ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2013) 32 P394 | DOI: 10.1530/endoabs.32.P394

Leptin and other adipocins in patients with type 2 diabetes

Andrey Verbovoy, Elena Solomonova & Anna Pashenceva


Samara State Medical University, Samara, Russia.


Aim: To evaluate leptin and other adipocins content in the blood with type 2 diabetes.

Materials and methods: Eighty six patients with type 2 diabetes were examined (59 women and 27 men) middle-aged 58.6±1.04 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The HOMA-IR, insulin, adiponectin, resistin, leptin, and omentin levels were investigated.

Results: In patients with type 2 diabetes HOMA-IR (6.13±0.8), insulin level (16.91±2.01 mcME/l) is actually higher than in control group (7.78±0.43 and 1.48±0.11 accordingly, P<0.001).

Adiponectin level in men with type 2 diabetes was evidently lower (7.5±0.4 μg/ml) than in control group (10.6±0.32 μg/ml, P>0.05). Resistin level in type 2 diabetes was statistically higher (10.37±0.55 ng/ml), than in control group (7.46±0.51 ng/ml, P<0.01). The lower omentin content in the patient's blood with type 2 diabetes (264.23±12.02 ng/ml) compared with the control group (395.6±5.3 ng/ml, P<0.001).

The leptin content in type 2 diabetes men (13.15±1.14 ng/ml) and women (34.88±2.99 ng/ml) is actually higher than in control group (3.59±0.38 ng/ml in men and 9.56±0.67 ng/ml in women, P<0.001). The leptin level in type 2 diabetes men positively correlates with insulin level (r=0.488, P<0.05) and HOMA-IR (r=0.476, P<0.05), but in type 2 diabetes women with IMB (r=0.652, P<0.001), WC (r=0.562, P<0.001) and insulin level (r=0.334, P<0.05).

Conclusion: The increase of leptin and resistin levels and reduction of adiponectin and omentin levels are noted in type 2 diabetes.

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