Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries (PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1 (ANOV+HA+PCO), phenotype 2 (ANOV+HA), phenotype 3 (HA+PCO) and phenotype 4 (ANOV+PCO). The differences between these four phenotypes are still undefined and the subjects of study.
Methods: We evaluate 92 PCOS women using stepwise linear discriminant analysis with phenotype as dependent variable and BMI, FSH, LH, LTH, oestradiol, testosterone, progesterone, HDL-cholesterol, LDL-cholesterol, HOMA-IR and HOMA-B as independent variables.
Results: The phenotype 1 was present in 32.6%, phenotype 2 in 21%, phenotype 3 in 28% and phenotype 4 in 14.1% of cases. We found that BMI, LH, HOMA-IR and HOMA-B were discriminante factors for different phenotypes, while the other variables did not reach statistically significant difference.
|ANOV+PCO+HA||27.1±6.0 kg/m2;||7.33±4.69 IU/L;||1.49±0.34;||371.8±391.7;|
|ANOV+HA||29.2±8.0 kg/m2;||5.30±3.81 IU/L;||1.32±0.39;||423.1±213.1;|
|ANOV+PCO||22.8±4.4 kg/m2;||11.13±6.13 IU/L;||1.18±0.28;||535.1±365.5;|
|PCO+HA||24.9±5.8 kg/m2;||4.12±2.62 IU/L;||1.40±0.49;||755.6±1436.2;|
Conclusions: We concluded that LH, BMI, HOMA-IR and HOMA-B could be useful as discriminant factors in different PCOS phenotypes.
27 Apr - 01 May 2013
European Society of Endocrinology