Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations


ea0032p678 | Neuroendocrinology | ECE2013

Genotype and phenotype characterization of the cohort of Italian patients with idiopathic central hypogonadism (ICH)

Bonomi Marco , Vladimiro Libri Domenico , Guizzardi Fabiana , Duminuco Paolo , Agostino Sinisi Antonio , Simoni Manuela , Magnie Mohamad , Krausz Csilla , Persani Luca , On behalf of the Italian Societies for Endocrinology and Pediatric Endocrinology

ICH is a rare disease characterized by a complex pathogenesis, but with a strong genetic component. ICH may be associated to several other morphogenetic or inborn defects, such as the osmic defects that identify the Kallmann syndrome (KS). The description of several pedigrees including relatives affected either with isolated osmic defects or KS or normoosmic ICH (nICH) justifies the emerging idea of ICH as a complex genetic disease characterized by variable expressivity and pe...

ea0032p679 | Neuroendocrinology | ECE2013

DHEA enhances working memory and prevents distraction: behavioural and ERP evidence from an auditory–visual distraction paradigm

Vale Sonia , Selinger Lenka , Martin Martins Joao , Bicho Manuel , Carmo Isabel , Escera Carles

Introduction: Several studies suggest DHEA and DHEAS (DHEA(S)) are related to memory enhancement and a better performance under stress. An anti-cortisol action may contribute to those relations. We looked for a new level of evidence, by studying DHEA(S) and cortisol relations to working memory (WM) and distraction in humans also at the electrophysiological level.Subjects and methods: Twenty-eight healthy female volunteers (18–26 years old) were pres...

ea0032p680 | Neuroendocrinology | ECE2013

High glucose induces hypogonadotropic hypogonadism by interfering with GPR54 signaling in the preoptic area of the hypothalamus

Morelli Annamaria , Vignozzi Linda , Erica Sarchielli , Comeglio Paolo , Filippi Sandra , Rastrelli Giulia , Maneschi Elena , Cellai Ilaria , Barbara Vannelli Gabriella , Maggi Mario

The metabolic syndrome (MetS) is a clustering of metabolic and cardiovascular risk factors, having in insulin resistance the key element. In males, MetS is also associated to hypogonadism. We recently found that high fat diet (HFD)-induced MetS rabbits also developed hypogonadotropic hypogonadism, showing a reduced immunopositivity for gonadotropin relasing hormone (GnRH) in the hypothalamus. In this study, we investigated the pathogenetic link between Mets components and the ...

ea0032p681 | Neuroendocrinology | ECE2013

Hypothalamic melanin-concentrating hormone influences liver and adipose lipid metabolism

Imbernon Monica , Beiroa Daniel , Vazquez Maria J , Morgan Donald A , Veyrat-Durebex Christelle , Porteiro Begona , Diaz-Arteaga Adenis , Senra Ana , Al-Massadi Omar , Velasquez Douglas A , Gallego Rosalia , Seoane Luisa M , Lopez Miguel , Davis Roger J , Sabio Guadalupe , Rohner-Jeanrenaud Francoise , Rahmouni Kamal , Dieguez Carlos , Nogueiras Ruben

Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...

ea0032p682 | Neuroendocrinology | ECE2013

Hormonal therapy satisfaction is associated with better quality of life in transsexual persons

Wierckx Katrien , Geerts Lieselot , Anseeuw Edward , Motmans Joz , Elaut Els , Heylens Gunter , Decuypere Griet , T'Sjoen Guy

Introduction: Quality of life in transsexual persons after transition is among the most important outcome factors.Methods: A specialist center cross-sectional study in 193 transsexual women and 128 transsexual men (mean age 42.5 years) after on average 7.4 years of cross-sex hormone therapy and 6.6 years since sex reassignment surgery (SRS), compared to an age-and gender matched control population (1 to 3 matching). Self-reported physical and mental heal...

ea0032p683 | Neuroendocrinology | ECE2013

The small GTPase Rab18 modulates neuroendocrine secretion by interacting with components of the microtubule-based secretory granule transport machinery

