Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Female reproduction

ea0032p574 | Female reproduction | ECE2013

Subcutaneous adipose tissue distribution and metabolic parameters in lean women with polycystic ovary syndrome

Zabuliene Lina , Urboniene Jurgita

Background: The objective of the study was to compare distributions of subcutaneous adipose tissue and metabolic parameters in lean women with PCOS and lean healthy women.Materials and methods: PCOS women (according to Rotterdam criteria, mean age 26.54±3.65 years) and 70 healthy control women (mean age 27.84±3.63 years) were investigated in Vilnius city (Lithuania) in 2009–2011. A skinfold caliper device was used to measure skinfolds thic...

ea0032p575 | Female reproduction | ECE2013

Effect of resistin on LH and FSH stimulated steroidogenesis in porcine ovarian follicles during estrous cycle

Rak-Mardyla Agnieszka , Karpeta Anna

Resistin is a recently discovered 12.5 kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes and plays important role in the development of insulin resistance and obesity. Recently, many investigators have linked resistin to reproductive function. Resistin expression was observed in bovine and rat ovaries and showed that resistin modulate granulosa cells function such as steroidogenesis and proliferation, in basal state or in response to IGF-I in vit...

ea0032p576 | Female reproduction | ECE2013

Relation of liver enzymes with indices of insulin resistance and hyperandrogenism in different PCOS phenotypes

Macut Djuro , Antic Ivana Bozic , Panidis Dimitrios , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Kastratovic Biljana , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan

Introduction: Insulin resistance is a common discriminator for a variety of chronic disorders including polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). It has recently been hypothesized that PCOS itself might be a risk for developing NAFLD.Methods: We analyzed 560 women with PCOS (BMI: 31.19±6.75 kg/m2, age: 25.62±6.05 years) diagnosed on the basis of ESHRE/ASRM criteria. The subjects were divided and ...

ea0032p577 | Female reproduction | ECE2013

The hinge region of the lutropin receptor mediates different activation mechanisms: CG induces trans- and LH only cis-initialization

Grzesik Paul , Kreuchwig Annika , Teichmann Anke , Furkert Jens , Rutz Claudia , Wiesner Burghard , Kleinau Gunnar , Schulein Ralf , Gromoll Jorg , Krause Gerd

The lutropin receptor (LHR) is associated with reproduction and becomes activated by choriogonadotropin (CG) or lutropin (LH) resulting in different physiological functions with regard to differing signaling cascades. The underlying mechanisms in receptor/hormone interaction are not yet understood. CG is known to induce trans-activation at LHR oligomers (activates a second receptor), but details of LH mechanisms were not clarified yet.To study this issue...

ea0032p578 | Female reproduction | ECE2013

AMHR2 polymorphism and risk for polycystic ovary syndrome: relationship to gonadotropin levels

Georgopoulos Neoklis , Karagiannidou Eleni , Koika Vasiliki , Roupas Nikolaos , Armeni Anastasia , Marioli Dimitra , Papadakis Efstathios , Welt Corine , Panidis Dimitrios

Introduction: The polycystic ovary syndrome (PCOS) is a common and complex disease without a clear pattern of inheritance. There is evidence that PCOS is affected by both genetic and environmental factors, but there is no single and unambiguous explanation for its pathogenesis. Anti-Müllerian-inhibiting hormone (AMH) has an inhibitory effect on FSH-stimulated follicle growth and it has also been shown that serum AMH levels are higher in women with PCOS than in normovulato...

ea0032p579 | Female reproduction | ECE2013

White blood cells levels and PCOS: direct and indirect relationship with insulin resistance, but not with hyperandogenemia

Papalou Olga , Livadas Sarantis , Karachalios Athanasios , Benetatos Nektarios , Boutzios George , Dracou Maria , Kokkoris Panayotis , Diamanti-Kandarakis Evanthia

Background: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder and hyperandrogenism and insulin resistance constitute the key players of syndrome pathogenesis. Another emerging important factor of PCOS is low-grade chronic inflammation. The aim of the present study was to investigate white blood cells count (WBC) in PCOS and assess its role as a possible marker of low-grade inflammation.Methods: Anthropometrical, metabolic and hormonal data...

ea0032p580 | Female reproduction | ECE2013

Interactions among resistin and peroxisome proliferator activated receptor-γ (PPAR-γ) in porcine ovarian follicles.

Rak-Mardyla Agnieszka , Karpeta Anna

Resistin, a new 12.5 kDa cysteine-rich protein, which is specifically secreted by adipocytes and describe as a potential link between obesity and insulin resistance. Recently, resistin and PPARs receptors was found in reproductive tissue such as ovary and it was found that resistin modulate ovarian follicle function. Additionally, thiazolidinediones, such as rosiglitazone, a synthetic agonist of PPAR-γ down-regulated resistin expression in rodents. The aim of the study wa...

ea0032p581 | Female reproduction | ECE2013

Differences in adrenocortical steroid response to ACTH in women with post-adolescent severe acne and PCOS

Cinar Nese , Cetinozman Fatma , Aksoy Duygu yazgan , Elcin Gonca , Yildiz Bulent O

Introduction: Increased adrenocortical production appears to be associated with acne and hirsutism in PCOS. However, the etiological role of androgens in the pathogenesis of acne per se is far from being clear. In the present study, we aimed to evaluate adrenocortical function in women with post-adolescent severe acne in comparison with patients with PCOS and healthy women.Design: The study included 32 women with post-adolescent severe acne, 32 ...

ea0032p582 | Female reproduction | ECE2013

Ovarian function is associated with obesity in very long-term female survivors of childhood cancer

van Dorp Wendy , Blijdorp Karin , Laven Joop , Pieters Rob , Visser Jenny , van der Lely Aart-Jan , Neggers Sebastian , van den Heuvel-Eibrink Marry

Introduction: Obesity and gonadal dysfunction are major side effects of treatment in adult childhood cancer survivors. In the general population, obesity has a negative influence on female fertility. The aim of the study was to evaluate whether obesity and serum insulin are associated with decreased ovarian reserve markers in childhood cancer survivors.Methods: We performed a retrospective single-center cohort study in 191 adult female survivors of child...

ea0032p583 | Female reproduction | ECE2013

New endocrine and intracellular regulators of ovarian functions

V S Alexander

This is the review of original data concerning the role of some metabolic hormones (GH, leptin, ghrelin, obestatin), growth factors (IGF-I, IGFBPs, EGF, thrombopoietin), intracellular mediators of their action (cyclic nucleotides, protein kinases, PKA, MAPK, CDK, transcription factors, CREB, STAT-1, p53 and related cDNA, siRNA and miRNA gene constructs) on basic ovarian functions (cell proliferation, apoptosis, secretion, oogenesis, ovulation, production and viability of pups)...

ea0032p584 | Female reproduction | ECE2013

Deletions of TCF2 gene in Rokitansky syndrome (MRKH): a new candidate gene? About two new cases

Ancelle Deborah , Hecart Annie Claude , Gaillard Dominique , Bertin Eric , Delemer Brigitte

Introduction: MRKH syndrome is a rare congenital disease, which affects 1/5000 female births. It is usually diagnosed in the course of primary amenorrhea investigation. Characteristics are mullerian agenesis with 46XX karyotype. Only Wnt4 gene (1) was involved in a few cases of MRKH with hyperandrogenism. We describe two new cases with MRKH syndrome and complete deletion of TCF2 gene in the heterozygous state, this gene is also involved in monogenic diabetes ...

ea0032p585 | Female reproduction | ECE2013

Thrombin generation in polycystic ovary syndrome: a marker of thrombosis

Aziz Mubeena , Sidelmann Johannes J , Skouby Sven O , Faber Jens

Background: Polycystic ovary syndrome (PCOS) is clinically associated with increased risk of CVD. Thrombin generation (TG) is a measure of the thrombotic potential. This can be expressed as endogenous thrombin potential (ETP) representing the total amount of generated active thrombin over the time (nmol/l×min). ETP is considered the most predictive parameter of thrombosis and is associated to both venous and arterial thrombotic disease. Setting: PCOS women prospectively r...

ea0032p586 | Female reproduction | ECE2013

The combination of genetic variants in the FSHR and FSHB genes affect serum FSH in women of reproductive age

Moriondo Valeria , La Marca Antonio , Papaleo Enrico , Alviggi Carlo , Ruvolo Gianni , Giuseppe De Placido , Candiani Massimo , Cittadini Ettore , De Michele Francesca , Catellani Valeria , Volpe Annibale , Simoni Manuela

