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15th International & 14th European Congress of Endocrinology

Poster Presentations

Thyroid (non-cancer)

ea0029p1562 | Thyroid (non-cancer) | ICEECE2012

Hypothyroidism is associated with increased intestinally derived lipoprotein particles and postprandial endothelial dysfunction

McGowan A. , Widdowson W. , Boran G. , Gibney J.

Atheroma is accelerated in overt hypothyroidism (OH) and possibly in subclinical-hypothyroidism (SCH), and is not completely explained by increased LDL-cholesterol. There is little data available regarding post-prandial metabolic changes in OH or SCH.Subjects with OH (n=21), SCH (n=28) and age, sex and BMI matched controls (n=50) were studied fasting and for up to 8-h following a mixed-meal. Investigations included apolipoprotein(apo...

ea0029p1563 | Thyroid (non-cancer) | ICEECE2012


This abstract is withdrawn due to incomplete authorship details and factual errors. These discrepancies came to our notice after the journal was printed and hence this abstract could not be withdrawn from the print version of the journal....

ea0029p1564 | Thyroid (non-cancer) | ICEECE2012

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism

Sanchez N Martinez , Varela L. , Martins L. , de Morentin P Martinez , Gallego R. , Vazquez M. , Roa J. , Gandara M. , Schoenmakers E. , Nogueiras R. , Chatterjee K. , Sempere M. Tena , Dieguez C. , Lopez M.

Hyperthyroid rats and humans exhibit increased energy expenditure and marked hyperphagia. Recent evidence has pointed that alterations of thermogenesis linked to hyperthyroidism are associated to dysregulation of hypothalamic AMPK and fatty acid metabolism; however, the central mechanisms mediating hyperthyroidism-induced hyperphagia remain largely unclear.Objective: The aim of our study was to assess if alterations in feeding in hyperthyroidism are asso...

ea0029p1565 | Thyroid (non-cancer) | ICEECE2012

Potassium iodide, but not potassium iodate, as a potential protective agent against oxidative damage to membrane lipids in porcine thyroid

Milczarek M. , Stepniak J. , Lewinski A. , Karbownik-Lewinska M.

Introduction: Fenton reaction (Fe2++H2O2 →Fe3++ ′OH+OH−) is of special significance in the thyroid gland, as both its substrates, i.e. H2O2 and Fe2+, are required for thyroid hormone synthesis. Also iodine, an essential element supplied by the diet, is indispensable for thyroid hormone synthesis. It is well known that iodine affects red-ox balance. One of the most frequent...

ea0029p1566 | Thyroid (non-cancer) | ICEECE2012

Response to high dose glucocorticoid therapy in patients with dysthyroid optic neuropathy (DON)

Covelli D. , Vannucchi G. , Curro N. , Campi I. , Guastella C. , Pignataro L. , Peccoz P Beck , Salvi M.

Dysthyroid optic neuropathy (DON) is a sight threatening complication occurring in 3–5% patients with Graves’ orbitopathy. The medical treatment consists in the infusion of high dose of methylprednisolone (MP), while surgical orbital decompression is mandatory in patients non responding to the medical treatment. We aimed at studying the response to high dose steroids in DON and parameters for predicting therapy effectiveness. Twenty-three patients with DON were studi...

ea0029p1567 | Thyroid (non-cancer) | ICEECE2012

Effect of environmental nitrates on the thyroid and salivary glands in the population affected by the chernobyl fall-out

Drozd V. , Leonova T. , Akulevich N. , Mityukova T. , Lushchyk M. , Platonova T. , Shimanskaya I. , Biko J. , Reiners C.

Introduction: An increase in thyroid diseases after the Chernobyl, mostly due to radioactive iodine, has been scientifically recognized. It is also known the effect of nitrate on iodine metabolism: being a competitive inhibitor of sodium-iodine symporter nitrate prevents iodide uptake by the thyroid and compromises thyroid hormone synthesis.The aim of the study was to investigate the incidence of thyroid and salivary glands’ abnormalities by ultraso...

ea0029p1568 | Thyroid (non-cancer) | ICEECE2012

Quantitative comparison of deiodinase I and II mRNA expression in ovine tissues

Dehghani H. , Foroughi abari M.

Iodothyronine deiodinases are important enzymes for metabolism of thyroid hormones. These enzymes which are expressed in a variety of tissues are able to catalyze removal of iodine from thyroid hormones. Iodothyronine deiodinases I and II (DIO1 and DIO2) remove iodine from T4 to convert it to a more biologically active T3. The relative contribution of different tissue deiodinases to the establishment of a euthyroid state (proper production and concentration of T3) is not known...

ea0029p1569 | Thyroid (non-cancer) | ICEECE2012

Correlation between thyroid volume and body mass index 2 and 6 years later

Chen D. , Tonks K. , Greenfield J. , El-Nouty C. , Hercberg S. , Czernichow S.

Background: Thyroid volume correlates positively with body mass index (BMI). This correlation holds true for both iodine-sufficient and mild/moderate iodine-deficient areas. We examined the association between thyroid volume and BMI and change in BMI over 4 years in middle-age adults recruited from the general population.Methods: A total of 2495 subjects, for whom thyroid volume, FT4 and TSH were available (women aged 35–60 years and men ...

ea0029p1570 | Thyroid (non-cancer) | ICEECE2012

The relation between severity of obstructive sleep apnea and diagnosis of Hashimoto's thyroiditis

Bozkurt N. Colak , Karbek B. , Cakal E. , Ozkaya E Cakir , Ozbek M. , Delibasi T.

Background: We investigated the frequency for diagnosis of Hashimoto’s thyroiditis (HT) in obstructive sleep apnea (OSA) patients, based on rising interest in potential links of OSA’s pathogenesis with impaired auto-immune mechanisms.Design and methods: Polysomnography was performed to 245 euthyroid eligible subjects consecutively. Study population divided according to apnea-hypopnea index (AHI) as control (n=59, AHI<5), mild OSA (<i...

ea0029p1571 | Thyroid (non-cancer) | ICEECE2012

An audit and patient satisfaction survey of the telephone endocrine clinic at University Hospital Lewisham, London

Mustafa O. , Gan J. , Evans K. , Mohandas C. , Miell J.

Introduction: The telephone endocrine clinic (TEC) was established as an adjunct to the face-to-face endocrine clinic to follow and monitor the progress in a selected group of patients after they were seen in main endocrine clinics. This model of care has been tried successfully in other specialities but not as widespread in endocrinology. We audited the effectiveness of TEC and patient satisfaction. Methods: A retrospective analysis of records of all patients contacted in TEC...

ea0029p1572 | Thyroid (non-cancer) | ICEECE2012

Gestational hyperthyroidism in women from mild to moderate iodine deficiency (ID) areas

Presti S. , Moleti M. , Di Bella B. , Sturniolo G. , Di Mauro F. , Trimarchi F. , Vermiglio F.

Graves’ disease (GD) and gestational transient thyrotoxicosis (GTT) are the main causes of hyperthyroidism in pregnancy, their prevalence ranging between 0.1–0.4% and 0.3–11%, respectively.Aim of the study: To evaluate both prevalence and outcome of gestational hyperthyroidism in mild to moderate ID areas.Subjects and methods: 482 consecutive pregnant women who had never undergone thyroid function evaluation before a...

ea0029p1573 | Thyroid (non-cancer) | ICEECE2012

The association between thyroid volume, L-thyroxine therapy and hepatocyte growth factor levels in euthyroid and hypothyroid goitrous and non-goitrous Hashimoto’s thyroiditis

Kilic M. , Akin S. , Topcuoglu M. , Yesilkaya Y. , Aydin K. , Cinar N. , Karakaya J. , Gurlek A.

Background and aim: Hashimoto’s Thyroiditis pathogenesis remains unclear in spite of many factors currently suggested. Aim of the study was to explore the relationship between hepatocyte growth factor (HGF) and Hashimoto’s Thyroiditis (HT), goiter formation, and to see if HGF levels are adjusted by TSH suppression.Materials and methods: Sixty-one premenopausal women who admitted our department between November 2010-September 2011 were enrolled ...

ea0029p1574 | Thyroid (non-cancer) | ICEECE2012

Adaptation of the hypothalamo-pituitary-thyroid axis to pubertal development and exposure to acute and chronic physical stresses

Younus A. , Naseem A. , Aslam S. , Irfan M. , Tahir F. , Qayyum M. , Mansoor R. , Murtaza S. , Rizvi S.

The hypothalamo-pituitary-thyroid axis undergoes adaptive changes in response to increased energy expenditure at puberty, a process called thyroidarche. Furthermore, the secretion of thyroid hormones (THs) is influenced by various kinds of acute and chronic stresses. Amongst others, persistent and severe physical stress may affect the secretion of THs. The present study investigates changes in the secretion of thyrotropin releasing hormone (TSH), trioiodothyronine (T3) and tet...

ea0029p1575 | Thyroid (non-cancer) | ICEECE2012

Thyroid nodules treated with percutaneous radiofrequency thermal ablation: a comparative study

Ramundo V. , Fonderico F. , Assanti A. , Marciello F. , Prete M. Del , Marotta V. , Lombardi G. , Misso C. , Marzano L. , Colao A. , Spiezia S. , Faggiano A.

Introduction: Percutaneous radiofrequency thermal ablation (RTA) is a new promising therapeutic approach to manage compressive thyroid nodules (TNs).Aim: To investigate effectiveness and safety of RTA in the treatment of compressive TNs in patients not receiving surgery or radioiodine.Study design: Forty patients (31–86 years) with compressive TNs were enrolled. Twenty-two patients had non-toxic TNs and 18 had toxic TNs and we...

ea0029p1576 | Thyroid (non-cancer) | ICEECE2012

Predictors of long-term remission in patients with Graves’ disease-a single centre experience

Anagnostis P. , Adamidou F. , Polyzos S. , Katergari S. , Karathanasi E. , Zouli C. , Panagiotou A. , Kita M.

Introduction: Antithyroid drugs (ATD) remain the first-line therapy in patients with Graves’ disease (GD), despite high relapse rate. The purpose of the present study was to identify predictors of long term remission of GD in patients who received ATD as primary treatment.Description of methods/design: We restrospectively identified patients with Graves’ disease initially treated with ATD between 1984 and 2011 and extracted relevant data from t...

ea0029p1577 | Thyroid (non-cancer) | ICEECE2012

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis and coagulation in patients with subclinical hypothyroidism

Efstathiadou Z. , Anagnostis P. , Dogramatzi F. , Slavakis A. , Selalmatzidou D. , Katergari S. , Kleta D. , Kita M.

Introduction: Subclinical hypothyroidism (SH) is associated with increased risk for atherosclerosis, mainly attributable to dyslipidemia, diastolic hypertension, altered coagulability and increased levels of inflammation markers. However, conflicting data exist regarding the effect of L-thyroxine substitution on these parameters.The purpose of the present study was to quantify the effect of L-thyroxine therapy on lipid profi...

ea0029p1578 | Thyroid (non-cancer) | ICEECE2012

A novel familial variation of the thyroid hormone receptor beta gene (I276N) associated with resistance to thyroid hormone

Moia S. , Monzani A. , Prodam F. , Petri A. , Genoni G. , Ricotti R. , Agarla V. , Bona G.

Introduction: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome, first identified in 1967 by Refetoff, characterized by reduced organ responsiveness to thyroid hormone. The most typical pattern being an elevated serum free T4 (fT4) concentration in association with non-suppressed TSH, usually accompanied by high serum levels of free T3 (fT3), with a considerable inter-individual variation and heterogeneous phenotype. The most frequent defect which causes R...

ea0029p1579 | Thyroid (non-cancer) | ICEECE2012

Short-term combined treatment with L-thyroxine plus L-triiodothyronine in drops (LT4 plus LT3) in patients with persistent hypothyroidism and malabsorption during replacement therapy with L-T4.

Ippolito S. , Arpaia D. , Peirce C. , Lombardi G. , Biondi B.

The objective of our study was to evaluate the potential benefit of short-term combined treatment with LT4plusLT3 in patients with persistent hypothyroidism and malabsorption. We report ten cases of patients with hypothyroidism secondary to total thyroidectomy, in which high doses of L-T4 (2,7-3.5 mcg/kg/die) were not adequate to normalize thyroid function. TSH was persistently high (from 10 to 100 mU/L) with low serum levels of thyroid hormones.<p class="ab...

ea0029p1580 | Thyroid (non-cancer) | ICEECE2012

The role of surgery in the treatment of amiodarone-induced thyrotoxicosis (AIT)

Tomisti L. , Materazzi G. , Marchello A. , Moretti M. , De Napoli L. , Brogioni S. , Miccoli P. , Bogazzi F. , Martino E.

Introduction: AIT develops in 15–20% of patients receiving amiodarone. Patients with persistent thyrotoxicosis or those with instable cardiac function, may be candidate for thyroidectomy; however, thyrotoxicosis and underlying cardiovascular disease may increased surgical risk.Matherials and methods: We retrospectively selected 23 AIT patients treated with a total thyroidectomy, from January 2000 to December 2010 [19 men, 4 women; mean (+SD), age 61...

ea0029p1581 | Thyroid (non-cancer) | ICEECE2012

Carbimazole induced ANCA associated renal vasculitis

Singh D. , Jayashekara A. , Kaplan F.

A 22-year old female diagnosed with thyrotoxicosis with raised free thryroxine (16.8 pmol/l) and suppressed thyroid-stimulating-hormone (TSH<0.03 mIU/l). She was started on Carbimazole 20 mg during end of August 2011. A fortnight later she presented with nausea, vomiting, fever and rigors. Her renal functions were deranged with a creatinine of 704 μmol/l, which worsened over the next 48 h. She subsequently needed renal replacement therapy with haemodialysis. She was c...

ea0029p1582 | Thyroid (non-cancer) | ICEECE2012

Thyroid dysfunction following cranial and craniospinal radiation in young adults

Bobrova E. , Fadeev V. , Mariya P. , Sych Y. , Mazerkina N.

Purpose: Radiation-induced anterior pituitary hormone deficiencie is the most common long-term complications of successful cancer treatment. The aim of our study was to analyze thyroid status in young adults after radiotherapy in childhood and their relationship with dose of radiotherapy.Materials and methods: Thyroid function (TSH, free T4, free T3) and thyroid ultrasound were evaluated in 29 young adults with a history of radiotherapy for brain tumors ...

ea0029p1583 | Thyroid (non-cancer) | ICEECE2012

Multi nodular goitre: when is it time for the surgeon?

Dam L. , In 't Hof K. , van Dijkum E Nieveen.

Introduction: Multi Nodular Goitre(MNG) has a slow, progressive growth. An apparently asymptomatic MNG can already have caused retrosternal upper airway obstruction. Yet MNG can also cause compressive manifestations without retrosternal extension. Timing of surgery can be critical for patients with a large goitre. The evidence is poor to guide management of large MNG with absolute indications for surgery. The aim of this uni-centre study is to analyze patients with large MNG a...

ea0029p1584 | Thyroid (non-cancer) | ICEECE2012

Amiodarone- induced thyroid dysfunction in an iodine- deficient region

Ismailov S , Abdusalamova N , Kayumova N

Objective: To determine the incidence of thyroid dysfunction in a cohort of patients started on amiodarone therapy at a cardiac clinic in Tashkent, Uzbekistan, which is believed to be an iodine- deficient area.Methods: Pharmacy records were used to obtain the names of patients who received amiodarone between 2006 and 2009.Results: The original sample size was 96; 3 patients were excluded to incomplete data and data analysis was com...

ea0029p1585 | Thyroid (non-cancer) | ICEECE2012

Hashimoto thyroiditis and carbohydrate metabolism disorders in patients hospitalized in Department of Endocrinology and Diabetology of Ludwik Rydygier Collegium Medicum in Bydgoszcz between 2001 and 2010

Gierach M. , Junik R.

