Neuroendocrinology

ea0029p1070 | Neuroendocrinology | ICEECE2012

SNPs and CNVs genotyping analysis of patients with idiopathic central hypogonadism (ICH). A novel approach to detect new candidate mechanisms

Libri D. , Bonomi M. , Duminuco P. , Guizzardi F. , Gentilini D. , Persani L.

Introduction: Idiopathic central hypogonadism (ICH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. ICH could be associated or not with hypo-anosmia respectively identifying the Kallmanns syndrome (KS) or the normosmic ICH (nICH). Even though 14 disease genes have been identified, in 70% of patients no genetic cause could be identified, suggesting additional regulatory genes and still unknown mechanisms. Thus, with the aim to identify new ...

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ea0029p1071 | Neuroendocrinology | ICEECE2012

Cidea as a posible mediator of ghrelin resistance induced by high fat diet

Martins L. , Morentin P. Martinez de , Martinez-Sanchez N. , Dieguez C. , Nogueiras R. , Lopez M.

Ghrelin is a peptide hormone secreted by the stomach with orexigenic properties that induce food intake trough the activation of hypothalamic AMP activated kinase (AMPK). In rodents fed on normal diet the central administration of ghrelin induces an increase in food intake, however, when fed a high fat diet (HFD) rodents are resistant to the orexigenic effect of ghrelin. Recent data show that Cidea interacts with AMPK β-subunit and promotes AMPK degradation trough ubiquit...

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ea0029p1072 | Neuroendocrinology | ICEECE2012

Effects of obestatin on proliferation and survival of adult rat hippocampal progenitor cells

Gargantini E. , Baragli A. , Settanni F. , Tagliano M. , Ghigo E. , Granata R.

Obestatin (Ob) is a peptide recently identified as a product of the ghrelin gene. It was claimed to bind to the orphan receptor GPR39, but this finding is still a matter of debate. Ob exerts peripheral effects, for example, it promotes cell survival and has antiapoptotic actions in different cell lines. In addition, Ob has central effects, such as inhibition of thirst, modulation of anxiety, sleep and mnemonic functions. Mnemonic processes involve neurogenesis; in particular, ...

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ea0029p1073 | Neuroendocrinology | ICEECE2012

Normalization of cortisol levels in Cushing's disease after medical pretreatment before surgery: effects on somatostatin receptor subtype expression and in vitro response to somatostatin analogs.

Pas R. van der , Feelders R. , Bruin C. de , Pereira A. , Sprij-Mooij D. , Waaijers M. , Schulz S. , Lamberts S. , Hofland L.

Introduction: Corticotroph pituitary adenomas that cause Cushings disease (CD) predominantly express the dopamine 2 receptor (D2) and somatostatin receptor subtype (sst) 5. The expression of sst2 is relatively low because of downregulating effects of high endogenous cortisol levels. This may explain why the sst2-preferring somatostatin analog octreotide is not effective in CD. To assess whether normalization of urinary free cortisol (UFC) excretion modulates the sst expr...

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ea0029p1074 | Neuroendocrinology | ICEECE2012

Mechanisms for the protective effects of 17-β-estradiol: relevance to depressive symptoms in Parkinson’s disease

Kumar P. , Kale R. , Cowsik S. , Baquer N.

Background: Parkinsons disease (PD) is a neurodegenerative disease and a movement disorder characterized by loss of dopaminergic neurons in the substantia nigra causing dopamine depletion in the striatum. Neurodegeneration in PD occurs due to multiple pathways including oxidative stress, mitochondrial damage, protein aggregation. These changes increase during menopausal condition in females when the level of estradiol is decreased. Recently, there has been a growing inte...

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ea0029p1075 | Neuroendocrinology | ICEECE2012

Transient inhibition of the resolvin system in the hypothalamus of diet-induced obese mice

Pascoal L. , Ignacio-Souza L. , Velloso L.

Inflammation and dysfunction of the hypothalamus is a common feature of experimental diet-induced obesity. As in any inflammatory process, both pro- and anti-inflammatory activity is expected to take place in the hypothalamus of obese animals. Here, we test the hypothesis that consumption of a saturated fatty acid-rich diet can modulate the activity of the important immunomodulatory system of the resolvins in the hypothalamus. Swiss mice were fed for 8 or 16 weeks (w) either o...

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ea0029p1076 | Neuroendocrinology | ICEECE2012

Predictors of neuropsychiatric side effects of dopamine-agonist therapy in patients with prolactinomas

Athanasoulia A. , Sievers C. , Ising M. , Brockhaus A. , Yassouridis A. , Stalla G. , Uhr M.

Introduction: Treatment with dopamine agonists in patients with prolactinomas and Parkinsons disease is associated with central side effects. Central side effects may depend on a substances ability to pass the blood-brain barrier which can be actively controlled by transporter molecules such as the P-glycoprotein encoded by the ABCB1 gene.Aim of the study: To determine whether cabergoline is transported by the P-glycoprotein and whether polym...

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ea0029p1077 | Neuroendocrinology | ICEECE2012

Shift work at young age is associated with elevated long-term cortisol levels and body mass index

Manenschijn L. , Kruysbergen Rvan . , Jong F. de , Koper J. , Lamberts S. , Rossum E. van

Introduction: The incidence of obesity and other features of the metabolic syndrome is increased in shift workers. This may be due to a misalignment between the internal circadian rhythm and the behavioral rhythm. The stress hormone cortisol could play a role in this phenomenon, because it is secreted in a circadian rhythm, and long-term elevated cortisol levels leads to components of the metabolic syndrome. Our aim was to study changes in long-term cortisol levels due to shif...

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ea0029p1078 | Neuroendocrinology | ICEECE2012

The limited screening value of insulin-like growth factor-I as a marker for alterations in body composition in very long term adult survivors of childhood cancer

Blijdorp K. , Heuvel M. Van den , Pieters R. , Lely A. Van der , Neggers S.

Introduction: The clinical relevance of low IGF-I levels, caused by cranial radiotherapy, in adult childhood cancer survivors has not been studied extensively. We evaluated whether IGF-I is a useful marker for altered body composition and growth hormone deficiency in this group.Methods: We analyzed retrospective data from 610 adult childhood cancer survivors, retrieved from the late effects clinic. Median age at diagnosis was 6 years (interquartile range...

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ea0029p1079 | Neuroendocrinology | ICEECE2012

Timing determines the suppressive effect of sleep loss on testosterone

Schmid S. , Hallschmid M. , Jauch-Chara K. , Lehnert H. , Schultes B.

Background: Sleep loss in the early morning has been shown to reduce secretory activity of the pituitarygonadal axis in men, but the determinants of this effect are unknown.Objective: To assess the effects of sleep restriction on serum concentrations of LH, testosterone , and prolactin (PRL).Methods: Fifteen young, healthy men were examined in a condition of sleep time restriction to 02450700 h for two consecutive night...

