Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

ea0032p726 | Obesity | ECE2013

The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet

Sieira Sonia Perez , Martinez Gloria , Porteiro Begona , Lopez Miguel , Vidal Anxo , Nogueiras Ruben , Dieguez Carlos

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

ea0032p727 | Obesity | ECE2013

Abstract unavailable....

ea0032p728 | Obesity | ECE2013

Serum- and glucocorticoid-regulated kinase 1 in obesity-related adipose tissue and peripheral inflammation

Reiter Marie Helene , Kiefer Florian , Zeyda Maximilian , Kopecky Chantal , Stulnig Thomas , Luger Anton , Vila Greisa

The serum- and glucocorticoid-regulated kinase 1 (Sgk1) is a direct transcriptional target of glucocorticoids and is post-translationally activated by the insulin/IGF1 pathway. Distinct polymorphisms in the Sgk1 gene are associated with increased body weight and type 2 diabetes. Here we investigate the expression and regulation of Sgk1 in human obesity.In both omental and subcutaneous human adipose tissue, Sgk1 expression is significantly increased in 20...

ea0032p729 | Obesity | ECE2013

New insights on molecular mechanisms regulating hepatic sex hormone-binding globulin production: clinical implications in obesity and type 2 diabetes

Saez-Lopez Cristina , Hernandez Cristina , Simo Rafael , Selva David M

Human sex hormone-binding globulin (SHBG) is produced and secreted by the liver and it binds androgens and estrogens with high affinity. In blood, SHBG acts as a carrier of these sex steroids and regulates their bioavailability. Low plasma SHBG levels are associated with obesity, abdominal adiposity and metabolic syndrome, and predict the development of type 2 diabetes. In addition, an inverse relationship between plasma SHBG levels and risk of cardiovascular disease has been ...

ea0032p730 | Obesity | ECE2013

Obesity: a paradox in the mortality of the elderly

Maralani Haleh Ghaem , Tai Bee Choo , Wong Tien Yin , Tai E Shyong , Li Jialiang , Wang Jie Jin , Mitchell Paul

Introduction: The effect of BMI on mortality amongst the elderly may be different from younger adults. Thus, this study aims to determine the relationship between BMI and its 5-year changes on all-cause and cause-specific mortality in the elderly.Methods: During 1992–1994, the Blue Mountains Eye Study recruited 3654 residents aged ≥49 years in Sydney, Australia. Of these, 75% of survivors returned for follow-up at 5 years. We initially examine...

ea0032p731 | Obesity | ECE2013

Brite adipocytes: a role for cannabinoid receptor type 1 in brown adipose cell recruitment

Mazza Roberta , Quarta Carmelo , Pasquali Renato , Pagotto Uberto

Recent data showed the existence of a specific adipocyte population composed of ‘brite’ cells in white adipose tissue (WAT), characterized by a peculiar gene expression pattern including PRDM16. Despite showing a low basal UCP1 expression, these cells display higher UCP1 expression when stimulated. In view of the involvement of the endocannabinoid system in energy homeostasis, the aim of our work is to establish whether the CB1 receptor could be a target for brown ph...

ea0032p732 | Obesity | ECE2013

Metabolic side effects of second generation antipsychotic drugs in adolescents

Dobrescu Iuliana , Rad Florina , Anghel Gianina Cristina , Petrescu-Ghenea Cristina , Trutescu Carmen

Introduction: Although for the last 2 decades we have witnessed a rise in the use of second generation antipsychotic treatment in children and adolescents suffering from psychiatric disorders we do not have enough studies in specialty literature to estimate the risks associated with this medication. Recent data and also our clinical experience shows that second generation antipsychotic drugs administration correlates with considerable weight gain and also with altering of gluc...

ea0032p733 | Obesity | ECE2013

Gastric banding vs gastric bypass: evolution of anthropometric parameters and related comorbidities during the 2 years after surgery

Caldas Ana Rita , Silva Ana Maia , Amaral Claudia , Freitas Claudia , Carvalho Andre Couto , Silva Isabel , Pichel Fernando , Silva Carla , Marcos Mario , Santos Jorge , Nogueira Carlos , Cardoso Maria Helena

Introduction: Bariatric surgery has proved to be effective in the management of morbid obesity. Our purpose was to compare the results obtained with adjustable gastric banding (GB) and Roux-en-Y Gastric Bypass (RYGB) during 2 years of follow-up after surgery, with regard to anthropometric parameters and related comorbidities.Methods: We evaluated prospectively patients who underwent GB and RYGB between 2004 and 2010 and compared the evolution of anthropo...

ea0032p734 | Obesity | ECE2013

Obesity-induced hepatic and placental inflammation are absent in obese gestating mice compared to control fed dams

Ingvorsen Camilla , Thysen Anna Hammerich , Fernandez-Twinn Denise , Ozanne Susan , Brix Susanne , Hellgren Lars

Introduction: Maternal obesity is associated with increased risk of metabolic dysfunction in the offspring. It is not clear which physiological aspects of the obese state that cause this metabolic programming. Obesity causes many metabolic changes but also low grade inflammation. In this study, we have determined if increased low grade inflammation was present in obese dams compared to controls dams during gestation.Methods: Female C57BL/6 mice were fed ...

ea0032p735 | Obesity | ECE2013

Serum IL18 concentration is associated with resting energy expenditure independently of BMI

Nikolajuk Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

ea0032p736 | Obesity | ECE2013

High fat diet induces site specific resistance to LPS-stimulated STAT3 activation in the CNS

