Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Male reproduction

ea0032p637 | Male reproduction | ECE2013

KISS1R mutations in normosmic congenital hypogonadotropic hypogonadism: clinical evaluation of two families and molecular characterization of a novel mutation

Brioude Frederic , Bouligand Jerome , Francou Bruno , Fagart Jerome , Roussel Ronan , Viengchareun Say , Combettes Laurent , Brailly-Tabard Sylvie , Lombes Marc , Young Jacques , Guiochon-Mantel Anne

Context: KISS1R mutations have been implicated in patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110).Objective: To describe in detail nCHH patients with biallelic KISS1R mutations belonging to two unrelated families, and to functionally characterize a novel KISS1R mutation.Results: The p.Tyr313His original mutant was found in the homozygous state in three affected kindr...

ea0032p638 | Male reproduction | ECE2013

Strength training and testosterone treatment have opposing effects on migration inhibitor factor levels in ageing men

Glintborg Dorte , L Christensen Louise , Kvorning Thue , Larsen Rasmus , Brixen Kim , M Hougaard David , Richelsen Bjorn , M Bruun Jens , S Andersen Marianne

Objective: The beneficial effects of testosterone treatment (TT) in men with low normal testosterone levels are debated. Chemokine levels have not previously been evaluated during TT in combination with strength training (ST).Design: A randomized, double-blinded, placebo-controlled study of 6 months TT (gel) in 54 men aged 60–78 years with bioavailable testosterone (BioT) <7.3 nmol/l and waist circumference >94 cm randomized to TT (50–1...

ea0032p639 | Male reproduction | ECE2013

Decreased expression of four memory genes in non-syndromic cryptorchid males

Hadziselimovic Faruk , Omar Hadziselimovic Niels , Demougin Philippe

Background: Egr1 has been widely recognized as essential for some aspects of learning and memory while Egr 4 has been shown to be involved in receptor – modulated memory processes. Furthermore, it has been shown that testosterone enhances memory by increasing biological salience of incoming information. In cryptorchid boys, an elevated odd ratio for low IQ was found. i) It is postulated that the hypothalamus–pituitary–testicular axis is implicated in maintaining...

ea0032p640 | Male reproduction | ECE2013

Complete aromatase deficiency in four adult men: detection of a novel mutation and two known mutations in the CYP19A1 gene

Pignatti Elisa , Unluhizarci Kursad , Kartal Ermine , Ajlouni Kamel , Khawaja Nahla , Carani Cesare , Marino Marco , Simoni Manuela , Vighi Eleonora , Rochira Vincenzo

Introduction: At present, only eight men with loss-of-function mutations in the CYP19A1 gene have been described. Here we report the genetic study of four adult men with undetectable serum estrogens, unfused epiphyses, eunuchoid skeletal proportions, continuing linear growth, tall stature, genu valgum, osteoporosis, obesity and achantosis nigricans. Patient 1 (26-years/182 cm) and 2 (28-years/187 cm) are from Turkey with a history of consanguinity. Patient 3 (44-years...

ea0032p641 | Male reproduction | ECE2013

Mortality is increased in men treated with testosterone compared to age and sex-matched controls

Karmisholt Jesper , Eriksen Stine , Rungby Jorgen , Vestergaard Peter

Background: Symptomatic hypogonadism is frequent and associated with increased risk of cardiovascular events. Hypogonadism is often treated with testosterone replacement. In a recent meta-analysis on adverse events in randomised placebo controlled testosterone replacement trials (RPCT), no differences between testosterone or placebo/non-intervention groups with regards to cardiovascular events or risk factors was observed. Conversely, a contemporary RPCT in elderly immobile pa...

ea0032p642 | Male reproduction | ECE2013

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Lotti Francesco , Corona Giovanni , Innocenti Selene Degli , Filimberti Erminio , Scognamiglio Vittoria , Vignozzi Linda , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility.Methods: Out of 367 consecutive subjects, 351 men without genetic abnormal...

ea0032p643 | Male reproduction | ECE2013

Effects of iron therapy on pituitary gonadal axis and sperm parameters in adults with iron deficiency anemia (IDA)

Soliman Ashraf , Yassin Mohamed , Abdelrahmanm Osman , Desanctis Vincenzo , Elawwa Ahmed

