Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2013

Clinical Management Workshops

Management controversies in parathyroid disease

ea0031cmw1.4 | Management controversies in parathyroid disease | SFEBES2013

Medical management of primary hyperparathyroidism

Hosking David

Surgical parathyroidectomy remains the most cost effective treatment for primary hyperparathyroidism but where surgery is inappropriate because of significant co-morbidity there is a place for medical therapy. Calcimimetics are type II agonists (requiring calcium for activity) of the calcium sensing receptor (CaSR). The first compound of this class is cinacalcet which reduces PTH by about 50% at 4 h with recovery to within 20% of baseline over the next 8 h. Despite these fluct...