Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology


Autoimmune endocrine disease - Old and new players

ea0032s28.1 | Autoimmune endocrine disease - Old and new players | ECE2013

Autoimmune thyroid disease

Wiersinga W

Graves’ hyperthyroidism (GH) and Hashimoto’s hypothyroidism (HH) are the opposite ends of the clinical expression of autoimmune thyroid diseases (AITD). AITD are multifactorial ‘complex’ diseases in which immune responses against thyroid antigens develop in genetic susceptible subjects, provoked by environmental factors. Susceptibility genes include immunoregulatory genes (HLA, CTLA-4, PTPN22, CD4 and FCRL3) and thyroid-specific genes (TSHR and Tg). Environ...

ea0032s28.2 | Autoimmune endocrine disease - Old and new players | ECE2013

Autoimmune Addison’s disease: new players in diagnosis and treatment

Badenhoop Klaus

Addison’s disease is a rare disorder and mostly due to an immune-mediated adrenal destruction similar to the organ specific loss of function in autoimmune hypothyroidism in Hashimoto’s thyroiditis or type 1 diabetes. Adrenal insufficiency occurs thereby as isolated disease or is accompanied by other autoimmune disorders forming the autoimmune polyendocrine syndrome (mostly APS2). A major problem of Addison’s disease is that the diagnosis is often late or may be ...

ea0032s28.3 | Autoimmune endocrine disease - Old and new players | ECE2013


Kelestimur F

Autoimmune hypophysitis (AH) is characterized by lymphocytic infiltration and eventually destruction of the pituitary tissue. AH accounts for ~1% of pituitary masses and 0.5% of hypopituitarism. Although it has been recognized as an uncommon pituitary disease, its true frequency is not known but certainly underestimated. AH may affect pre- and post-menopausal women, men and children, but most cases are reported in women during reproductive age. AH may be associated with other ...