Vazquez-Martinez Rafael , Almabouada Farid , Rabanal Yoana , Diaz-Ruiz Alberto , Garcia-Navarro Socorro , Malagon Maria M

Several Rab proteins control secretory granule trafficking and, hence, hormone release, by regulating the activity of different components of the secretory granule transport machinery. Particularly, Rab18 inhibits secretory granule movement, which leads to reduced neuropeptide and hormone secretion in PC12 pheochromocytoma cells and ACTH-secreting ATt20 cells, respectively, but how this GTPase accomplishes its role and the identity of the proteins that regulate Rab18 activity ...

ea0032p684 | Neuroendocrinology | ECE2013

Roles of kisspeptin partners, NKB and dynorphin, in the control of gonadotropin secretion: revisiting the KNDy paradigm

Ruiz-Pino Francisco , Garcia-Galiano David , Manfredi-Lozano Maria , Leon Silvia , Sanchez-Garrido Miguel A , Roa Juan , Pinilla Leonor , Navarro Victor , Tena-Sempere Manuel

KNDy neurons, which co-express kisspeptins, neurokinin B (NKB) and dynorphin (Dyn), play a key role in the tonic control of gonadotropin secretion by modulating the GnRH release. The assumed KNDy model proposes that NKB and Dyn (as stimulatory and inhibitory signals, respectively) auto-regulate the secretion of kisspeptins onto GnRH neurons. However, some aspects of this paradigm remain poorly defined. In this context, the aims of this work were to characterize i) the putative...

ea0032p685 | Neuroendocrinology | ECE2013

Antipsychotic-induced hyperpolactinemia: clinical particulars and relation to sexual dysfunction

Yunilainen Olga , Starostina Elena , Dzeranova Larisa , Kolesnikova Galina , Kazia Gulnara , Goncharov Nikolay , Dedov Ivan

Objectives: To assess prevalence of antipsychotic-induced hyperpolactinemia (AIH) in psychiatric in-patients and to describe its clinical characteristics and association of AIH with sexual function.Methods: A cross-sectional study in 143 consecutive psychiatric in-patients (F/M=65/78), mostly with schizophrenia (93%), currently taking antipsychotics. The patients were screened for serum prolactin, sex hormones, gonadotropin levels and macroprolactin. For...

ea0032p686 | Neuroendocrinology | ECE2013

Low carbohydrate/high fat energy intake decreases estrogen receptor alpha expression in the arcuate nucleus of the rat hypothalamus

Zengin Ayse , Bielohuby Maximilian , Horngacher Amon , Meurer Sarina , Bidlingmaier Martin

Low-carbohydrate/high fat diets (LC-HFD) effectively induce body weight loss in both animals and humans; however, in rats this is paralleled by increased visceral adiposity contributing to impaired glucose tolerance. Estrogen inhibits adipose tissue accumulation, with estrogen deficient female animals displaying increased body weight and visceral adiposity with reduced insulin sensitivity, which can be reversed with estrogen replacement. Consistent with the effects seen in fem...

ea0032p687 | Neuroendocrinology | ECE2013

Digenic and oligogenic cases in a large cohort of idiopathic central hypogonadism (ICH) patients

Libri Domenico , Bonomi Marco , Guizzardi Fabiana , Duminuco Paolo , Pincelli Ida , Russo Giovanni , Garolla Andrea , Krausz Csilla , Maghnie Mohamed , Padova Giuseppa , Persani Luca

ICH is a rare and heterogeneous condition due to defects in the onthogenesis, migration and action of GnRH secreting neurons. Recent publications indicate that ICH, though characterized by a strong genetic component, is a disease of multifactorial origin. Indeed, digenic and oligogenic defects have been described as a possible pathogenic explanation for this disease. Among the cohort of 315 ICH patients we identified 3 KS and 7 nICH patients (7 males, 3 females) with a biallel...

ea0032p688 | Neuroendocrinology | ECE2013

The characterization of sleep–wake pattern and its association with melatonin, as a marker of the circadian function of the suprachiasmatic nucleus, in craniopharyngioma patients