Borges Beatriz , Rorato Rodrigo , Uchoa Ernane , Marangon Paula , Antunes-Rodrigues Jose , Elias Lucila

Hypophagia and increased energy expenditure under inflammatory condition, such as observed after bacterial lipopolysaccharide (LPS) administration, are associated with activation of JAK2–STAT3 signaling in the CNS. High fat diet (HFD) is known to induce hypothalamic resistance to leptin signaling mediated by JAK2–STAT3 pathway. In this study we investigated the expression of p-STAT3 in the hypothalamus and brainstem of HFD treated animals under LPS (100 μg/kg) s...

ea0032p737 | Obesity | ECE2013

Association of mitochondrial respiratory chain polymorphisms with obesity and type 2 diabetes in the Spanish population

De Marco Solar Griselda , Mansego Maria L , Pineda-Alonso Monica , Rojo-Martinez Gemma , Martinez-Larrad Maria T , Morcillo Sonsoles , Morales-Suarez-Varela Maria M , Corbaton-Anchuelo Arturo , Duenas-Laita Antonio , Martin-Nunez Gracia M , Martin Escudero Juan C , Redon Josep , Soriguer Federico , Carmena Rafael , Serrano-Rios Manuel , Chaves Felipe Javier

Objective: To study the association between genes codifying for mitochondrial respiratory chain (MRC) subunits and BMI and obesity as well as the impact on the risk to develop type 2 diabetes in the general population from Spain.Research design and methods: Three thousand seven hundred and thirty-one subjects (age range 21–89) from three different population-based studies of Spain, were studied. Forty-eight single nucleotide polymorphisms (SNPs) of ...

ea0032p738 | Obesity | ECE2013

The FXR agonist obeticholic acid normalizes lipid droplet and triglyceride handling in visceral adipose tissue preadipocytes from a non-genomic rabbit model of metabolic syndrome

Maneschi Elena , Vignozzi Linda , Morelli Annamaria , Mello Tommaso , Filippi Sandra , Cellai Ilaria , Comeglio Paolo , Sarchielli Erica , Calcagno Alessandra , Vettor Roberto , Vannelli Gabriella Barbara , Adorini Luciano , Maggi Mario

Liver and visceral ectopic fatty tissue disposition is a major metabolic derangement leading to type 2 diabetes, hypertension, dyslipidaemia, recapitulated in the metabolic syndrome (MetS). We have demonstrated that the selective FXR agonist obeticholic acid (OCA, INT-747) ameliorates the metabolic profile and reduces visceral adipose tissue (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS. We now report the effects of OCA treatment in HFD (0.5% cholesterol and 4% p...

ea0032p739 | Obesity | ECE2013

Corticotrophin realising factor affects the immune phenotype of adipocytes via CRF1 and CRF2 receptors

Dermitzaki Eirini , Liapakis George , Androulidaki Ariadni , Tsatsanis Christos , Margioris Andrew

Introduction: The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors affect innate immunity. A fully working peripheral CRF system is present in adipose tissue. In obesity, macrophages and adipocytes interact causing local and systemic inflammation. In addition, macrophages and adipocytes share common characteristics including production of inflammatory cytokines in response to lipopolysaccharides (LPS) via the toll-like receptor-4 (TLR4) which b...

ea0032p740 | Obesity | ECE2013

Obese hypogonadal men treated with testosterone undecanoate injections up to 5 years substantially and progressively lose weight

Saad Farid , Haider Ahmad , Doros Gheorghe , Traish Abdulmaged

Introduction: Abdominal adipose tissue suppresses testosterone production by various mechanisms affecting the hypothalamic–pituitary–gonadal axis. Hypogonadism leads to further accumulation of fat mass thus creating a vicious circle. This study analysed the effects of restoring testosterone in obese hypogonadal men.Methods: Cumulative, prospective, registry study of 181 men (mean age: 59.11±6.06 years) with testosterone levels below 12.1 n...

ea0032p741 | Obesity | ECE2013

Consumption of low-carbohydrate/high fat diets impairs glucose tolerance in rats independent of changes in body composition

Bielohuby Maximilian , Zengin Ayse , Horngacher Amon , Meurer Sarina , Bidlingmaier Martin

Moderate, ‘Atkin’s-style’ low-carbohydrate/high fat diets (LC-HFD) are claimed to induce weight loss in overweight subjects and to ameliorate glucose metabolism, whereas extreme ketogenic LC-HFD are used to treat neurological disorders like pediatric epilepsy. To investigate the effects of both types of LC-HFD on glucose and insulin metabolism independent of the energetic intake, we pair-fed male Wistar rats isoenergetic of standard rodent chow (CH) or one of tw...

ea0032p742 | Obesity | ECE2013

Depression and suicidal ideation among adults with metabolic syndrome: data from the 2008--2010 Korea national health and nutrition examination survey

Kang Jun Goo , Yu Sung Hoon , Kim Chul Sik , Lee Seong Jin , Ihm Sung-Hee , Hwang Yoo-Cheol , Ahn Hong Yup , Park Cheol-Young

Aim: Suicide and depression are one of the highest public health problems worldwide. Suicidal ideation represents an important phase in the suicidal process and often precedes suicidal attempts or completed suicide. Patients with chronic medical disease are more likely to report suicidal thoughts and depression. However the studies on relationship between these conditions and metabolic syndrome are rare. We aimed at investigating the prevalence of depression and suicidal ideat...

