Background: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from pre-diabetes and diabetes. Conflicting results currently exists on the relationship between vitamin D and glucose metabolism. Hence, the aim of our study was to investigate the association of 25-hydroxyvitamin D (25(OH)D) levels and glucose tolerance in PCOS women.
Methods: Cross-sectional study including 23 PCOS patients (mean age 27 years). 25(OH)D levels were measured by chemiluminiscence (Cobas e 601 by ROCHE). Standard 75 g oral glucose tolerance test were performed. Results were analysed by SPSS 18.0.
Results: Serum 25(OH)D concentrations was 18.8±7.5 ng/ml. The prevalence of 25(OH)D insufficient (<30 ng/ml) and deficiency (<10 ng/ml) was 88 and 16% respectively. Three (12%), four (16%) and 16 (64%) women were patients with diabetes, glucose intolerance and normoglycemia respectively. PCOS women with glucose disturbance had lower 25(OH)D levels than PCOS women with normoglycemia (13.7±7.5 ng/ml vs 21.03±6.6 ng/ml P<0,05). In binary logistic regression analyses, 25(OH)D (OR 0.84, P<0.05) was independent predictors of glucose metabolic alteration in PCOS women. We found significantly negative correlations of 25(OH)D level with basal glucose (r −0.44, P<0,05).
Conclusion: Our results suggest that low 25(OH)D levels are associated with diabetes and glucose intolerance in PCOS women. Large intervention trials are warranted to evaluate the effect of vitamin D supplementation on glucose metabolic disturbances. PCOS women evaluate the effect of vitamin D supplementation on glucose metabolic disturbance in PCOS women. Glucose metabolic disturbances in PCOS women.
27 Apr - 01 May 2013
European Society of Endocrinology