Jakobsen Line Pickering , Jennum Poul , Gammeltoft Steen , Feldt-Rasmussen Ulla , Klose Marianne

Hypothesis: We hypothesised that damage to the hypothalamus by local tumour, surgical treatment, or irradiation might involve the suprachiasmatic nucleus and thereby melatonin secretion, leading to disturbed circadian function and clinical manifestations such as daytime sleepiness and fatigue in craniopharyngeoma patients.Objective: We aimed to assess the influence of craniopharyngiomas and their treatment on melatonin secretion, sleep pattern, sleep qua...

ea0032p689 | Neuroendocrinology | ECE2013

Pituitary adenoma and associated tumors

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Popovic Vera

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

ea0032p690 | Neuroendocrinology | ECE2013

Iron overload impairs the migratory ability of a model of immature and migratory GnRH neurons

Steffani Liliana , Nitto Francesca Di , Macchi Chiara , Dongiovanni Paola , Rametta Raffaella , Valenti Luca Vittorio , Fargion Silvia , Magni Paolo , Ruscica Massimiliano

Iron represents a micronutrient for cellular metabolism and aerobic respiration, and is essential for proper brain development in the fetal and early neonatal period. However, excess iron produces toxic build-up via free radical formation. In thalassaemic and juvenile hemochromatosis patients with pubertal failure, iron overload interferes with the correct function of the hypothalamic–pituitary axis, leading to hypogonadotrophic hypogonadism and growth failure, but the me...

ea0032p691 | Neuroendocrinology | ECE2013

The reproductive endocrine complications of antiepileptic drugs at woman’s epilepsy

Odintsova Galina , Koroleva Nadezda , Saykova Ludmila , Chugunova Anastasia

Purpose: To study reproductive endocrine complications (REC) of antiepileptic drugs (AEDs) at a woman epilepsyMaterials and methods: One hundred and fifty five women at the age of 16–45 years were included in prospective observational uncontrolled comparative study of the antiepileptic drugs reproductive side effects. Three groups were divided: 1 gr., monotherapy AEDs; 2 gr., polytherapy; 3 gr., no AEDs used. REC lasted more than 6 months were accou...

ea0032p692 | Neuroendocrinology | ECE2013

DHEA and cortisol response to working memory

Vale Sonia , Selinger Lenka , Martins Joao Martin , Gomes Ana , Bicho Manuel , Carmo Isabel , Escera Carles

Introduction: Several studies reported DHEA relations to memory and cognition improvement. An anti-cortisol action may contribute to those relations. The effect of working memory (WM) on DHEA levels is unknown. We studied DHEA and cortisol reactivity in humans after a WM stimulus with simultaneous distraction.Subjects and methods: Twenty eight healthy female volunteers (18–26 years old) were presented a well-established auditory-visual distraction t...

ea0032p693 | Neuroendocrinology | ECE2013

Neuroprotective effects of estrogen rely on neuroglobin upregulation

Fiocchetti Marco , Ascenzi Paolo , Marino Maria

Estrogens, in particular 17β-estradiol (E2), orchestrate cellular mechanisms involved in the development and differentiation of various neuron populations, modulation of synaptic plasticity, induction of neuronal survival, and neurogenesis. Beneficial effects of E2 have been widely reported against a variety of insults, including H2O2 injury, serum deprivation, and glutamate excitotoxicity. Recently, we identified E2 ...

ea0032p694 | Neuroendocrinology | ECE2013

Diagnosis and management of patients presenting hyponatremia while receiving parenteral nutrition

Hoyos Emilia Gomez , Hernandez Martin Cuesta , Capel Francisco Fernandez , Gracia Teresa Ruiz , Martin Maria Del Pilar Matia , Garcia Lucio Cabrerizo , Herrera Miguel Angel Rubio , Perez Ferre Natalia , Pascual Alfonso Calle , De La Vega Isabelle Runkle