ea0032p743 | Obesity | ECE2013

Early changes in glucose, insulin, C-peptide and GLP-1 levels after test meal in obese patients after gastric bypass surgery

Micic Dragan , Polovina Snezana , Sumarac-Dumanovic Mirjana , Cvijovic Goran , Ignjatovic Svetlana , Dajak Marijana , Micic Dusan , Pejkovic Danica , Milin Jelena , Jeremic Danka

Introduction: Various hypothesis exist about the mechanism of changes in glucose control and insulin sensitivity after bariatric surgery.Description of methods/design: The aim of our study was to determine glucose, insulin, C-peptide and GLP-1 levels after test meal (Fresubin drink a 200 ml given at 0 min; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric bypass surgery in a 22 obese patients (age: 36.22±12...

ea0032p744 | Obesity | ECE2013

Modulation of gene expression by 3-iodothyronamine: evidence of a lipolytic pattern

Mariotti Veronica , Ioffrida Caterina , Melissari Erika , Russo Manuela Di , Frascarelli Sabina , Pellegrini Silvia , Zucchi Riccardo

3-Iodothyronamine (T1AM) is a recently discovered compound which can be regarded as a novel hormone, since it is an endogenous relative of thyroid hormone with systemic distribution, which does not interact with thyroid hormone receptors, but rather with specific G protein-coupled receptors. T1AM has been reported to modulate energy metabolism, and in rodents chronic T1AM treatment has been associated with lipolysis and decreased body weight. T...

ea0032p745 | Obesity | ECE2013

Evaluation of gastric bypass effect on cardiovascular risk and quality of life in our area

Mateo-Gavira Isabel , Roldan-Caballero Pilar , Vilchez-Lopez Francisco Javier , Larran-Escandon Laura , Tamayo-Serrato Julian , Ojeda-Schuldt Maria Belen , Gavilan-Villarejo Inmaculada , Aguilar-Diosdado Manuel

Objectives: i) To determine the prevalence of major comorbidities of morbid obese, ii) to evaluate the gastric bypass effect on this comorbidities, on the 10 years estimated cardiovascular risk and iii) To assess the impact of bariatric surgery on the quality of life in these patients.Methods: Cohort study with intrasubject measures (before–after) in a sample of patients with morbid obesity who underwent gastric bypass. Demographic characteristics, ...

ea0032p746 | Obesity | ECE2013

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

Okuda Marcos Hiromu , Alves de Santana Aline , Moreno Mayara Franzoi , Hachul Ana Claudia , Neto Nelson Inacio , dos Santos Bruno , Oller do Nascimento Claudia Maria , Zemdegs Juliane , Ribeiro Eliane Beraldi , Oyama Lila Missae

Many mechanisms are proposed for green tea’s role as anti-obesity and anti-diabetic natural product. Two of them involve the hypothalamic control of energy balance: i) high-fat diets (HFD) rich in saturated fats induce low-grade inflammation, leading to leptin and insulin resistance; ii) serotonin receptors (SR) 1B and 2C activation have anorexigenic effects, SR2C activation improves insulin sensitivity, and HFD can also impair this system. We investigated the effects of ...

ea0032p747 | Obesity | ECE2013

Short-term ovariectomy did not cause tissues proinflammatory state, but associated with hyperlipidic diet caused hyperleptinemia and increased body weight gain

de Sousa Rodrigues Maria Elizabeth , Neto Nelson Inacio Pinto , Oyama Lila Missae , Okuda Marcos Hiromu , Hachul Ana Claudia , Santos Bruno dos , Moreno Mayara , do Nascimento Claudia Oller

Obesity leads to low-grade inflammation, and high-fat diet is one of the major causes. On the other hand, menopause can aggravate it by promoting food intake alterations, and metabolic and endocrine adaptations. Thus, we used ovariectomized rats fed with high-fat diet to evaluate changes on the tissue inflammatory state. Forty days-old female Wistar rats were fed with: a hyperlipidic diet enriched with lard – H-group; or chow diet – C-group; for 30 days. After this p...

ea0032p748 | Obesity | ECE2013

Differences among clinical, analytical and psychological outcomes among patients with an eating disorder after bariatric surgery

Nicolau Joana , Ayala Luisa , Rivera Rosmeri , Speranskaya Aleksandra , Olivares Josefina , Gil Apolonia , Puga Maria , Fortuny Regina , Masmiquel Lluis

Introduction: Information regarding eating disorders (ED) in postsurgical outcomes after bariatric surgery (BS) is scarce.Objectives: To analyze the effect of BS on ED and to investigate if ED influence clinical, biochemical or psychological outcomes.Methods: Sixty patients (78.3%♀, age 46.35±9.89, months since BS 46.28±28.1) who underwent BS, with a minimum follow up of 12 months, were evaluated cross-sectionally. ...

ea0032p749 | Obesity | ECE2013

BMI as a prognostic feature in patients with breast cancer treated with chemo/endocrine therapy

Katalinic Darko , Santek Fedor , Juretic Antonio , Basic-Koretic Martina , Loncar Kresimir , Soce Majana , Nikolac Nora , Plestina Stjepko

Introduction: High BMI has been associated with an increased risk for breast cancer among premenopausal and postmenopausal women. Several biological mechanisms play a significant role in the genesis and progression of breast cancer.Material and methods: This study aimed to investigate relationship between BMI and breast cancer diagnosis or progression in a Croatian population. BMI, presence or absence of breast cancer and its clinical-pathological charac...