Chronic lymphocytic thyroiditis, also known as Hashimoto thyroiditis, is the most frequent type of thyroiditis. An average 2% of the population suffer from the disease. The incidence of the disease is estimated as 0.3–1.5/1000 people a year.The main cause of the disease includes autoimmune disorders, that result in increased risk of diabetes type 1. Furthermore, during the course of Hashimoto thyroiditis, hypothyroidism may originate carbohydrate me...

ea0029p1586 | Thyroid (non-cancer) | ICEECE2012

Endocrine bioengineering: reconstruction of a bioartificial thyroid lobe using its natural, three-dimensional (3D) stromal / vascular matrix as a scaffold

Strusi V. , Zini N. , Dallatana D. , Mastrogiacomo S. , Parrilli A. , Giardino R. , Lippi G. , Spaletta G. , Bassoli E. , Gatto A. , Iafisco M. , Sandri M. , Tampieri A. , Toni R.

To test the feasibility of reconstructing ex situ an entire bioartificial thyroid gland suitable for transplantation we have bioengineered a rat thyroid lobe using its decellularized stromal / vascular matrix, eventually 3D recellularized with thyroid stem / precursor cells. Sprague-Dawley male rats (220–240 g) were used as thyroid donors, and lobe matrixes obtained by freezing / detergent / enzyme processing. Test matrixes were made electrondense and analyzed by m...

ea0029p1587 | Thyroid (non-cancer) | ICEECE2012

Thyroid hormone stimulates hepatic fatty acid metabolism via lipophagy

Sinha R. , Yen P.

Autophagy is a catabolic process that promotes hepatic cell survival during starvation and metabolic stress. Currently, little is known about the endocrine regulation of autophagy. Recent studies by Singh et al. (Nature 458, 1131–1135 (2009)) showed a critical link between autophagy and beta oxidation in hepatocytes. Accordingly, we examined whether hormones known to promote beta oxidation of fatty acids also stimulated autophagy in hepatic cells. Surprisingly, we found t...

ea0029p1588 | Thyroid (non-cancer) | ICEECE2012

Linking thyroid and central nervous system functions of cathepsin K: Implications for non-classical thyroid regulation

Dauth S. , Rehders M. , Sirbulescu R. , Wirth E. , Braun D. , Batbajar B. , Schweizer U. , Brocker-Preuss M. , Fuhrer D. , Saftig P. , Jordans S. , Brix K.

Cathepsin K is a cysteine protease known for its importance in bone remodelling. Inhibitors of cathepsin K are in clinical trials for osteoporosis treatment, but side effects included altered levels of related cathepsins in peripheral organs and in the central nervous system (CNS). Importantly, cathepsin K has been identified not only in osteoclasts but also in most epithelia and, recently, in brain parenchyma. Lately, we have also shown that cathepsin K deficiency in mice ind...

ea0029p1589 | Thyroid (non-cancer) | ICEECE2012

SECISBP2 syndrome: Mouse models for an atypical form of resistance to thyroid hormone

Seeher S. , Wirth E. , Mahdi Y. , Miniard A. , Driscoll D. , Carlson B. , Hatfield D. , Schweizer U.

An atypical form of resistance to thyroid hormone (RTH) leads to retarded growth and bone age in humans. Aberrant thyroid hormone levels (high T4, low T3, elevated rT3 and high/ normal TSH) indicate a defect in deiodinase-dependent thyroid hormone metabolism. Findings of reduced concentrations of plasma selenoproteins (SePP, GPx3) suggested a generalized defect of selenoprotein biosynthesis and led to the identification of mutations in the SECISBP2 gene. SECISBP2 is thought to...

ea0029p1590 | Thyroid (non-cancer) | ICEECE2012

Polymorphism of the PPAR-γ2 gene and Graves’ orbitopathy: the Ala variant confers decreased risk of eye symptoms

Daroszewski J. , Pawlak-Adamska E. , Bolanowski M. , Frydecka I.

Introduction: Peroxisome proliferatior-activated receptor-γ2 (PPAR-γ2) plays a crucial role in adipogenesis and has been shown to be involved in the control of immunoregulation and inflammation. Orbital fibroblast differentiation to adipocytes is a PPAR-γ dependent process essential for pathogenic tissue remodeling in Graves’ orbitopathy (GO). Genetic variation in PPAR-γ2 gene may modulate expression and/or function of molecule encoded by this gene.</p...

ea0029p1591 | Thyroid (non-cancer) | ICEECE2012

Thyroid hormone T3 induces ovarian activity in rat follicles and granulosa cells

Falzacappa C. Verga , Santaguida G. , Furno A. , Centanni M. , Misiti S.

Background: The menstrual pattern is influenced by thyroid hormones directly through impact on the ovaries and indirectly through impact on SHBG, PRL, and GnRH secretion and coagulation factors. Treating thyroid dysfunction can reverse menstrual abnormalities and thus improve fertility.Aim: Elucidating the molecular mechanisms underlying the link between thyroid and ovarian function is important for determining the relationship between thyroid status, fe...

ea0029p1592 | Thyroid (non-cancer) | ICEECE2012

Recurrence of Amiodarone induced thyrotoxicosis after reinstitution of this drug

Maqdasy S. , Batisse-Lignier M. , Lusson J. , Lamaison D. , Citron B. , Roche B. , Desbiez F. , Thieblot P. , Tauveron I.

Introduction: Amiodarone-induced thyrotoxicosis (AIT) contributes to increased morbidity and mortality in patients invariably having underlying heart disease. In clinical practice, amiodarone therapy often needs to be restarted. When amiodarone is reintroduced, what happens then?Objective: The aim of study is to evaluate the progression of thyroid function after reinstitution of amiodarone in patients with a previous history of AIT. Secondarily, to deter...

ea0029p1593 | Thyroid (non-cancer) | ICEECE2012

Subclinical and overt hyperthyroidism in a long-term iodine sufficient area of Sweden (Gothenburg) 2003–2005

Nystrom H. Filipsson , Jansson S. , Berg G.

Introduction: The incidence of hyperthyroidism is influenced by iodine nutrition. Sweden is a long-term iodine sufficient (IS) area with an iodination fortification program since 1936.Methods: In 2003–2005, all referred cases of subclinical (SH) and overt hyperthyroidism (OH) were registered from a targeted population of 631239 individuals in Gothenburg. Information on age, gender, etiology, smoking, thyroid associated ophtalmopathy (TAO), thyroid h...

ea0029p1594 | Thyroid (non-cancer) | ICEECE2012

Enhanced expression of the B cell activation factor (BAFF) and baff-receptor (BAFF-R) in the thyroid and in the orbital adipose tissue from patients with graves’ disease (GD) and associated orbitopathy (GO)

Campi I. , Vannucchi G. , Covelli D. , Rossi S. , Doi P. , Curro N. , Pignataro L. , Guastella C. , Beck-Peccoz P. , Salvi M.

BAFF, a member of the TNF family, promotes autoantibody production by increasing B cell survival and proliferation. We have previously shown that serum BAFF concentrations are increased in GD patients. In the present work, we studied the expression of BAFF and BAFF-R, by immunohistochemistry (IHC) on paraffin embedded sections of: 1. orbital adipose tissue from 22 patients (5 men, 17 women) with GO (3 of them with active GO) associated with GD or Hashimoto thyroiditis in 19 an...

ea0029p1595 | Thyroid (non-cancer) | ICEECE2012

Utility of thiazide diuretics in the management of post- thyroidectomy hypocalcemia: a pilot study

Panchangam R.

Introduction: The incidence of post thyroidectomy hypocalcemia varies from 10–50%. Treatment is either prophylactic or therapeutic calcium and vitamin D supplementation. We evaluated the utility of thiazide diuretics in the management of hypocalcemia prospectively.Material and methods: This study was conducted in Endocrine Surgery department of a teritiary care teaching hospital. We included 104 patients of total thyroidectomy in the study. 44 cases...

ea0029p1596 | Thyroid (non-cancer) | ICEECE2012

Maternal Graves’ disease induces more perinatal complications and higher risk of thyroid dysfunction at early childhood

Cao X. , Wnag L. , Yang C. , Mo X. , Li Y. , Xiao H.

Objectives: The most common cause of maternal hyperthyroidism during pregnancy is Graves’ disease (GD). The aim of this study was to investigate the perinatal complications and the risk of thyroid dysfunction at early childhood of mothers with GD during pregnancy.Method: Pregnant women with GD (n=93) and aged-matched randomly selected healthy pregnant women (n=140) were recruited retrospectively. The prenatal and newborn data were coll...

ea0029p1597 | Thyroid (non-cancer) | ICEECE2012

No Correlations between TSH receptor antibody levels assayed with Elecsys TRAb and the activity or severity of Graves’ ophthalmopathy

Noh J. , Iwaku K. , Suzuki M. , Sekiya K. , Matsumoto M. , Ohye H. , Kunii Y. , Yoshihara A. , Watanabe N. , Mukasa K. , Kosuga Y. , Ito K. Ito K.

Objective: This study was designed to determine whether TRAb levels are correlated with the activity and severity of Graves’ ophthalmopathy (GO).Subjects and Methods: The subjects were 179 untreated Graves’ disease patients. TRAb was assayed with Elecsys TRAb at the initial visit, and an ophthalmic assessment was performed within 3 months. The activity of the ophthalmopathy was assessed by clinical activity scores (CASs) and MRI T2 relaxation t...

ea0029p1598 | Thyroid (non-cancer) | ICEECE2012

The influence of recombinant human thyroid stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with toxic nodular goitre with low RAIU

Abdelrazek S. , Rogowski F. , Szumowski P. , Daniluk M. , Winska M. , Szorc M.

The aim of our study was to evaluate the influence of rhTSH on the efficacy of radioiodine therapy (RIT) in patients with toxic nodular goitre(TNG) with low RAIU. Materials and methods: The study was performed on 30 patients with TNG (22 female and 8 male aged 45–78years) referred for 131I therapy. All patients had low RAIU (16–18%) 24 hours after a diagnostic dose of I-131 (4 MBq). All the patients received a single intramuscular dose of 0.05 mg rhTSH (thyrogen). 24...

ea0029p1599 | Thyroid (non-cancer) | ICEECE2012

Peripheral blood lymphocyte apoptosis and its relationship with thyroid function tests in adolescents with hyperthyroidism due to Graves’ disease

Klatka M. , Grywalska E. , Surdacka A. , Ben-Skowronek I. , Rolinski J.

The aim of the present research was to assess changes in the degree of peripheral blood (PB) lymphocyte apoptosis during methimazole treatment in the group of teenage children.Material and methods: The percentage of PB apoptotic lymphocytes, assessed by the decrease in mitochondrial transmembrane potential (CMXRos staining), was measured in 30 adolescents at the time of diagnosis, as well as after receiving the normalization of the thyroid hormones level...

ea0029p1600 | Thyroid (non-cancer) | ICEECE2012

Individual plasma ghrelin changes evaluated in the same patients in hyperthyroidism, hypothyroidism and euthyroidism

Ruchala M. , Gurgul E. , Stangierski A. , Kosowicz J. , Zamyslowska H.

Ghrelin is a peptide discovered in 1999 as the first natural growth hormone secretagogue. It also proved to be an essential regulator of metabolism increasing appetite, body weight and stimulating peristalsis. Thyroid plays an important role in the maintenance of energy balance. Thus, correlation between ghrelin and thyroid function is worth consideration. Previous studies suggested, that ghrelin production is increased in hypothyroidism and decreased in hyperthyroism. However...

ea0029p1601 | Thyroid (non-cancer) | ICEECE2012

The effect of radioiodine therapy in 950 patients with subclinical hyperthyroidism

Abdelrazek S. , Rogowski F. , Szelachowska M. , Mojsak M. , Kraszynska A. , Kornas M. , Gorska M.

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism. Material and methods: We treated 950 patients, aged 30–70 years; 87% of them were female and 13% male; 320 patients with multinodular goitre (MNG), and 630 patients with autonomous nodule (ATN). Some of the patients were treated with antithyroid drugs for 1 to...

ea0029p1602 | Thyroid (non-cancer) | ICEECE2012

Genetic susceptibility to Graves’ ophthalmopathy: the role of polymorphisms in anti-inflammatory cytokine genes

Khalilzadeh O. , Anvari M.

Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves’ ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor-β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO.Methods: The following ...

ea0029p1603 | Thyroid (non-cancer) | ICEECE2012

The T and B cell subsets in thyroids of children with Graves’ disease and Hashimoto’s thyroiditis

Ben-Skowronek I. , Szewczyk L. , Piekarski R. , Klatka M. , Korobowicz E.

Background: Autoimmune thyroid disorders (AITD) similar in pathomorphology picture results in hyper- or hypothyreosis. The differences between Graves’ disease (GD) and Hashimoto thyroiditis (HT) suggested that changes in the subsets of T-cells may have an influence on the course of this reaction.Methods: The study involved 90 children: 30 with GD, 30 with HT and the control group – 30 children. After thyroidectomy, standard histological examina...

ea0029p1604 | Thyroid (non-cancer) | ICEECE2012

The thyroid gland is another victim of the insulin resistance syndrome university

Zakaria E. , Ghanem N. , Abd al salam R.

Insulin is a thyroid growth factor that stimulates proliferation of thyroid cells in culture. It has been observed that insulin receptors are over expressed in most thyroid tumors as an early step in thyroid carcinogenesis.Eighty women (mean age 36.85±4.71 years) were evaluated by a thyroid ultrasound (US), fasting plasma insulin and HOMA IR. Subjects were divided into four groups as follows: G1 (n: 24),subjects with IR and obesity; G2 (n<...

ea0029p1605 | Thyroid (non-cancer) | ICEECE2012

Four families with nonautoimmune hyperthyroidism harboring the same thyrotropin receptor germline mutation (Asn406Ser) in Kumamoto Prefecture, Japan

Hishinuma A. , Tajiri J. , Nakatake N. , Fukata S.

Nonautoimmune hyperthyroidism (NAH) due to activating mutation of the TSH receptor (TSHR) gene is extremely rare. We report 4 unrelated families with NAH experienced for the last two years in Kumamoto Prefecture, Kyushu, Japan. TSHR gene mutation site of these four families are all the same: p.Asn406Ser (heterozygous). Thyroid functions observed in these families were subclinical hyperthyroidism or overt hyperthyroidism except for one case with euthyroidism. Thyroid autoantibo...

ea0029p1606 | Thyroid (non-cancer) | ICEECE2012

Antigen mimicry between aeroallergens and thyroid antigens can modify the levels of thyroid hormones and antibodies in thyroid autoimmunity

Molnar I. , Kelemen E. , Somogyine-Vari E.

The allergic sensitization represents an environmental factor for thyroid autoimmunity and highlights a common pathway between autoimmunity and allergy. Elevated IgE levels are connected to hyperthyroid Graves’ disease. The allergic sensitization in thyroid autoimmunity seems mainly to be an associated immune reaction.Allergic sensitization to 20 aeroallergens and the levels of thyroid hormones and antibodies were studied in 121 patients with Graves...

ea0029p1607 | Thyroid (non-cancer) | ICEECE2012

Diagnostic accuracy of elastography in thyroid nodule ultrasound evaluation. A prospective multicenter trial

Trimboli P. , Misischi I. , Morgante S. , Graziano F. , Deiana M. , Wolosinska D. , Pascucci C. , Bonifacino A. , Bellotti C. , Valabrega S. , Bizzarri G. , Liverani A.

Background: Real-time elastography (RTE) was reported to improve the diagnostic accuracy of B-mode ultrasound (US) examination of thyroid nodules but the results on selected series of patients are still controversial.Aim of the study: To blindly evaluate on a consecutive series of solid thyroid nodules, devoid of confounding factors, the diagnostic accuracy of RTE and to compare it with the traditional B-mode features.Materials and...

ea0029p1608 | Thyroid (non-cancer) | ICEECE2012

FOXA1 and FOXA2 oppositely regulate human type 1 Iodothyronine deiodinase gene in liver

Kanamoto N. , Tagami T. , Ueda Y. , Miura M. , Yasoda A. , Arai H. , Nakao K.