Objective: To evaluate semen parameters and measure serum FSH, LH, Testosterone (T) concentrations before and 6 weeks after i.v. (800–1200 mg elemental iron iron therapy in adults with iron deficiency anemia.Patients and methods: This study investigated 11 adults with iron deficiency anemia (IDA) aged 40±5 years, with full pubertal development (Tanner stage 5, eugonadal) and capacity to ejaculate. They had iron deficiency anemia mainly due to d...

ea0032p644 | Male reproduction | ECE2013

Endocrine disruptors target ATP binding cassette transporters in the blood–testis barrier and impair Leydig cell steroidogenesis

Roelofs Maarke J E , Dankers Anita C A , Piersma Aldert H , Russel Frans G M , van den Berg Martin , Masereeuw Rosalinde , van Duursen Majorie B M

Efflux transporters in the blood–testis barrier (BTB) prevent entry and accumulation of xenobiotics in testis but are also involved in local transport of steroid hormones. Among these are the ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp/ABCB1) and multidrug resistance proteins 1 (MRP1/ABCC1) and 4 (MRP4/ABCC4). Here, we studied the interaction of suggested endocrine disruptors (EDCs) bisphenol A (BPA), tetrabromobisphenol A (TBBPA), bis(...

ea0032p645 | Male reproduction | ECE2013

Prenatal testosterone programming: ontogeny of changes in testis of fetal and prepubertal male sheep

Rojas-Garcia Pedro Pablo , Recabarren Monica Patricia , Sandoval Daniel , Carrasco Albert , Fornes Romina , Rey Rodolfo , Sir-Petermann Teresa , Recabarren Sergio E

The reprogramming effects of an excess of testosterone during pregnancy in males born to PCOS mothers as well as in animal models for PCOS has been only recently evaluated. We have found in a sheep model of PCOS that prenatal T (PT) excess impact on the testis of adults with increased Sertoli cell (SC) number, decreased sperm count, and reduced germ cell (GC) number. The ontogeny of such disruptions and the mechanisms have not been established. This study addressed the impact ...

ea0032p646 | Male reproduction | ECE2013

Androgen levels and sexual activity in young men (n=773), 20–29 years of age, a population based study. Odense Androgen Study

Magnussen Line Velling , Nielsen Torben Leo , Glintborg Dorte , Hagen Claus , Andersen Marianne

Introduction: Low androgen levels are associated with decreased sexual activity. However, to our knowledge no population based study has evaluated the association between androgen levels and sexual activity in young men.Aim: To evaluate associations between androgen levels and sexual activity in young men.Design: Seven hundred and seventy-three Danish men, aged 20–29 years, underwent clinical and biochemical examination: Total...

ea0032p647 | Male reproduction | ECE2013

Abstract withdrawn....

ea0032p648 | Male reproduction | ECE2013

Characterization of sumoylated proteins in human sperm

Marchiani Sara , Ricci Beatrice , Tamburrino Lara , Muratori Monica , Cambi Marta , Nosi Daniele , Forti Gianni , Baldi Elisabetta

SUMOylation is a post-translational protein modification involved in the regulation of essential cell functions. Our group found several SUMO-1 and SUMO-2/3ylated proteins in human ejaculated spermatozoa (Marchiani et al. 2011). We showed that SUMO-1 is mainly present in live spermatozoa and the percentage of SUMOylated spermatozoa was inversely correlated with total and progressive motility. SUMOylated proteins are mainly located in the nucleus and in the midpiece. T...

ea0032p649 | Male reproduction | ECE2013

Characterization of R31C GNRH1 mutation in congenital hypogonadotropic hypogonadism

Maione Luigi , Albarel Frederique , Bouchard Philippe , Gallant Megan , Flanagan Colleen A , Bobe Regis , Cohen-Tannoudji Joelle , Pivonello Rosario , Colao Annamaria , Brue Thierry , Lombes Marc , Millar Robert P , Young Jacques , Guiochon-Mantel Anne , Bouligand Jerome

Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare reproductive disease leading to lack of puberty and infertility. Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH. R31C GNRH1 is the only missense mutation that affects the conserved GnRH decapeptide sequence. This mutation was identified in a CpG islet in nine nCHH subjects from four unrelated families, giving evidence for a putative ‘hot spot&#...

ea0032p650 | Male reproduction | ECE2013

Abstract withdrawn....

