Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 29 | ICEECE2012 | Next issue

15th International & 14th European Congress of Endocrinology


Chronic inflammation and insulin resistance

ea0029s46.1 | Chronic inflammation and insulin resistance | ICEECE2012

AIMing at metabolic syndrome: towards development of novel therapies for modern metabolic diseases via macrophage-derived AIM

Miyazaki T.

Metabolic syndrome is a cascade of metabolic diseases starting with obesity and progressing to atherosclerosis and is often fatal because of serious cardiovascular problems such as heart/brain infarction and hemorrhage. Accumulating evidence has revealed a critical involvement of inflammatory responses triggered by lesional macrophages in its pathogenesis. Importantly, we found that macrophages are associated with the progression of these diseases not only in the induction of ...

ea0029s46.2 | Chronic inflammation and insulin resistance | ICEECE2012

Macrophage regulation of adipocyte biology

Scherer P.

During the progression from the lean to the obese state, adipose tissue undergoes hyperplasia as well as hypertrophy in an attempt to cope with the increased demand for triglyceride storage. This requires a high degree of plasticity at both the cellular and at the tissue level. Even though adipose tissue as a whole seems to be a relatively static tissue containing many adipocytes that turn over relatively slowly, these cells are embedded in an environment that can rapidly adap...

ea0029s46.3 | Chronic inflammation and insulin resistance | ICEECE2012

The inflammatory-adipokine hypothesis and stem cell abnormalities

Vettor R.

Increased body weight and adipose tissue accumulation amplifies the risk of developing various age-related diseases, such as cardiovascular disease, type 2 diabetes mellitus, musculoskeletal disorders. Adipose tissue-derived secreted pro-inflammatory adipokines generate a chronic low-grade inflammation which contributes to the pathogenesis of obesity-linked complications. Recent advancements in tissue-resident adult stem/progenitor cell research have revealed that inflammation...