ea0032p750 | Obesity | ECE2013

Osteocalcin: more than a bone marker: the Odense Androgen Study

Nielsen Torben Leo , Brixen Kim , Hermann Anne Pernille , Andersen Marianne

Introduction: The osteoblast derived bone formation marker osteocalcin has been reported to decrease adipose tissue in mice. In elderly men, osteocalcin was reported to correlate inversely with fat mass.Aim: To examine the relationship between osteocalcin and regional fat depots.Method: The Odense Androgen Study is a population-based, cross-sectional study of 779 randomly selected men aged 20–29 years. Total, central, upper ex...

ea0032p751 | Obesity | ECE2013

Associations between smoking and components of the metabolic syndrome

Slagter Sandra , van Vliet-Ostaptchouk Jana , Vonk Judith , Boezen Marike , van Beek Andre , van der Klauw, Bruce Wolffenbuttel Melanie

Background: The clustering of metabolic and cardiovascular risk factors is known as the metabolic syndrome (MetS). Lifestyle factors like smoking may contribute to the differences in prevalence of the MetS. The aim of this study was to examine the association between smoking and the MetS and its components in different BMI classes.Methods: The present cross-sectional evaluation comprised 24 762 men and 35 558 women, participating in the LifeLines Cohort ...

ea0032p752 | Obesity | ECE2013

Monocyte chemoattractant protein-1 is associated with apolipoprotein A-I and apolipoprotein e levels in obese premenopausal women

Silva-Nunes Jose , Peeraly Zulmira , Pedroso Nuno , Oliveira Ana , Duarte Leone , Brito Miguel , Veiga Luisa

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

ea0032p753 | Obesity | ECE2013

Chronic central administration of amylin decreases fat mass but does not modify body weight

Touceda David Gonzalez , Pico Amparo Romero , Piedra Monica Imbernon , Couto Begona Porteiro , Tarrio Daniel Beiroa , Lopez Miguel , Nogueiras Ruben , Dieguez Carlos

Aims (objectives): Energy intake and expenditure are regulated by different signals. One of the molecules implicated is islet amyloid polypeptide (IAPP or amylin), one of the major secretory products of β-cells of the pancreatic islets of Langerhans. It is a peptide that inhibits insulin and glucagon secretion, and can also act through the brain decreasing food intake and inhibiting gastric emptying. In this study, we investigated the potential effects of the chronic cent...

ea0032p754 | Obesity | ECE2013

Apelin levels in men with metabolic syndrome with or without late-onset hypogonadism

Angelova Petya , Kamenov Zdravko , Tsakova Adelina

Apelin is a new adipokine associated with obesity. Data about the relationship of apelin to the metabolic syndrome (MS) are still scarce. Late-onset hypogonadism (LOH) is common in men with MS, but we did not find data about the levels of apelin in men with LOH.The aim of this study was to determine the levels of apelin in men with MS with or without LOH.Patients and methods: Ninety nine men were included in the study. Of them 65 h...

ea0032p755 | Obesity | ECE2013

Apnoeic episodes impair insulin resistance independently of oxygen desaturations: evidence from morbid obese patients with discordant apnoea/desaturation indexes

Andrada Patricia , Chacon Ana , Pascual Eider , Silva Camilo , Iriarte Jorge , Gil Maria J , Pujante Pedro , Abreu Cristina , Escalada Javier , Fruhbeck Gema , Salvador Javier

Morbid obesity (MO) is often complicated by obstructive sleep apnoea (OSA), which in some cases is evaluated by pulsioximetry. This cross-sectional study was designed to investigate the prevalence of discordance between desaturation index (DI) and apnoea–hypopnoea index (AHI) and its effects on insulin resistance and secretion in MO patients candidate to bariatric surgery (n=496) in whom a full polysomnographic study was carried out. We identified 163 (33%) out o...

ea0032p756 | Obesity | ECE2013

Circulating endocannabinoids are differentially modulated during the oral glucose tolerance test

Fanelli Flaminia , Garelli Silvia , Mezzullo Marco , Di Dalmazi Guido , Ponti Federico , Manso Jacopo , Benetta Elisa Dalla , Bazzocchi Alberto , Vicennati Valentina , Battista Giuseppe , Pasquali Renato , Pagotto Uberto

The endocannabinoid system (ECS) is involved in the regulation of food intake and energy expenditure. Increased level of EC lipid mediators anandamide (AEA) and 2-arachydonoylglycerol (2AG) and/or a higher expression of cannabinoid receptor type 1 in central and peripheral districts are supposed to contribute to the development and maintenance of obesity and related dismetabolism. To understand the ECS response to insulin signal and to anthropometric and biochemical parameters...

ea0032p757 | Obesity | ECE2013

Adiponectin and leptin actions on DNA synthesis and cell death of porcine myoblasts are dependent on the cellular milieu and related to ERK1/2 signalling

Kuzinski Judith , Will Katja , Kalbe Claudia , Maak Steffen , Palin Marie-France , Rehfeldt Charlotte

Cross-talk between adipose tissue and skeletal muscle could be mediated in part by adipokines secreted from adipose tissue. Previously, we observed that adiponectin but not leptin decreased DNA synthesis rate in proliferating porcine myoblasts in growth factor-supplemented serum-free medium (GF-SFM) after 48-h exposure (Will et al. 2012). To further elucidate the effects of adiponectin and leptin on muscle cell growth and their mode of action, this study was conducted...

ea0032p758 | Obesity | ECE2013

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a meta-analytic study

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Saad Farid , Luconi Michaela , Lucchese Marcello , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Few randomised clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally showed an increase in testosterone levels. The aim of the present study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels.Methods: An extensive Medline searc...