Type 1 iodothyronine deiodinase (D1), a selenoenzyme that catalyzes the bioactivation of thyroid hormone, is expressed mainly in the liver. Its expression and activity are modulated by several factors, but the precise mechanism of its transcriptional regulation remains unclear. In the present study, we have analyzed the promoter of human D1 (hDIO1) gene to identify factors that prevalently increase D1 activity in the human liver. Deletion and mutation analyses demonstrated tha...

ea0029p1609 | Thyroid (non-cancer) | ICEECE2012

Dyrk1A (dual-specificity thyrosine (Y)-phosphorylation regulated kinase 1A) overexpression is linked to congenital hypothyroidism in Down syndrome

Kariyawasam D. , Martin-Pena M. , Rachdi L. , Carre A. , Houlier M. , Dupuy C. , Janel N. , Delabar J. , Polak M.

Introduction: Trisomy 21 or Down Syndrome (DS) patients have a predisposition for Congenital Hypothyroidism which can aggravate their mental status.Hypothesis: The presence of three copy of Dyrk1a gene, localized in chromosome 21 in Humans, is responsible for a thyroidal dysgenesis.Our aim is to understand the molecular mechanisms underlying this condition.Methods: The transgenic Dyrk1a (TgDyrk1a) mouse, our ...

ea0029p1610 | Thyroid (non-cancer) | ICEECE2012

Impaired absorption of thyroxine in occult celiac disease

Virili C. , Santaguida M. , Cellini M. , Gatto I. , Gargiulo P. , Centanni M.

Some case report suggested that increased need for thyroxine may occur in overt celiac disease (CD). However, overt CD (with typical gastrointestinal symptoms) only represents 10 to 20% of cases of CD, being the majority represented by the atypical CD and other occult forms, in which extra intestinal symptoms prevail. Few data on the need for oral T4 in patients with occult CD are available. In this study we analyzed the replacement T4 dose in 68 hypothyr...

ea0029p1611 | Thyroid (non-cancer) | ICEECE2012

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

Agretti P. , Ferrarini E. , De Marco G. , Dimida A. , Molinaro A. , Niccolai F. , Pinchera A. , Vitti P. , Tonacchera M.

Background: Nonautoimmune subclinical hypothyroidism is characterized by elevated serum levels of TSH in the presence of normal thyroid hormone levels and absence of anti-thyroid antibodies. As a result of a genomic-wide study, a strong association between three polymorphic variants in exon 1 of human phosphodiesterase 8B (PDE8B) gene (rs4704397, rs6885099 e rs2046045) and serum levels of TSH has been recently reported. The aim of the present study was to evaluate the frequenc...

ea0029p1612 | Thyroid (non-cancer) | ICEECE2012

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

Agretti P. , Ferrarini E. , Rago T. , Candelieri A. , De Marco G. , Dimida A. , Niccolai F. , Molinaro A. , Di Coscio G. , Pinchera A. , Vitti P. , Tonacchera M.

Objective: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that pair with target messengers regulating gene expression. They are involved in biological processes including development, organogenesis, tissue differentiation, cell cycle and metabolism. Changes in miRNA levels occur in human cancers, including thyroid cancer. Fine needle aspiration (FNA) with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytologic diagnos...

ea0029p1613 | Thyroid (non-cancer) | ICEECE2012

Effect of combination therapy with potassium iodide and 15 mg of methimazole for Graves’ hyperthyroidism

Mashio Y. , Senshu N. , Beniko M. , Ikawa H. , Ikota A.

Introduction: Iodide administration is generally recommended in combination with anti-thyroid drugs when a rapid return to normal thyroid hormone levels is required, such as in the treatment of patients with ‘thyroid storm’. However, there are few reports concerning the combination therapy for many patients with Graves’ hyperthyroidism. In this paper, we studied the effects of potassium iodide (KI) combined with 15 mg of methimazole (MMI) to the initial treatmen...

ea0029p1614 | Thyroid (non-cancer) | ICEECE2012

Estrogens block the apoptotic action of tgfb in human thyrocytes

Garcia-Rendueles M. , Bravo S. , Rodrigues J. , Garcia-Rendueles A. , Barreiro F. , Cameselle-Teijeiro J. , Alvarez C.

Introduction: Multinodular Goiter (MNG) is a thyroid neoplastic disease thirteen times more common in women than in men. While a local effect of estrogens at cellular levels could affect there can be other causes to explain the gender difference in incidence such as diet, environmental factors, genetic causes or alterations in metabolic pathways.Cellular effects of estrogens in human thyrocytes although previously studied are not completely clarified. So...

ea0029p1615 | Thyroid (non-cancer) | ICEECE2012

TRAb level and ophthalmopathy index as predictive factors of poor response and of severity of Graves ophthalmopathy in patients treated with anti-thyroid drugs and radioiodine

Baldys-Waligorska A. , Andrzej S. , Golkowski F. , Hubalewska-Dydejczyk A.

Introduction: In a prospective study we determined factors affecting GO activity and poor response to glucocorticoid therapy in patients treated with radioiodine (131-I group) or with anti-thyroid drugs (ATD group).Material and methods: The ATD and 131-I groups consisted of 168 patients (mean age 52.2±11.2 years) and of 46 patients (mean age 52.1±13.3 years), respectively. SoluMedrol pulses (8.0 g) were applied, followed by orbital irradiation ...

ea0029p1616 | Thyroid (non-cancer) | ICEECE2012

A possible common link between Graves’ disease and allergic immune response

Kim H. , Kim S. , Chae J. , Kim D. , Baek S. , Won K. , Sung Y.

Background: The elevation of serum immunoglobulin E (IgE) has been recently reported to be associated with Graves’ disease (GD). Interleukin 13 (IL-13) is a major cytokine involved in IgE synthesis and therefore may be a potential candidate gene influencing the clinical course of the GD. The aim of this study are to evaluate whether the atopic parameter such as total IgE is related to TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin: TBII) and wh...

ea0029p1617 | Thyroid (non-cancer) | ICEECE2012

Subclinical hyperthyroidism (SH) in the elderly: symptoms, depression and quality of life (QoL) and relationship with TSH concentration in a prospective cohort of 110 patients

Goichot B. , Vinzio S. , Kuhn J. , Meyer N. , Wemeau J. , Caron P. , Luca F. , Orgiazzi J.

SH is defined by a decrease of TSH with normal thyroid hormone (TH) concentrations. The clinical picture is not clear, whether these patients may have symptoms or alterations of QoL. It is well known that in overt hyperthyroidism, symptoms may be absent in old patients. In SH, one study in young patients has reported an increased symptom score and a slight decrease of QoL but these results have not been confirmed in middle-aged subjects. We report the initial data of the Pirat...

ea0029p1618 | Thyroid (non-cancer) | ICEECE2012

Thyroid function of Japanese elderly

Kato S. , Kuwahara T. , Tagami T. , Nishi S.

Serum TSH is the most sensitive index of thyroid function in the absence of hypothalamic–pituitary disease.However, TSH reference limits are controversial, particularly the upper limit. District and age subpopulations have unique TSH distribution. We investigated characterization of thyroid hormones in Japanese elderly. 859 participants (mean age 74.3 years) over 60 years without known thyroid disease were surveyed.Percentages...

ea0029p1619 | Thyroid (non-cancer) | ICEECE2012

Assessment of cognitive function in hypothyroidism using P300 evoked potentials

Sahay R. , Reddy R. , Pallagolu S.

The P300 wave is an event related potential which is used to assess cognitive function, it is recorded as positive deflection in voltage at latency of roughly 300 ms. P300 latency suggests that shorter latency times are related to cognitive performance. This study was undertaken to evaluate objectively effect of hypothyroidism on latencies of ERPs and response to thyroxine replacement.Biochemically proven new onset cases with hypothyroidism were enrolled...

ea0029p1620 | Thyroid (non-cancer) | ICEECE2012

Successful treatment of hyperthyroidism is associated with significant risks of overweight/obesity independent of the treatment modality employed

Torlinska B. , Holder R. , Franklyn J. , Boelaert K.

Introduction: Obesity is a growing health concern in developed countries. Patients undergoing treatment for hyperthyroidism frequently express concerns regarding excessive weight gain, especially when offered treatment with I-131.Methods: We investigated 1047 patients with overt hyperthyroidism attending a specialist thyroid clinic to determine the extent of weight changes and to identify risk factors for weight gain following treatment. Weight differenc...

ea0029p1621 | Thyroid (non-cancer) | ICEECE2012

Oral anticoagulant therapy: is it the same in hyperthyroid patients?

Barbu C. , Giba C. , Ionita D. , Florea S. , Fica S.

Aim of this study was to evaluate the effectiveness and safety of oral anticoagulant therapy in patients with atrial fibrillation and hyperthyroidism compared to those presenting the same cardiac disorder, but with normal thyroid function.Material and methods: The study included 61 patients admitted to the Endocrinology Department in Elias Hospital between January 2011–October 2011 with mean age of 64 years: 25 patients had primary hyperthyroidism a...

ea0029p1622 | Thyroid (non-cancer) | ICEECE2012

Thyroid hormone abnormalities in haemodialyzed patients: low triiodothyronine as well as high reverse triiodothyronine are associated with increased mortality

Horacek J. , Dusilova Sulkova S. , Kubisova M. , Safranek R. , Malirova E. , Kalousova M. , Svilias I. , Maly J. , Sobotka L. , Zak P.

Objective: Numerous abnormalities of thyroid hormones in end-stage renal disease (ESRD) have been described. Our aim was to analyze the impact of these abnormalities on survival.Design: In 167 haemodialyzed ESRD patients, TSH and thyroid hormone levels (including reverse T3, i.e. T4, fT4, T3, fT3, rT3) were determined. The patients were then prospectively followed up for up to 5 years and ...

ea0029p1623 | Thyroid (non-cancer) | ICEECE2012

Perioperative clinical outcomes after robot-assited thyroid surgery by transaxillary approach

Axente D. , Constantea N.

Background: Many endoscopic minimaly invasive procedures have been developed and are used now in thyroid and parathyroid surgery. However, the endoscopic approach is more technically demanding and due its limitations, endoscopic thyroidectomy remains limited in application and practiced in a relatively small number of centers. Recently robotic technology has been also applied to thyroid surgery. The aim of this study is to present our experience and to demonstrate the technica...

ea0029p1624 | Thyroid (non-cancer) | ICEECE2012

Hyperthyroidism in patients with acute atrial fibrillation attended at an emergency room

Moreno C. , Esperto H. , Silva N. , Fonseca I. , Ruas L. , Vieira A. , Alves M. , Sofia G. , Saraiva J. , Nascimento Costa J. , Carvalheiro M.

Introduction: Atrial fibrillation (AF) is the most common cardiac complication of hyperthyroidism, with significant mortality and morbidity resulting from embolic events. In patients who attend at an emergency room (ER) with acute AF, the thyroid hormones aren’t usually evaluated given the low prevalence of hyperthyroidism in the general population.Aims: To assess the prevalence of thyroid dysfunction in adult patients who presented at an ER with ac...

ea0029p1625 | Thyroid (non-cancer) | ICEECE2012

Alterations in adiponectin concentration in hyper- and hypothyroid patients; possible underlying mechanisms and role of metformin treatment in experimental animals

Ramadan N. , Shawky H. , Ghanem N. , Gamal M.

Recent reports on the interplay between adiponectin, thyroid hormones and metformin have given conflicting results. Our study aimed to investigate adiponectin concentration in thyroid disorders and to assess the possibility of involvement of adiponectin in the regulation of thyroid hormone production, also to clarify the role of pituitary-thyroid axis in the modulation of adiponectin production and to assess the interplay between metformin treatment, thyroid function and adipo...

ea0029p1626 | Thyroid (non-cancer) | ICEECE2012

A liquid formulation of L-thyroxine (L-T4) solves problems of incomplete normalization/suppression of serum TSH caused by proton pump inhibitors (PPI) on conventional tablet formulations of L-T4

Saraceno G. , Vita R. , Trimarchi F. , Benvenga S.

Background: PPI are known to diminish the intestinal absorption of L-T4, which is commonly ingested as tablets of L-T4 sodium salt. However, a liquid formulation is available (Tirosint, oral solution, IBSA Farmaceutici Italia s.r.l., Italy), in which the hormone is solubilized in 28.8% ethyl alcohol. One ml of this formulation (=28 drops) contains 100 mcg L-T4 sodium salt in 243 mg ethanol. Because this formulation contains L...

ea0029p1627 | Thyroid (non-cancer) | ICEECE2012

Serum chemokine CXCL10 is increased in chronic autoimmune thyroiditis associated with autoimmune gastritis

Santaguida M. , Ferrari S. , Duca S Del , Fallahi P. , Centanni M. , Antonelli A.

Autoimmune thyroiditis (AT) may occur as a single disease or associated with further endocrine and non endocrine autoimmune diseases (NEAD). Chronic autoimmune gastritis (CAG) is the more frequently associated NEAD. A prevalent Th1-representative pattern of cytokines and chemokines has been described in isolated autoimmune thyroiditis. However, the behaviour of chemokines when AT is associated with CAG is not known. Aim of the study has been to measure serum levels of CXCL10 i...

ea0029p1628 | Thyroid (non-cancer) | ICEECE2012

Association between preoperative value of TSH and pathological findings in nodular thyroid disease

Paja M. , EtxeberrIa E. , Iglesias N. , Gutierrez T. , Ugalde A. , Oleaga A. , Arosa V. , Elorza R.

Higher serum TSH has been recently postulated as a predictor of thyroid malignancy in nodular thyroid disease. In addition, some reports have demonstrated its association with more advanced stages of differentiated thyroid cancer (DTC).Material and methods: We collected retrospectively preoperative serum TSH from patients who underwent total thyroidectomy in the period 2005–2011 in a single tertiary center. We recorded demographic data, nodule numbe...

ea0029p1629 | Thyroid (non-cancer) | ICEECE2012

Clinical presentation (symptoms and complications) of hyperthyroidism in a cohort of 1,144 patients: results of the Thyrdel study

Goichot B. , Bouee S. , Ndaye N. , Caron P. , Landron F.

Symptoms and physical signs are variable and non specific in hyperthyroidism (HT). We report the results of a large study conducted among 263 French endocrinologists. Each investigator was asked to include all consecutive patients seen for HT during the study period. For each patient, symptoms, physical signs, biological data and treatment were recorded. The endocrinologists included 1,144 patients with HT: 802 Grave’s disease (GD), 121 multinodular goitres (MNG), 112 iat...

ea0029p1630 | Thyroid (non-cancer) | ICEECE2012

Beta (CCL2) and alpha (CXCL10) chemokines modulation by cytokines and by peroxisome proliferator-activated receptor-alpha agonists in Graves’ ophthalmopathy

Antonelli A. , Ferrari S. , Sellari-Franeschini S. , Corrado A. , Mancusi C. , Ferrini M. , Ferrannini E. , Fallahi P.

Introduction: No study has evaluated the effect of cytokines on the prototype beta chemokine (C-C motif) ligand (CCL)2 in Graves’ ophthalmopathy (GO), nor of peroxisome proliferator-activated receptor (PPAR)alpha activation on this chemokine secretion in fibroblasts or preadipocytes in GO.Design and methods: We have tested the interferon (IFN)gamma and tumor necrosis factor (TNF)alpha effect on CCL2, and for comparison on the prototype alpha chemoki...

ea0029p1631 | Thyroid (non-cancer) | ICEECE2012

Thyroid function in large elderly population – results of multicenter study performed in Poland

Bar-Andziak E. , Milewicz A. , Jedrzejuk D. , Arkowska A. , Mieszczanowicz U. , Krzyzanowska -Swiniarska B. , Sierdzinski J.

Multidimensional studies of medical aspects of ageing were performed in 6 provinces of Poland, the protocol included cross sectional analysis of thyroid function parameters.The sample was randomly chosen and included 4,051 respondents (49.2% females).Group consisted of 3,502 elderly subjects aged 65–90+y, divided into approximately equal six age subgroups; and 549 younger cohort, aged 55–59 y.Thyroi...

ea0029p1632 | Thyroid (non-cancer) | ICEECE2012

Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N 670 S TSH receptor germline mutation causing familial non-autoimmune autosomal dominant hyperthyroidism (FNAH)

Paschke S. , Oezerden M. , Schaarschmidt J. , Jaeschke H. , Huth S. , Eszlinger M. , Meller J. , Paschke R.

In the 27 families with FNAH the onset of hyperthyroidism varies from 18 months to 60 years. Also the manifestation of goiters is variable in these families.A 74 year old women first presented at the age of 69 years in 9/2006 with tachyarrythmia and hypertension. After the initial treatment of her hypertension and oral anticoagulation for her intermittant atrialfibrilation 3/2007 a thyroid workup revealed a suppressed TSH of 0.029 (normal< 0.4 mU/l) ...

ea0029p1633 | Thyroid (non-cancer) | ICEECE2012

The alterations of the endothelial function, haemostatic and inflammatory parameters in subclinical and overt hyperthyroidism

Poplawska-Kita A. , Siewko K. , Modzelewska A. , Mysliwiec J. , Dzieciol J. , Gorska M. , Szelachowska M.

Subclinical hyperthyroidism (SH) is characterised by supressed serum TSH concentration accompanied by fT3 and fT4 levels maintained within their reference ranges. The vascular endothelium as a specific target of thyroid hormones is strongly affected in hyperthyroidism. We aimed to compare the alterations of the endothelial function, haemostatic and inflammatory parameters in patients with SH in comparison with overt hyperthyroidism (OH) due to Graves’ disease and toxic no...

ea0029p1634 | Thyroid (non-cancer) | ICEECE2012

Prediction of remission rate in the patients with Graves’ disease after treatment with a minimum maintenance dose of Methimazole

Beniko M. , Ikawa H. , Mori T. , Kudo H. , Matsumoto A. , Sekiguchi M. , Mashio Y.

Introduction: According to the guideline for medical treatment of Graves’ disease by the Japan Thyroid Association in 2011, discontinuation of antithyroid drug is recommended when normal thyroid functions have been maintained for a certain period (≥6 months) after treatment with a minimum maintenance dose (mentioned below). We prospectively studied the remission rates in the patients with Graves’ disease.Methods: The subjects were 108 pat...

ea0029p1635 | Thyroid (non-cancer) | ICEECE2012

Predictors of relapse of Graves’ disease after thionamide drugs treatment in clinical practice

Pena V. , Vicente A. , Maqueda E. , Sastre J. , Val F Del , Marco A. , Luque I. , Lopez J.

Background: One of the main drawbacks of primary treatment of Graves’ disease (GD) with thionamide drugs (TD) is the high relapse rate estimated to be 50–60%. Fear about side effects, specially agranulocitosis and hepatic complications, is other drawback of this treatment option.Objective: To evaluate the clinical and/or biochemical characteristics that might predict relapse in patients with GD treated with TD.Design and ...

ea0029p1636 | Thyroid (non-cancer) | ICEECE2012

The significance of TSH receptor blocking antibody levels in gestational stage

Nishizawa Maiko , Horiuchi Toshiyuki , Iwashima Fumiko , Suzuki Sayaka , Murakami Masanori , Ohtaka Yoshiko , Fukazawa Hiroshi

Background & objectives: There are multiple forms of functional TSHR autoantibodies which stimulate or inhibit the thyroid. The TSH-Receptor blocking antibody (TSBAb) exists in the serum of Graves’ disease, which is functionally different from TSH receptor stimulating antibody (TSAb). TSBAb that blocks the action of TSH is also associated with idiopathic myxedema and some Hashimoto’s disease. We measured TSBAb levels and evaluated the pathogenetic significance of...

ea0029p1637 | Thyroid (non-cancer) | ICEECE2012

Evidence of humoral response to extracellular matrix proteins in Grave's diseace and thyroid associated ophtalmopathy

Romano M. , Capuani B. , Bei R. , Nucci C. , Pastore D. , Andreadi A. , Sconocchia G. , Caputo M. , Modesti A. , Lauro D. , Bellia A. , Bertoli A.

Thyroid Associated Ophtalmopathy (TAO) is considered one of the most difficult pathologies to treat and a big threat for Graves Disease (GD) patients. This has enhanced the interest in finding a marker that can predict the onset and the prognosis of TAO. It has been demonstrated that GD is a chronic inflamed tissue that there is a remodelling of the ECM structure which elaborate inflammatory signals itself and also promotes the recruitment of cells from the bloodstream; these ...

ea0029p1638 | Thyroid (non-cancer) | ICEECE2012

Thyroid dysfunction in rheumatoid arthritis

Mohammadi F. , Zayeni S. , Jafarnejhad A. , Omami M Hedayati , Amini N.

Introduction: Rheumatoid arthritis, the most common inflammatory arthritis, is commonly seen with thyroid hormone autoantibodies and thyroid dysfunction.In this survey we evaluate the thyroid function and the prevalence of thyroid autoantibody, autoimmune thyroiditis and other forms of thyroid dysfunction to determine whether these patients should be screened for thyroid disease.Material and methods: Our study included 224 rheumatoid arthritis patients (...

ea0029p1639 | Thyroid (non-cancer) | ICEECE2012

The usable markers of atherosclerosis measured by Doppler Ultrasound of lower limb artery in treatment- naive hypothyroid females

Gluvic Z. , Tica J. , Rasic-Milutinovic Z. , Vujovic M. , Popovic-Radinovic V. , Lackovic M. , Isenovic E.

Background: It has been shown that hypothyroidism is associated with atherosclerosis. The presence of atherosclerosis process could be registered by use of some Doppler Ultrasound parameters (DUP) – intima-media complex thickness (IMCT) and systolic velocity (SV). In this study we present initial DUP on the lower limb artery in treatment-naïve hypothyroid females and the influence of thyroid hormone levels and some metabolic components.Methods ...

ea0029p1640 | Thyroid (non-cancer) | ICEECE2012

Maternal-neonatal relationship of iodine metabolism in perinatal period: Changes in urinary iodine excretion in Japanese mothers and newborn infants

Fuse Y. , Ogawa H. , Fujita M. , Arata N. , Harada S. , Ohashi T. , Shishiba Y. , Irie M.

In the perinatal period iodine deficiency results in growth and mental impairment in fetus and newborns. However, there are limited data on iodine metabolism in mother and infants during this critical period.Objective: To assess the changes in urinary iodine concentration (UIC) in mothers and neonates.Methods: From July 2010 to October 2011, 155 pregnant women(31.1±2.1 years) without thyroid disease and their term infants (38....

ea0029p1641 | Thyroid (non-cancer) | ICEECE2012

Is Japan an iodine excess country? Current iodine status assessed by urinary iodine and food frequency questionnaire

Fuse Y. , Tanaka T. , Ogawa H. , Fujita M. , Fuse Y. , Yamaguchi S. , Yamaguchi M. , Arata N. , Harada S. , Ohashi T. , Shishiba Y. , Irie M.

Japan has been regarded as a nongoitorous country due to the regular intake of iodine-rich food. However, nationwide information on current status of iodine intake is not available because there is no survey system for iodine nutrition in Japan.Objective: The objectives of this study is to characterize current iodine status in Japan.Methods: Since 2002 we have conducted studies on iodine nutrition in the Metropolitan area including...

ea0029p1642 | Thyroid (non-cancer) | ICEECE2012

Determinants of children’s iodine nutrition and epidemiological features of children’s goiter and nodule in iodine-excessive areas

Lv S. , Xu D. , Wang Y. , Du Y. , Jia L. , Chong Z. , Ma J. , Zhao J.

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

ea0029p1643 | Thyroid (non-cancer) | ICEECE2012

Control of 217 hypothyroid women during pregnancy

Familiar C. , Anton T. , Marco A. , Tapia M. , Villa M. , Ramos A. , Moraga I.

Introduction: The new guidelines for the management of hypothyroidism (HP) during pregnancy recommend a tighter treatment with levothyroxine (Lt4) to reach TSH values similar to those of pregnant women without thyroid dysfunction (TSH <2.5 mU/l in the 1st trimester-T- and TSH <3mu/l in the 2nd and 3rd T).Objectives: To assess the degree of control of HP in women followed during pregnancy according to the current criteria and the possible associat...

ea0029p1644 | Thyroid (non-cancer) | ICEECE2012

Vitamin D deficiency is not associated with thyroid autoimmunity

Effraimidis G. , Badenhoop K. , Tijssen J. , Wiersinga W.

Context: Vitamin D deficiency has been identified as a risk factor for a number of autoimmune diseases including type 1 diabetes and multiple sclerosis.Objective: We hypothesized that low levels of vitamin D are related to the early stages of autoimmune thyroid disease.Design: Two case-control studies were performed. Study A: cases were subjects from the Amsterdam AITD cohort (euthyroid women who had 1st or 2nd degree relatives wit...

ea0029p1645 | Thyroid (non-cancer) | ICEECE2012

Iodine prophylaxis in pregnant women: effects on offspring and the mother’s thyroid hormones

Santiago P. , Velasco I. , Muela J. , Sanchez B. , Martinez J. , Sanchez C. , Rodriguez A. , Soriguer F. , Berrio Maria

Background and aims: Use of potassium iodide (PI) supplements during gestation in mild to moderate iodine deficiency areas remains a controversial issue.Objective: Comparing the pharmacological effect of iodized salt versus iodide potassium supplements on the maternal thyroid function and neurodevelopment (Bayley Scales) of the progeny.Methods: One hundred and thirty one pregnant women were included from the first trimester (below ...

ea0029p1646 | Thyroid (non-cancer) | ICEECE2012

Low prevalence of postpartum hyperthyroidism in women after radioiodine treatment for Graves' disease before the pregnancy

Yoshihara A. , Noh J. , Mukasa K. , Ohye H. , Watanabe N. , Sekiya K. , Kunii Y. , Suzuki M. , Matsumoto M. , Kosuga Y. , Iwaku K. , Ito K. Ito K.

Context: Postpartum hyperthyroidism (PH) is one of the postpartum thyroid disorders that occurs during the first year postpartum and PH is caused by destructive thyroiditis and recurrent Graves’ disease. PH is an exacerbation of an underlying autoimmune thyroiditis that is aggravated by the immunological rebound that follows the partial immunosuppression that occurs during pregnancy. The prevalence of PH among women with Graves’ disease (GD) who had been treated with...

ea0029p1647 | Thyroid (non-cancer) | ICEECE2012

The outcome of radioiodine therapy after five years in patient with non-toxic nodular goitre

Abdelrazek S. , Rogowski F. , Szumowski P. , Mojsak M. , Zonenberg A. , Siewko K.

The aim of our study was to evaluate the short term efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre. Material and Methods: We treated 120 patients, aged 20–76 years; (88%) of the studied groups were female and (12%) male. Initial 24 h RAIU was ranged between 22–44% and effective half-life was more than 3 days. Thyroid volume ranged between 42–170 ml. Malignant changes we...

ea0029p1648 | Thyroid (non-cancer) | ICEECE2012

Langerhans cell histiocytosis of the thyroid and pituitary gland

Feeney C. , Reddy M. , Todd J. , Tolley N. , Robinson S.

Langerhans cell histiocytosis is a disease caused by clonal proliferation of a group of antigen-presenting cells known as Langerhans cells. Its manifestations range from isolated lesions to multisystem disease usually involving bone, skin and the pituitary stalk. Thyroid involvement is rare.A 44-year old woman presented to the joint thyroid clinic with a short history of neck swelling, confirmed to be a smooth goitre on clinical examination. Initial bloo...

ea0029p1649 | Thyroid (non-cancer) | ICEECE2012

Celiac disease in patients with autoimunne thyroiditis – pilot study

Krcma M. , Balihar K. , Dvorakova E.

Introduction: Benefit of general screening for concomitant autoimunne diseases in patients with chronic autoimunne thyroiditis (AIT) is serious problem from medical, even from economic point of view. Some authors advice for screening, some advert to mass occurence of AIT and warn about huge expenses. Situation vary from one country (region) to another.Aim: To assess incidence of celiac disease in patients with chronic autoimunne thyroiditis and find any ...

ea0029p1650 | Thyroid (non-cancer) | ICEECE2012

Is thyroid volume (TV) in children related to the urinary iodine concentration (UIC) in urine spot sample?

Trofimiuk-Muldner M. , Buziak-Bereza M. , Sokolowski G. , Zygmunt A. , Adamczewski Z. , Szybinski Z. , Lewinski A. , Hubalewska-Dydejczyk A.

Goiter prevalence (GP) and median UIC in population studies are both considered markers of iodine nutrition. Controversy exists which of them is more reliable.Aim: To assess correlation between UIC and thyroid volume in Polish schoolchildren.Material and methods: 9402 Polish schoolchildren (51.3% girls, 48.7% boys) aged 6–12 years were examined in 1999–2011 (‘Thyromobil’ action). 40.9% of children were born at l...

ea0029p1651 | Thyroid (non-cancer) | ICEECE2012

Evaluation of health related quality of life and general symptoms in Hashimoto's thyroiditis: are factors other than thyroid function effective? Analysis of preliminary results

Anil C. , Kut A. , Demir C. , Mousa U. , Bozkus Y. , Bascil Tutuncu N.

Introduction: Factors affecting health related quality of life (HRQOL) in Hashimoto’s thyroiditis (HT) are controversial and research on the topic is limited. This study aimed to evaluate the factors that may affect HRQOL and admitting symptoms in a group of patients with HT.Methods: For the evaluation of HRQOL, SF-36, Beck anxiety scale and Beck depression scale were performed on subsequent 57 cases with HT admitting to outpatient clinic of Endocri...

ea0029p1652 | Thyroid (non-cancer) | ICEECE2012

Proptosis reduction in patients with Graves’ orbitopaty (go) at 12 weeks after intravenous steroid therapy is associated to disease inactivation

Vannucchi G. , Campi I. , Covelli D. , Curro N. , Cirello V. , Dazzi D. , Beck-Peccoz P. , Salvi M.

We have retrospectively studied the clinical outcome of 58 patients (14 men and 44 women) with autoimmune thyroid disease and active GO, treated with high dose intravenous methylprednisolone (MP; cumulative dose 7.5 g). Ophthalmological assessment was performed at baseline and at 6, 12 and 24–30 weeks after the first MP infusion. In 43/58 patients we have also studied NR3C1gene polymorphism, which has been associated to different sensitivity to steroids. The therapeutic o...

ea0029p1653 | Thyroid (non-cancer) | ICEECE2012

Evaluation of the effect of radioactive iodine treatment on urea breath test

Arduc A. , Ozuguz U. , Tutuncu Y. , Aycicek Dogan B. , Tuna M. , Peksoy I. , Gokay F. , Berker D. , Guler S.

Introduction: Helicobacter pylori (HP) infection is the most significant cause of gastritis and related morbidities. Radioactive iodine treatment (RAIT) is an important option in the treatment of hyperthyroidism. In addition to thyroid gland, RAI accumulates in stomach in significant amounts. In our study, we planned to investigate whether RAIT has an effect on carbon-14-urea breath test (UBT) in patients with hyperthyroidism.Materials-method: The...

ea0029p1654 | Thyroid (non-cancer) | ICEECE2012

Review of a thyrotoxicosis shared-care scheme: treatment choice and outcomes

Howlett T. , Kieffer V. , Robinson C. , Peat I. , Kong M. , Gleeson H. , Levy M.

