Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Plenary Lectures

Fondation IPSEN 2013 Endocrine Regulations Prize

ea0032pl4 | Fondation IPSEN 2013 Endocrine Regulations Prize | ECE2013

Nuclear receptor ‘master’ coactivators of physiology and pathology

O'Malley Bert

Nuclear receptors control gene expression by recruiting transcriptional coactivators (or corepressors). The coactivators are ‘master regulators’ that coordinately activate multiple distinct transcription factors and target genes and pathways to control major physiologic processes such as reproduction, inflammation, metabolism and growth. Because of their central role as ‘nodes’ of regulation, coactivators are major targets in the development of numerous inh...