ea0032p759 | Obesity | ECE2013

Serum levels of fetuin A and 8-hydroxydeoxyguanosine in morbidly obese subjects

Dincer Yildiz , Himmetoglu Solen , Teksoz Serkan , Zengin Kagan , Yesim Tijen , Taskin Mustafa

Insulin resistance is one of the feature of obesity. Fetuin A is inhibitor of insulin receptor which belongs the family of receptor tyrosine kinase. It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. Increased production of reactive oxygen species is suggested to be associated with insulin resistance. Attacks of reactive oxygen species to DNA results in base oxidation. Among the oxidized bases, 8-hyd...

ea0032p760 | Obesity | ECE2013

Off-label GLP-1 agonist treatment in 43 non-diabetic patients: are weight loss and treatment tolerance equally promising outside of clinical trials?

Sauer Nina , Rohani Zaina , Wiesch Clarissa Schulze zur , Reining Franziska , Aberle Jens

Context: Recent data from controlled clinical trials have demonstrated that GLP-1 agonists are a well-tolerated therapy-option for weight loss in obese patients without type 2 diabetes mellitus.Objective: To investigate whether continuation of treatment, side-effects and effect on weight loss of GLP-1 agonists are equally promising in dairy clinical practice settings in non-diabetics.Methods: Obese, non-diabetic patients of our int...

ea0032p761 | Obesity | ECE2013

SHBG and testosterone are associated with inflammation in obese men

Milin-Lazovic Jelena , Polovina Snezana , Sumarac-Dumanovic Mirjana , Stamenkovic-Pejkovic Danica , Jeremic Danka , Cvijovic Goran , Zoric Svetlana , Kendereski Aleksandra , Micic Dragan

Introduction: It was showed that low SHBG represent an independent bio-marker of proinflammatory states associated with insulin resistance. Recent studies provide additional evidence that insulin plays no role in decreasing hepatic SHBG production, and that proinflammatory cytokines, contribute indirectly to reducing SHBG expression in liver of obese persons by reducing hepatic HNF-4α. Obesity in men is commonly accompanied by a decline of serum total testosterone and bio...

ea0032p762 | Obesity | ECE2013

The effect of rutin on homocysteine induced proliferation of 3T3-L1 preadipocyte in vitro

Yu Sung Hoon , Kang Jun Goo , Hwang Yoo-Cheol , Ahn Hong Yup , Park Cheol-Young , Kim Dong Sun , Yoo Hyung Joon

Introduction: Rutin (C27H30O16) is the major representative of the flavonol subclass of flavonoids. Rutin has wide variety of pharmacological activity, however there are not sufficient data in 3T3-L1 preadipocyte. In this study, we demonstrated that the effect of rutin on the proliferation of 3T3-L1 preadipocyte.Methods: The 3T3-L1 preadipocyte were treated with homocysteine (1 mM), rutin (30 μM) and rutin after homo...

ea0032p763 | Obesity | ECE2013

Preoperative metabolic status is associated with adiponectin levels attained 6 months after laparoscopic sleeve gastrectomy, independently of the degree of weight loss

Sirbu Anca , Martin Sorina , Barbu Carmen , Copaescu Catalin , Florea Suzana , Fica Simona

Introduction: Adiponectin is an adipocyte-derived hormone with an important role in regulation of glucose and lipid metabolism. Its variation might mediate an ameliorated metabolic profile associated with weight loss after bariatric surgery. The aim of our study was to evaluate adiponectin change as early as 6 months after laparoscopic sleeve gastrectomy (LSG) and to indicate preoperative factors that might influence its dynamic.Methods: A number of 88 e...

ea0032p764 | Obesity | ECE2013

Evaluation of gastric bypass effect on cardiovascular risk and quality of life in type 2 diabetes patients

Mateo-Gavira Isabel , Roldan-Caballero Pilar , Vilchez-Lopez Francisco Javier , Tamayo-Serrato Julian , Larran-Escandon Laura , Ojeda-Shuldt Maria Belen , Ortego-Rojo Jose , Garcia-Valero Amor , Aguilar-Diosdado Manuel

Objective: To evaluate the gastric bypass effect in type 2 diabetic patients with morbid obesity, on the following terms: diabetes evolution, 10 years estimated cardiovascular risk and quality of lifeMethods: Cohort study with intrasubject measures (before–after) in a sample of patients with morbid obesity and type 2 diabetes who underwent gastric bypass. Demographic characteristics, anthropometric parameters, cardiovascular risk factors and surgica...

ea0032p765 | Obesity | ECE2013

Evaluation of the prevalence of obesity and overweight in the Belarus within the Framework of the National Campaign ‘Early Detection and Prevention of Type 2 Diabetes Mellitus’

Shepelkevich Alla , Salko Olha , Holodova Helen , Lobashova Veronika , Bilodid Irina , Pedchenets Lyudmila , Kovshik Lyudmila , Tulupova Mariya , Grigorovich Artur , Zalesskaya Olha , Selivanov Vladimir

The rapidly increasing epidemic of obesity is one of the most challenging dilemmas facing endocrinologists all over the world today. The aim of our research was within the framework of the National Campaign ‘Early Detection and Prevention of Type 2 Diabetes Mellitus’ to evaluate the prevalence of obesity and overweight in the Belarusian population.Materials and methods: The Campaign involved opportunistic screening of individuals applying to th...

