Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2013

Poster Presentations

Cytokines and growth factors

ea0031p136 | Cytokines and growth factors | SFEBES2013

Effect of acute hypoxia upon myostatin expression in healthy individuals

Elliott Bradley , Renshaw Derek , Getting Stephen , Watt Peter , Mackenzie Richard

We previously showed acute hypoxic conditions result in atrophy of myotubes in vitro. Chronic hypoxic exposure in vivo induces muscular atrophy in healthy mountaineering individuals and patients with COPD. Myotubes in vitro increase myostatin expression in response to hypoxic exposure. Further, hypoxic COPD patients show cachexia and increased serum myostatin expression. However, in vivo results are cofounded by disease factors in COPD patie...

ea0031p137 | Cytokines and growth factors | SFEBES2013

Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI

Narayanan Ram Prakash , Fu Bo , Payton Antony , Donn Rachelle , Heald Adrian , Ollier William ER , Gibson Martin

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...

ea0031p138 | Cytokines and growth factors | SFEBES2013

Comparing the effect of rimonabant and metformin on vascular endothelial growth factor levels in women with PCOS

Konya Judit , Sathyapalan Thozhukat , Cho Li Wei , Coady Anne Marie , Kilpatrick Eric S , Atkin Stephen L

Background: PCOS is associated with a clustering of cardiovascular risk factors. Increased serum levels of vascular endothelial growth factor (VEGF) are thought to be proatherogenic, and have also been found to be elevated in PCOS. This study was undertaken to determine the changes of VEGF in patients with PCOS after rimonabant and/or metformin intervention.Methods: A 6-month randomised open labelled parallel study of rimonabant or metformin in 20 patien...

ea0031p139 | Cytokines and growth factors | SFEBES2013

IGF binding protein-2 is associated with all-cause and cardiovascular mortality in type 2 diabetes

Narayanan Ram Prakash , Oliver Robert L , Siddals Kirk W , Heald Adrian H , Ollier William E R , Gibson J Martin

Low IGFBP2 is associated with the metabolic syndrome, but high IGFBP2 is longitudinally associated with worsening renal function. IGFBP2 binds IGF2 (and IGF1) and modified IGF bioavailablilty. The aim of our study was to identify whether baseline IGFBP2 concentrations were associated with all-cause and cardiovascular mortality in type 2 diabetes.554 subjects (59.3% male, mean age 63.7 (S.D. 10.7)) with type 2 diabetes from the Salford Diab...