Since 1994, after initial outpatient review (OPD) for thyrotoxicosis, we have minimised OPD attendance and provided shared-care advice to primary care physicians on thyroid function tests (TFT) and anti-thyroid drug (ATD) and levothyroxine (T4) dose titration using our electronic patient record (EPR). Using EPR data we analysed treatment (Rx) choice, effectiveness and outcomes, classifying patients as autoimmune (+ve TPO or other Graves’ features), nodular, mix...

ea0029p1655 | Thyroid (non-cancer) | ICEECE2012

Left-shifted set point of calcium/PTH-relation in patients with Grave’s thyrotoxicosis

Annerbo M. , Stalberg P. , Hultin H. , Hellman P.

Patients with Grave’s disease (GD) are more prone to develop low serum calcium values than patients operated on because of goitre after total thyroidectomy. Moreover, some patients with GD achieve hypercalcemia probably due to active bone disease. We have used citrate-calcium clamping (CiCa) in order to investigate the calcium homeostasis in detail in patients with Grave’s disease.Material and method: Our series of patients undergoing total thy...

ea0029p1656 | Thyroid (non-cancer) | ICEECE2012

Correlation between thyroid hormone values and carotid intima media thickness in patients with subclinical hypothyroidism

Velkoska Nakova V. , Krstevska B. , Srbinovska E. , Bosevski M.

Purpose: The aim of the study was to investigate the influence of TSH and free thyroxin (fT4) hormones on carotid intima media thickness (cIMT).Material and methods: Sixty nine consecutive patients who attended to the Department of University Clinic of Endocrinology, Diabetes and Metabolic disorders with newly diagnosed subclinical hypothyroidism (ScH) were evaluated for mean and maximal cIMT. ScH were defined as elevated TSH with normal fT<su...

ea0029p1657 | Thyroid (non-cancer) | ICEECE2012

miRNA expression of the thyroid after goiter formation and involution using different iodine regimens

Mao J. , Chong W. , Shan Z. , Teng W.

Background: Thyroid damage is known to occur during experimental iodine-induced goiter. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression. Dysregulation of specific miRNAs can interfere with tissue homeostasis. The purpose of this study was to investigate the dynamic expression profiles of miRNAs during adequate or mild-excess iodine supplementation in the iodine-deficient thyroid.Methods: Hyperplastic goiter was induced ...

ea0029p1658 | Thyroid (non-cancer) | ICEECE2012

Autoimmune thyroid disease and cardiovascular risk factors

Neves C. , Esteves C. , Pereira M. , Dias C. , Palmares C. , Sokhatska O. , Carvalho D. , Delgado L. , Medina J.

Aims: To examine whether Graves’ disease (GD) and Hashimoto thyroiditis (HT) are associated with insulin resistance (IR) and other cardiovascular risk factors. Patients and methods: We analyzed 479 patients with autoimmune thyroid disease, 354 (74%) with HT and 126 (26%) with GD, 94% woman, with a mean age of 46±16 years. The patients in both groups were properly treated in order to normalize TSH, FT3 and FT4 levels. We recorded thyroid function...

ea0029p1659 | Thyroid (non-cancer) | ICEECE2012

The syndromes of thyroid autoimmunity among patients with antiphospholipid syndrome

Jelic S. , Stojanovic L. , Marisavljevic D. , Popovic-Kuzmanovic D.

Background: Literature data regarding the prevalence of the syndromes of thyroid autoimmunity (AIT) in antiphospholipid syndrome (APS) are rather limited. However, quite frequently it is hypothesized on common pathophysiologic mechanisms underlining these disorders.Objectives: The aim of this investigation was to evaluate the frequency of disorders of thyroid function and occurrence of anti-thyroid antibodies (ATAs) among patients with antiphospholipid s...

ea0029p1660 | Thyroid (non-cancer) | ICEECE2012

Anti neutrophil cytoplasmic antibody levels in graves patients using propylthiourasil

Baser H. , Balkan F. , Dirikoc A. , Saglam F. , Ersoy R. , Cakir B.

Aim: Antineutrophil cytoplasmic antibody (ANCA) positivity is usually determined in medium and large vessel vasculitis. This antibody has two different forms. Cytoplasmic ANCA (PR3-ANCA) occurs against proteinase-3, while perinuclear ANCA (MPO-ANCA) occurs against myeloperoxidase and bactericidal- permeability increasing proteins. The presence of ANCA is mostly seen in systemic vasculitis and also in drug induced vasculitis. There is no sufficient data about prevalence of posi...

ea0029p1661 | Thyroid (non-cancer) | ICEECE2012

A rare case of interferon-α-induced hyperthyroidism in a patient with chronic hepatitis C with granulocytopaenia and transaminasemia treated successfully with radioiodine

Czarnywojtek A. , Waligorska-Stachura J. , Szczepanek-Parulska E. , Zgorzalewicz-Stachowiak M. , Bereszynska I. , Kurdybacha P. , Stangierski A. , Harasymczuk J. , Florek E. , Wasko R. , Ruchala M.

Background: Conventional management of Interferon-α-Induced Hyperthyroidism (IIH) with radioactive iodine (RAI) may be used when treatment with β blockers or antithyroid drugs (ATD), proves ineffective or is contraindicated.Case presentation: We present a 38-year-old woman who has been treated with combined pegylated interferon alpha (INF-α) and Ribavirin for chronic hepatitis C. Destructive thyrotoxicosis appeared after four months of con...

ea0029p1662 | Thyroid (non-cancer) | ICEECE2012

Elastography in the differential diagnosis of thyroid nodules

Cakal E. , Sahin M. , Ozturk Unsal I. , Gungunes A. , Tutal Akkaymak E. , Cakir Ozkaya E. , Colak Bozkurt N. , Ozbek M. , Delibasi T.

Objective: Despite the publication of a recent meta-analysis of elastography in thyroid nodules, further work is necessary on this issue in different populations. In this study we aimed to evaluate the clinical value of elastography in nodular goiter in mild iodine defficient region without excluding according to nodule charecteristics.Materials and methods: This prospective study was conducted between April 2010 and December 2011 in Yildirim Beyazit Dis...

ea0029p1663 | Thyroid (non-cancer) | ICEECE2012

Assessment of left atrial mechanical function in thyroid dysfunction

Karabag T. , Dogan S. , Bayraktaroglu T. , Sayin M. , Akpinar I. , Aydin M.

Introduction: The objective of this study was to investigate left atrial mechanical function (LAMF) and to associate these measurements with diastolic function in subclinical (SHT) and overt hypothyroidism (OHT).Methods: Twenty-six newly diagnosed patients with SHT (20F, 6M, mean age 42.2±12.5 years), 21 patients with OHT (17F, mean age 40.2±8.5 years) and 28 healthy volunteers (control group, 21F, 42.4±11.2 years) were enrolled in this st...

ea0029p1664 | Thyroid (non-cancer) | ICEECE2012

Prevalence, risk and clinical features of subclinical hyperthyroidism in patients with type 2 diabetes

Diez J. , Iglesias P.

Introduction: Both subclinical hyperthyroidism and type 2 diabetes (T2D) have been associated with an increase in cardiovascular disease risk and mortality. We aimed to assess the prevalence of newly diagnosed subclinical hyperthyroidism in a cohort of patients with T2D, and also to analyse the relationships between diabetes-related characteristics and the presence of subclinical hyperthyroidism.Methods: Nine hundred and thirty-three diabetic patients wi...

ea0029p1665 | Thyroid (non-cancer) | ICEECE2012

Softgel capsules of levothyroxine in the treatment of patients with gastric disorders: preliminary results

Santaguida M. , Virili C. , Del Duca S. , Gargano L. , Centanni M.

Increased need for thyroxine has been described in several gastrointestinal disorders (H. pylori infection, gastric atrophy, celiac disease), even in their occult or symptomless forms. A transitory or stable impairment of gastric acidity, by increasing pH value, seems to interfere with thyroxine availability, highlighting a novel role for the stomach in the following intestinal T4 absorption. Distinctive dissolution profiles of different T4 prepara...

ea0029p1666 | Thyroid (non-cancer) | ICEECE2012

Serum thyrotropin, leptin concentrations, thyroid autoimmunity and smoking status, in an euthyroid, iodine-sufficient, Mediterranean population with different body mass index

Lucas A. , Granada M. , Olaizola I. , Castell C. , Julian M. , Pellitero S. , Puig-Domingo M.

Introduction: A positive correlation between serum thyrotropin concentrations (TSH) and body mass index (BMI) has been demonstrated. Some studies not shown this, in euthyroid subjects, or observed only if thyroid autoimmunity (TA) is present or in non-smokers (NS). Leptin (Lp) could be the major link between BMI and TSH.Design: To analyze the relationship between TSH, free thyroxine (FT4), Lp, TA (peroxidase and/or thyroglobulin antibodies) an...

ea0029p1667 | Thyroid (non-cancer) | ICEECE2012

Resistance to thyroid hormone: clinical, biochemical and genetic features of Mediterranean population

Amor A. , Oriola J. , Quiros C. , Alfayate R. , Borras V. , Escribano A. , Gonzalez C. , Gutierrez A. , Mauri M. , Perez P. , Pico A. , Vourliotaki I. , Halperin I.

Introduction: Resistance to thyroid hormones (RTH) is a genetic disorder caused in 85% of cases by mutations in thyroid hormone receptor beta gene (TRβ). The current information about it in Spanish population is scarce, limited to case reports or short series of patients. Thus, we aimed to describe the clinical, biochemical and genetic features of Mediterranean patients with RTH referred to our institution (one of the referral centres in Spain) for genetic testing during ...

ea0029p1668 | Thyroid (non-cancer) | ICEECE2012

Diagnosis and therapeutic practices of hyperthyroidism in france. results of a survey on 263 endocrinologists and 1214 patients (the thyrdel study)

Goichot B. , Caron P. , Bouee S. , Luca F. , Landron F.

There are considerable variations in diagnosis and therapeutical practices in hyperthyroidism (HT) between countries. Few of these differences rely on a scientific basis. we present the results of a study conducted among a representative sample of 263 French endocrinologists. All consecutive patients seen for HT during the study period were included. Symptoms, biological data and treatment were recorded. 1214 patients with hyperthyroidism were included, 1144 had an identified ...

ea0029p1669 | Thyroid (non-cancer) | ICEECE2012

The impact of TSH on diffusion of thyroglobulin through follicular lumina: possible relation to hormone formation

Milicevic Z. , Bajic V. , Kasapovic J. , Ciric J.

Although the physico-chemical properties of colloid are not usually considered among the factors regulating thyroid function, it is conceivable that decreasing the viscosity of the intrafollicular colloid may facilitate diffusion of thyroglobulin (Tg) molecules within the lumina. The resulting increase in the number of contacts between Tg molecules and peroxidase at the apical membrane may promote the coupling reaction. Rats on a hormonal diet were given 0.5 μg T4</s...

ea0029p1670 | Thyroid (non-cancer) | ICEECE2012

Iodine supply and prevalence of thyroid autoimmunity and autoimmune thyroiditis in children and adolescents between 1 and 16 years old in our city

Garcia-Garcia E. , Vazquez-Lopez M. , Garcia-Fuentes E. , Rodriguez-Sanchez F. , Munoz-Vico J. , Bonillo A. , Soriguer F.

Introduction: Thyroid autoimmunity is related to iodine supply. Iodine nutrition has improved in our country, but the prevalence of autoimmune thyroiditis in our children is unknown.Objectives: To determine the status of iodine nutrition in children and adolescents in our city. To calculate local prevalence of thyroid autoimmunity and autoimmune thyroiditis in pediatric ages.Design: Cross-sectional epidemiological study.<p clas...

ea0029p1671 | Thyroid (non-cancer) | ICEECE2012

Prevalence of thyroid diseases in a population of non-endocrine tumors in north-east Italy

Lio S. , Roiter I.

Few data on prevalence of thyroid diseases in neoplastic groups of patients has been reported. A slight increased prevalence of hypothyroidism and autoimmune thyroiditis in patients with breast cancer and cutaneous melanoma are been described.Aim: Of the study was to evaluate the prevalence of thyroid diseases in a group of non-endocrine neoplasm consecutively evaluated by the oncologist and endocrinologist in a iodine-sufficient area of north-east Italy...

ea0029p1672 | Thyroid (non-cancer) | ICEECE2012

Serum concentrations of thrombospondin-1 and adiponectin in patients with hyperthyroidism before and after normalisation of thyroid function

Dabrowska K. , Lewandowski K. , Skowronska-Jozwiak E. , Brona A. , Milewicz A. , Lewinski A.

Background: Hyperthyroidism is a common endocrine disorder that is linked to increased cardiovascular morbidity and mortality. Thrombospondin, the matricellular protein, is an important player in the process of cardiac remodelling with complex effects on cardiovascular disease (e.g. prothrombotic and antiangiogenic effects vs potential protective effects in heart failure). Adiponectin is an adipose tissue-derived hormone that shows beneficial effects on atherogenesis, endothel...

ea0029p1673 | Thyroid (non-cancer) | ICEECE2012

Changes in serum homocysteine, lipid, vitamin B12, folate levels and glomerular filtration rate before and after treatment in overt hypothyroidism

Kutluturk F. , Yuce S. , Tasliyurt T. , Yelken B. , Aytan P.

Overt hypothyroidism is associated with an increased risk for cardiovascular disease. We aimed in this study, to assess the changes in renal function, serum lipids, vitamin B12, folate and homocysteine levels before and after treatment in hypothyroid patients.Fifty-four (male/female;7/47) hypothyroid patients enrolled to study. We measured homocysteine(tHcy), total cholesterol(TC), triglyceride(TG), HDL-cholesterol (HDL-C), creatinine, folic acid, and vi...

ea0029p1674 | Thyroid (non-cancer) | ICEECE2012

Decreased echogenicity and increased vascularization of fetal thyroid on 2D-ultrasonography caused by mother’s Graves’ disease

Gietka-Czernel M. , Debska M. , Kretowicz P. , Jastrzebska H. , Wasniewska G.

Fetal ultrasonography is recommended in pregnant women with elevated TSH receptor antibodies (TRAK) or treated with antithyroid drugs in attempt to recognize fetal thyroid dysfunction. We report two cases of pregnant women with Graves’ disease in whom fetal thyroid ultrasonography was especially useful in diagnosing child involvement.A 33-year-old woman at 30-week pregnancy with 3-months history of hyperthyroidism treated with propylothiouracil (PTU...

ea0029p1675 | Thyroid (non-cancer) | ICEECE2012

Measurement of TSH, FT4 and FT3 with immunoassays based on LOCI technology

Lepoutre T. , Daumerie C. , Gruson D.

Background: Measurements of TSH, free tetraiodothyronin (FT4) and triiodothyronin (FT3) are essential to achieve assessment of thyroid function. Luminescent Oxygen Channelling Immunoassays (LOCI) have recently been developed for the measurement of biomarkers of thyroid function. Such homogeneous immunoassays allow a faster delivery of the results. The aim of our study were therefore to determine the reference values for LOCI TSH, FT4 and FT<sub...

ea0029p1676 | Thyroid (non-cancer) | ICEECE2012

Thyroid function tests in acute kidney injury

Iglesias P. , Olea T. , Vega-Cabrera C. , Heras M. , Bajo M. , del Peso G. , Arias M. , Selgas R. , Diez J.

Methods: A prospective study in 35 patients hospitalized for AKI for two consecutive years was carried out. TFT (serum thyrotropin, TSH; free thyroxine, FT4; and total triiodothyronine, T3 concentrations) were measured in each patient on three occasions: at admission, at hospital discharge and at their first outpatient visit.Results: Total prevalence of alterations in TFT was 82.9% (n=29). Of those, euthyroid sick syndrome (E...

ea0029p1677 | Thyroid (non-cancer) | ICEECE2012

Spectrum and prevalence of thyroid diseases detected by ultrasonographic examination in west black sea region of Turkey, the MELEN study

Aydin Y. , Besir F. , Erkan M. , Demirin H. , Yazgan , Gungor A. , Onder E. , Aydin L. , Dikici S.

