Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 30 | BSPED2012 | Next issue

40th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Oral Communications

Oral Communications 4

ea0030oc4.1 | Oral Communications 4 | BSPED2012

Metformin in obese children and adolescents: the MOCA trial

Kendall Deborah , Amin Rakesh , Barrett Timothy , Dimitri Paul , Ivison Fiona , Kibirige Mohammed , Mathew Verghese , Matyka Krystyna , Govern Ann Mc , Stirling Heather , Tetlow Lesley , Vail Andy , Wales Jerry , Wright Neil , Clayton Peter , Hall Catherine

Background: Childhood obesity is increasingly associated with type 2 diabetes (T2D). Metformin reduces the risk for T2D in adult obese non-diabetic patients, but the evidence in obese children and young people (CYP) is inconclusive.Design: The metformin in obese children and adolescents (MOCA) trial was a prospective, multi-centre, randomized, double-blind, placebo-controlled trial of 1.5 g metformin daily in CYP with raised fasting or post-prandial insu...

ea0030oc4.2 | Oral Communications 4 | BSPED2012

Patterns of presentation and initial management of type I diabetes mellitus in the UK: the early care survey

Lokulo-Sodipe Kemi , Moon Rebecca J , Edge Julie , Davies Justin H

Background: Unrecognised type I diabetes (TIDM) can have serious consequences which may be avoidable with early diagnosis. Many children have delayed diagnosis, however contributing factors are unclear.Aims: To evaluate the patient pathway before diagnosis and initial hospital management of children with TIDM.Methods: Over a 3-month period, parents of children newly diagnosed with TIDM across the UK completed a questionnaire. Addit...

ea0030oc4.3 | Oral Communications 4 | BSPED2012

White UK children are older, more obese and more insulin resistant than non-White UK children at diagnosis of type 2 diabetes: baseline results of the UK national type 2 diabetes cohort

Gray Zoe , Ilsley Emma , Cotter Catherine , Makusha Lydiah , Ford Anna , Turner Kelly , Heywood James , Barnett Anthony , Dunger David , Hamilton-Shield Julian , Wales Jeremy , Barrett Timothy

Objectives: Type 2 diabetes (T2DM) has increased in UK children since the first reports in 2000; however it is poorly characterised and management practice varies across the UK. We aimed to describe the characteristics of the first 125 children recruited to the UK national study.Methods: We recruited children with: paediatrician diagnosis of T2DM; body mass index (BMI) above 85th centile for age and sex; other diagnoses such as monogenic diabetes exclude...

ea0030oc4.4 | Oral Communications 4 | BSPED2012

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 protein, which regulates its stability and expression

Gharanei Seley , Zatyka Malgorzata , Astuti Dewi , Fenton Janine , Sik Attila , Nagy Zsuzsanna , Barrett Timothy

Wolfram syndrome is an autosomal recessive disorder characterised by neurodegeneration and diabetes mellitus. The gene responsible for the syndrome (WFS1) encodes an endoplasmic reticulum (ER) resident transmembrane protein, that also localises to secretory granules in pancreatic β cells. Although its precise functions are unknown, WFS1 protein deficiency affects the unfolded protein response, intracellular ion homeostasis, cell cycle progression, and granular acidificati...

ea0030oc4.5 | Oral Communications 4 | BSPED2012

The effect of insulin intensification on glycaemic control and lipid levels in children and young persons with type 1 diabetes differs in relation to ethnic group

Dias Renuka , Brown Freya , Wyatt Claire , Cheema Sharanjit , Allgrove Jeremy , Amin Rakesh

Background: Previous studies identify non-White ethnicity as predictive of poor diabetes related outcomes. However, many of these reports originate from the United States and may, in part, reflect complex interactions between ethnicity, healthcare inequality and social deprivation.Objective and hypotheses: We aimed to prospectively determine the effect of insulin intensification on glycaemic control and lipid levels in relation to ethnicity in a UK cohor...