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ea0029p1080 | Neuroendocrinology | ICEECE2012

CT Scan of the anterior skull base in Kallmann syndrome reveals specific ethmoid abnormalities

Maione L. , Benadjaoud S. , Ducreux D. , Sinisi A. , Chanson P. , Benoudiba F. , Young J.

Context: Kallmann syndrome (KS) is a developmental disease associating congenital hypogonadotropic hypogonadism (CHH) and sense of smell impairment owing to olfactory structures (OS) aplasia/hypoplasia. Although rhinencephalic MRI allows to detect specific KS OS abnormalities useful to discriminate KS from normosmic CHH (nCHH), this technique is not efficient enough to study anterior skull bone structures.Objectives: To search for specific anterior skull...

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ea0029p1081 | Neuroendocrinology | ICEECE2012

Wrist actigraphy detects sleep disorders in patients with Cushing's syndrome

Angelo V D' , Balbo M. , Beccuti G. , Berardelli R. , Karamouzis I. , Picu A. , Marinazzo E. , Fussotto B. , Zichi C. , Giordano R. , Ghigo E. , Arvat E.

Interrelationships between HPA axis and sleep architecture are well documented and increased glucocorticoid levels seem associated with quantitative and qualitative sleep disruptions. The knowledge about sleep parameters in chronic hypercortisolism in humans is scanty. Our aim was to evaluate sleep efficiency in patients with Cushings syndrome (CS) at time of diagnosis, without ongoing specific therapy, using wrist actigraphy, a methodology that provides good estimations...

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ea0029p1082 | Neuroendocrinology | ICEECE2012

Comparison of Chinese herbal mixture and electro-acupuncture on regulating endocrine disturbances and hypothalamic androgen receptor in rats with DHT-induced PCOS

Xu T. , Song L. , Li X. , Ma S. , Li L. , Feng Y.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting reproductive women. Treatments with Chinese herbal mixtures (HM) and electro-acupuncture (EA) have been proven efficient in clinic. This study evaluated the peripheral and central effects of HM and EA in dihydrotestosterone (DHT)-induced PCOS rats. The female Wistar rats were divided into control (C), control with placebo (CP), DHT-induced PCOS model (PCOS), PCOS model exposed to herbal mi...

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ea0029p1083 | Neuroendocrinology | ICEECE2012

Endogenous estradiol levels in female acute stroke patients: an independent determinant of stroke severity and early outcome

Pappa T. , Mantzou E. , Vemmos K. , Stamatelopoulos K. , Vassileiou V. , Alevizaki M.

Introduction: Data on the role of endogenous sex steroids in cerebrovascular disease is sparse. Our aim was to investigate the clinical relevance of circulating sex steroids in a postmenopausal acute stroke population and search for associations with disease severity and short-term outcome.Patients and methods: We prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals, during a time period of 2...

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ea0029p1084 | Neuroendocrinology | ICEECE2012

Long term evolution of patients with transsphenoidal surgery due to pituitary adenomas

Arnes J Garcia . , Gonzalez-Molero I. , Dominguez-Lopez M.

Aim: To study the results of transsphenoidal surgery in our Neuroendocrinology Unit in last 10 years.Methods: We reviewed all patients operated in our hospital and followed in our Neuroendocrinology Unit in the last 10 years. We excluded patients with previous surgery or irradiation on this area. We obtained data about type and size of tumor, previous hormonal deficit, local symptoms,complications of surgery and the status after this (remission, persiste...

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ea0029p1085 | Neuroendocrinology | ICEECE2012

Panhypopituitarism treated and untreated with GH: long term evolution of echocardiographic parameters

Arnes J. Garcia , Gonzalez-Molero I. , Lopez M. Dominguez , Marin M. Gonzalo , Penafiel R. , Madero G. Fernandez

Objective: To evaluate the effects of GH on cardiac structure and function of patients with panhypopituitarism.Material and methods: We performed echocardiographic studies of patients with panhypopituitarism treated and not treated with GH at baseline and after 12 years of follow up. We collected clinical and echocardiographic data (systolic and diastolic ventricular diameter (LVEDD and DTSVI), interventricular septum thickness (IVS), left ventricular po...

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ea0029p1086 | Neuroendocrinology | ICEECE2012

Relationship between sex hormones, cognitive performance and substance use

Zilbermint M , Xu X. , Wisniewski A. , Selnes O. , Dobs A.

Hypogonadism is prevalent with opiate-like drug use and might be a factor in cognitive abnormalities. With the increasing substance use (SU) worldwide, it is critical to recognize its impact on cognition, which may decrease adherence to treatment and alter quality of life. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or drug use, may demonstrate impaired cognitive function.We recruited men aged 1850 from a low-in...

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ea0029p1087 | Neuroendocrinology | ICEECE2012

The proliferation and apoptosis activity of blood lymphocytes in acromegaly

Dudina M , Dogadin S , Savchenko A

Introduction: The number of cells in tissue is governed by two processes the proliferation and programmed cell death apoptosis. Both processes in the body are controlled by enabling or inhibiting factors that are expressed on the surface of CD25+ and CD95+-lymphocytes. Somatotropin (GH) and insulin-like growth factor 1 (IGF1) stimulate proliferation, differentiation, and division of immune cells simultaneously inhibits their apoptosis and can cause tu...

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ea0029p1088 | Neuroendocrinology | ICEECE2012

Long term evolution of patients with prolactinoma in a neuroendocrinology unit

Arnes JGarcia , Gonzalez-Molero I , Dominguez-Lopez M

Aims: To know characteristics and long term evolution of patients with prolactinoma in our Neuroendocrinology Unit.Material and methods: We studied retrospectively all patients with diagnosis of prolactinoma in our Neuroendocrinology Unit in last 12 years.Results: We studied 126 patients. Predominant sex was female (69.07%), 56.7% were macroadenomas. The time from the onset of symptoms until they are seen by the specialist ranges 1...

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ea0029p1089 | Neuroendocrinology | ICEECE2012

Influence of various doses of Cabergoline in dynamics of long-term treatment on the level of blood soluble apoptosis markers in patients with inactive pituitary adenomas

Khalimova Z. , Kholova D.

Aim: Studying of influence of various doses of cabergoline in dynamics of 6, 12 and 24 months of treatment on level of blood serum soluble apoptosis markers P53, Bcl-2 and TNF-α in patients with IPA.Materials and methods: One hundred and twenty-seven patients with IPA (38 men, 89 women) were observed, among them 65 (51.2%) with microadenoma and 62 (48.8%) with macroadenoma/ patients were at the age from 35 till 60 years.Patients with pituitar...

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ea0029p1090 | Neuroendocrinology | ICEECE2012

The blood lymphocytes oxidoreductases activity in patients with active acromegaly

Dudina M. , Dogadin S. , Savchenko A.

Introduction: Somatotropin (GH) and insulin-like growth factor 1 (IGF1) realize their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in pati...

