We have proposed twelve years ago that bone mass accrual, energy metabolism and reproduction must be coordinately regulated by hormones that would appear during evolution with bone. This hypothesis has been tested and verified in several ways one of them being to show that osteocalcin, the most osteoblast-specific secreted protein, is a hormone that regulates insulin secretion, glucose homeostasis, energy expenditure and male fertility. The metabolic function of osteocalcin has been confirmed, through correlative studies, in humans. Work in our laboratory has begun to unravel the signaling pathway used by osteocalcin to fulfill some of its actions. We will present at the meeting the current state of knowledge signaling the functions and mode of action of this hormone.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details are unavailable.