Introduction: The relationship between SNPs of the FSHR gene and serum FSH has not been completely clarified. Genetic variants of the FSHB gene have been associated to variation in gene transcription and to serum FSH levels in men. An interesting joint effect of both FSHB −211G>T and FSHR 2039 A>G on male reproductive parameters has been recently observed. No data have been published on the effect of the FSHB −211G>T in combination with the FSHR 2039 A&...

ea0032p587 | Female reproduction | ECE2013

The hypothalamo--pituitary--adrenal axis sensitivity in women with polycystic ovary syndrome

Ilic Dusan , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Damjanovic Svetozar

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

ea0032p588 | Female reproduction | ECE2013

Value of lipid accumulation product for the assessment of metabolic syndrome in women with polycystic ovary syndrome

Bozic Antic Ivana , Bjekic-Macut Jelica , Panidis Dimitrios , Milutinovic Danijela Vojnovic , Kastratovic Biljana , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Macut Djuro

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy, age and BMI matched women. The aim of this study was to determine if novel abdominal adiposity index – lipid accumulation product (LAP), could predict MS in women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. We evaluated 218 non-obese PCOS women (PCOS group: 22.4±3.6 kg/m2; 24.8±4.6 years)...

ea0032p589 | Female reproduction | ECE2013

The assessment of metabolic derangements including metabolic syndrome in relation to the degree of hyperandrogenism in women with polycystic ovary syndrome

Bjekic-Macut Jelica , Bozic Antic Ivana , Panidis Dimitrios , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Petakov Milan , Popovic Bojana , Bogavac Tamara , Ognjanovic Sanja , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Macut Djuro

Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome (MS). In this study, we evaluated the degree of metabolic disorders in women with PCOS and different degree of hyperandrogenism (HA).Methods: We analyzed 234 women with PCOS (group PCOS; BMI: 22.4±3.6 kg/m2, age: 24.8±4.7 years) diagnosed on the basis of ESHRE/ASRM criteria, and 45 healthy BMI-matched women who compri...

ea0032p590 | Female reproduction | ECE2013

Gynecological aspects of prolactinoma

Abdesselem Haifa , Haouat Emna , Salem Leila Ben , Kandara Hajer , Turki Zinet , Slama Claude Ben

Prolactinoma is a pituitary adenoma producing prolactin. Central hypogonadism is a major consequence of prolactinoma leading, in women, to menstrual troubles and infertility. The aim of this study was to specify gynecological characteristics of prolactinomas.Patients: This retrospective study included 28 female patients with prolactinoma. Mean age at diagnosis was 35.46 years (ext: 20–78). Mean serum prolactin level was 3442.4 ng/ml (ext: 31.9–...

ea0032p591 | Female reproduction | ECE2013

Levonorgestrel inhibits human endometrial cell proliferation through the up-regulation of gap junctional intercellular communication via the increased expression of Connexin43 and the nuclear translocation of its Ser255 phosphorylation

Zhao Xiaomiao , Tang Xuelian , Xie Meiqing

Context: Gap junction intercellular communication (GJIC) and its constructed protein Connexin (Cx) participates in cell apoptosis and tumorigenesis. Our clinical studies demonstrated that a levonorgestrel (LNG)-releasing intrauterine system can reverse atypical endometrial hyperplasia.Objective: This study assesses whether LNG exerts anti-proliferation effects on human endometrial cells through changes in the GJIC function and Cx43 expression.<p clas...

ea0032p592 | Female reproduction | ECE2013

Overnight 1 mg dexamethasone androgen suppression test is useful diagnostic tool in hyperandrogenism.