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ea0029p1091 | Neuroendocrinology | ICEECE2012

Hypercortisolism in patients with diabetes mellitus, adrenal incidentaloma and obesity

Dreval A. , Komerdus I. , Murzina A. , Nechaeva O.

Some studies reports the high prevalence of unsuspected hypercortisolism in high-risk populations.Aim: To evaluate the prevalence of undiagnosed hypercortisolism in patients with diabetes mellitus (DM), adrenal incidentaloma and obesity.Material and methods: We prospectively evaluated 30 DM patients (8 male, 22 female, 53.5 years old (18; 73), HbA1c-7.1% (5.6; 13.8)), 22 patients with adrenal incidentaloma (6 male, 16 female, 53.5 ...

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ea0029p1092 | Neuroendocrinology | ICEECE2012

Levothyroxine therapy in patients with secondary hypothyroidism in nonfunctioning pituitary adenomas

Aripova V. , Shakirova M. , Saydalieva G. , Nagmutdinova D. , Urmanova Y. , Murtazaeva L. , Akbutaev A. , Alieva D. , Salakhova N. , Kayumova N.

Aim: To study the effectiveness of levothyroxine therapy in patients with secondary hypothyroidism in nonfunctioning pituitary adenomas (NFPA).Materials and methods: We followed 35 patients with NFPA. Of them, 17 were females and 18 males. Mean age of patients was 37.2 years old. All patients were evaluated for hormones levels (GH, LH, FSH, TSH, estradiol, progesterone, testosterone, prolactin, cortisole, free thyroxine, etc.), visual fields, pituitary M...

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ea0029p1093 | Neuroendocrinology | ICEECE2012

Neuroendocrine abnormalities in adolescents with the Turkish saddle volume formations

Urmanova Y. , Mavlonov U. , Shoraimova M.

Aim: To study character of neuroendocrine disorders in children and adolescents with the Turkish saddle volume formations.Materials and methods: we examined 35 children and adolescents, 17 girls and 18 boys among them with the Turkish saddle volume formations at the neuroendocrine department of the Center for the scientific and clinical study of endocrinology. All examinees underwent general clinical examination as well as biochemical and hormonal invest...

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ea0029p1094 | Neuroendocrinology | ICEECE2012

Somatostatin analogue treatment of acromegaly

Khalikova A. , Khalimova Z.

Aim: To study complications in patients with acromegaly receiving somatostatin after radiotherapy.Materials and methods: We examined 16 patients with mean disease duration 8.5±4.2 years (mean age 41.5±5.6 years) receiving distant gamma-therapy in the total dose of 60 Gy. The patients were divided into two groups: eight patients receiving somatostatin in the dose of 0.5 mg thrice a day and symptomatic therapy for 2 months were included into the ...

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ea0029p1095 | Neuroendocrinology | ICEECE2012

Clinical manifestations of depression in patients with primary hyperparathyroidism

Rikhsieva N. , Ismailov S.

Aim: The work was initiated to study depression manifestations in patients with primary hyperparathyroidism.Materials and methods: Symptoms of anxiety and depression were assessed in 67 patients with primary hyperthyroidism aged from 16 to 30 years examined by means of SpielbergerKhanins test and Becks Depression Inventory.Problem of marginal psychoneurotic disturbances in patients with various somatic pathologies...

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ea0029p1096 | Neuroendocrinology | ICEECE2012

Discovery of a novel peptide, neuroendocrine regulatory peptide-2 regulating feeding behavior and glucose metabolism

Matsuo T. , Toshinai K. , Yamaguchi H. , Sakai K. , Minamino N. , Nakazato M.

Discovery of novel peptides leads to the elucidation of unknown regulatory systems in the body and to the clinical development of diagnosis and therapeutics for diseases. We have used peptidomics approach to profile a complete set of secretory peptides from cultured human endocrine cells and identified two novel carboxy-terminally amidated peptides, 25-amino acid neuroendocrine regulatory peptide (NERP)-1 and 38-amino acid NERP-2, derived from a neurosecretory protein VGF (JBC...

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ea0029p1097 | Neuroendocrinology | ICEECE2012

Effects of low sodium concentrations on neuronal cell models

Deledda C. , Luciani P. , Benvenuti S. , Giuliani C. , Fibbi B. , Marone I. , Chelli E. , Squecco R. , Francini F. , Forti G. , Peri A.

Hyponatraemia is the most frequent electrolyte disorder encountered in hospitalized patients. Hyponatraemia causes a wide variety of neurological signs and symptoms, depending on the rate and degree of serum sodium drop. The negative effects of low extracellular sodium concentrations ((Na+)) on neuronal cells are known to be due to the entry of fluids into the cells, as a consequence of reduced plasma osmolality. To date, it has not been investigated whether low (Na+) ...

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ea0029p1098 | Neuroendocrinology | ICEECE2012

SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development

Young J. , Metay C. , Bouligand J. , Tou B. , Francou B. , Maione L. , Tosca L. , Sarfati J. , Brioude F. , Esteva B. , Briand A. , Goossens M. , Tachdjian G. , Guiochon-Mantel A.

Background: Kallmann syndrome (KS) is a genetic disorder associating pubertal failure with anosmia/hyposmia. KS is related to defective neuronal development affecting both the migration of olfactory nerve endings and GnRH neurons. The discovery of several genetic mutations responsible for KS led to the identification of signaling pathways involved in these processes, but the mutations so far identified account for only 30% of cases of KS. Here we attempted to identify new KS r...

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ea0029p1099 | Neuroendocrinology | ICEECE2012

Stimulatory role of neurokinin B in the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism and regulation by gonadal steroids

Ruiz-Pino F. , Navarro V. , Bentsen A. , Sanchez-Garrido M. , Garcia-Galiano D. , Manfredi-Lozano M. , Leon S. , Clifton D. , Steiner R. , Mikkelsen J. , Pinilla L. , Tena-Sempere M.

Recent studies in various species have pointed out that Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, are important regulators of reproduction. NKB is co-expressed in Kiss1 neurons of the arcuate nucleus (ARC) and stimulates, via auto-regulatory loops, kisspeptin output onto GnRH neurons, therefore stimulating gonadotropin secretion. However, important aspects of the roles of NKB as regulators of the gonadotropic axis remain unknown. We report here th...

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ea0029p1100 | Neuroendocrinology | ICEECE2012

Intracerebroventricular administration of metformin inhibits ghrelin-induced hypothalamic AMP-kinase signalling and food intake

Stevanovic D. , Janjetovic K. , Misirkic M. , Vucicevic L. , Sumarac-Dumanovic M. , Micic D. , Starcevic V. , Trajkovic V.

The antihyperglycaemic drug metformin reduces food consumption through mechanisms that are not fully elucidated. The present study investigated the effects of intracerebroventricular administration of metformin on food intake and hypothalamic appetite-regulating signalling pathways induced by the orexigenic peptide ghrelin. Rats were injected intracerebroventricularly with ghrelin (5 μg), metformin (50, 100 or 200 μg), AICAR (25 μg) and L-leucine (1 μg) in ...

