Endocrine Abstracts

Aim: To study microcirculatory disorders in adolescents with type 1 diabetes mellitus (T1DM).

Patients and methods: Eighty-five adolescents 12–17 years with T1DM were examined. The duration of T1DM was: <1 year – in 29 (HbAc1 7.1±0.4%) – group 1, from 1 to 5 years – in 26 (HbAc1 9.2±1.1%) – group 2, more then 5 years – in 30 patients (HbAc1 10.7±1.1%) – group 3. The indexes of tromboresistance of vessel wall measured by manjetic method. The indexes of trombocyte aggregation by laser method and intravascular aggregation were evaluated.

Results: Tromboresistance of vessel wall was normal in group 1 (P<0.05). Levels of adrenalin-stimulating and intravascular aggregation of thrombocytes were increased (P<0.05). Tromboresistance of vessel wall was decreased in group 2 (P<0.05). Levels of ADP-, kollagen-stimulating and intravascular aggregation (P<0.05) were increased in group 2. Decrease of tromboresistance of vessel wall (P<0.001), increase of activity of thrombocytes (P<0.05) and intravascular aggregation (P<0.001) were found in patients of group 3.

Conclusions: Microcirculatory disorders in adolescents with T1DM correlated with duration of the disease and may demand treatment.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.