Ambroziak Urszula , Kepczynska-Nyk Anna , Nowak Karolina , Morawska Emilia , Kunicki Michal , Bednarczuk Tomasz

Introduction: Low dose dexamethasone (DEX) androgen suppression test (LDDAST) is considered a tool to distinguish between the sources of androgen excess and to exclude/confirm autonomy of androgen overproduction.Aim: To assess whether 1 mg DST can be used instead of LDDAST.Materials and methods: Thirty-three consecutive women with hyperandrogenism age 18–38 years undergone overnight 1 mg DEX androgen suppression test and LDDAS...

ea0032p593 | Female reproduction | ECE2013

Low dose oral contraceptive use and the risk of thrombosis in polycystic ovary syndrome

Akin Safak , Cinar Nese , Aydin Kadriye , Akman Umit , Buyukasik Yahya

Background and aim: Oral contraceptives (OC) are the mainstay of long-term treatment for women with polycystic ovary syndrome (PCOS). OC use is associated with increased risk of venous thromboembolism. The aim of the present study was to determine whether treatment with a low dose OC induce changes on coagulation and fibrinolysis in women with PCOS.Materials and methods: Sixteen lean, normal-glucose tolerant patients with PCOS (mean age, 22.4±2.4 ye...

ea0032p594 | Female reproduction | ECE2013

PCOS subphenotypes stratification reveals an apparent increase of metabolic syndrome frequency in patients with concomitant hyperandrogenism and menstrual irregularities

Baculescu Nicoleta , Radian Serban , Gussi Ilinca , Gheorghiu Monica , Poiana Catalina , Grigorescu Florin , Coculescu Mihail

Background: PCOS-associated increased metabolic risk may be selective, owing to its heterogeneous nature. Identification of high-risk individuals could enable better studies and prevention of complications.Aim: To characterize the metabolic risk, as metabolic syndrome (MetS), of specific PCOS subphenotypes.Subjects and methods: Romanian PCOS (Rotterdam criteria) and 64 controls, 18–35 years. PCOS subphenotypes were defined: i)...

ea0032p595 | Female reproduction | ECE2013

Association of serum 25-hydroxyvitamin D and glucose levels in polycystic ovary syndrome

Lopez-Gallardo Gema , Rozas-Moreno Pedro , Reyes-Garcia Rebeca , Tenias-Burillo Jose Maria , Lopez-Iglesias Maria , Garcia-Manzanares Alvaro , Gomez Francisco-Javier , Gomez-Garcia Ines

Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from pre-diabetes and diabetes. Conflicting results currently exists on the relationship between vitamin D and glucose metabolism. Hence, the aim of our study was to investigate the association of 25-hydroxyvitamin D (25(OH)D) levels and glucose tolerance in PCOS women.Methods: Cross-sectional study including 23 PCOS patients (mean age 27 ...

ea0032p596 | Female reproduction | ECE2013

Prevalence of prediabetes state is not equal in all phenotypes of polycystic ovary syndrome

Madani Tahereh , Hosseini Roya , Ramezanali Fariba , Jahangiri Nadia , Ahmadi Jila , Rastegar Fateme , Zolfaghari Zahra

Introduction: Polycystic ovary syndrome (PCOS) frequently accompanied by insulin resistance metabolic abnormality. There are limited data on metabolic complications in women belonging to the PCOS phenotypes as defined by the Rotterdam criteria. Our objective was to investigate the prevalence of impaired fasting glucose (IFG) metabolism and dyslipidemia between different phenotypes in Iranian infertile women with PCOS.Methods: We conducted a cross section...

ea0032p597 | Female reproduction | ECE2013

Metabolic features in patients with polycystic ovary syndrome (PCOS) during different stages of reproductive life

Sir-Petermann Teresa , Ladron de Guevara Amanda , Echiburu Barbara , Crisosto Nicolas , Vantman Natalie , Pereira Cecilia , Perez-Bravo Francisco , Galgani Jose

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

ea0032p598 | Female reproduction | ECE2013

Association of thyroid autoimmunity and thyroid dysfunction with obstetric antiphospholipid syndrome

Jelic Svetlana , Stojanovich Ljudmila , Marisavljevic Dragomir

Background: The association of antiphospholipid syndrome (APS) with various endocrine disorders is already known. However, data on the influence of thyroid autoantibodies and/or disorders of thyroid function on the expression of classical APS manifestations are rather limited.Objectives: The aim of this investigation was to evaluate the impact of thyroid autoimmunity and dysfunction on frequency of recurrent miscarriages in patients with primary antiphos...

ea0032p599 | Female reproduction | ECE2013

Inflammatory markers in polycystic ovarian syndrome and their association with cardiovascular risk factors