Objective: Aim of the study was to investigate the spectrum and prevelance of goiter and thyroidal diseases by ultrasonography in moderately iodine deficient area.The MELEN study is a prospectively designed survey on the prevalence of cardio metabolic risk factors and thyroid diseases in Turkish adults. A total of 2298 subjects with a mean age of 50 (age range 18–92) were interviewed. Thyroid ultrasonography was performed and interpreted by the same...

ea0029p1678 | Thyroid (non-cancer) | ICEECE2012

Optimal timing of thyroxine dose adjustment for treating patients with primary hypothyroidism: what is the estimated time required to reach stable TSH levels?

Kohler S. , Senn O. , Saleh L. , Wass J. , Schmid C.

Aim: Serum TSH is the target value by which adequate thyroid hormone supply can easily be monitored in patients with primary hypothyroidism. It is controversial when TSH should be measured before thyroxine dose adjustments are made, 4–8 weeks are recommended. To define the time when dose adjustments of thyroxine are feasible more clearly, we looked at the time required to reach stable TSH levels.Methods: We prospectively studied a case series of pat...

ea0029p1679 | Thyroid (non-cancer) | ICEECE2012

The concept of ultrasonographic thyroid pattern: re-evaluation after 10 years

Peretianu D. , Poiana C. , Carsote M. , Staicu D. , Clodeanu A.

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 10 years ago.Material/method: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) Description – eight ETP: pattern 0 – lack of thyroid, 1 – hypoechogenous pseudonodular; 2 – hypoecogen homogenous; 3 – micronodular hypoechogenous; 4 – macro (> 10 mm; ±micro) nodular;...

ea0029p1680 | Thyroid (non-cancer) | ICEECE2012

The role of color-flow Doppler ultrasonography for differential diagnosis between gestational transient thyrotoxicosis and Graves' disease

Zuhur Sayid Shafi , Ozel Alper , Bugdaci Mehmet Sait , Cil Esra , Altuntas Yuksel

Introduction: The differential diagnosis between Graves’ disease (GD) and gestational transient thyrotoxicosis (GTT) is difficult in the absence of history and clinical features of GD. In this study, we aimed to determine the role of peak systolic (PSV) and end-diastolic velocities (EDV) of the right and left inferior thyroid arteries (ITA) as measured by color-flow Doppler ultrasonography (CFDUSG) for discriminating GTT from treatment naive GD.Meth...

ea0029p1681 | Thyroid (non-cancer) | ICEECE2012

The prevalence of hypercreatininemia in patients with primary hypothyroidism

Danciulescu R. , Margina D. , Poiana C. , Musat M.

Background and aims: Clinical studies demonstrated that hypothyroidism can be a cause of hypercreatininemia. The aims of the present study were to investigate the prevalence of hypercreatininemia in patients with primary hypothyroidism.Materials and methods: We retrospectively studied serum creatinine levels in 54 patients with primary iatrogenic hypothyroidism (iatrogenic hypothyroidism result seccondary to radioactive iodine therapy and surgery). Resul...

ea0029p1682 | Thyroid (non-cancer) | ICEECE2012

Prevalence of thyroid diseases in patients with colon cancer and benign colon polyps

Dirikoc A. , Oguz A. , Akin E. , Tuna S. , Ozdemir D. , Aydin C. , Ersoy O. , Ersoy R. , Cakir B.

Aim: In this study, we aimed to evaluate thyroid functions, thyroid antibody positivity, thyroid ultrasonography (US) findings and prevalence of thyroid cancer in patients with colon cancer and benign colon polyps. Also, we aimed to compare prevalence of thyroid diseases in two groups.Materials and methods: Fifty-seven patients with colon cancer and 50 patients with colon polyps were included in the study. All patients were evaluated with thyroid US and ...

ea0029p1683 | Thyroid (non-cancer) | ICEECE2012

‘Racing heart’: a case of unrecognized hyperthyroidism presenting as monomorphic ventricular tachycardia

Lim A. , Sedurante M.

Ventricular tachycardia may occur in the setting of primary hyperthyroidism despite the absence of typical hyperthyroid symptoms. The case is a 40-year old female coming in for epigastric pain and vomiting who was incidentally found to have monomorphic ventricular tachycardia. Despite this she was in no respiratory distress, and exhibited no symptoms of heart failure. Other than agitation, physical examination showed no signs of hyperthyroidism. Initial management included num...

ea0029p1684 | Thyroid (non-cancer) | ICEECE2012

A rare case of periodic hypokalaemic paralysis secondary to Graves’ thyrotoxicosis

Wernig F. , Wincup C. , Wynne K.

A 42-year-old gentleman of Ghanaian origin presented with a 1 month history of worsening severe proximal myopathy. On presentation his symptoms had progressed to the extent that he was unable to mobilise from his bed. Prior to this illness he had been fit and well. Examination revealed severe proximal myopathy and a uniformly enlarged, smooth thyroid gland. There was no clinical evidence of hyperthyroidism.Blood tests on admission showed a serum potassiu...

ea0029p1685 | Thyroid (non-cancer) | ICEECE2012

Ultrasonographic aspects in post-partum thyroiditis

Stanciu M. , Popa F. , Totoian I.

Introduction: Post-partum thyroiditis (PPT) is an autoimmune disorder of the thyroid gland, which occurs in the first year after parturition. Post-partum thyroiditis occurs in 50% of TPO AB+ve women and is characterised by transient hyperthyroidism followed by transient hypothyroidism during the first 6 months, post-partum. A third of the latter group develop permanent hypothyroidism. The aim of this study was to evaluate sonographic characteristics in a g...

ea0029p1686 | Thyroid (non-cancer) | ICEECE2012

Primary and secondary autoimmune thyroiditis in rheumatoid patients

Odin V. , Tyrenko V. , Tzygan E. , Blohin M. , Avtandilashvily N.

Aim: Studying of features autoimmune thyroiditis associated with rheumatoid arthritis (AIT/RA).Methods and materials: Twenty-nine women with AIT/RA were examined. Study design included: special protocol of anamnesis, sonography of thyroid gland, evaluation of thyroglobulin antibodies (Tg-Ab), thyreoperoxidase antibodies (TPO-Ab), the thyroid hormones (T3, T4) and TSH in serum. Two groups of patients have been allocated: I group (...

ea0029p1687 | Thyroid (non-cancer) | ICEECE2012

The effect of radio-iodine treatment on Helicobacter pylori eradication

Usluogullari A. , Caner S. , Ozdemir E. , Onal E. , Ersoy O. , Ersoy R. , Cakir B.

Aim: Radioactive treatment after surgery forms the basis of treatment of differentiated thyroid cancers (DTC) and also used as permanent theraphy of hyperthyroidism. Iodide is being transported into the thyrocytes by the NIS system that located on the thyrocytes’ cell membran. NIS system also has been shown at the gastric mucosa. In this study we proposed to analyse the effect of low and high dose radio-iodine treatment on Helicobacter pylori eradication.<p cla...

ea0029p1688 | Thyroid (non-cancer) | ICEECE2012

Hashimoto’s (chronic) thyroiditis in perimenopausal women

Katai M. , Kondo N. , Yokota J. , Kazuka N. , Todoroki K. , Kawamata M. , Yamaguchi K. , Otsuka K.

Background: One in 10–30 women in general population has Hashimoto’s (chronic) thyroiditis. Development of thyroid dysfunction depends on age. The ratio of woman around 50 with TSH elevation is 10% in general population. Menopause occurs at this age for most women. Many symptoms of hypothyroid state are similar to symptoms of menopause except hot flashes and night sweats. We analyzed the relationship of Hashimoto’s disease and menopausal symptoms.<p class="a...

ea0029p1689 | Thyroid (non-cancer) | ICEECE2012

Hyperglycaemia in hyperthyroidism predictive factors

Azzoug S. , Remini D. , Fellah S. , Koceir E. , Chentli F.

Glucose abnormalities are frequent in hyperthyroidism; the aim of our study is to determine the predisposing factors of glucose disturbances in hyperthyroidism.Subjects and methods: It is a retro and prospective study including 263 hyperthyroid subjects, patients having fasting glycaemia <1 g/l and/or glycaemia after OGTT <1.40 g/l (G1) were compared to patients having fasting glycaemia ≥1 g/l and/or glycaemia after OGTT ≥1.40 g/l (G2...

ea0029p1690 | Thyroid (non-cancer) | ICEECE2012

An unusual case of hyperthyroidism

Boumpaki A. , Vourliotaki I. , Bonapart I. , Alexaki S. , Stamataki K.

Introduction: During embryogenesis the descent of the thyroid may not proceed normally and may stop at various sites from the base of the tongue to any site of the thyroglossal duct.Ectopic thyroid tissue, defined as thyroid tissue not located at its normal site (anterolaterally to the second and fourth tracheal cartilages) is rare. Most often, ectopic tissue is located in the base of the tongue.Case report: We report a 75-year old...

ea0029p1691 | Thyroid (non-cancer) | ICEECE2012

Do thyroid hormone levels in critical illness predict outcome? Experience from a medical ICU in north east India

Saikia U. , Gadve S. , Choudhury S.

Alterations in thyroid hormone levels are commonly observed in critical illness with thyroxine replacement remaining a controversial issue. We undertook a prospective observational cohort study in medical intensive care unit of Gauhati Medical College to evaluate whether thyroid hormone levels at admission could be used to predict mortality and compared it to the well established APACHE II scoring system for ICU patients. Serum T3, T4 and TSH were estimat...

ea0029p1692 | Thyroid (non-cancer) | ICEECE2012

Vitamin E and selenium have a protective role in apoptosis induced by H2O2 in human thyrocytes

Yan S. , Shi S. , Wang Y. , Yu X. , Wang L.

Objective: To investigate the influence of vitamin E (VE) and selenium (Se) on apoptosis of human thyrocyte induced by H2O2.Methods: The human thyroid epithelium cells (TEC) from normal para-adenoma tissues of patients with thyroid adenoma resection were cultured. In prevention groups, vitamin E (50 μmol/l), selenium (10–7 mol/l) or serum-free medium was respectively added into thyrocytes of monolayer culture before H...

ea0029p1693 | Thyroid (non-cancer) | ICEECE2012

Exophtalmoses due to a bilateral lacrymal gland MALT lymphoma in first occurrence of Graves’disease

Solmon C. , Gisserot O. , Hammoutene D.

Introduction: Bilateral exophtalmoses is common at Graves’ disease diagnosis, but context and clinical abnormalities lead sometimes to consider other diagnosis.Case report: A 52-year-old man had a previous history of pulmonary MALT lymphoma in complete remission and Hashimoto’s thyroiditis, which were diagnosed simultaneously 6 years before. He presented recently with hyperthyroidism (TSH <0.001 mUI/l; T4=25 pmol/l) after 2 month...

ea0029p1694 | Thyroid (non-cancer) | ICEECE2012

A correlation study of thyroid nodule cytopathology and histopathology

Roldan P. , Lopez-Tinoco C. , Mateo I. , Larran L. , Ojeda B. , Gavilan I. , Vallejo E. , Martinez-Parra D. , Aguilar-Diosdado M.

Background: Fine-needle aspiration (FNA) biopsies are the cornerstone of preoperative evaluation of thyroid nodules, but FNA diagnostic performance has varied across different studies. We conducted a study to evaluate the effectiveness of ultrasound guided FNA in the thyroid nodule and to review the correlation between cytopathology and histopathology.Methods: Prospective FNAs were collected from 511 patients who underwent a ultrasound guided FNA between...

ea0029p1695 | Thyroid (non-cancer) | ICEECE2012

Prevalence of thyroid dysfunction in a subgroup of male patients with HIV

Sanchez-Ortiga R. , Cerezo-Vidal R. , Sanchez-Pacheco Tardon M. , Mijares M. , Negueruela-Avella G. , Portilla-Sogorb J. , Pico-Alfonso A. , Moreno-Perez O.

Introduction: Thyroid dysfunction has been described as a common clinical entity in HIV infected patients, commonly with negative autoimmune tests. The aim of this work was to determine the prevalence of thyroid abnormalities in a cohort of HIV-infected males in a stable clinical state, the effect of exposure to ART on thyroid function and to identify the risk factors.Materials and methods: This is a cross-sectional, observational study of 90 HIV infecte...

ea0029p1696 | Thyroid (non-cancer) | ICEECE2012

Thyroid concentrations and leptin levels in patients with anorexia nervosa

Nikolic Djurovic M. , Jankovic D. , Petakov M. , Antic J. , Damjanovic S.

Anorexia nervosa (AN) is known as a state of gonadotrophin and leptin deficiency. Leptin, the product of OB gene, secreted by adipocytes, is proved to play an important role in regulating apetite and energy expenditure. Thyroid hormones are Important regulators of total energy expenditure are thyroid hormones and also are able to increase oxygen consumption by tissues. The aim of the study was to evaluate a possible interaction of thyroid hormones (T3, T4...

ea0029p1697 | Thyroid (non-cancer) | ICEECE2012

Congenital hypothyroidism as a rare cause of precocious puberty

Hoxha P. , Puca E. Dyrmishi B. , Ylli Z. , Ylli A. , Puca E.

Severe hypothyroidism is a rare cause of precocious puberty, because long-standing primary hypothyroidism traditionally leads to both pubertal and growth delay. We report a case of a 4.7 year old girl presented with abdominal/pelvic pain and vaginal bleeding since 1 week. The child was diagnosed as a case with a right ovarian mass and was planned for surgery. She was born at term pregnancy without complication. Physical examination revealed typical features of hypothyroidism. ...

ea0029p1698 | Thyroid (non-cancer) | ICEECE2012

Evaluation of subclinical thyroiditis among Egyptian type 1 diabetic patients by Hesham El-Hefnawy, Atef Bassyouni*, Mohamed Abdel-Kareem**, Nibal Abdel-Rahman***, Mary Aziz****And Ibrahim Emara****

El Hefnawy M.

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...

ea0029p1699 | Thyroid (non-cancer) | ICEECE2012

Significant immune associations in chronic thyroiditis

Poiana C. , Carsote M. , Clodeanu A. , Staicu D. , Peretianu D.

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1092, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =61, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =5, D. idiopathic myxedema (hypothyroidism, no A, B,C) =70; E. control...

ea0029p1700 | Thyroid (non-cancer) | ICEECE2012

On cohorts (over 1000 patients), there are relationships between antithyroperoxydase antibody levels and thyroid function in chronic thyroiditis

Carsote M. , Poiana C. , Staicu D. , Clodeanu A. , Peretianu D.

Aim and objectives: To investigate the rapport between the level of thyroid function, through blood level of TSH, both at onset, and in evolution and the level of antithyroperoxydase antibodies (ATPO) and antithyroglobuline antibodies (ATG) in Hashimoto thyroiditis and related diseases.Material and method: Diagnosis: a. ATPO >34 μ/ml = Hashimoto thyroiditis (HT); b. ATPO=normal with high ATG = thyroiditis with only hyper-ATG (T-ATG); c. hypothyr...

ea0029p1701 | Thyroid (non-cancer) | ICEECE2012

How evolves thyroid function in Hashimoto thyroiditis and related disorders

Poiana C. , Carsote M. , Staicu D. , Clodeanu A. , Peretianu D.

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–15 years.Materials and methods: A) Diagnostic: Hashimoto thyroiditis (HT): i) antithyroperoxydase antibodies (ATPO) cut-off 34. ii) If ATPO=normal (N), was considered thyroiditis with only antithyroglobuline antibodies (T-ATG); iii) idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, no TRAB.B) Patients: i) HT: 1092; T-ATG: 61; ...

ea0029p1702 | Thyroid (non-cancer) | ICEECE2012

Influence of thyroxin replacement therapy on cardiovascular system in patients with primary hypothyroidism and arterial hypertension

Orlov Y. , Kileynikov D. , Mazur V. , Platonov D. , Mazur E.