Introduction: Hyponatremia is the most frequent electrolyte alteration in hospitalized patients, and is associated with increased morbimortality. Hyponatremia in patients receiving parenteral nutrition (PN) is generally overlooked. Our objective was to classify the types of hyponatremia observed in patients on PN, and to describe the prescribed treatments and evolution.Material and methods: We undertook a prospective study of all patients on medical ward...

ea0032p695 | Neuroendocrinology | ECE2013

Des-acyl ghrelin acts directly and independently and counteracts acyl-ghrelin-induced neuronal activity in the central melanocortin system of rats

Stevanovic Darko , Delhanty Patric , Themmen Axel , Popovic Vera , Holstege Joan , van der Lely Aart-Jan

Ghrelin, the endogenous GH secretagogue, has an important role in metabolic homeostasis. It exists in two major molecular forms: acylated (AG) and des-acylated (DAG). Many studies suggest different roles for these two forms in energy balance regulation. In the present study, we compared the effects of acute intracerebroventricular (ICV) administration of AG, DAG and their combination (AG+DAG) to young adult Wistar rats on food intake and central melanocortin system modulation....

ea0032p696 | Neuroendocrinology | ECE2013

Evaluation of the efficacy of midnight salivary cortisol plus dexamethasone suppression test as screening for the diagnosis of hypercortisolism within an at-risk population

Leal-Cerro Alfonso , Madrazo-Atutxa Ainara , Garcia-Arnes Juan , Lamas-Oliveira Cristina , Boronat-Cort Mauro , Lillo Juan A , Fajardo Carmen , Urgell-Rull Eulalia , Salvador Javier , Salinas Isabel , Bernabeu Ignacio , Paramo Concha , Webb Susan , Torres-Vela Elena , Diaz Angel , Aller Javier , Leon-Justel Antonio

Introduction: Endogenous Cushing’s syndrome (CS) is a rare, infradiagnosed and severe disease that carries high morbidity and mortality. Delays in treatment initiation reduce reversibility of symptoms and increase mortality rate. Current gold standard for screening, 24 h urinary free cortisol, has a low reproducibility and specificity, and sampling is complicated. Midnight salivary cortisol (MSVC) determination is considered an easy and cheap test. We intend to assess its...

ea0032p697 | Neuroendocrinology | ECE2013

Impact of long acting somatostatin analogs vs successful surgery on glucose metabolism in Cretan acromegalic patients

Daraki Vasiliki , Konstantinidou Chrystalla , Karipidou Evgenia , Spyrou Fotis , Volanaki Eleni , Mamalaki Evangelia , Papavasiliou Stathis

Introduction: Acromegaly is associated with increased cardiovascular morbidity and mortality, in part, as a consequence of the increased insulin resistance that frequently accompanies GH hypersecretion. Glucose tolerance may worsen in patients treated with somatostatin analogs (SSA).Objective: To compare the long term effects of SSA treatment to successful surgery on glucose metabolism in Cretan acromegalic patients.Design and meth...

ea0032p698 | Neuroendocrinology | ECE2013

Prevalence and causes of hyponatremia in patients with endocrine disorders

Pigarova Ekaterina , Cherepanova Elena , Dzeranova Larisa

Objectives: To study the prevalence and causes of hyponatremia in patients with various endocrine diseases.Methods: We had retrospectively analyzed the results of biochemical laboratory studies performed during one calendar month at the tertiary care clinic for endocrinology patients for the variations in the serum sodium concentrations. Blood sodium levels <135 mmol/l were considered as hyponatremia. For all patients with hyponatriemia addition data...

ea0032p699 | Neuroendocrinology | ECE2013

Acute exposure of Bisphenol-A from electronic gadgets does not induce oxidative stress in the rat’s brain

Kumar Neeraj , Kumar Pardeep , Sharma Vinod Pravin

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of Bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

ea0032p700 | Neuroendocrinology | ECE2013

Oxytocin modulates olfaction-related behaviour and essential for onset of sexual behaviour in both sexes of mice