ea0032p766 | Obesity | ECE2013

No long-term weight reduction after gastric banding (LAGB) in obese patients with craniopharyngioma involving hypothalamic structures: experiences from KRANIOPHARYNGEOM 2000

Sterkenburg Anthe , Gebhardt Ursel , Hioffmann Anika , Maroske Jorn , Hanisch Ernst , Muller Hermann

Background: Craniopharyngiomas are embryogenic malformations which lead to eating disorders and morbid obesity due to hypothalamic involvement. The experience with laparoscopic adjustable gastric banding (LAGB) in obese craniopharyngioma patients is limited especially in regard to long-term effects and tolerability.Patients and methods: We are reporting on four patients with childhood craniopharyngioma diagnosed at age 2, 13, 12, and 20 years.<p clas...

ea0032p767 | Obesity | ECE2013

Long-term weight development and psychosocial status in childhood craniopharyngioma patients

Sterkenburg Anthe , Hoffmann Anika , Gebhardt Ursel , Muller Hermann

Background: Craniopharyngioma (CP) are the most common sellar tumors in children. Patients often develop excessive weight gain and obesity due to several factors as involvement or damage of the hypothalamus. Previous studies on the weight development in craniopharyngioma patients have shown an increase in weight before and in the first 10 years after diagnosis leading to an impaired quality of life. The long-term weight development in these patients has not been investigated t...

ea0032p768 | Obesity | ECE2013

Assessment of dietary habits in obese patients

Gonzalez-Molero Inmaculada , Dominguez-Lopez Marta , Ruiz de Adana MArisol , Soriguer Federico

Introduction: A key factor in the progressive increase in the prevalence of obesity is poor dietary habits. The treatment of obesity with regular diets often fail, so knowing the specific habits of these patients can be very useful to individualize treatment.Objective: Evaluate the dietary habits of subjects consulting for obesity in our clinic of Endocrinology and NutritionMaterials and methods: We conducted a survey of eating hab...

ea0032p769 | Obesity | ECE2013

Sub clinical hypercortisism in patients with metabolic syndrome

Mansour Mona , Abdo Randa , El Mogy Fatma

Objectives: Patients with metabolic syndrome who presents with vascular, metabolic or bone disorders of recent onset, or are difficult to control, or are progressively deteriorating is potentially linked to cortisol excess the aim of the study is to evaluate the prevalence of occult CS in metabolic syndrome patients.Method: In a cross-sectional study, 30 females with metabolic syndrome chosen from Endocrinology Clinic without any phenotypical features of...

ea0032p770 | Obesity | ECE2013

Testosterone concentrations in obesity, an outcome of lipotoxicity?

Bekaert Marlies , Van Nieuwenhove Yves , Calders Patrick , Kaufman Jean-Marc , Ouwens Margriet , Ruige Johannes

Objective: Testosterone levels are decreased in male obesity, the mechanism of which is incompletely understood. The aim of this study was to explore determinants affecting the feedback mechanism of the hypothalamic–pituitary–gonadal axis in male obesity and type 2 diabetes (DM2), such as aromatase expression and lipotoxicity.Materials and methods: Circulating levels of testosterone were quantified (<1000 h with LC–MS/MS) in 37 middle-...

ea0032p771 | Obesity | ECE2013

Hypogonadal men receiving testosterone treatment for 5 years had significant and clinically meaningful reductions in weight and waist circumference

Saad Farid , Yassin Aksam , Doros Gheorghe , Traish Abdulmaged

Objective: This study investigated effects of testosterone replacement therapy (TRT) on the metabolic syndrome in hypogonadal men over 5 years.Methods: Cumulative, prospective registry study of 164 men with erectile dysfunction and testosterone below 12 nmol/l presenting to a urological institution. All patients received testosterone undecanoate injections 1000 mg every 12 weeks following an initial 6-week interval for a total of 5 years.<p class="ab...

ea0032p772 | Obesity | ECE2013

Moderating role of cognitive ability on the obesity: inflammation: insulin resistance triplet

Spyridaki Eirini , Margioris Andrew , Simos Panagiotis , Avgoustinaki Pavlina , Dermitzaki Eirini

Obesity, the condition resulting from excess of body fat, is often accompanied by chronic low-grade levels of inflammation. These have been strongly associated with the development of insulin resistance (IR). Elevated BMI has also been linked to reduced cognitive performance, especially in executive functions, independently of medical co-morbidities.Aim of this research is to investigate whether higher cognitive resources may present a moderating, ‘...

ea0032p773 | Obesity | ECE2013

Should all the obese patients be screened for Cushing’s syndrome?

Baydur Sahin Serap , Sezgin Hacer , Ilkkilic Kadir , Uslu Gur Emine , Ayaz Teslime

Background: Cushing’s syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. The 1-mg dexamethasone suppression test (1 mg-DST) is the most frequently used screening tool for CS. However, the lack of suppression after 1-mg DST may be found in obese patients. In the current study, our aim was to evaluate the clinical signs of CS and the 1 mg-DST in obese patients.Materials and methods: 354 patients ...

ea0032p774 | Obesity | ECE2013

Diabetes remission after bariatric surgery may be jeopardized by remission criteria and previous hypoglycemic treatment

Ramos-Levi Ana , Sanchez-Pernaute Andres , Cabrerizo Lucio , Matia Pilar , Barabash Ana , Hernandez Carmen , Calle-Pascual Alfonso , Torres Antonio , Rubio Miguel

Introduction: Controversy exists regarding type 2 diabetes (T2D) remission rates after bariatric surgery (BS) due to heterogeneity in its definition and patients’ baseline features. We evaluate T2D remission using recent criteria, according to preoperative characteristics and insulin use.Materials and methods: Retrospective study from a cohort of 657 BS performed in a single centre (2006–2011) of which 141 (57.4% women) had T2D. Evaluation of a...

ea0032p775 | Obesity | ECE2013

Should remission of type 2 diabetes mellitus be the foremost goal after bariatric surgery?

