Endocrine Abstracts

The diagnosis of GHD in young adults is not straightforward and represents a major clinical challenge. The key predictors of persistent GHD are the severity of the original GH deficiency, the presence of additional pituitary hormone deficits, severely low IGF1 concentrations, and structural hypothalamic–pituitary (HP) abnormalities. We have demonstrated that patients with GHD and congenital HP may not require re-evaluation of GH secretion, whereas patients with isolated G...

The multiple endocrine neoplasia syndromes comprise a group of heredity conditions which predispose individuals to various tumours of the endocrine glands. The conditions are inherited in an autosomal dominant fashion.Children can be affected by the conditions and it is important to recognise who is at risk because of the options of preventative strategies (MEN2) and screening to reduce morbidity (MEN1). However, genetic testing of children is problemati...