Endocrine Abstracts

Objective: Menopause-related changes in female body are associated with the greater risk of metabolic syndrome (MS), which includes obesity, dyslipidemia, impaired glucose tolerance, hypertension.

Aim: The purpose of our study was to reveal peculiarities of fat and lean mass distribution between postmenopausal women with abdominal obesity and with MS.

Design and Method: The sample consisted of 43 postmenopausal 60–69 years old women (age: mean=64.8; S.D.=0.4); duration of menopause: mean=14.5; S.D.=0.9). The diagnosis of MS was considered according to IDF (2005 year) criteria. Lean and fat mass distrubution were measured by dual-energy X-ray absortiometry, and were compared for the cohorts with and without MS. Data were analyzed using Statistical Package 6.0 (Statsoft).

Results: Findings revealed that 24 (55.8%) of postmenopausal women had MS. In patients with and without MS compared, fat mass was higher in the former group (41248.25±2263.89 and 29817.68±2397.78 respectively; F=11.9; P=0.001) and at different body regions also: gynoid fat (6563.72±348.19 and 5115.21±392.43 respectively; F=7.6; P=0.008), android fat (3815.45±200.8128 and 2798.15±282.79 respectively; F=9.06; P=0.004. Lean mass comparing didn’t show significant differences in female with and without MS (42548.0±1239.18 and 40667.53±1223.78 respectively; F=1.1; P=0.29) and at different body regions also.

Conclusion: These findings suggest that in postmenopausal women with MS there is prevalence of fat mass without increasing of lean mass quantity in compare to female with abdominal obesity without MS.