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objectives: i) To determine and compare inflammatory markers including adiponectin, visfatin and IL-18 in patients with polycystic ovarian syndrome (PCOS). ii) To find out whether adiponectin and interleukin-18 (IL-18) is associated with markers of insulin resistance, hyperandrogenism and carotid intima-media wall thickness (CIMT) as a cardiovascular risk factor.Methods: This is a prospective controlled study involving 60 consecutive euglycemic patients ...

ea0032p600 | Female reproduction | ECE2013

The effect of metformin on pregnancy outcome among filipino women with polycystic ovary syndrome

Uyking-Naranjo May , Paulo Consencino Evan , Mirasol Roberto , Tan-Garcia Joan

Background: Polycystic ovary syndrome (PCOS) affects 5–10% of women in the reproductive age group. It is associated with insulin resistance and hyperinsulinemia which is further aggravated during pregnancy. The use of metformin in PCOS is increasingly accepted but its therapeutic use during pregnancy is still a debatable issue. There are few local studies on the use of metformin among PCOS patients and data are lacking among Filipinos.Objectives: To...

ea0032p601 | Female reproduction | ECE2013

Flutamide-induced alterations in CYP17A1 gene expression and local testosterone synthesis in porcine luteal tissue – a new insight into androgens action during pregnancy

Grzesiak Malgorzata , Knapczyk-Stwora Katarzyna , Wieciech Iwona , Ciereszko Renata E , Slomczynska Maria

It was established that androgens are able to modulate luteal function during pregnancy by stimulation of corpus luteum (CL) progesterone release. In pigs, CL is the main source of progesterone through the entire gestation. Our previous study revealed that porcine CL is capable of androgen synthesis during second half of pregnancy. Therefore, we suggest that androgens, in addition to progesterone, are essential for the maintenance of pregnancy in pigs.Th...

ea0032p602 | Female reproduction | ECE2013

Relation of adiponectin and leptin to antropometric and metabolic parameteres in women with polycystic ovaries syndrome

Bogavac Tamara , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Vojnovic Milutinovic Danijela , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

ea0032p603 | Female reproduction | ECE2013

PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenemia

Mastorakos George , Paltoglou George , Tavernarakis George , Christopoulos Panagiotis , Vlassi Margarita , Gazouli Maria , Deligeoroglou Efthimios , Creatsas George

Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.Design: Case–control genetic association study.Patients: PCOS cases (NIH criteria) and 112 controls.Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.16...

ea0032p604 | Female reproduction | ECE2013

C-reactive protein and gestational diabetes mellitus

Kononova Oksana , Pristrom Andrei , Vasilkova Volha , Mokhort Tatiana

Aim: The aim of this study was to investigate the role of C-reactive protein (CRP) in gestational diabetes mellitus.Material and methods: We studied 65 healthy pregnant women aged 29.75±5.59 years. All women referred for a 100–g oral glucose tolerance test following an abnormal result on a screening. The demographic data, waist circumference, height, and weight of the participants were recorded. Fasting levels of insulin, triglycerides (TG), CR...

ea0032p605 | Female reproduction | ECE2013

Ovarian functions and polycystic ovary syndrome in women with type 1 diabetes mellitus

Karaca Zuleyha , Tanriverdi Fatih , Unluhizarci Kursad , Kelestimur Fahrettin

Background: Type 1 DM has been shown to be associated with increased rate of hyperandrogenemia, polycystic ovarian changes (PCO) and PCOS. Although stimulated 17-OH progesterone responses to leuprolide has previously been shown to be increased in pubertal girls with type 1 DM, the effect of gonadotropin releasing hormone analog stimulation has not been studied in adult women.Materials and methods: Fifty-two adult women with type 1 DM and 15 healthy adult...

ea0032p606 | Female reproduction | ECE2013

Concordance study of pathological results of fertility hormones

Roman Miriam Menacho , Fernandez Antonio Becerra , Lopez Gilberto Perez , Vicente Rosa Villar , del Rey Sanchez Jose Manuel

Introduction: During a normal menstrual cycle, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P4) can vary widely between cycles for the same woman, as well as between different women. Reliable reference values based on the local population are important for correct interpretation of laboratory results.Aims: To evaluate the discrepancy of the results on fertility hormones by two different t...

ea0032p607 | Female reproduction | ECE2013

Main determinants of serum uric acid concentrations in polycystic ovary syndrome patients

