Endocrine Abstracts (2013) 32 P620 | DOI: 10.1530/endoabs.32.P620

Potential discriminant factors for different pcos phenotypes

Mirjana Stojkovic, Biljana Beleslin, Jasmina Ciric, Slavica Savic, Tanja Nisic, Milos Stojanovic, Tijana Lalic, Bozo Trbojevic & Milos Zarkovic


Clinic of endocrinology, diabetes and metabolic diseases Clinical Center of Serbia, Belgrade, Serbia.


Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries (PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1 (ANOV+HA+PCO), phenotype 2 (ANOV+HA), phenotype 3 (HA+PCO) and phenotype 4 (ANOV+PCO). The differences between these four phenotypes are still undefined and the subjects of study.

Methods: We evaluate 92 PCOS women using stepwise linear discriminant analysis with phenotype as dependent variable and BMI, FSH, LH, LTH, oestradiol, testosterone, progesterone, HDL-cholesterol, LDL-cholesterol, HOMA-IR and HOMA-B as independent variables.

Results: The phenotype 1 was present in 32.6%, phenotype 2 in 21%, phenotype 3 in 28% and phenotype 4 in 14.1% of cases. We found that BMI, LH, HOMA-IR and HOMA-B were discriminante factors for different phenotypes, while the other variables did not reach statistically significant difference.

BMILHHOMA-IRHOMA-B
ANOV+PCO+HA27.1±6.0 kg/m2;7.33±4.69 IU/L;1.49±0.34;371.8±391.7;
ANOV+HA29.2±8.0 kg/m2;5.30±3.81 IU/L;1.32±0.39;423.1±213.1;
ANOV+PCO22.8±4.4 kg/m2;11.13±6.13 IU/L; 1.18±0.28;535.1±365.5;
PCO+HA24.9±5.8 kg/m2;4.12±2.62 IU/L;1.40±0.49;755.6±1436.2;

Conclusions: We concluded that LH, BMI, HOMA-IR and HOMA-B could be useful as discriminant factors in different PCOS phenotypes.

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