Objective: Menopause-related changes in female body are associated with the greater risk of metabolic syndrome (MS), which includes obesity, dyslipidemia, impaired glucose tolerance, hypertension.
Aim: The purpose of our study was to reveal peculiarities of fat and lean mass distribution between postmenopausal women with abdominal obesity and with MS.
Design and Method: The sample consisted of 43 postmenopausal 6069 years old women (age: mean=64.8; S.D.=0.4); duration of menopause: mean=14.5; S.D.=0.9). The diagnosis of MS was considered according to IDF (2005 year) criteria. Lean and fat mass distrubution were measured by dual-energy X-ray absortiometry, and were compared for the cohorts with and without MS. Data were analyzed using Statistical Package 6.0 (Statsoft).
Results: Findings revealed that 24 (55.8%) of postmenopausal women had MS. In patients with and without MS compared, fat mass was higher in the former group (41248.25±2263.89 and 29817.68±2397.78 respectively; F=11.9; P=0.001) and at different body regions also: gynoid fat (6563.72±348.19 and 5115.21±392.43 respectively; F=7.6; P=0.008), android fat (3815.45±200.8128 and 2798.15±282.79 respectively; F=9.06; P=0.004. Lean mass comparing didnt show significant differences in female with and without MS (42548.0±1239.18 and 40667.53±1223.78 respectively; F=1.1; P=0.29) and at different body regions also.
Conclusion: These findings suggest that in postmenopausal women with MS there is prevalence of fat mass without increasing of lean mass quantity in compare to female with abdominal obesity without MS.
27 Apr - 01 May 2013
European Society of Endocrinology