Ramos-Levi Ana , Matia Pilar , Cabrerizo Lucio , Barabash Ana , Sanchez-Pernaute Andres , Hernandez Carmen , Calle-Pascual Alfonso , Torres Antonio , Rubio Miguel

Introduction: Remission of type 2 diabetes (T2D) is a yearned outcome after bariatric surgery (BS). Attention to individuals who do not strictly fulfil remission criteria has been frequently left behind. The aim of this study was to evaluate metabolic control status in patients considered as diabetes ‘non-remitters’.Materials and methods: Retrospective study of 125 patients (59.2% women) with preoperative diagnosis of T2D who underwent BS in a ...

ea0032p776 | Obesity | ECE2013

Development of metabolic syndrome is influenced by the thyroid function and age

Mityukova Tatiana , Akulevich Natallia , Lushchyk Maxim , Leonava Tatsiana , Platonova Tamara , Drozd Valentina

A lot of new data have been recently generated regarding the complex relationship between the thyroid function and metabolic parameters.The aim of the study was to estimate the obesity and metabolic syndrome (MS) rates according to the age and the thyroid function in the residents of Belarus.We have examined 894 subjects aged 18–44 years (82.2% females) living in Stolin district, Brest region of Belarus. The endocrinological e...

ea0032p777 | Obesity | ECE2013

Frequency of attention-deficit/hyperactivity disorder (ADHD) in a bariatric post surgery sample: clinical, analytical and psychological differences among bariatric patients with ADHD criteria

Nicolau Joana , Ayala Luisa , Frances Carla , Zubillaga Ivana , Jose Muniz Maria , Rodriguez Irene , Alberto Gomez Luis , Fortuny Regina , Masmiquel Lluis

Background: There is an increasingly aware of strong associations between obesity and attention-deficit/hyperactivity disorder (ADHD), with high rates of ADHD (26–61%) in patients seeking weight loss. Psychological evaluation is mandatory in patients presenting for bariatric surgery (BS), although it is focused on eating disorders and depression, with data lacking on ADHD. ADHD could increase the risk for less successful results after surgery because of noncompliance with...

ea0032p778 | Obesity | ECE2013

Do the association of phthalates and some parameters of obesity persist? Pilot study

Medic-Stojanoska Milica , Milic Natasa , Vukovic Bojan , Bosic-Zivanovic Dragana , Tomic-Naglic Dragana , Stokic Edita , Benc Damir , Mitrovic Milena , Curic Nikola

Background: Phthalates present endocrine disruptors widely used as plasticisers, solvents and additives in many consumer products. Experimental data and human cross-sectional studies suggest association of phthalates and obesity. This study focused to association between urinary levels of some phthalate metabolites and BMI and waist circumference.Methods: We recruited 87 obese persons (44 females and 43 males), age 38.57±8.14 years and 103 healthy c...

ea0032p779 | Obesity | ECE2013

‘Diabesity' in women: the EEM study

Guanipa-Sierra Wilfredo , Sanchez-Zambrano Martha , Feijoo Josefina , Pizzi Rita , Marquez Ingrid

‘Diabesity’ is the term for diabetes occurring in the context of obesity. Obesity is a cardiovascular major risk factor. The National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) report designated diabetes as a coronary heart disease equivalent. Cardiovascular disease is the leading cause of death in women. The ‘Estudio Epidemiologico de la Mujer’ (EEM) study aimed to explore obesity, diabetes and diabesity in 3500 women over 18 yea...

ea0032p780 | Obesity | ECE2013

The medical and moral obligation of healthcare professionals to address complications in obesity during pregnancy

Jones Benjamin

Summary: This audit highlights a shortfall in healthcare provision when discussing the potentially sensitive issue of obesity. Given the significance of complications in pregnancy, and in future life, discussing such issues openly and encouraging patient responsibility without blame is integral to optimise antenatal benefit.Introduction: The prevalence of obesity is increasing in the UK. Obesity in pregnancy is associated with various maternal and fetal ...

ea0032p781 | Obesity | ECE2013

Circulating adiponectin as marker of obesity-induced chronic low grade inflammation

Dermitzaki Eirine , Avgoustinaki Pavlina , Venihaki Maria , Tsatsanis Christos , Margioris Andrew

Introduction: Obesity lowers adiponectin levels. Adiponectin has anti-inflammatory effects. It has been suggested that the lower levels of adiponectin in obesity results in chronic low grade inflammation (CLGI). Aim of this study was to examine if plasma adiponectin is a valid marker of CLGI in normal weight, overweight and obese individuals. In addition, we also assessed adiponectin as marker of body fat and insulin resistanceMethods: We measured adipon...

ea0032p782 | Obesity | ECE2013

Prevalence of obesity, diabetes and prediabetes in Tirana, the capital of Albania 2010–2011

Toti Florian , Bruka Luftime , Kelmendi Matilda , Cakerri Luljeta , Ylli Agron

Introduction: Obesity and diabetes are strongly associated as causes of morbi-mortality in developing countries. The aim of our study was to evaluate the prevalence of overweight, obesity and undiagnosed diabetes in Tirana district, where 1/4 of the total population lives.Method: Anthropometric and capillary glucose measures for healthy people unknown of diabetes. Diabetes familiar anamnesis, HTA treatment and smoking were included in the questionnaire.<...