Dhungel Sunil , Rai Dilip , Nishimori Katsuhiko , Kondo Yasuhiko , Sakuma Yasuo

In microsmatic animals, the olfactory cues initiate wide variety of neuroendocrine and behavioural responses. These behaviours are under the influence of sex hormones however some neuropeptide plays pivotal role. Oxytocin is involved in various social behaviours in mammalian species. However, oxytocin-deficient (OTKO) mice successfully accomplish reproduction although females cannot rear their pups because of lack of lactation. Though oxytocin is not essential for sexual behav...

ea0032p701 | Neuroendocrinology | ECE2013

Obestatin is associated to muscle strength, functional capacity and cognitive status in old women

Mora Mireia , Luisa Granada Maria , Palomera Elisabet , Serra-Prat Mateu , Puig-Domingo Manuel

Introduction: Obestatin has been proposed to have anorexigenic and anti-ghrelin action. An association has been found between ghrelin and its decline with ageing and muscle strength and functional capacity, probably mediated by GH–IGF1 axis. However, no information is available in relation to the role of obestatin in muscle strength and functional capacity.Objective: The objective was to study obestatin concentrations in relation to handgrip strengt...

ea0032p702 | Neuroendocrinology | ECE2013

Copeptin for subtype differentiation of abnormal vasopressin release in SIADH: reclassification and characterization of a novel subtype

Fenske Wiebke , Horning Anna , Simet Jessica , Christ-Crain Mirjam , Szinnai Gabor , Rutishauser Jonas , Stork Stefan , Allolio Bruno

Introduction: The syndrome of inappropriate antidiuresis (SIADH) is the most common cause of hypoosmolality. Ectopic AVP hypersecretion has long been considered as the primaryn mechanism of SIADH. But different types of osmoregulatory defect in AVP release have been described in this disorder. A comprehensive characterization of these different forms of SIADH in a large cohort of patients may provide important new insights into the still incompletely understood pathophysiology...

ea0032p703 | Neuroendocrinology | ECE2013

Neurodegenerative and inflammatory biomarkers in cerebrospinal fluid in patients with Cushing's syndrome

Ragnarsson Oskar , Berglund Peter , Eder Detek N , Zetterberg Henrik , Hietala Max A , Blennow Kaj , Johannsson Gudmundur

Background: Patients with Cushing’s syndrome (CS) in long-term remission have impaired cognitive function. Cerebrospinal fluid (CSF) biomarkers are important diagnostic tools in the work-up of patients with cognitive impairment. The aim of this study was to analyze biological markers in CSF from patients with CS in remission. Owing to the overlapping similarities between patients with CS and dementia, i.e. cognitive dysfunction and hypercortisolemia, the main hypothesis w...

ea0032p704 | Neuroendocrinology | ECE2013

Evaluation of GH deficiency and central adrenal insufficiency in patients following craniospinal irradiation in young ages: comparison between the glucagon stimulation test and the insulin tolerance test

Yudina Alla , Tselovalnikova Tatiana , Pavlova Maria , Mazerkina Nadezhda

The patients following craniospinal irradiation (CSI) in young ages due to posterior fossa tumors had high risk of hypopituitarism. The glucagon stimulation test (GST) may be used as alternative the insulin tolerance test (ITT) in the diagnosis of GH deficiency (GHD) and central adrenal insufficiency (CAI) when insulin-induced hypoglycaemia is contraindicated e.g. history of convulsions, coronary heart disease, also it can be carry out as an outpatient. The aim of this study w...

ea0032p705 | Neuroendocrinology | ECE2013

Diurnal melatonin profile in patients with acromegaly

Khyzhnyak Oksana , Mykytyuk Myroslava , Sulima Tatayna , Karachentsev Yuri

Introduction: Cardiovascular complications are the most relevant cause of mortality in patients with acromegaly.Aims: To evaluate the association of diurnal melatonin profile with arterial hypertension in acromegalic patients.Subjects and methods: Thirty seven patients (15 men and 22 women; aged 18–75 years) with acromegaly were under investigation. Blood samples for GH and, IGF1 were taken in fasting state. 6-Sulfatoxymelaton...