Leustean Letitia , Preda Cristina , Ungureanu Maria Christina , Cristea Cristina , Mogos Voichita , Ungureanu Didona , Vulpoi Carmen

Introduction: Uric acid may increase cardiovascular risk, exerting proinflammatory, pro-oxidant and proliferative actions at the endothelial cell level. Classic and non-classic cardiovascular risk markers cluster in women with polycystic ovary syndrome (PCOS), uric acid being proposed as one of them. The studies available at present regarding serum uric acid levels in PCOS patients are scarce and controversial. The aim of the study was to examine the relationship between uric ...

ea0032p608 | Female reproduction | ECE2013

Vitamin D level in polycystic ovary syndrome patients is not different from healthy control in Turkish population

Unal Asli Dogruk , Tarcin Ozlem , Cigerli Ozlem , Takir Mumtaz , Parildar Hulya , Ergen Nilay , Demirag Nilgun Guvener

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

ea0032p609 | Female reproduction | ECE2013

Prevalence of polycystic ovary syndrome in infertile patients in Albania

Dollenga Mimoza , Fureraj Thanas , Dhima Kosta , Bizbiqi Edmond , Simaku Artan

Introduction: Polycystic ovary syndrome (PCOS) is the most common gynecological endocrinopathy. Women with PCOS are at increased risk of reproductive problems including infertility, endometrial cancer, late menopause and also metabolic aberrations, including insulin resistance, type 2 diabetes mellitus, dyslipidemia and cardiovascular diseases. There is very few data available on prevalence of PCOS on infertile population in Albania. The aim was to evaluate the prevalence of P...

ea0032p610 | Female reproduction | ECE2013

Association of advanced glycosylation end products receptor polymorphisms with coronary heart disease in postmenopausal women

Xyrafis Xenofon , Toutouzas Konstantinos , Livadas Sarantis , Karachalios Athanasios , Stefanadis Christodoulos , Georgopoulos Neoklis , Diamanti-Kandarakis Evanthia

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

ea0032p611 | Female reproduction | ECE2013

Association of gonadotroph pituitary macroadenoma and contiguous brain chordoma in a young woman with ovarian hyperstimulation syndrome

Slim Ines , Bouguizen Sassi , Chadli Molka , Ach Koussay , Kacem Maha , Maaroufi Amel , Chaieb Larbi

Introduction: Among pituitary adenomas comprise approximately 10% of benign pituitary adenomas. These adenomas often arise in middle-aged men presenting with tumoral syndrome and endocrine profile of primary hypogonadism. Gonadotroph adenomas are more difficult to diagnose in women generally in perimenopausal or postmenopausal periods.Case report: A 33-year-old woman with a 10 years of history of sterility with dysmenorrhea and pelvic pain in relation to...

ea0032p612 | Female reproduction | ECE2013

Menstrual function in women of reproductive age with acromegaly

Dreval Alexander , Logutova Lidia , Zaydieva Yana , Stashuk Galina , Perfilyev Andrey , Ilovayskaya Irena

In purpose to characterize the disturbances of menstrual function in acromegalic women of reproductive age, we investigated 19 women with de novo acromegaly diagnosed at the age of 19–37 (median age 28) years. Before diagnosis, an average duration of acro-signs was 3.8 years, after diagnosis we observed women for 5 years. Among the first meaningful symptoms menstrual irregularities and/or infertility were noted in 13 (73.7%) cases. Initial levels of GH were 71 (3...

ea0032p613 | Female reproduction | ECE2013

Mechanisms of menstrual disorders in type1 diabetic women

Kammoun Ines , Wassai Ikram , Kandara Hajer , Kacem Faten Haj , Turki Zinet , Ben Slama Claude

Introduction: Type 1 diabetic women have generally more menstrual disorders than healthy women.Objectives: Identify the main mechanisms responsible of menstrual disorders in type1 diabetic women.Patients and methods: We conducted a comparative transversal study including 70 patients with type 1 diabetes: Thirty-three having menstrual disorders (group M) and 37 with regular menses (control group T).We compared...

ea0032p614 | Female reproduction | ECE2013

Mitochondrial function of pregnant women with subclinical hypothyroidism and gestational hypertension

Feldthusen Anne-Dorthe , Larsen Jacob , Pedersen Palle Lyngsie , Kristensen Tina Toft , Anthonsen Stine , Kvetny Jan

