Endocrine Abstracts (2012) 29 P1724

Prevalence of goiter and thyroid nodular disease in patients with class III obesity

P. Sousa, L. Guimarães, H. Freitas, J. Carneiro, C. Mayan, M. Pinheiro, S. Liechocki, M. Vaisman & P. Teixeira

Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil.

Aim: To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and also correlate the findings with serum insulin, leptin and HOMA-IR.

Methods: A cross-sectional study with thyroid ultrasound and serum glucose, insulin, leptin and TSH was performed with obese patients and a control group without known thyroid diseases, matched for age and sex, but with BMI of <25 kg/m2.

Results: Twenty-one patients and 40 controls, 36.7±8.8, 35.9±9.1 years old, respectively, were included. Median BMI was 50 kg/m2 (patients) and 23 kg/m2 (controls). Median TSH and thyroid volume were 2.2 mUI/ml and 7.9 cm3 (patients) and 1.8 mUI/ml and 7.4 cm3 (controls); P=0.200 and P=0.369. Medians of serum leptin were 4194 and 762 ng/ml (P<0.001). Medians of HOMA-IR were 5.6 and 1.1 (P<0.001). Thyroid volume was correlated with BMI (rs=0.356, P=0.04) and HOMA-IR (rs=0.291; P=0.016) in the whole group. This last association was stronger in the obese group (rs=0.571, P=0.01), but also also present among the controls (rs=0.251, P=0.05). This correlation was independent from confounding parameters (TSH, BMI, leptin), as detected in the partial correlation, controlled for BMI (rs=0.349; P=0.04). The correlation between BMI and volume was related to the serum levels of leptin and HOMA-IR. Leptin only correlated with volume in obese patients. Normal ultrasound was found in 47.6% of patients and in 75% of controls, P=0.30. Nodules were found in 35 and 20%, respectively; P=0.171. The nodules were on average higher in patients, but not significantly.

Conclusion: The prevalence of thyroid nodular disease was not significantly

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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