Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder present in 5–15% of women in the reproductive age group. There have been a number of international consensus meetings that have focussed on diagnosis and management, with the third ESHRE/ASRM sponsored PCOS consensus workshop in 2010 looking at the various health aspects of PCOS, apart from the well known effects on reproduction. These include problems during adolescence, hirsutism and acne, men...

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Metformin has been used extensively in multiple reproductive settings including to ameliorate hyperandrogenism and chronic anovulation, to treat infertility, to prevent miscarriage and to prevent later pregnancy complications. Metformin does result in modest improvements in the PCOS phenotype with reductions in circulating insulin and testosterone levels, weight loss, and improved menstrual/ovulatory frequency. It is relatively ineffective as a solo agent to treat infertility,...

Hirsutism is the presence of excessive terminal hair in androgen dependent areas of the female body. A frequent medical complaint that affects ∼ 12% of Caucasian premenopausal women, hirsutism usually results from relatively benign functional disorders. Among them, the polycystic ovary syndrome is the most frequent etiology.The most important tool for the diagnosis of hirsutism is a complete clinical history and physical examination. Functional cau...