Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2013

Young Endocrinologists Session

Young endocrinologists' prize lectures

ea0031yep1.1 | Young endocrinologists' prize lectures | SFEBES2013

Clinical and pre-clinical studies of neuroendocrine tumours (NETs) in multiple endocrine neoplasia type 1 (MEN1), and evaluation of MEN1 gene replacement therapy for MEN1-associated NETs.

Walls Gerard , Newey Paul , Lemos Manuel , Javid Mahsa , Piret Sian , Reed Anita , Thakker Rajesh

We have studied clinical and pre-clinical models to investigate neuroendocrine tumour (NET) development and efficacy of novel therapy for NETs. We focused on multiple endocrine neoplasia type 1 (MEN1), an autosomal dominantly inherited condition characterised by the combined occurrence of pancreatic islet and anterior pituitary NETs with parathyroid and adrenocortical tumours. MEN1 is due to MEN1 gene mutations that inactivate Menin, a tumour suppressor. Our clinical studies r...

ea0031yep1.2 | Young endocrinologists' prize lectures | SFEBES2013

The Wnt/β-catenin effector Tcf3/TCF7L1 is required for normal hypothalamic–pituitary development

Gaston-Massuet Carles , McCabe Mark , Wu Chun-I , Gharavy S. Neda Mousavy , Koniordou Markella , Merrill Bradley J , Dattani Mehul , Martinez-Barbera Juan Pedro

The pituitary gland, is a small midline organ situated at the base of the brain, that acts as a master regulator of multiple physiological functions: such as growth, puberty, metabolism, stress response, reproduction and lactation. The pituitary gland is composed of three lobes: the anterior and intermediate, which form the anterior pituitary (AP and contains hormone producing cells), and the posterior lobe which constitutes the posterior pituitary (PP contains axonal inputs)....