The urgency of metabolic syndrome problem in modern medicine is caused by metabolic syndrome prevalence in the general population of 1424%. The metabolic syndrome plays an essential role in cardiovascular diseases development acceleration. Components are abdominalvisceral obesity, insulinresistance, hyperinsulinemia, dyslipidemia, arterial hypertension and carbohydrate metabolism disorder.
Aim: Frequency estimate 2nd type diabetes and insulin resistance in obesity
Materials and methods: For metabolic syndrome severity and obesity degree verification the BMI was calculated. Immunoreactive insulin level was defined by the immunofermental analysis metod. The insulinresistance was defined by HOMA-index calculation. Data are presented in a format of Me (Q25; Q75). The difference importance was estimated by MannWhitneys criterion.
Results: 50 patients with obesity and without verified diagnosis of diabetes were examined. The age of the patients is 41.09 (27.88; 46.80) years. BMI is 42.88 (35.32; 46.24) kg/sq per m. The average immunoreactive insulin level of the patients is 17.70 (13.20; 23.70). At 50.0% of patients immunoreactive insulin level exceeded 17 μU/ml which is a hyperinsulinemia indicator. HOMA-index is 4.39 (2.87; 7.00). 70.0% of patients had the normal HOMA-index value excess that testifies insulin resistance formation.
During carried-out inspection it was established that 24% of patients had boundary glicemia value level from 6.00 to 6.40 mmol/l. 2nd Type diabetes is diagnosed for 8.0% of patients for the first time.
Output: This research confirms high insulin resistance prevalence and the asymptomatic diabetes course at patients with obesity.
27 Apr - 01 May 2013
European Society of Endocrinology