ICEECE2012 Poster Presentations Neuroendocrinology (83 abstracts)
Levothyroxine therapy in patients with secondary hypothyroidism in nonfunctioning pituitary adenomas
V. Aripova , M. Shakirova , G. Saydalieva , D. Nagmutdinova , Y. Urmanova , L. Murtazaeva , A. Akbutaev , D. Alieva , N. Salakhova & N. Kayumova
Tashkent Pediatric Medical Institute, Bogishamol Street 223, Tashkent 100140, Uzbekistan.
Aim: To study the effectiveness of levothyroxine therapy in patients with secondary hypothyroidism in nonfunctioning pituitary adenomas (NFPA).
Materials and methods: We followed 35 patients with NFPA. Of them, 17 were females and 18 males. Mean age of patients was 37.2 years old. All patients were evaluated for hormones levels (GH, LH, FSH, TSH, estradiol, progesterone, testosterone, prolactin, cortisole, free thyroxine, etc.), visual fields, pituitary MRI, thyroid ultrasonography, etc. None of the patients had thyroid disorders.
All evaluations were repeated in 6 months after levothyroxine (Euthyrox, Nycomed, Germany) therapy with the dosage of 100 μg a day before meals.
Results: In patients with long disease background we revealed hypopituitarism with GH, LH, FSH, and TSH deficit as well as IGF1, estradiol, testosterone and thyroxine (100%). All patients had symptoms characteristic for hypothyroidism including sleepiness, loss of memory, dry skin, constipations etc. Blood tests showed dyslipidemia.
Six months therapy with levothyroxine showed significant improvement in well-being of patients such as regression of applicable complaints, laboratory and biochemical values improvement in 25 patients (71.4%).
Conclusion: i) Levothyroxine therapy significantly improves clinical and biochemical values in patients with NFPA ii) it should be recommended to administer levothyroxine therapy to patients with NFPA.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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