ICEECE2012 Poster Presentations Adrenal cortex (113 abstracts)
Background: Cushings syndrome is a disease that presents with clear symptoms and causes considerable harm to the body if left untreated, yet often remains undiagnosed for prolonged periods of time. Face-classification software might recognize typical changes of the face and thus aid in diagnosing the disease early as we have previously shown in the classification of acromegaly.
Methods: Using a regular compact digital camera, we took frontal and side-view pictures of 21 female patients with Cushings syndrome (14 endogenous, seven iatrogenic) and of 42 age- and sex-matched controls (2:1 matching).
Nodes were then placed on disease-relevant structures of the face to analyze the pictures using computerized similarity analysis based on Gabor-jets and geometry functions. The leave-one-out cross-validation method was employed to classify subjects by the software.
Results: Using the same combination of Gabor-jets and geometry functions as in our previous publication, 80.1% of patients and 97.6% of controls were correctly classified by the software. This resulted in a total classification accuracy of 92.1%. If only frontal views and only one control person for each patient was included, the classification accuracy was 85.7 and 66.7% in patients and controls, respectively.
Conclusions: In this preliminary analysis we found a good classification accuracy of Cushings syndrome by face-classification software. By employing 2:1 matching and implementing side-view pictures into the classification process, we could substantially improve classification accuracy.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.