ea0032p706 | Neuroendocrinology | ECE2013

Comparative analysis of the hormonal, MRI and morphological characteristics of patients with Cushing's disease remission and no remission after neurosurgical treatment

Marova Eugenia , Arapova Svetlana , Kolesnikova Galina , Lapshina Anastasiya , Rozhinskaya Ludmila

Introduction: Long term remission of CD is achieved in 65–83% after neurosurgery, while the remaining cases have recurrence or continued tumor growth. This paper deals with the problem of CD prognostic factors after neurosurgery.Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline–eosine staining) and immunohistochemistry (with antibodies to the pituitary tropic hormones, Ki-67, CD31 and VEGF) of th...

ea0032p707 | Neuroendocrinology | ECE2013

Prevalence and clinical significance of hook-effect and macroprolactinaemia phenomenons in patients with prolactinomas

Nasybullina Farida , Vagapova Gulnar , Pashaev Bakhtiyar

Introduction.: Circulating prolactin is predominantly monomeric, but when there presents more than 60% of polymeric, less bioactive forms, phenomenon of macroprolactinemia is diagnosed.For prolactinomas, serum prolactin levels generally parallel to tumor size, but tumor mass and prolactin levels may be dissociated due to hook-effect, when falsely low prolactin level observed. It is excluded by serial dilutions of serum samples.The ...

ea0032p708 | Neuroendocrinology | ECE2013

Hyponatremia in the emergency room: characteristics, and initial diagnostic approach

Cuesta Hernandez Martin , Gomez Hoyos Emilia , Fernandez Capel Francisco , Ruiz Gracia Teresa , Calle Pascual Alfonso , Martin Sanchez Javier , Runkle De La Vega Isabelle

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

ea0032p709 | Neuroendocrinology | ECE2013

Modulation of Na+/K+-ATPase activity of rat brain synaptosome by norepinepherine and serotonin

Sinha Sukrat

Sleep and wakefulness are behavioral and physiological activities. It is a modified form of the basic rest activity cycle. Humans usually fall asleep by entering in non Rapid Eye movement sleep, a phase accompanied by characteristic changes in the encephalogram (EEG). The person next moves to REM sleep, which is characterized not only by rapid eye movements but also by inhibition of skeletal muscle tone. These two states alternate with each other during sleep cycle. It has bee...

ea0032p710 | Neuroendocrinology | ECE2013

Adulthood germ cell tumor: a case report

Menezes Nunes Joana , Rodrigues Elisabete , Pereira Josue , Portugal Raquel , Castro Ligia , Bernardes Irene , Osorio Ligia , Faria Olinda , Carvalho Davide

Introduction: Germ cell tumors (GCTs) are classified as extragonadal if there is no evidence of a primary tumor in the gonads. They typically occur in the midline structures. Newly diagnosed adult cases of pituitary or pineal glands germinomas are very rare since most of the cases are diagnosed in the mid teens, presenting 14:1, on behalf of the male gender. The estimated incidence of this tumor in western countries is between 0.4–3.4%, being more frequent in the Asia.</p...

ea0032p711 | Neuroendocrinology | ECE2013

Infrasellar gangliocytoma causing cushing's disease: a case report

Domingue Marie-Eve , Marbaix Etienne , Godfraind Catherine , Col Vincent , Raftopoulos Christian , Maiter Dominique

Gangliocytomas are uncommon neuronal tumors that can sometimes cause endocrine syndromes. A few such cases have been reported in association with Cushing’s disease. In most instances, the tumor contained CRH and was associated with pituitary corticotroph hyperplasia or adenoma (mixed lesion). Only one case of isolated gangliocytoma causing Cushing’s disease per se has been described.We report the case of a 62 year-old woman whose clinical pictu...

ea0032p712 | Neuroendocrinology | ECE2013

Effects of GH therapy in carbohydrate metabolism in spanish adults with GH deficiency

Andrea Parra Ramirez Paola , Perez Fernandez Laura , Fernandez Martinez Alberto , Grande Aragon Cristina , Alvarez-Escola Cristina

