Endocrine Abstracts (2013) 32 P787 | DOI: 10.1530/endoabs.32.P787

Insulinresistance at obesity and diabetes

Victoria Lesyukova, Kulyash Zekenova, Irina Savasteeva, Elena Bondareva, Elena Snitsarenko & Nina Komisarova


The Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus.


The urgency of metabolic syndrome problem in modern medicine is caused by metabolic syndrome prevalence in the general population of 14–24%. The metabolic syndrome plays an essential role in cardiovascular diseases development acceleration. Components are abdominal–visceral obesity, insulinresistance, hyperinsulinemia, dyslipidemia, arterial hypertension and carbohydrate metabolism disorder.

Aim: Frequency estimate 2nd type diabetes and insulin resistance in obesity

Materials and methods: For metabolic syndrome severity and obesity degree verification the BMI was calculated. Immunoreactive insulin level was defined by the immunofermental analysis metod. The insulinresistance was defined by HOMA-index calculation. Data are presented in a format of Me (Q25; Q75). The difference importance was estimated by Mann–Whitney’s criterion.

Results: 50 patients with obesity and without verified diagnosis of diabetes were examined. The age of the patients is 41.09 (27.88; 46.80) years. BMI is 42.88 (35.32; 46.24) kg/sq per m. The average immunoreactive insulin level of the patients is 17.70 (13.20; 23.70). At 50.0% of patients immunoreactive insulin level exceeded 17 μU/ml which is a hyperinsulinemia indicator. HOMA-index is 4.39 (2.87; 7.00). 70.0% of patients had the normal HOMA-index value excess that testifies insulin resistance formation.

During carried-out inspection it was established that 24% of patients had boundary glicemia value level from 6.00 to 6.40 mmol/l. 2nd Type diabetes is diagnosed for 8.0% of patients for the first time.

Output: This research confirms high insulin resistance prevalence and the asymptomatic diabetes course at patients with obesity.

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