ea0032p783 | Obesity | ECE2013

Madelung's disease: a case report

Jorge Georgina , Queiros Joana , Mequista Joana , Oliveira Ana , Silva Pedro , Carvalho Davide

Introduction: Madelung’s disease is a rare disorder characterized by a disturbance in the adipocyte metabolism. Mainly occurs in alcoholic Mediterranean male, presenting multiple, symmetrical lipomas.Case report: A 49-year-old obese man with a history of alcoholism, complaint of weight gain, soft and slow-growing swelling of the neck, and shoulders. His past history: epilepsy, alcoholic CHD, hypothyroidism, severe sleep apnea, vitiligo and HTA. His ...

ea0032p784 | Obesity | ECE2013

PTH one year after gastric bypass in morbidly obese patients

Polovina Snezana , Micic Dragan , Gligorijevic Jelena , Sumarac-Dumanovic Mirjana , Cvijovic Goran , Stamenkovic-Pejkovic Danica , Milin Jelena , Micic Dusan , Jeremic Danka

Introduction: After gastric bypass, gastric secretion decreased and resorption of minerals and vitamins may be compromised. Lower resorpion of serum calcium and vitamin D could stimulate PTH secretion after restictive and malabsorptive bariatric procedures.Methods: We have measured serum calcium, D vitamin and PTH in patients (n=50, 17 males and 33 females) 6 and 12 months after R en Y gastric bypass, 38.6±12.6 years of age, with BMI 43&#17...

ea0032p785 | Obesity | ECE2013

Neck circumference association with metabolic risk factors in patients undergoing neck surgery

Grizelj Danijela , Pandzic Jaksic Vlatka , Boscic Drago , Ajduk Marko , Ozegovic Ivan , Pavic Predrag , Subaric Marin , Jaksic Ozren

Adipose tissue distribution is one of the key determinants of metabolic dysfunction in obesity. Several large scale studies found that enlarged neck circumference is independently associated with cardiovascular risk.The aim of this study was to examine the association of neck circumference with metabolic risk factors in patients undergoing neck surgery.In 36 patients undergoing thyroid or vascular neck surgery we determined serum l...

ea0032p786 | Obesity | ECE2013

Rapid reversal of hyperglycemia despite modest weight loss in a patient post gastric bypass surgery: a case report and review of the literature

Weiliang Chen Abel , Shang Ming Lee Samuel , Feng Lee Wei , Liu Yuan Cher Gabriel , Jye Seow Cherng , Tar Khor Hong

Background: Bariatric surgery has been shown to decrease insulin requirements even before significant weight loss has occurred. We report a patient with marked improvement in glycemic control despite modest weight loss post bariatric surgery.Case presentation: A 47 years old Chinese man with obesity (weight 90 kg, BMI 31.2), hypertension, hyperlipidemia and type 2 diabetes mellitus diagnosed in 2005 is on follow up with our endocrine clinic. Despite comp...

ea0032p787 | Obesity | ECE2013

Insulinresistance at obesity and diabetes

Lesyukova Victoria , Zekenova Kulyash , Savasteeva Irina , Bondareva Elena , Snitsarenko Elena , Komisarova Nina

The urgency of metabolic syndrome problem in modern medicine is caused by metabolic syndrome prevalence in the general population of 14–24%. The metabolic syndrome plays an essential role in cardiovascular diseases development acceleration. Components are abdominal–visceral obesity, insulinresistance, hyperinsulinemia, dyslipidemia, arterial hypertension and carbohydrate metabolism disorder.Aim: Frequency estimate 2nd type diabetes and insulin ...

ea0032p788 | Obesity | ECE2013

Lean mass and fat mass distribution in Ukrainian women with metabolic syndrome in postmenopausal period

Povoroznyuk Vladyslav , Martyntyuk Larysa , Martyntyuk Lilya

Objective: Menopause-related changes in female body are associated with the greater risk of metabolic syndrome (MS), which includes obesity, dyslipidemia, impaired glucose tolerance, hypertension.Aim: The purpose of our study was to reveal peculiarities of fat and lean mass distribution between postmenopausal women with abdominal obesity and with MS.Design and Method: The sample consisted of 43 postmenopausal 60–69 years old w...

ea0032p789 | Obesity | ECE2013

Lean and fat mass in Ukrainian women of different age

Povoroznyuk Vladyslav , Dzerovych Nataliia

Aim: The aim of this study is evaluating of body composition and frequency of sarcopenia in women depending on age.Materials and methods: We’ve examined 8637 women aged 20–89 years (mean age – 56.7±0.14 years; mean height – 162.5±0.07 cm; mean weight – 73.5±0.16 kg). The patients were divided into two groups depending on age: 20–24 (n=143), 25–29 (n=209), 30–34 (n=271), 35&...

ea0032p790 | Obesity | ECE2013

Dieting attitudes among college students in Romania

Mocanu Veronica

Objectives: The aim of the study was to assess the eating attitudes and behaviors, including weight concerns and dieting behavior, among medical college students.Methods: The sample consisted of 70 undergraduate students from the School of Medicine, Iasi, Romania, 22 males and 48 females, aged 25±6 years. Eating-related behaviors were measured using the EAT–26 questionnaire. Study of food intake and physical activity was conducted using a quest...