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

ea0032p713 | Neuroendocrinology | ECE2013

Clinical case of silent corticotropinoma

Dzeranova Larisa , Lipatenkova Anna , Pigarova Ekaterina , Voronkova Iya

Silent corticotropinomas (SCAs) are a subtype of non-functioning pituitary adenomas (NFPAs) demonstrating positive immunoreactivity for ACTH, but without clinical or biochemical features of hypercortisolism. SCAs typically present as macroadenomas with symptoms related to a local mass effect. In some cases SCAs can transform into hormonal active formations with gradually developing symptoms of hypercortisolism.The aim: To describe a patient with NFPA who...

ea0032p714 | Neuroendocrinology | ECE2013

Central diabetes insipidus, as the first sign of Langerhans cell histiocytosis in an adult

Egana Nerea , Ruiz Irune , Bilbao Ismene , Aramburu Maite , Yoldi Alfredo , Garcia Cristina , Alvarez Coca Mariano , Luisa Antunano Maria , Goena Miguel

Introduction: Langerhans cell histiocytosis (LCH) is a rare granulomatous disease of unknown etiology. LCH may be localized or be a systemic disease. The diagnosis is frecuent in pediatric age. In adults, infiltration is most frecuently in bones, lungs and skin, and shows particular predilection for hypothalamo-pituitary axis.Case: A 51 years old man was referred due to polyuria of ~15 l of daily urine output. His past medical history revealed bronchiect...

ea0032p715 | Neuroendocrinology | ECE2013

RET codon 618 mutation is the most frequent genotype in saudi families with multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma

Qari Faiza , Nasser Tariq

Background and objectives: Certain diseases, such as multiple endocrine neoplasia type 2A (MEN2A), MEN2B, familial and sporadic medullary thyroid carcinoma (MTC) and renal dysgenesis are related to abnormalities of the RET protein. Our aim was to evaluate the frequency of RET mutation in ten Saudi families with MEN2A and familial medullary thyroid carcinoma.Design and setting: Cross-sectional prospective study of patients followed up at King Abd...

ea0032p716 | Neuroendocrinology | ECE2013

Neurological manifestations of Vitamin D deficiency, is there any significant clinical correlation?

Qari Faiza , Nasser Tariq

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of Vitamin D deficiency and the levels of 25(OH) D and bone profile.Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2010 and December 2011. We collected information on demographic data, etiological factors for Vitamin D deficiency, clinical pr...

ea0032p717 | Neuroendocrinology | ECE2013

Craniopharyngioma – a diagnosis not to be missed

Nunes Joana Menezes , Rodrigues Elisabete , Salvador Sergio , Cerejo Antonio , Reis Ricardo , Silva Sergio , Augusto Luis , Guimaraes Marcos , Vaz Rui , Carvalho Davide

Introduction: Craniopharyngiomas are intracranial tumors that develop from Rathke’s pouch rests of epithelium. They have a bimodal age distribution, with peak incidence at childhood and in the adult/elderly, although in our series we have more patients in a middle peak. Usually they are benign but responsible for significant morbidity, particularly when located near critical structures such as optic chiasm, pituitary gland and hypothalamus, and thus might cause visual, ne...

ea0032p718 | Neuroendocrinology | ECE2013

Features of family inheritance in patients of non-functional pituitary adenomas in Uzbekistan

Khalimova Zamira , Sharipova Dilorom , Fayzullaev Rovshan , Urmanova Yulduz , Alieva Dinara , Alimukhamedova Gulrukh , Karimova Munira , Safarova Shokhsanam

Aim: To study features of family inheritance in patients of non-functional pituitary adenomas (NFPA) in Uzbekistan.Materials and methods: We included 71 patients with NFPA, intrasellar localization (mean size >3 mm). Mean age was from 18 to 70 years old (range 44.5±3.85 years). Of 71 patients, 30 (42.3%) were men and 41 (57.7%) were women.All patients underwent clinical and biochemical evaluations including endocrine check...

ea0032p718.1 | Neuroendocrinology | ECE2013

Abstract withdrawn....