Introduction: We investigated short-term influence of thyroxin replacement therapy on blood pressure (BP) and cardiovascular status in patients with first identified primary hypothyroidism (PH) and earlier diagnosed arterial hypertension (AH).Methods: 52 patients with PH and AH were observed twice: prior to replacement therapy and after reaching euthyroid status. All patients underwent daily BP monitoring, echocardiography, and high frequency ultrasound ...

ea0029p1703 | Thyroid (non-cancer) | ICEECE2012

Psychosis in hyperthyroidism: a case report

Nacpil P.

Background: The most common psychiatric syndromes in thyrotoxicosis are anxiety and mood disturbances. Psychosis, however, is a rare complication. Here is a report of such a case.Case report: A twenty-six year old female presented with a 13 year history of palpitations, easy fatigability and anterior neck mass. Patient denies any comorbid conditions. No family history of psychiatric illness. On March 2011, she was admitted due to logorrhea, auditory hall...

ea0029p1704 | Thyroid (non-cancer) | ICEECE2012

TSH receptor antibody measurement in the diagnosis and management of Graves disease

Ylli D. , Ylli Z. , Husi G. , Hoxha V. , Ylli A.

Introduction: Graves’ hyperthyroidism is an autoimmune disease sustained by autoantibodies binding to and activating the TSH receptor located on the thyroid follicular cell. The objective of study was to determine the presence of anti-receptor TSH antibodies for the diagnosis of Grave’s diseases and the following up after surgery, iodine and treatment with antithyroid drug.Results: In years 2006–2010 in our clinic in 265 patients for thyro...

ea0029p1705 | Thyroid (non-cancer) | ICEECE2012

Life-threatening amiodarone induced thyrotoxicosis: optimizing the treatment and choosing radical therapy according to clinical course: own experience

Kostecka-Matyja M. , Fedorowicz A. , Motyka M. , Pach D. , Hubalewska-Dydejczyk A.

Amiodarone is a widely used antiarhrythmic agent. Although life-threatening side effects of amiodarone therapy are well known, it’s not always possible to replace it with dronedarone. Some clinical trials showed that treatment with dronedarone led to significantly more unfavourable end-points (e.g. in congestive heart failure). Therapy of amiodarone induced thyrotoxicosis still raises many questions concerning optimal treatment choice to achieve euthyreosis as soon as pos...

ea0029p1706 | Thyroid (non-cancer) | ICEECE2012

Thyroid hemiagenesis and bilateral parathyroid adenoma

Oruci M. , Markovic I. , Buta M. , Djurisic I. , Jevric M. , Pupic G. , Dzodic R.

We present a 66 year old patient with right thyroid hemiagenesis and double parathyroid adenoma one on the side of hemiagenesis and the other on the side of present left lobe. The patient came to our Clinic because of pain in the neck and was diagnosed a primary hyperparathyroidism with elevated parathyroid hormon as well as Hashimoto thyroiditis with high level of Tg and TPO antibodies. Ultrasound and technetium sestamibi scintigraphy determined the absence of the right lobe ...

ea0029p1707 | Thyroid (non-cancer) | ICEECE2012

Laminin and poly-laminin, a polymeric form of laminin assembled at acidic pH, differentially modulate PCCL3 thyroid cell behavior

Palmero C. , Barroso M. , Souza E. , Merlmestein C. , Takiya C. , Carvalho D. , Miranda-Alves L. , Nasciutti L.

The extracellular matrix protein laminin forms polymers both in vivo and in vitro. Acidification of pH leads to the formation of an artificial polymer with biomimetical properties, named poly-laminin (polyLM). Follicular cells in the thyroid are in close contact with laminin, but their response to this important extracellular signal is still poorly understood. Thyroid PCCL3 epithelial cells cultivated either on glass, regular laminin (LM) or laminin previously po...

ea0029p1708 | Thyroid (non-cancer) | ICEECE2012

Steroid-responsive encephalopathy associated with Graves’ disease

Dobrescu R. , Morosanu D. , Jercalau S. , Tiu C. , Badiu C.

A 29-year-old female diagnosed 1.5 years ago with Graves’ disease, presented with severe thyrotoxicosis and a large, diffuse goiter after an attempt to taper the anti-thyroid medication. She had also noticed 4 days before presentation right arm mild paresis. The neurological exam confirmed the sensitive and motor deficit. Blood assays confirmed severe thyrotoxicosis (TSH <0.03 mUI/l, fT4=25.6 pmol/l, T3 >500 ng/dl), high levels of anti-thyroi...

ea0029p1709 | Thyroid (non-cancer) | ICEECE2012

Evaluation of the cytopathologic findings of the thyroid nodules which include macrocalcification

Arpaci D. , Ozdemir D. , Cuhaci N. , Dirikoc A. , Kilicyazgan A. , Guler G. , Ersoy R. , Cakir B.

Aim: In our study, we aimed to evaluate the cytologic findings of the thyroid nodules, in which macrocalcification is determined with ultrasonography.Method: We evaluated retrospectively 907 nodules of 269 patients, who have nodular or multinodular goiter and have macrocalcification at least in one nodule. The same patients’ nodules that don’t have macrocalcification are taken into the control group. Patient’s thyroid function tests, ultra...

ea0029p1710 | Thyroid (non-cancer) | ICEECE2012

Autoimmune and allergic diseases associated with autoimmune thyroid diseases

Dagdelen I. , Agbaht K. , Soykan I. , Gullu S.

Background: Sometimes, although the serum thyroid hormone levels are in desired ranges, the patient still has complaints. On the other hand, the dose of levothyroxine replacement may be variable in patients with hypothyroidism. These factors directly influencing the clinical practice may be, to some extent, associated with other immunological/allergic diseases that accompany autoimmune thyroid diseases (ATDs).Aim: To document the other autoimmune/allergi...

ea0029p1711 | Thyroid (non-cancer) | ICEECE2012

L-Thyroxine therapy and depression in subclinical hypothyroidism

Unal M. , Yazgan Aksoy D. , Cinar N. , Okan Yildiz B. , Bayraktar M. , Usman A.

Background and aim: Subclinical hypothyrodism (SH) appears to be associated with mood and changes. The aims of this study were: i) to determine whether depression is more common in SH, and ii) to investigate the effects of L-thyroxine (LT4) therapy on depressive symptoms.Methods: 31 patients with SH and 36 age amd BMI matched healthy controls were included. Beck and Hamilton scales were used to evaluate depression...

ea0029p1712 | Thyroid (non-cancer) | ICEECE2012

‘Too slow for the heart to go’: a case of hypothyroidism-induced cardiomyopathy presenting as acute cardiogenic shock

Lim A. , Cruz M.

Cardiomyopathy can occur due to hypothyroidism or hypocalcemia but often resolves with judicious treatment with levothyroxine and correcting calcium levels to acceptable levels. We discuss a case of a 37-year-old woman presenting with acute cardiogenic shock and a history of total thyroidectomy 6 years prior for papillary thyroid carcinoma stage 1 (T2N1aM0). Patient was non-compliant to levothyroxine treatment and developed easy fatigability and exertional dyspnea 5 months bef...

ea0029p1713 | Thyroid (non-cancer) | ICEECE2012

Graves’ disease and gene polymorphism of TNF-α, IL2, IL6, IL12, and IFN-γ

Anvari M. , Khalilzadeh O. , Esteghamati A.

The role of genetic factors in the pathogenesis of Graves’ disease (GD) is not clear. The purpose of this study was to investigate the association between single nucleotide polymorphisms in pro-inflammatory cytokine genes and GD in Iranian patients. A case–control hospitalbased study was carried out on 107 GD patients and 140 healthy controls. Cytokine typing was performed by PCR with sequence-specific primers (PCR-SSP) assay. The allele and genotype frequencies of t...

ea0029p1714 | Thyroid (non-cancer) | ICEECE2012

Evaluation of CD4+CD161+CD196+ and CD4+IL17+ Th17 cells in the peripheral blood of young patients with Graves’ disease and Hashimoto's thyroiditis

Bossowski A. , Moniuszko M. , Dabrowska M. , Jeznach M. , Sawicka B. , Borysewicz-Sanczyk H. , Rusak M. , Bossowska A.

Up till now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells that have been classified as a new lineage, distinct from Th1, Th2 and Treg cells. Despite wide interest, role of Th17 cells in the pathogenesis of inflammatory and autoimmune diseases is still debated. Th17 cells are involved ...

ea0029p1715 | Thyroid (non-cancer) | ICEECE2012

Study thyroid function in patients with acromegaly

Shestakova T. , Dreval A. , Ilovaiskaja I. , Zaharevich E.

Goal: Study thyroid function in patients with acromegaly. Materials and method: 88 patients with acromegaly, age 54.6±13.2 years, mediana diagnosis acromegaly 4 years, IGF1 528 (265; 701.3 ng/ml, HG 10.4 (3.7; 30.1) μE/ml, only 12 patients had a remission of disease. All patients were taken TSH, fT4, TPO antibodies, revealed anamnesis of thyroid diseases.Results: 19 from 88 patients (21.6%) had hypothyreosis and 2 (2.3%) had subclini...

ea0029p1716 | Thyroid (non-cancer) | ICEECE2012

Subclinical hypothyroidism and thyroid autoimmunity during the 1st quarter of pregnancy in oran area

Amani M. , Chentli F. , Amani S. , Midoun N. , Benfeghoul N. , Rih A. , Zemour L. , Boumansour N.

Introduction: Subclinical hypothyroidism and euthyroid thyroiditis have in common the clinically asymptomatic character. These two diseases can occur during pregnancy with no clinical impact.Our objectives are:– Prevalence of subclinical hypothyroidism during the 1st trimester of pregnancy.– Frequency of autoimmunity in euthyroid pregnant women in 1st quarter.– Analysis o...

ea0029p1717 | Thyroid (non-cancer) | ICEECE2012

Evaluation of hearing and balance functions in patients with Hashimoto's thyroiditis

Arduc A. , Isik S. , Allusoglu S. , Iriz A. , Gokay F. , Aycicek Dogan B. , Tutuncu Y. , Gocer C. , Berker D. , Guler S.

Introduction: It is commonly known that hearing and balance functions are affected in thyroid function disorders. In literature, there are very few studies demonstrating that hearing may be affected due to autoimmunity in euthyroid Hashimoto’s thyroiditis (HT) independent from thyroid functions. In addition, hearing disorders have also been reported in other autoimmune diseases. For this reason, we investigated the functions of the peripheral and central sections of audit...

ea0029p1718 | Thyroid (non-cancer) | ICEECE2012

Stessful life events and Graves’ disease

Kostoglou-Athanassiou I. , Gkountouvas A. , Kaldrymides P.

Stress appears to activate the immunoneuroendocrine network and seems to be related to the development of autoimmune diseases. Graves’ disease is a multisystem disorder characterized by hyperthyroidism, eye disease and pretibial myxedema. Stress appears also to be related to the development of Graves’ disease.The aim was to describe cases of Graves’ disease which developed immediately after a stressful life event.Pat...

ea0029p1719 | Thyroid (non-cancer) | ICEECE2012

Thyrotoxic storm: clinical challenges

Altaf Q. , Syed A. , Shakher J. , Karamat A. , Kamal A.

Thyrotoxic storm is one of the rare but serious, and sometimes life threatening endocrine emergencies, the mortality rate ranges from 20 to 30%.We report the case of a 44-year-old female who had an emergency hospital admission with diarrhoea, vomiting and palpitations in September, 2011. She was diagnosed with Graves thyrotoxicosis in 2004 and was commenced on carbimazole. She was non compliant with the treatment and did not attend her hospital appointme...

ea0029p1720 | Thyroid (non-cancer) | ICEECE2012

A case of toxic multinoduler goiter coexists in TSH-producing pituitary tumor

Kunii Y. , Noh J. , Mukasa K. , Matsumoto M. , Suzuki M. , Iwaku K. , Ohe H. , Watanabe N. , Sekiya K. , Yoshihara A. , Ito K.

Introduction: The frequency of toxic multinoduler goiter (TMNG) is different among the countries depending on an intake of iodine, but it is said to be ~1% of adenomatous goiter in Japan. In addition, the frequency of TSH-secreting pituitary adenoma (TSHoma) is rare with 0.5–1.0% of pituitary gland tumor. There is no report that TMNG coexists in TSHoma so far.Case: A 58 years old female was complained swelling of thyroid and palpitation. We found se...

ea0029p1721 | Thyroid (non-cancer) | ICEECE2012

Pattern of thyroid dysfunction in metabolic syndrome

Gyawali P. , Shrestha R. , Bhattarai P.

Introduction: Thyroid dysfunction is a common endocrine disorder affecting 300 million people around the world and over half are expected to be unaware of the condition. The number of people suffering from metabolic syndrome is also on the rise and it is estimated that a quarter of the world’s adults have metabolic syndrome. Thyroid dysfunction and metabolic syndrome (Met S) are both associated with atherosclerotic cardiovascular disease, hyperlipidemia and low grade infl...

ea0029p1722 | Thyroid (non-cancer) | ICEECE2012

Alteration of clinical characteristics of subacute thyroiditis in last two decades in our hospital

Hamamatsu K. , Matsumoto R. , Takeshima K. , Yamada G. , Murabe H. , Yokota T.

Objective: Subacute thyroiditis (SAT) is a transient inflammatory disease of the thyroid. As we hypothesized that clinical characteristics of SAT were changing recent years, we evaluated data of our patients.Patients and methods: We retrospectively reviewed the medical records of 192 patients (45 men and 147 women) with SAT who visited our hospital from 1990 to 2009. We analyzed these records dividing into two groups by decade, i.e. the first 10 years (1...

ea0029p1723 | Thyroid (non-cancer) | ICEECE2012

Disseminated tuberculosis involving the thyroid: an unlikely scenario

Lim A.

Tuberculosis involving the thyroid gland is known to be rare with 76 cases being reported as of 2006, and may vary in their presentation*. We present a case of a previously well 67-year-old male who consulted for decreased sensorium, jaundice and hypotension, all attributed to sepsis. Patient exhibited no hyper-or hypothyroid symptoms and physical examination did not reveal clues to an underlying thyroid disease. Cultures of the blood, urine and sputum were inconclusive and de...

ea0029p1724 | Thyroid (non-cancer) | ICEECE2012

Prevalence of goiter and thyroid nodular disease in patients with class III obesity

Sousa P. , Guimaraes L. , Freitas H. , Carneiro J. , Mayan C. , Pinheiro M. , Liechocki S. , Vaisman M. , Teixeira P.

Aim: To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and also correlate the findings with serum insulin, leptin and HOMA-IR.Methods: A cross-sectional study with thyroid ultrasound and serum glucose, insulin, leptin and TSH was performed with obese patients and a control group without known thyroid diseases, matched for age and sex, but with BMI of <25 kg/m2.Results: Twent...

ea0029p1725 | Thyroid (non-cancer) | ICEECE2012

Serum nesfatin-1 levels in overt and subclinical hyperthyroidism

Gungunes A. , Ginis Z. , Demirci T. , Cakir E. , Karbek B. , Sayki Arslan M. , Ozturk Unsal I. , Tutal Akkaya E. , Ucan B. , Cakal E. , Gultuna Ozguclu S. , Ozbek M. , Sahin M. , Topaloglu O. , Delibasi T.

Objective: Nesfatin-1, was recently discovered in the brain which is derived from nucleobindin2 (NUCB2). Central and peripheral administration of nesfatin-1, inhibits food intake, dose-dependently. Hyperthyroid patients have increased appetite and food intake with a craving for carbohydrate-rich food, at the beginning of disease, but the physiological mechanisms underlying this behavior is not known exactly. In this study, we investigated whether nesfatin-1 is involved in the ...

ea0029p1726 | Thyroid (non-cancer) | ICEECE2012

Spontaneous splenic rupture following plasmapheresis in a patient with refractory amiodarone-induced thyrotoxicosis

Streuli R. , Pfisterer D. , Fischli S. , Burget L. , Metzger J. , Kauper M. , Henzen C.

