Searchable abstracts of presentations at key conferences in endocrinology
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15th International & 14th European Congress of Endocrinology


Molecular mechanisms of differentiated thyroid cancer

ea0029s1.1 | Molecular mechanisms of differentiated thyroid cancer | ICEECE2012

Molecular consequences of deregulated RNA genes in papillary thyroid carcinoma

de la Chapelle A.

Early miR expression analyses in papillary thyroid carcinoma (PTC) disclosed profound differences in the expression of several, microRNAs in thyroid tumor compared with unaffected thyroid tissue. For instance, miR146 and miR221 were 19- and 11-fold upregulated in PTC. These and other miRs target the thyroid hormone receptor THRB gene. Transfection of cell lines with miR146a and other miRs in vitro resulted in down-regulation of THRB transcript and protein. Promoter luci...

ea0029s1.2 | Molecular mechanisms of differentiated thyroid cancer | ICEECE2012

Correlation between the BRAF V600E mutation, TGFβ pathway and tumour invasiveness in papillary thyroid carcinomas

Riesco-Eizaguirre G. , Santisteban P.

The V600E mutation of BRAF oncogene is one of the most frequent genetic events in thyroid cancer, particularly in papillary thyroid carcinomas (PTC) and in some anaplastic carcinomas that derive from preexisting PTC. It has been associated with advanced clinical stages, extrathyroidal extension, and a high risk of recurrences, particularly those that have lost the ability to accumulate iodide, a property mediated by the sodium iodide symporter (NIS).Our ...