper P.

Introduction: EPODE is a coordinated, capacity-building approach for communities to implement effective and sustainable strategies to prevent childhood obesity.Methods: At central level, a coordination team using social marketing and organizational techniques trains and coaches a local project manager nominated in each EPODE town by the local authorities. The local project manager is also provided with tools to mobilize local stakeholders through a local...

ea0029p1228 | Obesity | ICEECE2012

Reduction of body weight and waist circumference after long-term treatment of hypogonadal men with testosterone undecanoate

Saad F. , Haider A. , Gooren L.

Introduction: Obesity is associated with reduced testosterone, and low testosterone induces weight gain. This study analysed the effects of normalization of serum testosterone in mainly elderly, hypogonadal men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤ 3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 6...

ea0029p1229 | Obesity | ICEECE2012

Connection of adipocitokines and inflammatory markers in obese woman: influence of body weight reduction

Velojic Golubovic M. , Dimic D. , Stojic D. , Radenkovic S. , Antic S.

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have posi...

ea0029p1230 | Obesity | ICEECE2012

Proteomic analysis identifies adiponectin as a key plasma protein associated to vitamin D deficiency in pediatric obesity

Walker G. , Prodam F. , Ricotti R. , Riccomagno S. , Moia S. , Roccio M. , Bellone S. , Genoni G. , Petri A. , Bona G.

Key circulating molecules that link the emerging role of vitamin-D to pediatric obesity and its co-morbidities remain unclear. To identify potentially involved regulators, this study analyzed plasma proteoma from obese children dichotomized by 25OH-vitamin D (25OHD) levels and upon vitamin-D3 therapy in 25OHD deficient subjects.A total of 42 obese children (M/F=18/24, bmi>95° centile) were selected and divided according to 25OHD levels into defi...

ea0029p1231 | Obesity | ICEECE2012

Plasma adipokines and improvement of insulin sensitivity during multi-phase long-term dietary intervention

Stich V. , Rossmeiselova L. , Malisova L. , Siklova M.

Context: Weight-reducing dietary intervention (DI) promotes an improvement in insulin sensitivity (IS) since early stage of the diet. The diet-induced changes of plasma levels of cytokines and chemokines that are expressed in adipose tissue (adipokines) have been suggested to play a role.Aim: To examine relationship between the diet-induced changes of IS (assessed using homeostatic model assessment of insulin resistance (HOMA-IR)) and those of plasma adi...

ea0029p1232 | Obesity | ICEECE2012

Obesity the first year of life: influence of glycemia at pregnancy, breastfeeding and sleep

Davalos-Perez A. , Garay-Sevilla M. , Malacara J.

Introduction: Pre- and postnatal factors have an influence on obesity the first year of life. Among them maternal glucose levels, breastfeeding, ablactation and recently sleep duration are under study in diverse populations.Methods: In a prospective study, we recruited 139 pregnant women and obtained fasting and post-load (75 g) glucose levels. We studied children robustness (waist girth/height) at 6 months and one year of age, and the influence of alter...

ea0029p1233 | Obesity | ICEECE2012

Anthropometric, hormonal and nutritional correlates of epicardial fat in obese women

Vicennati V. , Cavazza C. , Garelli S. , Pizzi C. , Bugiardini R. , Rinaldi E. , Pagotto U. , Pasquali R.

Background and aim: Epicardial fat (EF) is a metabolically active organ as well as visceral fat (VF). EF has been recognized as a potential additional marker of cardiac risk in obesity and type 2 diabetes. This study wants to assess the relation between EF and VF and the correlation with nutritional and hormonal parameters.Material and Methods: Fifty-nine overweight/obese women were enrolled in the study. All women underwent anthropometric measurements, ...

ea0029p1234 | Obesity | ICEECE2012

How informative is visceral fat measurement by bioelectrical impedance?

Mousa U. , Kut A. , Bozkus Y. , Cicek Demir C. , Anil C. , Bascil Tutuncu N.

Although obesity is a powerful risk factor for developing metabolic syndrome (MetS), it is not present in all obese individuals. Increased visceral adipose tissue is the hallmark of this syndrome. In this cross sectional survey abdominal bioelectrical impedence was used to measure the visceral adipose tissue (VAT) and trunk fat percentages (TF%) in participants. A total of 286 patients (196 female and 90 males) were enrolled in the study. In both sexes VAT was significantly po...

ea0029p1235 | Obesity | ICEECE2012

A selective androgen receptor modulator, S42 possesses beneficial metabolic effects

Murase K. , Min L. , Tanaka T. , Akehi Y. , Nomiyama T. , Nawata H. , Yanase T.