ea0032p651 | Male reproduction | ECE2013

Sexual dysfunction in cirrhotic patients awaiting liver transplantation

Prol Agustin Ramos , Medina Beatriz Rodriguez , Berenguer Haym Marina , Leon de Zayas Beatriz , Almanza Matilde Rubio , Campos Alborg Vicente , Torres Juan Francisco Merino

Introduction: Data on sexual dysfunction (SD) in cirrhotic patients are limited. Sexual function is a complex area of human behavior with great impact on quality-of-life (QOL). Despite its relevance, it is rarely evaluated in clinical practice in cirrhotic patients. Indeed, published studies are heterogeneous, differ in the way sexual function is assessed, and usually evaluate only one specific aspect of sexual life. Our aim was to evaluate in detail the sexual function of pat...

ea0032p652 | Male reproduction | ECE2013

Fifteen years of experience with intramuscular testosterone undecanoate for substitution in male hypogonadism: beneficial effects on the metabolic syndrome and high safety profile

Zitzmann Michael , Saad Farid

Background: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount for hypogonadal men. The i.m. injection of the long-acting ester testosterone undecanoate (TU) offers a convenient modality for testosterone substitution.Methods: We report data from 334 patients (147 with primary (including 38 Klinefelter patients), 100 with secondary hypogonadism and 87...

ea0032p653 | Male reproduction | ECE2013

Metabolic syndrome correlates with prostate volume and biochemical and ultrasound signs of prostate inflammation in male members of infertile couples

Lotti Francesco , Corona Giovanni , Vignozzi Linda , Rossi Matteo , Maseroli Elisa , Gacci Mauro , Forti Gianni , Maggi Mario

Introduction: The impact of metabolic syndrome (MetS) on male infertility has been poorly studied. We recently reported that MetS is associated with hypogonadism, poor sperm morphology and testis ultrasound inhomogeneity. However, the possible associations between MetS and prostate-related symptoms and signs are still lacking.Methods: Out of 351 subjects without genetic abnormalities previously evaluated for couple infertility clinically and by scrotal u...

ea0032p654 | Male reproduction | ECE2013

Identification of vitamin D (VDR) and retinoic X (RXR) receptor in normal and neoplastic human reproductive tissues

Cariati Federica , Gigantino Vincenzo , Coppola Giorgio , Pivonello Claudia , Galdiero Mariano , Botti Gerardo , Gandini Loredana , Lenzi Andrea , Franco Renato , Colao Annamaria , Pivonello Rosario

Background: Vitamin D is an important modulator of cell growth, differentiation and death in normal and neoplastic cells. Its actions are mediated by vitamin D receptor (VDR), which heterodimerizes with nuclear retinoid X receptors (RXRα). Recently, it has been suggested that vitamin D system have a role in male reproduction. The aim of this study was to investigate the VDR and RXRα localization in normal and neoplastic human male reproductive tissues.<p class="a...

ea0032p655 | Male reproduction | ECE2013

Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

Vignozzi Linda , Gacci Mauro , Cellai Ilaria , Santi Raffaella , Corona Giovanni , Morelli Annamaria , Rastrelli Giulia , Comeglio Paolo , Sebastianelli Arcangelo , Maneschi Elena , Nesi Gabriella , De Nunzio Cosimo , Tubaro Andrea , Mannucci Edoardo , Carini Marco , Maggi Mario

Background: Metabolic syndrome (MetS) and benign prostate hyperplasia (BPH) are often comorbid. Chronic inflammation, a determinant pathogenic factor for BPH, is a putative link between the two conditions.Methods: In a multi-center cohort of BPH patients (n=244) who underwent prostatectomy, we evaluated whether MetS is associated with prostatic inflammation in BPH specimens. In addition, we investigated the in vitro inflammatory effects...

ea0032p656 | Male reproduction | ECE2013

CATSPER calcium channels in human spermatozoa and their role in responsiveness to progesterone (P)

Tamburrino Lara , Marchiani Sara , Cambi Marta , Muratori Monica , Forti Gianni , Baldi Elisabetta

CATSPER is a family of sperm-specific calcium channels activated by P in human spermatozoa (Lishko et al. 2011, Strunker et al. 2011). KO mice for CATSPER are infertile due to severe defects in sperm motility.We studied the involvement of CATSPER in human sperm motility and P responsiveness.Western blot analysis with an anti-CATSPER1 antibody demonstrated the presence of three major bands corresponding to CATSPER1...

