Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P933

ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)

Prevalence of chronic autoimmune thyroiditis in patients with polycystic ovary syndrome

A. Vryonidou 1 , E. Vassilatou 2 , D. Ioannidis 3 , M. Panagou 3 , K. Katsoulis 3 , K. Stefanaki 1 & I. Tzavara 3

1Red Cross Hospital, Athens, Greece; 2‘Attikon’ Hospital, Athens, Greece; 3‘Amalia Fleming’ General Hospital, Athens, Greece.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age and is characterized by chronic anovulation and clinical and/or biochemical hyperandrogenism. Chronic autoimmune thyroiditis (AIT) is a common disease of organ-specific autoimmunity affecting predominantly women, that is attributed to an interaction between a genetic background and environmental factors. There are few data showing higher AIT prevalence in PCOS patients.

Objective: To investigate the prevalence of AIT in women with PCOS.

Patients/methods: We studied 272 women diagnosed with PCOS according to the NIH (1990) criteria and 164 age- and weight-matched control women. All patients underwent a hormonal and biochemical evaluation. AIT was diagnosed in women with high levels of anti-Tg and/or anti-TPO antibodies who were further evaluated with thyroid ultrasound. Insulin resistance was assessed by homeostasis model assessment (HOMA-IR).

Results: No significant difference was found in the prevalence of AIT between the two groups (34/272 (12.5%) PCOS patients and 24/164 (14.6%) controls were diagnosed with AIT). PCOS patients with AIT compared to PCOS patients without AIT were significantly older (P<0.01), more obese (P<0.001) and had lower serum SHBG levels (P<0.001). Control women with AIT compared to control women without AIT were significantly older (P<0.001), had lower serum total testosterone and DHEAS levels (P<0.05 and P<0.001 respectively) and were more insulin resistant as assessed by HOMA-IR (P<0.001).

Conclusion: In our cohort, the prevalence of AIT was similar in PCOS women and normal ovulatory women. Further studies with a greater number of participants are needed in order to clarify a possible relationship between these two common entities.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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