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ea0029p1101 | Neuroendocrinology | ICEECE2012

Genetic variation of the hypothalamo-pituitary axis may increase susceptibility of postnatal depression

Engineer N. , Darwin L. , Deole N. , Ngianga-Bakwin K. , Smith S. , Grammatopoulos D.

Objective: To investigate whether genetic variants in the glucocorticoid receptor (GR) and corticotropin releasing hormone receptor 1 (CRHR1) genes are associated with increased susceptibility for postnatal depression (PND).Methods: A prospective longitudinal cohort study at University Hospital, Coventry, England. Two hundred pregnant women were recruited and assessed for PND using the Edinburgh postnatal depression score (EPDS) upon recruitment and agai...

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ea0029p1102 | Neuroendocrinology | ICEECE2012

Differential diagnosis of acromegaly: a new gene for pachydermoperiostosis

Dalantaeva N. , Dzeranova L. , Atamanova T. , Diggle C. , Bonthron D. , Trivellin G. , Korbonits M.

Case report: 24-year. old man presented with change in facial appearance and joint pain. His symptoms began at puberty with the thickening and folding of the skin on the forehead and scalp and thickening of his fingers. These changes progressed over the next 5 years with marked seborrhoea, hyperhidrosis and linear palmarplantar keratosis. The lower legs and forearms are cylindrically thickened, hands and feet increased in size, the terminal phalanges of the fingers show ...

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ea0029p1103 | Neuroendocrinology | ICEECE2012

Magnetic risonance imaging (mri) of olfactory bulbs and other brain structures in kallmann syndrome

Bellastella G. , Elefante A. , Palumbo V. , D'Errico A. , Napoli M. , Maione L. , Visconti D. , Vargas O. , Briganti F. , Brunetti A. , Sinisi A.

Kallmann syndrome (KS) is characterized by hypogonadotropic hypogonadism and other non-reproductive disorders including smell deficiency due to olfactory bulb developmental abnormalities. The aim of our study was to evaluate retrospectively the role of MRI in patients with clinical diagnosis of KS, searching for any abnormalities of the brain structures involved.Methods: We evaluated 25 KS pts (1432 years, 4F, 21 M). KS cases were classified as hyp...

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ea0029p1104 | Neuroendocrinology | ICEECE2012

Kisspeptin is the peptide linking metabolism and reproduction

Sliwowska J. , Kaczmarek P.

There is a strong correlation between metabolic status (e.g. obesity, diabetes, alcohol use and abuse) and reproductive functions. Disruptions of metabolic status affecting the reproductive system are often manifested as decrease in secretion of hormone (GnRH) and (LH), disruptions of secretion of sex steroids and estrus cycles (in animals) or menstrual cycles (in women), and may even lead to infertility. Diabetes and obesity are also correlated with hypogondism, which is repo...

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ea0029p1105 | Neuroendocrinology | ICEECE2012

Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice

Caricilli A. , Penteado , Mittestainer F. , Abreu L. , Quaresma P. , Santos A. , Guadagnini D. , Razolli D. , Velloso L. , Saad M. , Prada P.

Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a side effect frequently reported in patients and animal models treated with TPM. Some studies showed that TPM may decrease energy storage, and thus increase energy expenditure and thermogenesis. However, the mechanisms by which TPM reduces body weight are not completely understood. Anorexigenic hormones such as insulin and leptin regulate the activity of d...

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ea0029p1106 | Neuroendocrinology | ICEECE2012

Insulin improves memory and cognition via protein kinase c delta (δ)

Apostolatos A. , Cooper D. , Patel N.

Older population and people with type II diabetes have a significantly higher rate of decline in cognitive function. However, the mechanisms are poorly understood. There are strong links between insulin and cognitive function supported by epidemiological data from humans and animal studies and in vitro research. Protein kinase C (PKC) signaling cascades and insulin pathways are closely integrated. The consequences of PKC activation by insulin in the CNS influence memory...

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ea0029p1107 | Neuroendocrinology | ICEECE2012

The Tuebingen Cushing's disease quality of life inventory: development and normative data from 1784 healthy people

Psaras T. , Honegger J. , Milian M.

Objective: In part I of the study a health related quality of life (HRQoL) inventory for Cushings disease (CD), the Tuebingen Cushing-25 quality of life inventory (Tuebingen CD-25) was developed. In the second part, we assessed normative data from healthy controls (HC) with which the individual patients scores can be compared.Methods: Sources for item generation consisted of technical literature, interviews with patients and the rating of neu...

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ea0029p1108 | Neuroendocrinology | ICEECE2012

Oligogenicity in the idiopathic central hypogonadism

Bonomi M. , Libri D. , Pincelli A. , Guizzardi F. , Maiolo E. , Maghnie M. , Krausz C. , Persani L. , On behalf of the Italian Network for ICH

Introduction: ICH is a rare and heterogeneous condition due to defects of GnRH secretion or action. Recent data indicate that ICH, though characterized by a strong genetic component, is a disease of multifactorial origin. Indeed, digenic defects have been described as a possible pathogenic explanation for ICH.Subjects: We present two familial cases with particular clinical and genetic profiles, out of a cohort of 300 ICH patients.R...

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ea0029p1109 | Neuroendocrinology | ICEECE2012

Investigating glucose responsive neuropeptide release using a static hypothalamic incubation system

Hussain S. , Richardson E. , Bewick G. , Bloom S. , Gardiner J.

The activity of certain hypothalamic neuronal populations is altered by changes in glucose. in-vitro studies have identified several glucose-sensitive neuronal populations in hypothalamic regions controlling energy homeostasis. Subsets of orexigenic arcuate nucleus Neuropeptide Y (NPY)-releasing neurones are known to be glucose responsive. These neurones may allow glucose to influence appetite. Cocaine and amphetamine regulated transcript (CART) is a neurotransmitter ab...

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ea0029p1110 | Neuroendocrinology | ICEECE2012

Expanding the clinical and genetic spectrum of the reversal of congenital hypogonadotropic hypogonadism

Laitinen E. , Tommiska J. , Sane T. , Vaaralahti K. , Toppari J. , Raivio T.

Introduction: Up to 10% of patients with congenital hypogonadotropic hypogonadism (HH) may undergo reversal of hypogonadotropism and some of them even attain normal sperm count in adulthood. However, clinical and molecular genetic features of these patients and the triggers leading to reversal of HH are not well understood. We studied whether Finnish reversal variants displayed a common phenotypic or genotypic feature that would predict the clinical course of HH.<p class="...

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ea0029p1111 | Neuroendocrinology | ICEECE2012

Retinoic acid regulates growth-related gene expression in the rat hypothalamus

Stoney P. , Morgan P. , McCaffery P.

The vitamin A-derived hormone retinoic acid (RA) is best known for its essential role in development, but components of the RA signalling pathway are also expressed in regions of the adult brain, including the hypothalamus, which regulates feeding behaviour, metabolism and body weight. RA is synthesised by the tanycytes lining the third ventricle and has recently been found to regulate cell proliferation in the hypothalamus. Some animals, such as the hamster and F344 rat, alte...

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ea0029p1112 | Neuroendocrinology | ICEECE2012

Crf type 2 receptor mediates estradiol-induced increase in hypothalamic leptin sensitivity

Marangon P. , Antunes-Rodrigues J. , Elias L.

Energy homeostasis is controlled by neural, endocrine and adipocyte factors and CNS plays a key role in this control. We have previously observed that ovariectomized (OVX) rats treated with estradiol have lower body weight gain associated with an increased hypothalamic CRF mRNA expression. We investigated the role of CRF on activation of hypothalamic CART neurons by leptin in estradiol-treated OVX rats. Female Wistar rats (200250 g) were subjected to both OVX and cannula...

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ea0029p1113 | Neuroendocrinology | ICEECE2012

Retinal growth hormone: local regulation by GH-releasing hormone (GHRH)?

Harvey S. , Qiang W. , Lin W. , Sanders E.

Introduction: The (GH) gene, identical to that in the pituitary, is expressed in retinal ganglion cells (RGCs) in chickens, rats, mice and humans. Retinal GH is a neuroprotective factor, as it promotes RGC survival and, in humans, the concentration of GH in vitreous fluid may be a marker for ocular disease. Increasing retinal GH expression could thus have therapeutic potential. The factors regulating retinal GH expression are, however, unknown. The possibility that GH-releasin...

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ea0029p1114 | Neuroendocrinology | ICEECE2012

Cu–gnrh and pacap-induced cAMP/PKA and cGMP/PKG pathways activity in anterior pituitary cells in vitro.

Gajewska A. , Wolinska-Witort E. , Zielinska M. , Krawczynska A. , Antushevich H.

Hypothalamic neuropeptide PACAP is a potent endogenous stimulator of adenylate cyclase synthesis in gonadotrope cells. Previously we found that, in contrast to GnRH, also CuGnRH complex is able to induce cAMP/PKA pathway activity.The aim of the study was to determine whether CuGnRH can act via GnRH-R and/or PAC-1 receptors to stimulate cAMP/PKA intracellular signaling. Moreover, we compared PACAP and CuGnRH ability to activate cGMP/PKG ...

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ea0029p1115 | Neuroendocrinology | ICEECE2012

Corticosterone interferes with the stimulatory effect of cAMP on proTRH transcription by promoting a GR–PKAc interaction and not through chromatin remodelling

Sotelo-Rivera I. , Cote-velez A. , Perez-Maldonado A. , Charli J. , Joseph-Bravo P.

The activity of hypothalamuspituitarythyroid (HPT) axis is essential for energy homeostasis. TRH expression in the PVN is rapidy stimulated by energy demanding situations as cold exposure or locomotion, but blunted by stress-induced increased corticosterone serum levels. In primary cultures of rat hypothalamic cells (RHC), PKA activators as forskolin (Fsk) increase TRH mRNA levels, effect reverted by coincubation with dexamethasone. Fsk-dex coincubation also impede...

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ea0029p1116 | Neuroendocrinology | ICEECE2012

Effects of mineralocorticoid agonists and antagonists on survival, proliferation and differentiation of adult rat hippocampal progenitor cells

Gesmundo I. , Gargantini E. , Settanni F. , Ghigo E. , Arvat E. , Granata R.

Introduction: Hippocampus is a key area in the brain and influences the neuroendocrine functions, especially the hypothalamopituitaryadrenal (HPA) axis that is mainly regulated by corticotrophin-releasing hormone (CRH), vasopressin (ADH) and glucocorticoid (GC). This feed-back action is mediated by both glucocorticoid (GRs) and mineralocorticoid (MRs) receptors. GRs are distributed throughout the brain, but mostly in hypothalamic neurons, while the MRs highest expr...

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ea0029p1117 | Neuroendocrinology | ICEECE2012

Sleep deprivation-induced changes in rat hypothalamic arginine–vasopressin content

Gardi J. , Magony S. , Nyari T. , Valkusz Z. , Julesz J. , Krueger J.

Neurohypophysial hormone, argininevasopressin (AVP) concentrations in human plasma and in the plasma, and hypothalamus of the rat display diurnal variations with rising levels over the hours of sleep. Previous reports indicate that AVP infusions reduce rapid-eye-movement sleep in humans and increase the amount of time spent in waking in rats. Our aim was to determine whether AVP content of the rat hypothalamus is altered by sleep deprivation (S.D.). Adult ...

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ea0029p1118 | Neuroendocrinology | ICEECE2012

Abstract withdrawn....

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ea0029p1119 | Neuroendocrinology | ICEECE2012

Ghrelin, leptin and adiponectin plasma levels in narcolepsy with cataplexy

Lakocevic M. , Petakov M. , Barisic M. , Radosavljevic B. , Antic J. , Damjanovic S.

Introduction: Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and REM-sleep abnormalities. Lateral hypothalamic hypocretin/orexin neurones are critical for normal wakefulness and energy expenditure, and the reduction of their activity has been linked with narcolepsy. Their activity is inhibited by extracellular glucose and the satiety hormone leptin but stimulated by the hunger hormone ghrelin. Patients with narcolepsy ...

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ea0029p1120 | Neuroendocrinology | ICEECE2012

High serum cortisol levels in patients with Alzheimer’s Disease

Rizoulis A. , Karaoulanis S. , Dardiotis E. , Rizouli K. , Papadimitriou A.

Introduction: Alzheimers Disease (AD) is a multifactorial disease. The hypothalamo-pituitaryadrenal (HPA)-axis shows extensive changes in AD. It is observed a hyperactivation of corticotropin-releasing hormone (CRH) neurons with age, which is significantly present in men. The aim of this study is to compare serum levels of cortisol in patients with Alzheimers disease and normal controls.Material and Methods: Ninety patients with AD and ...

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ea0029p1121 | Neuroendocrinology | ICEECE2012

Melatonin levels, sleep and psychosocial impairment in patients after radiotherapy for brain tumors or leukemia

Kreitschmann-Andermahr I. , Siegel S. , Thissen A. , Rosenkranz E. , Piroth M. , Brabant G.

Objective: Melatonin is a hormone secreted by the pineal gland which modulates sleep and wakefulness rhythms. Decreased melatonin secretion has been shown to be associated with increased daytime sleepiness and disturbed circadian rhythm in (irradiated) survivors of childhood craniopharyngeoma. The present study was performed to explore possible relationships between disturbed sleep, psychosocial impairment and melatonin secretion in patients treated with cranial radiotherapy a...

