Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology

Symposia

HPA axis, stress metabolism and adaptation

ea0029s66.1 | HPA axis, stress metabolism and adaptation | ICEECE2012

Neuroendocrine and (epi)genetic impact on HPA function

de Kloet E.

The HPA axis facilitates adaptation to stress and is essential for metabolism and health, but dysregulation of the HPA axis compromises resilience and promotes vulnerability to stress-related diseases. This includes diseases of the brain where an aberrant stress hormone action targeting susceptibility pathways causes emotional and cognitive disturbances, and affects the onset and progression of neurodegenerative processes, while impairing recovery and neurogenesis. This action...

ea0029s66.3 | HPA axis, stress metabolism and adaptation | ICEECE2012

Modulation of cortisol action

Jangani M. , Berry A. , Matthews L. , Farrow S. , Donn R. , Ray D.

Variation in glucocorticoid (Gc) sensitivity underlies metabolic disease, and affects therapeutic response in inflammation. Using an in-vitro screening approach we identify two new mechanisms capable of regulating Gc sensitivity.The first involves interferon induced factor 16 (IFI16). IFI16 potentiated both transactivation, and Gc repression of NFκB. IFI16 did not affect glucocorticoid receptor (GR) expression, ligand dependent repression of GR expr...