ECE2013 Poster Presentations Male reproduction (41 abstracts)
Effects of testosterone replacement therapy on hepcidin levels in young hypogonadal men
Vincenzo Palumbo 1 , Dario Esposito 1 , Daniela Visconti 1 , Adele Topa 1 , AnitaLa Rezza 1 , Giuseppe Bellastella 2 , Annamaria De Bellis 1 & Antonio Agostino Sinisi 1
1Dpt Scienze Cardiotoraciche e Polmonari, Second University of Napoli, U. Endocrinology, Napoli, Italy; 2Dpt Internistica Clinica e Sperimentale Magrassi-Lanzara, Second University of Napoli, Napoli, Italy.
Erythrocytosis is a frequent adverse event associated with testosterone (T) administration in aged hypogonadal men, but the mechanisms involved remain poorly understood. T administration to aged men reduced hepcidin (Hpc) levels, a cytokine regulating iron availability, suggesting a potential role in deregulated erythropoiesis. Aim of present study was to evaluate the effects of T replacement therapy on Hpc levels in young hypogonadal men.
Methods: Fifty-eight subjects (18–36 years) with hypogonadism due to Kallmann syndrome (16), idiopathic hypogonadism (12), multiple pituitary deficiency (7), Klinefelter syndrome (18), and anorchidism (5) were studied. Blood samples were obtained basally (pts. never treated or after 3-months suspension) and after 6–12 months of T substitution therapy with 1 g of T undecaonate (TU) i.m. every 10–12 weeks (30 cases), or 250 mg of T enanthate (TE) im every 2–3 weeks (20 c), or 50–100 mg T gel/d (6 c). In all samples haematocrit (Ht), Hpc (by Elisa) and T (by RIA) were determined. T therapy increased T and Ht, and decreased Hpc levels (P<000.1). Hpc levels were negatively related to T and Ht. Fifteen subjects (26%) developed polycythaemia (Ht>50); 10 out 15 (67%) received TE.
Conclusion: Erythrocytosis is also frequent in T treated young hypogonadic. TE administration seems favour polycythaemia respect to other formulations. T-induced suppression of Hpc may contribute mechanistically to stimulate erythropoiesis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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