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ea0029p1122 | Neuroendocrinology | ICEECE2012

Ten years of gastroenteropancreatic neuroendocrine tumours: evolution of the classification and correlation with follow-up in 50 patients

Albertelli M. , Grillo F. , Giannone A. , Mastracci L. , Annunziata F. , Arvigo M. , Minuto F. , Fiocca R. , Ferone D.

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are rare neoplasms with heterogeneous clinical behavior and potential long-term survival. In the last decade GEPNET nomenclature has been twice reviewed. However, the 2000 WHO classification had poor prognostic power in well differentiated (WD) neoplasms. This led to the introduction of two new important parameters by the European Neuroendocrine Tumors Society (ENETS), grade and stage; the former became part of t...

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ea0029p1123 | Neuroendocrinology | ICEECE2012

Orexigenic neuropeptide 26RFa: new evidence for an adaptive profile of appetite regulation in anorexia nervosa

Galusca B. , Jeandel L. , Germain N. , Chartrel N. , Estour B.

Background: Restrictive anorexia nervosa (AN) presents an adaptive appetite regulating profile including mainly high levels of ghrelin. Because this adaptive mechanism is not effective on food intake, other appetite regulating peptides need to be explored. 26RFa is a hypothalamic neuropeptide that stimulates appetite, gonadotropin release and bone metabolism. The aim of the current study was to evaluate circadian levels of 26RFa in AN patients compared with healthy subjects, o...

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ea0029p1124 | Neuroendocrinology | ICEECE2012

Autoimmune thyroid disease and neuroendocrine gastric tumors: early detection and efficacy of somatostatin analogue treatment

Accardo G. , Renzullo A. , De Bellis A. , Bizzarro A. , Romano M. , Federico A. , Gravina A. , Faggiano A. , Marotta V. , Esposito D. , Bellastella A. , Pasquali D.

Autoimmune chronic thyroid disease (AITD) is associated with atrophic gastritis (CAG) in 2942% of the cases. CAG and the consequent hypergastrinemia, listed as precancerous lesion, can predispose to neuroendocrine cells hyperplasia and the development of neuroendocrine gastric tumors (NET). Aim of this study was to evaluate the association of AITD with risk of gastric NET and the efficacy of somatostatin analogues treatment.Patients: From 2009 to 2...

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ea0029p1125 | Neuroendocrinology | ICEECE2012

Contemporary microsurgical treatment of Cushing’s disease

Honegger J. , Psaras T.

Introduction: Transsphenoidal surgery (TSS) is the treatment option of first choice for Cushings disease (CD). The traditional microsurgical technique has recently been challenged by endoscopic surgical methods. We present endocrine outcome of TSS in CD with a modified contemporary microsurgical concept.Methods: Eighty three patients underwent TSS for newly-diagnosed CD (72 microadenomas and 11 macroadenomas). An enlarged resection was performed in...

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ea0029p1126 | Neuroendocrinology | ICEECE2012

Effect of ghrelin on aromatase gene expression and estradiol 17-β concentrations in ventromedial and lateral hypothalamic area

Khazali H.

The goal of this study was to determine whether ghrelin increase aromatase gene expressions and estradiol 17-β concentrations in ventromedial (VMH) and lateral hypothalamic area (LH). Forty rats were randomly divided into four groups. Animals in different groups were received either saline, 1, 2 or 4 ng ghrelin into their VMH and LH. After infusion of ghrelin, VMH and LH tissue were separated and homogenized. Homogenized sample were assayed for aromatase gene expression b...

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ea0029p1127 | Neuroendocrinology | ICEECE2012

Regional distributions of kisspeptin and gonadotropin-inhibiting hormone peptides in ovine and rat brains

Hasegawa Y. , Hashimoto O. , Tsutsui K.

The reproductive system is controlled by (GnRH) secretion from the brain, which is finely modulated by a number of factors, including gonadal sex steroids and inhibins. It was recently claimed that kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion. Therefore, we have developed highly specific and sensitive fluoro-immunoassays (FIAs) using Eu-labeled antigens for KP 10 and GnIH. In this study, the distributions of KP 10 and GnIH...

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ea0029p1128 | Neuroendocrinology | ICEECE2012

Right hemicolectomy in the treatment of patients with appendiceal neuroendocrine tumors: does size matter?

Grozinsky-Glasberg S. , Alexandraki K. , Barak D. , Kaltsas G. , Gross D.

Background: A recent study of a small series of patients with appendiceal neuroendocrine tumors (ANETs) fulfilling various criteria for right hemicolectomy (RHC) revealed that ≈ 25% may harbor identifiable extra-appendiceal disease. The residual disease might not have been detected using the latest European Neuroendocrine Tumors Society (ENETs) revised pathological criteria.Aims: To evaluate the latest pathological criteria for completion right hem...

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ea0029p1129 | Neuroendocrinology | ICEECE2012

Delay in the onset of puberty of intrauterine growth retarded female rats cannot be rescued by hypernutrition after birth

Matsuzaki T. , Gereltsetseg G. , Iwasa T. , Kinouchi R. , Nakazawa H. , Irahara M.

Perinatal undernutrition is known to disturb reproductive development, in particular by delaying the onset of puberty in certain species. Using a rat model, we studied whether hypernutrition after birth can rescue the delayed onset of puberty in intrauterine undernourished female rats. Pregnant rats were divided into two groups the maternal normal nutrition (mNN, n=8) and maternal undernutrition (mUN, n=9) groups. In the mUN group, dams received 50% of the daily ...

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ea0029p1130 | Neuroendocrinology | ICEECE2012

Fasting induces a delayed increase of thyrotropin-releasing hormone degrading ectoenzyme activity in the tanycytes of the median eminence of the rat hypothalamus

Lazcano I. , Joseph-Bravo P. , Sanchez E. , Charli J.

Fasting produces a rapid reduction of the activity of the central arm of the hypothalamicpituitarythyroid (HPT) axis, with a drop in biosynthesis of thyrotropin releasing hormone (TRH) in periventricular and medial parvocellular neurons of the paraventricular nucleus (PVN), and decreased TRH release into the pituitary portal capillaries. These events contribute to fasting-induced suppression of serum thyroid hormone levels, an adaptive mechanism to conserve energy....

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ea0029p1131 | Neuroendocrinology | ICEECE2012

Estradiol effects on hypothalamic stat3 phosphorylation induced by leptin

Goncalves G. , Borges B. , Marangon P. , Melo C. , Elias L. , Antunes-Rodrigues J.

Besides its critical functions as a reproductive hormone, 17β-estradiol (E2), plays an important role in the control of energy homeostasis. In experimental animals, reduction of circulating estrogen levels by bilateral ovariectomy leads to the development of obesity, which can be reversed or prevented by E2 treatment. E2 effects on energy balance resemble many similarities to the actions of leptin, key molecule involved in the control of e...

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ea0029p1132 | Neuroendocrinology | ICEECE2012

Evaluation of cushings disease remission and serum cortisol dynamic early after transsphenoidal surgery

Rodrigues T. , Costenaro F. , Rolim G. , Czepielewski M.

