Endocrine Abstracts

Introduction: The incidence of non-Hodgkin lymphoma (NHL) during pregnancy is quite low. There have been a few anecdotal reports of NHL that arises from the thyroid gland.

Case Report: A 28-year-old female patient presented with a neck swelling, pain and respiratory distress while she was in the 17th week of her first pregnancy. Subtotal thyroidectomy was performed and combined histological and immunohistochemical analyses led to the diagnosis of diffuse large B cell lymphoma with a high proliferation index (Ki-67: 80%) and positive CD20, CD10 and BCL6. Chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), 6 cycles every 4 weeks) was planned and the patient underwent the first 4 cycles without vincristine. Twenty weeks after the initiation of chemotherapy she had cesarean delivery of a healthy, full-term male infant. Four additional courses of chemotherapy were administered, after which the patient was reevaluated. She had no complaints and a total body CT did not show relapse of the disease.

Conclusions: Because of the rarity of NHL and the variety of subtypes of NHL during pregnancy it is not possible to make accurate assessment of outcomes. Our case is a one of the few examples that thyroid lymphoma associated with pregnancy can be successfully managed with a combination of surgery and chemotherapy.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector