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15th International & 14th European Congress of Endocrinology

Symposia

Genetic breakthroughs in reproductive pathology and physiology

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Pathogenesis of primary aldosteronism
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Circadian regulation of metabolism

ea0029s49.1 | Genetic breakthroughs in reproductive pathology and physiology | ICEECE2012

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ea0029s49.2 | Genetic breakthroughs in reproductive pathology and physiology | ICEECE2012

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ea0029s49.3 | Genetic breakthroughs in reproductive pathology and physiology | ICEECE2012

RANK ligand mediates hormone induced mammary epithelial proliferation and carcinogenesis

Gonzalez Suarez E. , Jacob A. , Jones J. , Miller R. , Roudier M. , Erwert R. , Pinkas J. , Branstetter D. , Dougall W.

RANK and RANKL are essential for mammary gland development in mice. We demonstrated that RANK signalling promotes proliferation and impairs mammary epithelial differentiation in mice. RANK and RANKL expression is detected in breast cancer cells. MMTV-RANK acini show hallmarks of transformation in a RANKL dependent manner. After multiple pregnancies MMTV-RANK females spontaneously develop adenocarcinomas, and after DMBA (dimethylbenz(a)anthracene) and MPA (medroxiprogesterone) ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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