C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of CRP.
Material and method: We included in the study 154 subjects with BMI below 25 kg/m2, with no history of diabetes mellitus, conditions and medications that influence glucose control. We excluded patients with diabetes mellitus and CRP higher than 10 mg/l. In all subjects we measure body weight and height, BMI, CRP, FBG and insulin and calculated HOMA-IR.
Results: Regarding HOMA-IR values we divided all subjects in Group A with HOMA-IR less than 2 and Group B HOMA-IR higher than 2. In Group A CRP level was 1.76±0.72 mg/l. In Group B CRP level was 3.84±1.45 mg/l. There is statistically significant higher value of CRP in group B comparing to Group A, P<0.001.
Conclusion: Our results show that greater HOMA-IR is associated with higher levels of CRP and that low-grade inflammation is associated with insulin resistance. Sublicinal inflammation leads to endothelial dysfunction and increased peripheral resistance that promotes insulin resistance further. Levels of CRP higher than 3 mg/l seems too be associated with increased risk for cardiovascular disease and diabetes mellitus. Our observation maybe can be used like adjunctive method for early detection of type 2 diabetes mellitus.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
05 - 09 May 2012
European Society of Endocrinology