Endocrine Abstracts

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The search for eternal youth has created a market for treatments that might affect the process of aging, and testosterone (T) is one of the hormones that have been in focus. It is well accepted that T levels decline with increasing age, although the individual variation is large. Male hypogonadism is characterised by a low serum T level in combination with a diversity of symptoms and signs such as reduced libido and vitality, decreased muscle mass, increased fat mass and depre...

Testosterone is a vital hormone in women, circulating in nanomolar concentrations. Not only is testosterone a precursor for estradiol biosynthesis in the ovaries and extragonadal tissues, but testosterone acts directly via androgen receptors throughout the body. Levels decline with age in women with the greatest fall in total and free testosterone occurring before the menopause. Large RCTs involving naturally and surgically postmenopausal women presenting with hypoactive sexua...