Androgen is an important factor for determining body composition in males. Abdominal obesity is inversely correlated with serum androgen levels in men. Androgen receptor (AR) null male mice revealed late-onset visceral obesity, accompanying energy balance abnormality. We previously reported a novel synthetic steroid, S42 as a promising candidate of a selective androgen receptor modulator (SARM). When orchiectomized Sprague-Dawley rats were administered with S42 for 3 weeks, th...

ea0029p1236 | Obesity | ICEECE2012

Effect of orlistat in Russian adolescents with metabolic syndrome: a randomized controlled trial

Melnichenko G. , Peterkova V. , Savelyeva L. , Zubkova N. , Vasyukova O. , Kosygina A.

Background: Metabolic syndrome (MS) in children is associated with future risk of developing type 2 diabetes mellitus and cardiovascular disease in adults. In the pediatric population lifestyle interventions alone are often insufficient.Objective: To evaluate the efficacy and safety of orlistat in obese adolescents with MS.Design: A 6 month open, comparative, randomized study of 60 obese adolescents (aged 12–17 years; mean bod...

ea0029p1237 | Obesity | ICEECE2012

Extreme obesity partly blunts the discriminative metabolic effects of polycystic ovary syndrome (PCOS)

Marzullo P. , Brunani A. , Uccelli E. , Maestrini S. , Mai S. , Berselli M. , Rinaldi M. , Guzzaloni G. , Tagliaferri A. , Aimaretti G. , Liuzzi A.

The epidemic of obesity and diabetes is increased worldwide, and both are more prevalent in PCOS than non-PCOS ovulatory women. In the general population, the risk of cardiovascular mortality is at least doubled in women with extreme obesity (BMI>40 kg/m2). To explore if PCOS adds further metabolic detriment to extreme obesity, this prospective study compared the metabolic profiles, OGTT-derived insulin sensitivity and body composition between 30 adult PCOS and ...

ea0029p1238 | Obesity | ICEECE2012

Low dose 3-iodothyronamine increases acute lipolysis followed by protein catabolism in mouse

Chiellini G. , Assadi-Porter F. , Haviland J. , Butz D. , Reiland H. , Ghelardoni S. , Tonelli M. , Scanlan T. , Zucchi R.

3-iodothyronamine (T1AM) is a recently discovered fast-acting thyroid hormone derivative. To date, the physiological effects of endogenousT1AM remain elusive, although there is increasing interest in its physiological function and pharmaceutical potential due to the role it plays in lipid and glucose metabolism (1.2).The present study monitored the effect of weeklong, daily, low dose T1AM administration on weight and metabolism in spontaneously...

ea0029p1239 | Obesity | ICEECE2012

Lipid metabolism is impaired in obesity/diabetes model mice

Kobayashi Y. , Tagawa N.

A new genetic animal model of type 2 diabetes, the Tsumura Suzuki Obese Diabetes (TSOD) mouse, has been developed in 1999. The TSOD mouse develops a moderate degree of obesity and diabetes. The aim of this study was to investigate the potential association of impairment of lipolysis and lipid metabolism on the development of obesity and diabetes in TSOD mice.Methods: Three month old TSOD and the age-matched control (TSNO: Tsumura Suzuki Non-Obesity) male...

ea0029p1240 | Obesity | ICEECE2012

Comparing effects of lifestyle modification-induced weight loss on androgen levels, endothelial, sexual and urinary function, and quality of life in obese men with and without androgen deficiency

Khoo J. , Chen R. , Cho L. , Tan E. , Tay T. , Au V. , Soh S. , Ng B.

Introduction: Androgen deficiency (AD) is associated with endothelial and erectile dysfunction, lower urinary tract symptoms (LUTS) and reduced quality of life (QoL) in obesity. We aimed to compare effects of weight loss induced by lifestyle modification on endothelial and erectile function, LUTS and QoL in obese men with and without AD.Methods: abdominally obese Asian (body mass index≥30 kg/m2, waist circumference [WC] ≧ 90 cm) m...

ea0029p1241 | Obesity | ICEECE2012

How safe is the use of herbal weight-loss products sold over the Internet?

Ozdemir B. , Sahin I. , Kapucu H. , Celbis O. , Karakoc Y. , Erdogan S. , Onal Y.