Introduction: Subclinical hypothyroidism (subhypo) is linked to gestational hypertension (gestHT) and preeclampsia. Thyroid hormones have major influence on mitochondrial activity and the mitochondrial membrane potential (MMP) reflects the functional status of the mitochondria.Aim: The aim was to estimate whether mitochondrial function is impaired in pregnant women with or without gestHT.Methods: We included third trimester pregnan...

ea0032p615 | Female reproduction | ECE2013

Hormonal disorders and breast diseases in adolescent girls

Gumeniuk Olga , Chernenkov Yuriy , Zakharova Nataliya , Ivanenko Irina , Kunina Svetlana , Kunina Anna

Introduction: The breast is a hormone-dependent organ.Purpose: To study hormonal disorders peculiarities and breast diseases in adolescent girls.Patients and methods: Examined were 867 adolescent girls (aged 12–18), including 154 girls with breast diseases and dysmorphogenies (macromastia, hypoplasia, striae). The questioning, total clinical examination, hormonal analysis and ultrasound examination were conducted. Data are exp...

ea0032p616 | Female reproduction | ECE2013

Menstrual cycle length is associated with metabolic syndrome in young Korean women with oligomenorrhea

Oh Jee-Young , Sung Yeon-Ah , Lee Hye Jin

Introduction: Although menstrual irregularity, including oligomenorrhea (OM), is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with OM is unclear. We evaluated whether a longer menstrual cycle length is associated with less favorable metabolic features in young women.Methods/design: A total of 1296 young women (aged 15–39 years old) with ...

ea0032p617 | Female reproduction | ECE2013

Obstructive sleep apnea in Bulgarian patients with polycystic ovarian syndrome

Gateva Antoaneta , Kamenov Zdravko , Mondeshki Tsanko , Bilyukov Radoslav , Georgiev Ognian

Introduction: OSA is a rare condition in premenopausal women that do not have PCOS and is most frequently associated with obesity. On the other hand the risk in PCOS patients is thought to be significantly higher. The aim of the study was to investigate the prevalence of sleep apnea in Bulgarian patients with PCOS and/or obesity.Methods: The study included 30 women – 11 obese, 13 nonobese PCOS and six obese PCOS patients. Anthropome...

ea0032p618 | Female reproduction | ECE2013

Plasma kisspeptin levels in polycystic ovary syndrome

Yerlikaya Emrah , Akin Fulya , Turgut Sebahat , Yaylali Guzin , Topsakal Senay , Ayada Ceylan , Hatipoglu Celile

Introduction: Kisspeptin is a 54-amino acid peptide, which comprise a diverse group of peptides with many different functions related to energy metabolism and reproduction, pubertal development. It activates GPR54 receptor. Subcutaneous administration of kisspeptin-54 to women with regular menstrual cycles results in an increase in LH and FSH. All these findings show that the GPR54 system may play a role in the function of the hypothalamic–pituitary–gonadal axis. PCO...

ea0032p619 | Female reproduction | ECE2013

Relation of plasma kisspeptin levels with obesity and insulin resistance in polycystic ovary syndrome

Yerlikaya Emrah , Akin Fulya , Turgut Sebahat , Yaylali Guzin , Topsakal Senay , Ayada Ceylan , Hatipoglu Celile

Introduction: Majority of polycystic ovary syndrome (PCOS) women are anovulatory, overweight/obese and insulin resistant. Kisspeptins are the endogenous ligands for GPR54 highly expressed in pancreas. Some studies showed that kisspeptins may play in the regulation of islet function and they stimulate insulin secretion from mouse and human islets. Adipose tissue acts as an endocrine organ and its function may be regulated by kisspeptins. We designed this study based on that obe...

ea0032p620 | Female reproduction | ECE2013

Potential discriminant factors for different pcos phenotypes

Stojkovic Mirjana , Beleslin Biljana , Ciric Jasmina , Savic Slavica , Nisic Tanja , Stojanovic Milos , Lalic Tijana , Trbojevic Bozo , Zarkovic Milos

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries (PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1 (ANOV+HA+PCO), phenotype 2 (ANOV+HA), phenotype 3 (HA+PCO) and phenotype 4 (ANOV+PCO). The difference...