Aim: serum cortisol dynamic after transsphenoidal pituitary surgery (TSS) in predicting remission and recurrence of CD.Methods: A cohort of 103 CD patients from a referral center was prospectively analyzed at 111 TSS in 6.0±4.8 years of follow-up. Twenty patients received glucocorticoids in transoperative and had serum cortisol measured at 1012 days after TSS (Protocol I). Eighty six patients had serum cortisol measured at each 6 h in the firs...

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ea0029p1133 | Neuroendocrinology | ICEECE2012

Hyponatremia in hospitalised patients: are we investigating and managing them properly?

Murtaza A. , Al-Hourani K. , De P.

Introduction: Hyponatremia is common in hospitalised patients and can be due to a number of aetiologies. Investigations and management are often quite varied.Aims: To find out the prevalence, aetiology, investigations and management of hyponatremia in our hospitalised patients over a 2 week period (1 May and 15 May 2011).Methods: Case notes and electronic data assessment of all patients admitted with sodium level <130 mmol/l.</...

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ea0029p1134 | Neuroendocrinology | ICEECE2012

Epidemiology, clinical behaviour and prognostic factors of gastroenteropancreatic neuroendocrine tumours in Castilla-La Mancha (Spain) from 1995 to 2010

Marco A. , Vicente A. , Lohuibi L. , Alramadan M. , Aguirre M. , Gomez I. , Herranz S. , Roa C.

Neuroendocrine gastroenteropancreatic tumours (GEPNETs) are considered rare malignancies that are characterized by their ability to produce a great variety of peptides that may cause characteristic hormonal syndromes. In this study, we examined the epidemiology, clinical behaviour and prognostic factors of GEPNETs identified in Castilla La Mancha (Spain) from 19952010.Patients and methods: Two hundred and sixteen patients with GEP...

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ea0029p1135 | Neuroendocrinology | ICEECE2012

Effect of galanin on aromataze gene expression and estradiol 17-β concentrations in ventromedial and lateral hypothalamic area

Namdar F. , Khazali H.

The goal of this study was to determine whether galanin increase aromataze gene expressions and estradiol 17-β concentrations in ventromedial (VMH) and lateral hypothalamic area (LH). Forty rats were randomly divided into four groups. Animals in different groups were received either saline, 1, 2 or 4 ng galanin into their VMH and LH. After infusion of galanin, VMH and LH tissue were separated and homogenized. Homogenized sample were assayed for aromataze gene expression b...

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ea0029p1136 | Neuroendocrinology | ICEECE2012

Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge are associated with high ptp1b expression in the hypothalamus

Borges B. , Rorato R. , Marangon P. , Uchoa E. , Antunes-Rodrigues J. , Elias L.

Repeated exposure to lipopolysaccharide (LPS) leads to endotoxin tolerance. Desensitization of hypophagia in response to repeated exposure to endotoxin is related to an inability of leptin to phosphorylate STAT-3 protein. Protein tyrosine phosphatase 1B (PTP1B) activity is known to contribute to leptin resistance by inhibiting leptin signaling. In this study, we induced endotoxin tolerance, injecting repeated LPS doses (6LPS) (100 μg/kg, i.p.) in comparison with single (1...

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ea0029p1137 | Neuroendocrinology | ICEECE2012

Obestatin does not modify weight and nutritional behavior but is associated to metabolic syndrome in old women

Mora M. , Granada M. , Puig R. , Roca M. , Palomera E. , Olaizola I. , Julian M. , Serra-Prat M. , Puig-Domingo M.

Introduction: Ghrelin gene products ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although this latter has not been firmly demonstrated for obestatin in humans. So far, no information has been reported in relation to its potential association to metabolic syndrome (MS).Objective: To study obestatin concentrations in relation to nutritional parameters and eating behavior in old women.Methods: One ...

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ea0029p1138 | Neuroendocrinology | ICEECE2012

Hypopituitarism 3 and 12 months after TBI and SAH

Jonasdottir A. , Sigurjonsson P. , Olafsson I. , Sigthorsson G. , Karason S. , Karlsdottir G. , Sigurjonsdottir H.

Introduction: Recent studies have found hypopituitarism (HP) to be a common complication of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). In Iceland most patients with moderate TBI and all patients with severe TBI and SAH are transferred to Landspitali University Hospital (LSH). The aim of this study was to assess the prevalence of HP following TBI/SAH in Iceland, 3 and 12 months after the incidence.Methods: All adult patients with mode...

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ea0029p1139 | Neuroendocrinology | ICEECE2012

Pituitary incidentaloma: clinical presentation and endocrine evaluation in a Spanish population

Alhambra Exposito M. , Galvez Moreno M. , Tenorio Jimenez C. , Moreno Moreno P. , Benito Lopez P.

Introduction: The incidence of previously unrecognized lesions within the pituitary has been studied by MRI. The data suggest that up to 10% of people have clinically unsuspected pituitary tumors, the majority being<10 mm. Currently, little information is available about the prevalence of incidentally-discovered sellar masses.Objective: To perform a clinical audit on pituitary incidentalomas in order to establish an appropriate clinical approach to t...

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ea0029p1140 | Neuroendocrinology | ICEECE2012

Comparison of the effect of chronic restraint and crowding on hypothalamic-pituitary-adrenocortical response to acute restraint stress

Rachwalska P. , Tadeusz J. , Gadek-Michalska A. , Bugajski J.

Stressful events affect numerous physiological processes including central nervous system and endocrine responses. Repeated stress alters basic mechanisms for the maintenance of hypothalamic-pituitary-adrenocortical (HPA) homeostasis. The purpose of the present study was to determine whether, and to what extent prior repeated restraint or social crowding stress during 3 days affects the HPA response to an acute short-lasting restraint stress. Male Wistar rats were restrained 2...

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ea0029p1141 | Neuroendocrinology | ICEECE2012

Circulating interleukin 6 and soluble forms of interleukin 6 receptor and glycoprotein 130 in women with anorexia nervosa

Karczewska-Kupczewska M. , Kowalska I. , Nikolajuk A. , Adamska A. , Otziomek E. , Gorska M. , Straczkowski M.

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

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ea0029p1142 | Neuroendocrinology | ICEECE2012

Ghrelin and growth hormone levels are decreased in Saudi autistic children

Alhader A. , Al-Zaid F. , AL-Ayadhi L.

Introduction: Autism is a neurodevelopmental disorder with a pathogenesis that is not completely understood. Although a genetic origin has been recognized, a potential role for environmental factors, immune dysfunctions, and variations of hormonal levels was suggested. Ghrelin is a peptide hormone which can stimulate growth hormone (GH) release by activating GH secretagogue receptor. In addition, ghrelin exerts neuroprotective effects, inhibits apoptosis in hypothalamic neuron...