ea0032p657 | Male reproduction | ECE2013

Impaired masturbation induced erections: a new cardiovascular risk factor for male subjects with sexual dysfunction

Rastrelli Giulia , Boddi Valentina , Corona Giovanni , Forti Gianni , Maggi Mario

Introduction: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking.Aim: To evaluate the clinical correlates of impaired mas...

ea0032p658 | Male reproduction | ECE2013

PSA as a marker of testosterone biological activity

Rastrelli Giulia , Corona Giovanni , Maseroli Elisa , Monami Matteo , Mannucci Edoardo , Forti Gianni , Maggi Mario

Objective: To verify whether, in a large sample of male subjects seeking medical care for sexual dysfunction (SD), prostate-specific antigen (PSA) might represent a reliable marker of testosterone bioactivity, even downstream to its receptor binding.Design: Cross-sectional study.Methods: A consecutive series of 3156 patients attending our Unit for SD studied. Among them, only subjects without history of prostate disease and with PS...

ea0032p659 | Male reproduction | ECE2013

Effects of testosterone replacement therapy on hepcidin levels in young hypogonadal men

Palumbo Vincenzo , Esposito Dario , Visconti Daniela , Topa Adele , Rezza AnitaLa , Bellastella Giuseppe , De Bellis Annamaria , Agostino Sinisi Antonio

Erythrocytosis is a frequent adverse event associated with testosterone (T) administration in aged hypogonadal men, but the mechanisms involved remain poorly understood. T administration to aged men reduced hepcidin (Hpc) levels, a cytokine regulating iron availability, suggesting a potential role in deregulated erythropoiesis. Aim of present study was to evaluate the effects of T replacement therapy on Hpc levels in young hypogonadal men.Methods: Fifty-...

ea0032p660 | Male reproduction | ECE2013

D3 levels and hypogonadism in men

Banarova Adriana , Zelinkova Zuzana , Payer Juraj

Objective: 25-OH vitamin D3 (D3) possibly affects testosterone production. In some cross sectional studies the level of D3 correlates positively with total testosterone (TT) and free androgen index (FAI). In the European Male Ageing Study positive association of D3 with secondary and compensated hypogonadism was confirmed.Aim: The aim of the study was to determine the relationship between D3 levels and levels of TT, LH, FSH and FAI in men. Secondary aim ...

ea0032p661 | Male reproduction | ECE2013

Changes of neuroactive steroids caused by the smoking discontinuance

Duskova Michaela , Hruskovicova Hana , Hill Martin , Pospisilova Hana , Kralikova Eva , Starka Luboslav

Introduction: Tobacco dependence is considered to be a serious psycho-social problem. Chronic smoking can cause fertility disorders with both sexes. The literature brings up contradictory results in relation to the effects of the smoking on the steroid hormones levels. Only a few papers discuss the effect of the nicotine addiction treatment.Methods: We observed 26 smokers who decided to quit smoking and abstained from smoking for one year. With everyone ...

ea0032p662 | Male reproduction | ECE2013

Testosterone undecanoate 1000 mg at 3 months does not increase prostatic specific antigen level: study on over 100 patients, December 2012

Pisoschi Matei , Cristina Staicu Daniela , Peretianu Dan

Aim: To find if testosterone undecanoat 1000 mg injection (Nebido; Bayer-Schering) has a negative effect on prostate.Materials and methods: i) PSA (ng/ml) was registred retrospective (from files) and prospective analysis (onset 2010). ii) From over 175 patients to whom testosterone undecanoate 1000 mg, i.m. was administrated at 3 months, in the last 4 years, and to whom the prostatic volume was quantified (Journal of Sexual Medicine8</st...

ea0032p663 | Male reproduction | ECE2013

Analysing by decade, testosterone undecanoat depot injectable does not increases prostate volume. Study during up to 6 years on hypogonadic patients

Peretianu Dan , Carsote Mara , Poiana Catalina , Cristina Staicu Daniela , Pisoschi Matei

Aim: Re-analyzing the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-method: i) Patients: at onset 175 men with hypogonadism (median age: 64 years). ii) Distribution: by decade. iii) TUD (Nebido-Bayer-Schering) 1000 mg was injected one per 3 months i.m. iv) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm3), Aloka 550. v) Time of analysis: before start...