Aim/background: The consumption of herbal weight-loss products sold over the Internet has rapidly increased, but the safety profile of these products has not been well known yet. Likewise, the declared ingredients in these products could be different than the marketed contents.Material and Methods: Nine different herbal weight-loss products sold over the Internet were included. The content of each product were evaluated in the Laboratory of Forensic Medi...

ea0029p1242 | Obesity | ICEECE2012

Obesity related comorbidities 2 years following bariatric surgery in a group of 215 German subjects

Sauer N. , Wienecke J. , Schulze zur Wiesch C. , Reining F. , Wolter S. , Dupree A. , Mann O. , Aberle J.

Background: Bariatric surgery has shown to effectively reduce body weight and the prevalence of obesity associated comorbidities. However, especially data concerning diabetes is still conflicting. Also the benefit of surgical therapy varies strongly depending on individual patient characteristics.Methods: Therefore we intended to investigate a heterogeneous group of obese patients (n=215) undergoing bariatric surgery in terms of related comorbidit...

ea0029p1243 | Obesity | ICEECE2012

Changes in gut hormone levels and glucose homeostasis in obese patients during the first year after laparoscopic sleeve gastrectomy

Papamargaritis D. , le Roux C. , Sioka E. , Vincent R. , Kapelouzou A. , Tzovaras G. , Koukoulis G. , Zacharoulis D.

Background: Changes in gut hormone levels after laparoscopic sleeve gastrectomy (LSG) has been proposed as a possible mechanism that explains the long-term weight loss and the improvement in glucose homeostasis after bariatric operations. In this prospective study we evaluated the changes in the fasting and postprandial levels of glucagon like peptide-1 (GLP-1), peptide YY (PYY), insulin and glucose during the first postoperative year after LSG.Methods: ...

ea0029p1244 | Obesity | ICEECE2012

Changes of peripheral α-melanocortin stimulating hormone (α-MSH) in childhood craniopharyngioma patients in comparison with other forms of childhood obesity

Muller H. , Enriori P. , Gebhardt U. , Hinney A. , Hebebrandt J. , Reinehr T. , Cowley M. , Roth C.

Objective: Relationships of blood circulating melanocortins to childhood obesity are not well established. We evaluated serum α-melanocyte stimulating hormone (α-MSH) in lean children and different study groups of childhood obesity.Methods: We examined serum α-MSH in 52 otherwise healthy children with childhood obesity (Ob, mean age 11 years, 32 girls / 20 boys), 27 normal-weight children of same age, 7 additional obese patients with reduc...

ea0029p1245 | Obesity | ICEECE2012

Measurement of serum high-molecular-weight (HMW) adiponectin level using recently-developed chemiluminescence enzyme immunoassay (CLEIA) at health check-up

Hirose H. , Kawabe H. , Saito I.

Aim: A chemiluminescence enzyme immunoassay (CLEIA) for high-molecular-weight adiponectin (HMW-ADPN) was recently developed, and has been shown to be faster, more accurate and less expensive than conventional ELISA. In this study, we investigated the relationships between metabolic parameters and the HMW-ADPN level measured by CLEIA in a health check-up setting.Methods: Informed consent was obtained from 1036 male and 416 female Japanese, 40 to 71 years ...

ea0029p1246 | Obesity | ICEECE2012

Anti-inflammatory effects of full-length and globular protein fragments of the new adipokine CTRP-3

Schmid A. , Kopp A. , Buechler C. , Schaeffler A.

Introduction: C1q/TNF-related protein-3 (CTRP-3) is a newly discovered adipokine with anti-inflammatory impact on monocytes by down-regulation of pro-inflammatory cytokines, e.g. interleukine 6 (IL6) and tumor necrosis factor alpha (TNF-alpha), in both adipocytes and monocytes. So far it is unclear which kind of interactions and molecular mechanisms are underlying the observed effects. Our aim is to characterize the differential effects of the globular and the collagenous doma...

ea0029p1247 | Obesity | ICEECE2012

Cholinergic and purinergic markers are increased in lymphocytes of patients with Metabolic Syndrome

De Bona K. , Bonfanti G. , Cargnelutti L. , Bittencourt P. , da Silva P. , Ceolin R. , Pimentel V. , Moretto M.

Metabolic syndrome (MetS) is a condition characterized by abdominal obesity, insulin resistance, dyslipidaemia and hypertension, that is associated with cardiovascular disease and inflammatory metabolic disorders. This study aimed to ascertain the effect of selected parameters of purinergic and cholinergic systems in lymphocytes of MetS patients. The adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV) and acetylcholinesterase (AChE) activities, as well as γ-glutam...

ea0029p1248 | Obesity | ICEECE2012

Association between osteocalcin and insulin resistance in obese women

Sumarac-Dumanovic M. , Milin J. , Stamenkovic-Pejkovic D. , Jeremic D. , Cvijovic G. , Zoric S. , Jorga J. , Micic D.

Introduction: Recent animal’s studies suggest that osteocalcin have influence on beta cell proliferation, insulin secretion and insulin sensitivity. Osteoblasts appear to regulate energy expenditure by acting on adipocytes and pancreatic islet cells via osteocalcin, a 49-residue polypeptide. In turn, adipose tissue may also influence bone remodeling by regulating the activity of osteoblasts through adipokines, including leptin and adiponectin. Some of the complex mechanis...

ea0029p1249 | Obesity | ICEECE2012

Serum leptin levels in patients with type 1 gaucher disease

Petakov M. , Suvajdzic N. , Lakocevic M. , Petakov M. , Ognjanovic S. , Isailovic T. , Macut D. , Djurovic M. , Elezovic V. , Popovic B. , Bozic I. , Bogavac T. , Damjanovic S.

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

ea0029p1250 | Obesity | ICEECE2012

Relationship between neck circumference and cardiometabolic parameters in non-obese brazilian adult population

Sales A. , Castelo M. , Ponte C. , Fernandes V. , Mendes P. , de Mesquita S. , Montenegro A. , Quidute A. , Negrato C. , Montenegro Jr R.

Recent studies have suggested that upper body adiposity is associated with major cardiovascular risk (CVR). However most of them were conducted in obese patients. This study aimed to evaluate the relationship of neck circumference (NC) in a non-obese Brazilian adult population, considering that it would be a simple and time-saving measurement to identify patients with worse cardiometabolic profile. We evaluated 279 non-obese Brazilian adults [86 men (♂), 193 women (&#979...

ea0029p1251 | Obesity | ICEECE2012

A different method in obesity treatment; external gastric balloon

Basak M. , Gozden H. , Aktas H. , Saler T.

Obesity is an important and chronic disease. It is known that obesity closely related with many chronic disorders.Also it is known as a result of serious morbidity and mortality. For treatment of obesity, dietary, medicine, egzercise and surgery should be useful but they have also some adverse effects and surgery should be cause of mortality and severe morbidity.Our method of EGB is completely non-invasive and we investigated the efficacy of obesity trea...

ea0029p1252 | Obesity | ICEECE2012

Hyperuricemia and components of metabolic syndrome among patients of different age

Povoroznyuk V. , Dubetska G.

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia among women and men of different age and their relation with some components of metabolic syndrome.Object of research: Women (n=450) and men (n=120), age of examined patients was from 20 to 89 years old. They were divided into the following groups: I group (BMI=18.5–24.9), II group (BMI=25.0–29.9), III group (BMI=30.0–34.9), IV group (...

ea0029p1253 | Obesity | ICEECE2012

The comparison of obesity treatment with intragastric balloon and bihevioral-cognitive approach

Klobucar Majanovic S. , Ruzic A. , Pokrajac Bulian A. , Licul V. , Turk T. , Crncevic Orlic Z. , Persic V. , Stimac D.

Objectives: To compare obesity treatment with intragastric balloon (BIB – Bioenterics intragastric balloon) and behavioral-cognitive approach in order to determine the effectivness of these two methods in inducing weight loss, their impact on different features of metabolic syndrome and liver enzymes profile, and finally to evaluate patients attitudes and expectations regarding weight loss together with motivation and readiness to change their behaviour in order to lose w...

ea0029p1254 | Obesity | ICEECE2012

Therapeutic efficacy of obesity treatment methods in teenagers

Viazava L. , Solntsava A. , Sukalo A.

Aim: The aim of our study was to evaluate the effectiveness of the body mass (BM) decreasing program in pubertal children with alimentary obesity during the year of observation.Materials and methods: Anthropometric changes in body mass index (BMI) and waist circumflex (WC) were analyzed every 1, 3, 6 and 12 months in 100 obese pubertal children (boys/girls =50/50) with different treatment methods: the 1st group – only reducing diet (b/g=30/30), the ...

ea0029p1255 | Obesity | ICEECE2012

Insulin and C-peptide response after a test meal in obese patients before and 5 days after bariatric gastric by pass surgery

Micic D. , Bajec D. , Polovina S. , Radenkovic D. , Sumarac-Dumanovic M. , Gregoric P. , Cvijovic G. , Ignjatovic S. , Dajak M. , Micic D. , Jeremic D.

