ICEECE2012 Poster Presentations Diabetes (248 abstracts)
Glycemic control influences CA19-9, CEA and ferritin levels in type 2 diabetes.
O. Ure 1 , N. Ata 1 , M. Kucukazman 1 , E. Tutal 1 , F. Caglar 1 , M. Hokkaomeroglu 1 , K. Akin 1 , K. Dal 1 , H. Yilmaz 2 , G. Kizilca 1 , E. Beyan 1 & D. Ertugrul 1
1Kecioren Research and Training Hospital, Ankara, Turkey; 2Aydin State Hospital, Aydin, Turkey.
Objective: Diabetes mellitus is associated with various types of cancer. Exocrine pancreas function is also influenced by diabetes.
Materials/Subjects and Methods: In this study we aimed to investigate the effect of glycemic control on tumor and inflammatory markers. Sixty eight type 2 diabetic patients, and 70 healthy controls comprised the study population. We measured fasting blood glucose (FBG), postprandial blood glucose (PPBG), serum total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, akaline phosphatase (ALP), amylase, lipase, high sensitive C-reactive protein (hsCRP), ferritin, carcinoembryonic antigen (CEA), CA19-9, HbA1c concentrations with an automatic analyzer in diabetic and control subjects.
Results: Diabetic group had significantly higher body mass index (BMI), FBG, PPBG, HbA1c, VLDL, TG, ALT, GGT, ALP, CA19-9, CEA, ferritin, hsCRP and erythrocyte sedimentation rate (ESR) values. AST, HDL-C, LDL-C, amylase and lipase levels were significantly lower in the diabetic group. HbA1c showed significant correlation with ferritin (r: .335, P: < .0001), CA19-9 (r: .415, P: < .0001), CEA (r: .485, P: < .0001), ESR (r: .252, P: .003), LDH (r: .369, P: < .0001) and amylase (r: -.309, P: < .0001) levels. FBG was correlated with both CA19-9 (r: .386, P: < .0001) and CEA (r: .465, P: < .0001). PPBG was also correlated with both CA19-9 (r: .394, P: < .0001) and CEA (r: .560, P: < .0001).
Conclusions: We propose to consider the effect of hyperglycemia on CA19-9, CEA, amylase, lipase, ESR and ferritin measurements.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
Figure 1. Correlation between HbA1c and CEA.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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