ea0032p664 | Male reproduction | ECE2013

Male pseudohermaphroditism Leydig cell hypoplasia

Belo Sandra , Magalhaes Angela , Carvalho Davide

Introduction: LH receptor plays an important role in sexual development and reproductive function. Mutations of this receptor lead to the development of three clinical conditions: Leydig cell hypoplasia, hypergonadotropic hypogonadism with primary amenorrhea and familial male limited precocious puberty. The first two entities result from inactivating mutations. In Leydig cell hypoplasia, with autosomal recessive inheritance, the phenotypic spectrum correlates with the degree o...

ea0032p665 | Male reproduction | ECE2013

Immunohistochemical detection of Prok1 and ProkR1 in normal testis and germ cell tumour tissue microarrays

Gigantino Vincenzo , Franco Renato , Chieffi Paolo , Palumbo Vincenzo , Cioffi Iolanda , De Masi Adriana , Agostino Sinisi Antonio

Prokineticins (Prok1 and Prok2) are chemokine-like peptides, which regulate through two G-protein-coupled receptors, ProkR1 and ProkR2, different physiological and pathological functions. Prok1 plays a significant role in tumour development and progression in several tissues. There are few data on the involvement of Prok1 and ProkR1 in testicular cancer. Aim of this study was to evaluate the expression of Prok1 and ProkR1 in a series of testicular germ cell tumours (GCT).<...

ea0032p666 | Male reproduction | ECE2013

Endocrine disruptors in seminal fluid: bisphenol A, triclosan and benzophenone-3

Krause Marianna , Frederiksen Hanne , Almstrup Kristian , Skakkebaek Niels E , Juul Anders , Andersson Anna-Maria

Introduction: There is concern that unintended environmental exposures to numerous chemicals, including bisphenol A (BPA), triclosan (TCS) and benzophenone-3 (BP-3), all of which can be detected in serum and urine, may have adverse endocrine effects on human reproduction. Less is known about the concentrations of these chemicals in other body fluids. Here we present data, which show that these three chemicals can also be present in seminal fluid of young men.<p class="abst...

ea0032p667 | Male reproduction | ECE2013

Sperm DNA fragmentation as assessed by TUNEL/PI: mean values in fertile men and intra individual variability

Muratori Monica , Tamburrino Lara , Cambi Marta , Marchiani Sara , Natali Ilaria , Noci Ivo , Maggi Mario , Forti Gianni , Baldi Elisabetta

Tests detecting sperm DNA fragmentation (SDF) could be included in the clinical management of male infertility. TUNEL/PI is an innovative version of the TUNEL assay, and it is able to distinguish between two different populations: PI brighter and PI dimmer sperm. The aims of the study were to determine the average value of SDF in recruited men of proven fertility and to verify whether SDF discriminates between fertile and subfertile men independently from semen quality. In add...

ea0032p668 | Male reproduction | ECE2013

The identification of pre-diabetes condition with ARIC algorithm, predicts long-term CV events in patients with erectile dysfunction

Corona Giovanni , Rastrelli Giulia , Silverii Antonio , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: The Atherosclerosis Risk in Communities (ARIC) algorithm is one of the most efficient instruments for the prediction of incident type 2 diabetes (T2DM). Recently it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease.The aim of the present study is to verify whether, in patients with erectile dysfunction (ED), the use of ARIC diabetes risk score might improve the efficacy in predicting ...

ea0032p669 | Male reproduction | ECE2013

Is pericentromeric inversion of the heterochromatic region of chromosome 9 involved in couple infertility?

Popa Oana-Monica , Neamtu Corina , Padure Adriana

Pericentromeric inversion of the heterochromatic region of chromosome 9 has been reported in almost 4% of the cases of male infertility.Objective: Determining the karyotype from an infertile couple scheduled to perform IVF.Materials and methods: Slides with metaphasic chromosomes were GTG-banded according to standard protocol for cytogenetic analysis (karyotype). FISH analysis – inverted DAPI (4′-6-diamidino-2-phenylindo...

ea0032p670 | Male reproduction | ECE2013

The hypothalamus–hypophysis–gonads axis in men in reproductive age with obesity and different pituitary adenomas

Urmanova Yulduz , Nabieva Iroda

The aim: To study of functional status of hypothalamic–hypophysis–gonads axis men in reproductive age with obesity and different pituitary adenomas (PA).Materials and methods: We examined 44 males with obesity 1–3 degrees with associated pathology (11 of them – pro and 33 – retrospectively). Mean age of patients was 22.9 years old. Control group constituted by 20 healthy men with different age.All patients ...