Different hypothesis exist about the mechanism of glycose control after bariatric surgery involving intestinal bypass. The aim of our study was to determine the insulin and C-peptide response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric by pass surgery. Glycaemia (mmol/l; glucose oxidase), insulin (ECLIA, Roche Diagnostics, pmol/l) and C-peptide (ECLIA, Roche Diagnostics, pmol/l) were det...

ea0029p1256 | Obesity | ICEECE2012

The oxidative stress parameters within the context of metabolic syndrome evolution in men

Tsygankova O. , Platonov D. , Bondareva Z. , Latyntseva L.

Introduction: The aim of study was to assess diversity of oxidative stress as a dynamic process throughout metabolic syndrome (MS) continuum ending with coronary heart disease (CHD) or diabetes mellitus (DM).Methods: Main group (MG) of 154 men aged 25–60 years with abdominal obesity (waist circumference above 94 cm) was examined in comparison to 30 healthy men of similar age. In MG 28 men were diagnosed with CHD, 24 – with DM. Fasting glucose (...

ea0029p1257 | Obesity | ICEECE2012

Relationships between metabolic syndrome components and bone mineral density in ukrainian postmenopausal women

Martynyuk L. Povoroznyuk V. , Martynyuk L.

Objective: Postmenopausal period in women is associated with the accelerated bone loss, contributing to the development of osteoporosis, fractures and decreasing of quality and duration of life. The metabolic syndrome (MS), which includes obesity, dyslipidemia, hyperglycemia, and hypertension, is a major public health problem also.The purpose of our study was to reveal associations between tissue body composition, compounds of MS and BMD in postmenopausa...

ea0029p1258 | Obesity | ICEECE2012

Allograft inflammatory factor 1 is a new human adipokine regulating adipose inflammation

Ekberg K. , Lorente-Cebrian S. , Arner P. , Dahlman I.

Introduction: Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene which may influence the function of white adipose tissue (WAT).Objective: To study the role of AIF-1 in human WAT.Design and main outcome measures: mRNA expression and WAT secretion of AIF-1 was determined in subcutaneous and visceral WAT from non-obese subjects. Differentiated human adipocytes were treated with recombinant AIF-1 in vitro.<p...

ea0029p1259 | Obesity | ICEECE2012

Body composition and radiation exposure in the Adult Health Study

Tatsukawa Y. , Misumi M. , Yamada M. , Nakanishi S. , Fujiwara S.

Background: Several studies have shown that medical radiation exposure in childhood might cause alteration in body composition, although all such studies were of a small scale and individual radiation doses were not estimated.Objective: The aim of this cross-sectional study was to evaluate whether or not atomic-bomb (A-bomb) radiation exposure is associated with alteration of body composition using dual energy X-ray absorptiometry (DXA).<p class="abs...

ea0029p1260 | Obesity | ICEECE2012

Usefulness of preoperativee exenatide in control of risk factors for bariatric surgery on type 2 diabetic patients with morbid obesity

Martin-Hernandez T. , Clara G. , Gonzalez N. , Martin V. , Torres A. , Gentil A. , Morales A.

Introduction: The aim of this study was to evaluate effects on glycemic control, body weight and cardiovascular risk factors (BP, lipids and Epworth sleepiness scale) in diabetic patients with morbid obesity treated with exenatide.Material and methods: We studied consecutively 21 T2DM patients, all of them treated with metformin full dosage and insufficient metabolic control referred to our clinic for preoperative control of bariatric surgery. Twelve of ...

ea0029p1261 | Obesity | ICEECE2012

Preclinical anti-obesity activity and safety assessment of a novel drug affecting CB1 receptor

Dugina J. , Kheifets I. , Bugaeva L. , Spasov A. , Vorobyova T. , Epstein O.

Dietressa is a novel drug for the treatment of obesity containing ultra low doses of antibodies to CB1 receptor. A number of new drugs are now at different stages of development, and cannabinoid receptor type 1 is one of the most challenging targets for obesity treatment. However, there are some safety concerns over CB1 receptor antagonists, especially their psychological adverse effects.The study included two parts: the first one was performed on 33 C57...

ea0029p1262 | Obesity | ICEECE2012

Green tea consumption, weight loss and resting energy expenditure

Aksoy D. , Cinar N. , Aydin K. , Mercanligil M. , Yildiz B. , Bayraktar M. , Usman A.

Introduction: Green tea consumption has been reported to be associated with weight loss although the results of the studies are inconclusive and potential underlying mechanism is not yet clear. We aimed to evaluate the effect of green tea extract on weight loss, body composition and resting energy expenditure in obesity.Methods: Twenty-nine obese patients (body mass index (BMI) >30 kg/m2) were included in the study. Weight, BMI, waist circ...

ea0029p1263 | Obesity | ICEECE2012

Waist and abdominal circumference in seven years old children: relationship between methods

Braunerova R. , Riedlova J. , Vignerova J. , Hill M. , KuneSova M.

Introduction: Waist circumference serves as a key indicator of abdominal obesity and predictor of cardiovascular and metabolic risk even in children. Under the current WHO standard methodology, waist circumference is measured midway between the lowest rib and the iliac crest. However, comparison of current and earlier data is complicated as different waist circumference measurement methodologies have been used in the past. For instance, previous Czech studies commonly worked w...

ea0029p1264 | Obesity | ICEECE2012

Bariatric surgery in men: effects on gonadal hormones, body composition, glucose, lipid and bone metabolism

Aarts E. , van Wageningen B. , Loves S. , Janssen I. , Berends F. , Sweep F. , de Boer H.

Background: Obesity-related, isolated hypogonadotropic hypogonadism (IHH) occurs in more then 40% of morbidly obese men.Hypothesis: IHH and prolonged persistence of low testosterone levels after bariatric procedures may reduce the beneficial effects of surgery.Objective: To evaluate the impact of IHH on the results of bariatric surgery.Patients and methods: observational study with measurement of gonadal horm...

ea0029p1265 | Obesity | ICEECE2012

Outcome of obese adults after laparoscopic adjustable gastric banding: a retrospective follow-up study

Evora T. , Mirasol R. , Oliveros E. , Dineros H.

Background: Laparoscopic adjustable gastric banding (LAGB) is now the most common surgical treatment for obesity. However, few data exist on the outcome of LAGB in our setting.Objective: This study aimed to assess the outcome of obese adults after LAGB in terms of weight loss.Methods: We conducted a retrospective review of records of all patients who underwent LAGB between January 2004 and December 2009 at St Luke’s Medical Ce...

ea0029p1266 | Obesity | ICEECE2012

Proteomic analysis of adipose tissue in health and disease

Malagon M. , Guzman-Ruiz R. , Diaz-Ruiz A. , Vazquez-Martinez R. , Lopez-Miranda J. , Tinahones F. , Peinado-Mena J.

Adipose tissue is a highly active metabolic organ which, together with its role as an energy storage depot, produces a wide variety of bioactive molecules (i.e. adipokines) with important roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. Alterations in lipid metabolism and/or in adipokine production associated to the excess of adipose tissue that defines obesity or to adipose tissue deficiency, as occurs in lipodystrophy, are linked to in...

ea0029p1267 | Obesity | ICEECE2012

Is fat mass index superior to total fat mass percentage in predicting the metabolic syndrome?

Bozkus Y. , Kut A. , Mousa U. , Demir C. , Anil C. , Tutuncu N.

Aim: We aimed to compare the cut off values, defined to express the excess total body fat (TBF) percentange and increased fat mass index (FMI) as predictors of metabolic syndrome (MS).Subjects and methods: A total of 162 obese (body mass index (BMI) >30 kg/m2) subjects’ TBF were measured by ‘Tanita TBF 300 Body Composition Analyzer’. Patients were divided into two groups called normal obese (NO) and fatty obese (FO) accordin...

ea0029p1268 | Obesity | ICEECE2012

Relationships between hypovitaminosis D, low-grade chronic inflammation, and leptin-to-adiponectin ratio in PCOS: is this a matter of fatness?

Pizza G. , Di Somma C. , Orio F. , Valentino R. , Nedi V. , Brancato V. , Lombardi G. , Colao A. , Savastano S.

Introduction: Several cross-sectional studies evidence the association between hypovitaminosis D, obesity, insulin resistance (IR), and polycystic ovary syndrome (PCOS) cohorts, although the role of obesity per se is still debatable. Increased leptin-to-adiponectin ratio (L/A) and low-grade chronic inflammation markers, both due to accumulation of dysfunctional adipocytes, have been recently reported in PCOS. Aim of our study was to investigate the relative roles of obe...

ea0029p1269 | Obesity | ICEECE2012

Incidence of glucose and lipid metabolism disorders in overweight children and adolescents in Croatia

Ille J. , Furic-Cunko V. , Cigrovski N. , Bogdanic A. , Rojnic Putarek N. , Radica A. , Dumic M.

