ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)
High plasma level of long pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome
A. Aydogdu 1 , I. Tasci 1 , S. Tapan 1 , Y. Basaran 1 , U. Aydogan 1 , C. Meric 1 , A. Sonmez 1 , S. Aydogdu 2 , H. Akbulut 1 , A. Taslipinar 1 , C. Haymana 1 , G. Uckaya 1 & O. Azal 1
1Gulhane School of Medicine, Ankara, Turkey; 2Mevki Military Hospital, Ankara, Turkey.
PCOS is characterized by insulin resistance. Inflammation has been anticipated to play role in the pathogenesis of both insulin resistance and atherosclerosis. Pentraxin 3 (PTX3) is an inflammatory mediator synthesized in a variety of cells and tissues. In the present study, serum PTX3 level and its relationship with insulin resistance were investigated in patients with PCOS. In total, 40 patients with PCOS and 40 age and body mass index (BMI) matched healthy controls were enrolled in the study. Plasma levels of PTX3, hs-CRP and HOMA-IR scores were all significantly higher (P=0.021, P=0.002, and P=0.0001 respectively) in women with PCOS compared to healthy controls. Blood PTX3 level correlated positively with hs-CRP, BMI, waist-to-hip ratio, HOMA-IR, and negatively with high-density lipoprotein cholesterol level (P<0.05, for all). After adjustment for age and BMI, PTX3, total testosterone levels and BMI remained as independent predictors of HOMA-IR scores (P<0.05, for all). PTX3 level is increased in patients with PCOS in concordance with insulin resistance.
Declaration of interest: I fully declare a conflict of interest. Details below:
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
| Variable | PCOS (n=40) | Control (n=40) | P |
| Age (year) | 21.3±4.7 | 21.9±3.5 | 0.062 |
| BMI | 24.7±5.3 | 22.5±2.4 | 0.232 |
| WHR | 0.73±0.5 | 0.73±0.1 | 0.705 |
| Fasting plasma glucose (mg/dl) | 88.3±8.1 | 82.3±6.8 | 0.001 |
| Total cholesterol (mg/dl) | 160.4±33.9 | 165.7±34.4 | 0.513 |
| LDL-cholesterol (mg/dl) | 89.1±25.1 | 98.3±29.5 | 0.162 |
| HDL-cholesterol (mg/dl) | 48.8±11.1 | 53.7±9.3 | 0.705 |
| Triglyceride (mg/dl) | 109.8±74.1 | 68.3±23.7 | 0.004 |
| LH/FSH ratio | 1.5±1.0 | 0.9±0.6 | 0.002 |
| Estradiol (pg/ml) | 66.8±78.3 | 64.1±87.0 | 0.679 |
| Testosterone (ng/dl) | 68.1±29.9 | 41.9±13.4 | 0.0001 |
| DHEA-S (μg/dl) | 337.3±147.1 | 268.9±82.2 | 0.018 |
| Pentraxin 3 (ng/ml) | 1.0±3.6 | 0.8±0.3 | 0.021 |
| hs-CRP (μg/ml) | 1.9±1.6 | 1.0±1.0 | 0.002 |
| Insulin (mIU/ml) | 11.3±4.7 | 6±1.8 | 0.0001 |
| HOMA-IR | 2.5±1.1 | 1.3±0.5 | 0.0001 |
| BMI, body mass index; WHR, waist to hip ratio; HDL, high density lipoprotein; LDL, low density lipoprotein; C, cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance. | |||
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