ea0032p671 | Male reproduction | ECE2013

A case of idiopathic hypogonadotropic hypogonadism which attained remission by LH and FSH treatment

Watanabe Yui , Hayashi Takeshi , Yamazaki Hiroyuki , Tojo Katsuyoshi , Utsunomiya Kazunori

A 17-year-old male was referred to our hospital with lack of secondary sex characteristics. His voice didn’t break and he lacked of pubes and hircus. His bilateral testicular volume was small and his sense of smell was normal. There was no varicocele or pituitary adenoma. His chromosomal study showed no aberrations. Serum levels of LH, FSH, total testosterone and free testosterone were 1.05 mIU/ml, 1.68 mIU/ml, 0.26 ng/ml and <0.6 pg/ml respectively. A repeated GnRH t...

ea0032p672 | Male reproduction | ECE2013

Risk factors associated with primary and secondary reduced libido in male patients with sexual dysfunction

Corona Giovanni , Rastrelli Giulia , Jannini Emmanuele , Vignozzi Linda , Mannucci Edoardo , Forti Gianni , Maggi Mario

Introduction: Hypoactive sexual desire is defined as a persistent or recurrent deficient or absent sexual fantasies or desire for sexual activity which should not be comorbid with other medical conditions or with the use of psychoactive medications. Reduced libido is a symptom referring more to a reduction in sexual drive for sexual activity. The aim of the present study is to investigate the risk factors of primary reduced libido (i.e. not associated with conditions causing l...

ea0032p673 | Male reproduction | ECE2013

The role of testosterone augmentation in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) in improving functional recovery and hospital stay

H K Puar Troy , Tud Richard Chen Yuan

Introduction: Low testosterone levels are found in up to 50% of male patients with chronic obstructive pulmonary disease (COPD), and acute illness is associated with further suppression of the central and peripheral gonadal axis. Testosterone supplementation in chronic stable COPD patients has yielded mixed results, demonstrating increased lean body mass, and improved exercise capacity in some studies, but not others. Use of anabolic steroids during acute illness has shown ben...

ea0032p674 | Male reproduction | ECE2013

Fourty six, XX male sex reversal syndrome with infertility: a case report

Akkurt Aysen , Sisman Pinar , Ersoy Canan , Erturk Erdinc , Tuncel Ercan , Imamoglu Sazi

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

ea0032p675 | Male reproduction | ECE2013

Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Bandini Elisa , Strada Carolina , Maseroli Elisa , Ricca Valdo , Faravelli Carlo , Mannucci Edoardo , Maggi Mario

The role of psychological symptoms in recognizing late-onset hypogonadism (LOH) is still controversial. The aim of the study is to evaluate the association between LOH and specific psychological symptoms and to verify whether investigating intra-psychic domain improves the accuracy of a validated case-history tool (ANDROTEST) in detecting LOH. A consecutive series of 1009 subjects (mean age 49.23±13.34) consulting for sexual dysfunction was studied. Intra-psychic symptoms...

ea0032p676 | Male reproduction | ECE2013

Two unconventional risk factors for major adverse cardiovascular events in subjects with sexual dysfunction: low education and reported partner's hypoactive sexual desire in comparison with conventional risk factors

Rastrelli Giulia , Corona Giovanni , Daphne Fisher Alessandra , Mannucci Edoardo , Maggi Mario

Introduction: The classification of subjects as low or high cardiovascular (CV) risk is usually performed by risk engines, based upon multivariate prediction algorithms. However, their accuracy in predicting major adverse CV events (MACE) is lower in high-risk populations, since they take into account only conventional risk factors.Aim: To evaluate the accuracy of Progetto Cuore risk engine in predicting MACE in subjects with erectile dysfunction (ED), a...

ea0032p677 | Male reproduction | ECE2013

‘It takes two to tango’: the relational domain in a cohort of subjects with erectile dysfunction (ED)

Boddi Valentina , Rastrelli Giulia , Corona Giovanni , Daphne Fisher Alessandra , Forti Gianni , Maggi Mario

Introduction: The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, which assesses, beside the organic (Scale1) and intra-psychic (Scale 3) domains, also the relation one (Scale 2). We previously established a pathological threshold for SIEDY Scale 1 and 3.Aim: To identify a pathological threshold of SIEDY Scale 2.Metho...