Prevalence of obesity in children and adolescents is reaching epidemic proportions. It is followed by the increase in incidence of type 2 diabetes (DM2) and dyslipidemia, and both disorders are risk factors of cardiovascular complications.Aim: The aim was to define the prevalence of impaired glucose tolerance (IGT), DM2, hypercholesterolemia and hypertriglyceridemia in overweight children and adolescents in Croatia.Subjects and met...

ea0029p1270 | Obesity | ICEECE2012

Factors determining weight gain in adults and relation with glucose tolerance

Soriguer F. , Rojo-Martinez G. , Valdes S. , Tapias M. , Botas P. , Delgado E. , Esteva I. , Ruiz de Adana M. , Diaz-Cadorniga F. , Garcia-Fuentes E.

Objective: Modifications in lifestyle and diet are major contributors for the high prevalence of obesity. Very few longitudinal studies have evaluated the changes in body weight over time. Dynamic changes in body weight are also an important indicator of risk for type 2 diabetes. The aim of this study is to assess factors associated with weight gain in a population of Spanish adults.Methods: The study was undertaken in two population-based cohorts of Spa...

ea0029p1271 | Obesity | ICEECE2012

Obesity prevention: main findings of the EPODE European network project

Borys J. , du Plessis H. , Walter L. , Harper P.

Introduction: EPODE is a coordinated, capacity-building methodology for communities to implement effective and sustainable strategies to prevent childhood obesity. Since 2008, the EPODE European Network (EEN), supported by the European Commission (DG SANCO), is aimed at facilitating the implementation of interventions using the EPODE methodology in other regions and countries.Methodology: From 2008 to 2011, four committees – gathering universities a...

ea0029p1272 | Obesity | ICEECE2012

Dietary habits and body weight in an unselected population of Italian high-school students

Prontera O. , Altieri P. , Cavazza C. , Repaci A. , Di Dalmazi G. , Gambineri A. , Pasquali R.

Aim: This study was aimed to estimate the nutritional status and the prevalence of weight excess in a wide unselected population of adolescent and young students from Emilia Romagna.Material and methods: Three thousand and ninety-one high school students, aged 15–19 years were consecutively contacted. One thousand eight hundred sixty out of 3091 (60.2%) accepted to participate in an epidemiologic study, whose procedures included anthropometric measu...

ea0029p1273 | Obesity | ICEECE2012

Relationship between obesity and Leptin (G-2548A) and Leptin receptor (668A>G (Q223R)) gene polymorphisms in Turkish population

Rustemoglu A. , Sahin S. , Tasliyurt T. , Kutluturk F. , Guven H.

Obesity is due to the combined effects of genetic, environmental, lifestyle and the interactions of these factors. Leptin (LEP) is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. In humans, LEP and LEPR have been mapped to 7q31.3 and lp31, respectively. The LEP and LEPR genes have been investigated in the search for gene variants potentially related to the pathophy...

ea0029p1274 | Obesity | ICEECE2012

Atherosclerosis risk factors before and 90 days after bariatric surgery

Polovina S. , Sumarac-Dumanovic M. , Bajec D. , Radenkovic D. , Stamenkovic-Pejkovic D. , Gligorijevic J. , Micic D. Micic D.

Introduction: Morbid obesity is associated with systemic inflammation, possible impaired glucose toleration and changes in serum lipids. Association of these parameters is risk for atherosclerosis and cardiovascular diseases.Methods: We have analyzed body weight, BMI, lipid profile, glucose, HbA1c and C reactive protein in 36 obese subjects, 8 males and 28 females, 37.9 (±18.6) years of age, before and three monts after bariatric surgery. There was ...

ea0029p1275 | Obesity | ICEECE2012

Obesity prevalence in west black sea region of turkey, the Melen Study

Aydin Y. , Celbek G. , Kutlucan A. , Onder E. , Gungor A. , Alemdar R. , Coskun H. , Ozhan H.

Aim: Obesity prevalence increase fastly and become important health problem all around the world. Aim of our study to determine obesity and abdominal obesity prevalence in west black sea region and to display the prevalence of chronic diseases especially diabetes mellitus (DM) in obese population.Material and method: We evaluate 2222 (1418 female, 804 male, mean age 50) participant in Yigilca region. We took medical history and physical examination of al...

ea0029p1276 | Obesity | ICEECE2012

Association between metabolic syndrome and serum leptin level in postmenopausal women

Lee S. , You Y.