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ea0029p1143 | Neuroendocrinology | ICEECE2012

Basal and stimulated GH secretion in active cushing’s syndrome and 2 years after remission

Picu A. , D'Angelo V. , Karamouzis I. , Berardelli R. , Marinazzo E. , Fussotto B. , Zichi C. , Giordano R. , Ghigo E. , Arvat E.

Impaired GH secretion occurs in Cushings syndrome (CS), reflecting hypothalamic and pituitary alterations, without IGF-I impairment. Obesity is known to blunt GH release, leading to BMI-related tests for GHD. Evaluation of GH in CS after remission is difficult, due to chronic previous hypercortisolism and persistent overweight. Aim of this study was to evaluate in 22 patients with Cushings syndrome (16 Cushing disease, CD, 6 adrenal adenomas, CS) GH response to GHR...

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ea0029p1144 | Neuroendocrinology | ICEECE2012

Overly rapid correction of severe hyponatremia with vasopressin receptor antagonists poses a risk of inducing osmotic demyelination syndrome

Takagi H. , Sugimura Y. , Suzuki H. , Kiyota A. , Fukuoka K. , Oiso Y.

Rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome(ODS). Recent days, vasopressin receptor antagonists(VAs) are clinically used for the treatment of congestive heart failure or hyponatremia including SIADH. To date, few cases of ODS caused by VAs have reported; however, it is presumed that the treatment with VAs for severe hyponatremia may be associated with an increased risk of ODS. Therefore, in this study, we investigated whether rapid correct...

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ea0029p1145 | Neuroendocrinology | ICEECE2012

Relationship between leptin, markers of bone turnover, bone mineral density, and body weight in patients with schizophrenia treated with long acting risperidone (LAIR)

Doknic M. , Maric N. , Britvic D. , Pekic S. , Miljic D. , Stojanovic M. , Damjanovic A. , Jasovic-Gasic M. , Popovic V.

Introduction: Leptin, adipose-tissue-derived hormone has a prominent role in bone remodeling by activating, through CNS relay, the sympathetic tone which inhibits bone formation. Schizophrenia is a CNS disease associated with low bone mass and changes in bone remodeling. Risperidone, atypical antipsychotic, may be related to increase in body weight (BW). Increased BW is thought to be protective to the bone.Aim: To determine relations between leptin, bone...

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ea0029p1146 | Neuroendocrinology | ICEECE2012

Estrogen receptor alpha PvuII polymorphism in female acute stroke patients: no associations with disease severity and short-term prognosis

Pappa T. , Vemmos K. , Mantzou E. , Stamatelopoulos K. , Saltiki K. , Anastasiou E. , Alevizaki M.

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

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ea0029p1147 | Neuroendocrinology | ICEECE2012

The incidence of acromegaly in iceland from 1955 through 2010

Hoskuldsdottir G. , Fjalldal S. , Sigurjonsdottir H.

Objective: Acromegaly is a rare disease with multiple serious comorbidities. The aim of this study was to gather information on patients diagnosed with Acromegaly from 1955 through 2010.Materials and methods: Information on patients with pituitary adenomas diagnosed from 1950 has aldready been gathered and and imported to patient journals at the National University Hospital in Iceland. In this retrospective study information on patients diagnosed with Ac...

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ea0029p1148 | Neuroendocrinology | ICEECE2012

The incidence of hypoglycaemia in non-diabetic hospital patients outside critical care estimated by a capture-recapture technique: retrospective analysis

Nirantharakumar K. , Marshall T. , Hodson J. , Narendran P. , Deeks J. , Coleman J. , Ferner R.

Introduction: Unexplained or a cluster of non diabetic hypoglycaemia has at times been the only clue to malicious use of Insulin in hospitals. We wished to establish the incidence of hypoglycaemia in non-diabetic adult patients outside the intensive care unit (ICU) in a 1200-bed university hospital.Methods: We retrospectively analysed data for 2010 from three distinct sources to identify patients: bedside and laboratory blood glucose measurements; medica...

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ea0029p1149 | Neuroendocrinology | ICEECE2012

An initial dose of 7.5 mg Tolvaptan is safe and effective in the treatment of hyponatremia caused by SIADH

Cuesta M. , Gomez-Hoyos E. , Montanez C. , Martin P. , Marcuello C. , de Miguel P. , Calle A. , Runkle I.

Tolvaptan (TV), an ADH V2-receptor blocker, is useful in treating SIADH-induced hyponatremia. Maximum aquaresis following 15 mg TV occurs on day 1, when excess body water is greatest. This can cause a sharp rise in natremia, and poses a risk of overcorrection. Our aim was to evaluate an initial dose of 7.5 mg.Methods: We studied 7 hospitalized patients with SIADH (4 females), median age 80 (5795), with nadir natremias (Nap) ranging from ...

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ea0029p1150 | Neuroendocrinology | ICEECE2012

Role of endocrine nurse in simultaneous bilateral inferior petrosal sinus sampling (BIPSS): single center experience

Pantovic M. , Stamenovic M. , Simic S. , Zivkovic V. , Tosic M. , Jevtic B. , Kujovic A.

Background: Simultaneous bilateral petrosal sinus sampling is valuable in differentiating the etiology of ACTH dependent Cushings syndrome. It is used to locate the source of ACTH production when pituitary magnetic resonance imaging is negative.Nurses role: Specially trained endocrine nurses are part of the team for inferior petrosal sinus sampling. They prepare necessary material and documentation, mark all test tubes, handle the samples tak...

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ea0029p1151 | Neuroendocrinology | ICEECE2012

PTHrP-induced hypercalcemia: a rare and challenging presentation in metastatic pancreatic neuroendocrine tumour

Pan S. , Curran S. , Corrie P. , Simpson H.

Introduction: Hypercalcemia due to parathyroid-hormone-related-peptide (PTHrP) is rare in neuroendocrine tumours.A 63-year-old lady initially presented to ENT surgeons with symptoms of reflux, dysphagia, and weight loss. Past medical history included hysterectomy eight years previously for uterine prolapse. There was no family history of note. Investigations revealed corrected calcium was elevated at 2.94 (2.12.5) mmol/l. ALP: 184 (30135) U/l...

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ea0029p1152 | Neuroendocrinology | ICEECE2012

Profile of neurosarcoidosis observed in internal medecine practice

Zemmour D. , hakem D. , Fedala-Haddam S. , Yagoubi M. , Abada-Bendib M. , Kessaci F. , Berrah A.

Introduction: Neurological achievements of sarcoidosis or neurosarcoidosis NS is rare (5%), but revealing of the disease in 50%. Neurological and endocrinous signs vary according to the topography of the damage. Cerebral forms results from the infiltration of the meningeal spaces, the granulomatous process spreads secondarily in the cerebral and spinal nerves, in the vessels and in the cerebral parenchyma. NS are individualized better with the contribution of the n...

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15th International & 14th European Congress of Endocrinology

BiosciAbstracts