Introduction: Amiodarone-induced thyrotoxicosis (AIT) is a well-known complication of amiodarone therapy. Type 1 AIT is caused by excessive iodine-induced thyroid hormone synthesis in abnormal thyroid glands and treated with thionamides; type 2 AIT is a drug induced destructive thyroiditis that responds to glucocorticoids. Mixed forms of AIT need a combined treatment of thionamides and glucocorticoids. In refractory cases of AIT plasmapheresis before total thyroidectomy is an ...

ea0029p1727 | Thyroid (non-cancer) | ICEECE2012

Does serum inflammatory and cytokine profile influence graves disease severity at diagnosis?

Martin S. , Sirbu A. , Fica S.

Introduction: Autoimmune thyroid disease affects 1% of the population and comprises several disorders, including Graves’ disease(GD). Local and serum cytokines are increased in patients with Graves disease, play a central role in co-ordinating immune reactions and have immunolgical and functional effects on thyroid cells.Aim: To investigate serum inflammatory and cytokines profile in untreated patients with Graves’ disease at diagnosis, when th...

ea0029p1728 | Thyroid (non-cancer) | ICEECE2012

TSH according to age and sex. The future of normality

Menacho Roman M. , Perez Lopez G. , del Rey Sanchez J. , Becerra Fernandez A. , Villar R. , Ripoll Sevillano E.

Introduction: Reference ranges for classifying a patient as hyper-, normo- and hypothyroidism vary from one laboratory to another, because the techniques used, regional factors (race, iodine..), but there is also the variables of age and sex of the patient are not taken. Article Thyroid Volume 21, Number 1, 2011, 5–11 Boucai et al, published equations to adjust the normal range in terms of these variables. Evaluate these equations and see if there are significant changes ...

ea0029p1729 | Thyroid (non-cancer) | ICEECE2012

Evaluation of the psychoemotional status of patients after surgical treatment of Graves' disease by catamnesis data

Nechaeva O. , Dreval A. , Mamedova T. , Shestakova T. , Chikh I. , Komerdous I.

Materials and methods: The study included 58 patients (50 female, 8 males) aged from 38 to 60 years, have received surgical treatment for GD with the period of follow-up after treatment for 2 to 10 years. The patients were divided into 2 groups depending on the initial level of TSH. In the first group (33 persons) included patients with low-normal level of TSH (0.4–2.5 mU/ml), the in second group (25 persons) with upper-normal level of TSH (2.6–4.0 mU/ml). An estimat...

ea0029p1730 | Thyroid (non-cancer) | ICEECE2012

Quality of life of patients after surgical treatment of Graves' disease by catamnesis data

Dreval A. , Nechaeva O. , Mamedova T. , Shestakova T. , Chikh I. , Komerdous I.

Materials and methods: The study included 58 patients (50 female, 8 males) aged from 38 to 60 years, have received surgical treatment for GD with the period of follow-up after treatment for 2 to 10 years. The patients were divided into 2 groups depending on the initial level of TSH. In the first group (33 persons) included patients with low-normal level of TSH (0.4–2.5 mU/ml), the in second group (25 persons) with upper-normal level of TSH (2.6–4.0 mU/ml). Quality of...

ea0029p1731 | Thyroid (non-cancer) | ICEECE2012

Thyroid dysfunctions in patients with chronic hepatitis c virus infection with and without interferon therapy

Hammad A. , Hamad F. , Fawzy O. , Hassan Z. , Abaza D. , Elshazly S. , Eltayeb I.

Objective: to assess the frequency and pattern of thyroid dysfunctions (TD) in Egyptian patients with chronic hepatitis C virus infection (HCV) with and without interferon alpha (IFN) therapy.Methods: thyroid function as well as thyroid peroxidase antibodies (TPO Ab) were assessed in 40 untreated Chronic HCV patients (HCV group), 30 HCV patients under IFN alpha therapy, for more than three months (IFN group) and 50 healthy age and sex matched controls.</...

ea0029p1732 | Thyroid (non-cancer) | ICEECE2012

Elevated levels of thyroid hormones without TSH suppression in two patients

Vourliotaki I. , Boumpaki A. , Alexaki S. , Oriola J. , Stamataki K.

Introduction: Resistance to thyroid Hormones (RTH) is a syndrome characterized by reduced tissue responsiveness to thyroid hormones (TH).This results to constantly elevated levels of TSH despite high levels of free T3 (FT3) and free T4 (FT4).RTH is due to mutations of the gene encoding the b-isoform of the receptor of TH (THR-b gene), inherited in the autosomal dominant manner.Clinical expression of RTH varie...

ea0029p1733 | Thyroid (non-cancer) | ICEECE2012

Hyper - and hypothyroidism without symptoms - how much can a patient tolerate ?

Zmire J. , Peros K. , Kljajic Babic K. , Martinac K. , Colak B. , Sokolic L.

Disturbances of thyroid hormones produce clinical symptoms but hormonal level at which this happens vary from patient to patient. In order to determine how much hormonal change patients can tolerate before developing symptoms we retrospectively collected data of 86 hyperthyroid and 48 hypothyroid patients, 120 females and 14 males aged 28–85 and 23–74 yrs respectively. We included only patients who at some time during treatment had abnormal values of TSH and/or thyro...

ea0029p1734 | Thyroid (non-cancer) | ICEECE2012

The influence of chronic stimulation of thyrotropin on nodular thyroid goiter

Medenica S. , Trbojevic B. , Ciric J. , Beleslin B. , Stojkovic M.

Introduction: Nodular goiter is clinically recognizable restricted structure changes of the thyroid gland. FNA is the first line diagnostic test for an enlarged thyroid gland. TSH is known as a thyroid growth factor, but the pathogenic role of this hormone in thyroid oncogenesis is unclear.Objective: The aim of this study is to analyze the relationship between elevated serum TSH concentrations and thyroid malignancies in patients with nodular thyroid goi...

ea0029p1735 | Thyroid (non-cancer) | ICEECE2012

Ischemic stroke without cardiac arrhythmia in a middle age female with thyrotoxicosis

Palermo C. , Torres O. , Martinez J. , Gonzalez E. , Miranda M. , Figueroa J. , Gonzalez J. , Silva F. , Kolodjiev F.

51 y/o female with past medical history of migraine headache, brought to UR because of hypoactivity, generalized weakness, confusion, lack of balance and dysarthria since one day of evolution. No medications. No Habits. Past history: negative for hypertension, cardiac disease or dyslipidemia. Physical examination: normal vital signs and weight. Alert, awake, and oriented only in person. Palpable nontender left thyroid lobe. Bilateral hyperreflexia.Labs: ...

ea0029p1736 | Thyroid (non-cancer) | ICEECE2012

Middle age female with long standing multinodular goiter, cardiac arrhythmia and thyroid dysfunction: the endocrinology and cardiology connection

Palermo C. , Torres O. , Martinez J. , Gonzalez E. , Miranda M. , Figueroa J. , Gonzalez J. , Silva F.

67 y/o old female, with long history of hyperthyroidism, without treatment and hypertension. Two months prior to admission, she received amiodarone 200 mg daily due to cardiac arrhythmia. One week prior to admission, she developed symptoms of Congestive Heart Failure and weight loss. Family history: hyperthyroidism in two sisters. Physical examination: acutely ill, thin female, in moderate respiratory distress. Alert, oriented x 3.BP: 155/119 mmHg HR: 150.Prominent findings: m...

ea0029p1737 | Thyroid (non-cancer) | ICEECE2012

Body Mass Index and goiter in school children. Are there any relationship?

Khalili N. , Hashemipour M.

Introduction: Iodine deficiency is a common problem of public health that usually causes thyroid enlargement called goiter. It is estimated that 750 million people worldwide are at risk of Iodine Deficiency Disorders (IDD). IDD can be presented with a wide variety of clinical manifestations, which induce congenital anomalies, cretinism, deaf mutism, psychomotor defects and severe goiter.About 17 years after the initiation of salt iodization in Iran, this...

ea0029p1738 | Thyroid (non-cancer) | ICEECE2012

The concept ‘one thyroid specific immune mechanism - a specific thyroid disease’. Pleading for adoption of a new nomenclature for immune thyroid diseases

Peretianu D. , Carsote M. , Poiana C. , Staicu D. , Clodeanu A.

Aim, Objectives: Conceptualizing new data related to type and level of autoantibodies in thyroiditis Hashimoto, Graves-Basedow disease and releated conditions.Material: ###1. Adoption the integrative concepts of immune network (Nobel Prize, 1984) for immune thyroid diseases. 2. Searching on “” for papers with keywords: thyroid autoantibody, thyroiditis (~2500 papers). 4. New (auto)-antibodies (and antigens/epitopes) f...

ea0029p1739 | Thyroid (non-cancer) | ICEECE2012

The metabolic syndrome in thyroid disorders

Ogbera A.

Introduction: The objective of this report is to determine the presence of the metabolic syndrome and its components in people with thyroid disorders.Methods: 112 subjects with a history of thyroid disorders were consecutively enrolled for the study. Clinical data was obtained by interviewing the patients and referring to their Case folders and their prescriptions. The subjects were categorized into three; thyrotoxic, euthyroid, hypothyroid based on clin...

ea0029p1740 | Thyroid (non-cancer) | ICEECE2012

The influence of cure of subclinical hyperthyroidism on the level of serum triglycerides and cholesterol fractions

Kaminski G. , Zielinski G. , Podgorski J.

Introduce: Subclinical hyperthyroidism (SH) affects 0.2 - 11.8% of world human population and is associated with important cardiovascular risk factors. It remains controversial whether or not to treat patients with low serum TSH levels. Between unwanted potential outcomes of treatment of SH there is an elevation of the level of serum triglycerides and cholesterol which may be responsible for higher risk of cardiac death.Aim: To estimate an influence of c...

ea0029p1741 | Thyroid (non-cancer) | ICEECE2012

Increase of Serum Adiponectin And Stable Concentrations of Matrix Metalloproteinases Confirm Safety of Radioiodine Treatment of Thyrotoxicosis

Lewinski A. , Brona A. , Lewandowski K. , Bienkiewicz M. , Milewicz A.

Background: Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), remodel extracellular matrix under physiological and pathological conditions and are implicated in pathogenesis of cardiovascular diseases, cancer and in chronic inflammation. We have endeavoured to assess whether concentrations of MMPs, TIMPs, proinflammtory thrombospondin and anti-inflammatory adiponectin are altered by administration of radioiodine during treatment of thyrotoxicosis...

ea0029p1742 | Thyroid (non-cancer) | ICEECE2012

Hyperthyroidism and Pregnancy

Amani M. , Chentli F. , Amani S. , Midoun N. , Benfeghoul N. , Rih A. , Zemour L. , Boumansour N.

Introduction: Hyperthyroidism affects 2 to 3% of pregnant women. The prevalence of clinical hyperthyroidism during pregnancy is variously appreciated. Hyperthyroidism prior to pregnancy is probably more common than in connection with the gestationnal state as gestational hyperthyroidism usually blocks fertility. Our objectives are the prevalence and the causes of hyperthyroidism in pregnant women in the 1st quarter.Description of methods: Prospective stu...

ea0029p1743 | Thyroid (non-cancer) | ICEECE2012

Histopathological results of patients that were undergone thyroidectomy due to results of repeated non-diagnostic cytology

Arpaci D. , Cuhaci N. , Saglam F. , Kiyak G. , Yalcin S. , Akbaba S. , Guler G. , Ersoy R. , Cakir B.

Objective: In our clinic we aimed to assess ultrasonographic and histopathologic data of thyroid nodules of patients with nodular thyroid disease reported their repeated cytologic results as non-diagnostic.Methods: Seventy-five patients with nodular thyroid disease whom their TFNAB results were reported 2–3 times non-diagnostically (due to large nodule, ultrasonographically suspicious nodule, high elastosonographic score or strain index, family hist...

ea0029p1744 | Thyroid (non-cancer) | ICEECE2012

Chlorpyrifos induced alterations in serum electrolytes (calcium, phosphate and magnesium) and endocrine glands (calcitonin cells and parathyroid gland) of Wistar rat

Tripathi S. , Srivastav A.

Wistar rats (male) were divided into three groups – group A (GA) served as control, group B (GB) were daily administered orally chlorpyrifos at a dose of 5 mg/kg b wt. and animals in group C (GC) received daily an oral administration of chlorpyrifos at a dose of 10 mg/kg b wt. Rats were sacrificed on 1st, 2nd, 4th, 6th, and 8th week after initiation of the experiment. Changes in serum electrolytes (calcium, phosphate and magnesium) and endocrine glands (calcitonin cells a...

ea0029p1745 | Thyroid (non-cancer) | ICEECE2012

Utility of sonographic features and citology obtained by ultrasound-guided fine needle aspiration in preoperative management of thyroid nodules

Pacheco L. , Rius F. , Hernandez M. , Buetas P. , Matias-Guiu X. , Mauricio D. , Maravall F.

Introduction: Nodular thyroid disease is common in the general population, but only 5% of thyroid nodules are carcinomas. The diagnostic challenge is to identify those nodules that are malignant neoplasias. Some sonographic features of nodules have been correlated with the risk of malignancy, but at present, thyroid cytology obtained by ultrasound-guided FNA is probably the best tool in the preoperative management of nodular disease.Design: We designed a...

ea0029p1746 | Thyroid (non-cancer) | ICEECE2012

Thyroid disorders and lipid abnormalities: An association between primary hypothyroidism and lipid profile pattern

Acharya D. , Dhital 1R. , Mahato R.

Introduction: The correlation between lipid profile changes & overt hypothyroidism is well established. Overt hypothyroidism is associated with increased risk for cardiovascular disease (CVD) as indicated by hypertension, elevated lipids levels, hypercholesterolemia, and particularly increased low-density lipoprotein cholesterol (LDL-C) levels. However, lipid profile alterations in primary and subclinical hypothyroidism are controversial. There are hardly any studies from ...

ea0029p1747 | Thyroid (non-cancer) | ICEECE2012

Clinical experience in a high-resolution thyroid nodule clinic

Sebastian-Ochoa N. , Sebastian-Ochoa A. , Fernandez-Garcia D. , Fernandez-Garcia J. , Mancha Doblas I. , Tinahones Madueno F.

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Patients and methods: All patients referred to Virgen de la Victoria Hospital (Málaga) from 2005 to 2007 were evaluated foll...

ea0029p1748 | Thyroid (non-cancer) | ICEECE2012

Hypothyroxinemia and pregnancy

Amani M. , Chentli F. , Amani S. , Midoun N. , Benfeghoul N. , Rih A. , Zemour L. , Boumansour N.

Introduction: The maternal hypothyroxinemia would be an adaptive process of the thyroid gland to iodine deficiency, regardless of the TSH. Our objectives are the prevalence and pathophysiological approach of hypothyroxinemia in pregnant women in the 1st quarter.Description of methods: Labor-looking statements, made in Oran area, on 270 pregnant women in 1st quarter. Women who smoke (active smoking confessed) and those followed for thyroid disease or taki...

ea0029p1749 | Thyroid (non-cancer) | ICEECE2012

A case of subacute thyroiditis in a patient on Adalimumab for treatment of refractory palmo-plantar pustular psoriasis

Chiriac A. , Miron C. , Foia L. , Chiriac A. , Solovan C. , Ancuta C.

We describe a case of subacute thyroiditis in a psoriatic patient treated with Adalimumab, with a very good clinical evolution with nonsteroidal anti-inflamatory medication.Tumor necrosis factor alpha (TNF-α) is a pleiotropic cytokine produced by a variety of cells, comprehending T lymphocytes. TNF-α mediates its effects through two receptors, known as p55 (TNF-R1), and p75 (TNF-R2). TNF-α plays a primary role in both the induction and the...