Menopausal status is associated with weight gain, increased central fat mass, abnormal lipid metabolism, insulin resistance, and susceptibility to metabolic syndrome (MetS). Leptin is synthesized and secreted by adipocytes. Serum leptin levels are highly correlated with fat mass. We determined the association between MetS and serum leptin levels in 153 postmenopausal women. The difference in serum leptin level between MetS and non-MetS groups showed a statistical significance ...

ea0029p1277 | Obesity | ICEECE2012

Effects of diet and physical activity-induced weight loss on insulin resistance in severely obese patients

Tancic Gajic M. , Vujovic S. , Ivovic M. , Vukcevic M. , Marina L. , Arizanovic Z. , Micic D.

Introduction: Insulin resistance is quite common among obese individuals. Lifestyle interventions like diet interventions and regular physical activity are still important and safe first-line therapy.The aim of this study was to assess the effects of diet and physical activity-induced weight loss on insulin resistance in extremely obese patients.Methods: Forty-four patients (mean age 41.05±10.23 years) were consecutively recru...

ea0029p1278 | Obesity | ICEECE2012

Evaluation of depressive symptoms and quality of life in obese patients

Angay S. , Haydardedeoglu F. , Kirim S. , Bozkirli E. , Canataroglu A.

Objective: Obesity is a chronic disorder and a serious public health problem. Obesity which affects quality of life cause several physical and psychological problems. The aim of the current study was to evaluate depressive symptoms and quality of life in a group of obese patients.Material and methods: A total of 203 subjects, 103 obese patients with no chronic disorders except diabetes mellitus and hypertension and 100 healthy subjects with normal weight...

ea0029p1279 | Obesity | ICEECE2012

Plantar heel pain and relation with different diseases in obese Turkish patients

Topsakal S. , Erurker T. , Akin F. , Yaylali G. , Yerlikaya E. , Kaptanoglu B.

Plantar heel pain (PHP) is one of the most common musculoskeletal disorders of the foot, yet its etiology is poorly understood. Although obesity is the most common cause of PHP, there is little information available about the prevalence and associated factors in obese patient with PHP. The aim was to determine prevalence of various co-morbidities in obese patients with PHP and assess associations. A hundred and fourthy nine obese and overweight participants (29 males, 120 fema...

ea0029p1280 | Obesity | ICEECE2012

Relationship between visceral fat and neck circumference in patients with metabolic syndrome

Gulmez H. , Kut A.

The metabolic syndrome is a combination of multi-factorial risk factors, which affects more people because of increased incidence of obesity and diabetes. The metabolic syndrome is one of the major health problems for the 21st century.In this study, we compared neck circumferences measurements with some of the metabolic and anthropometric measurements in patients presenting with complains of weight, and aimed to show the correlation between visceral fat ...

ea0029p1281 | Obesity | ICEECE2012

Morbid child obesity-possible Rohhadnet syndrome: case report

Valea A. , Silaghi A. , Paul A. , Duncea I.

Introduction: ROHHADNET syndrome is a newly described condition characterized by rapid-onset obesity, pulmonary hypoventilation, hythalamic, autonomic dysregulation and, neural tumors. The severity of the clinical manifestations can rapidly lead to death by cardiorespiratory arrest.Case report: We present the case of a 5.10 years old girl, who was admitted in the Endocrinology department for evaluation of a significant weight gain began 2.5 years ago.</p...

ea0029p1282 | Obesity | ICEECE2012

The correlation between metabolic syndrome and serum resistin, adiponectin, TNFα, leptin levels and abdominal adipose tissue thickness

Basak M. , Gozden H. , Ayeser T. , Saler T.

Advanced research to investigate possible methods of treatment in patients with metabolic syndrome is required. Adipocytokines are secreted by the adipose tissue. These polypeptides and their functions are also known last few years.Adipocytokines are also anti-inflammatory and antiatherogenic, and they increase insulin sensitivity. As result of these skills, adipocytokines should be useful for diagnosis and treatment for metabolic syndrome. In this study...

ea0029p1283 | Obesity | ICEECE2012

Study of insulin resistance in overweight and obese children by: M Hesham El Hefnawy and Ibrahim Emara

Hefnawy M. El

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a cluster...