Diabetes | 0032 | ECE2013 | 15th European Congress of Endocrinology

ea0032p346 | Diabetes | ECE2013

Elevation of circulating free fatty acids abolishes down-regulation of skeletal muscle adiponectin receptor 1 (AdipoR1) expression caused by insulin infusion

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Stefanowicz Magdalena , Matulewicz Natalia , Kowalska Irina , Nikolajuk Agnieszka

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

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ea0032p347 | Diabetes | ECE2013

Short stature, low-set ears, short 5.finger, undescended testis, bradycardia

Cakir Evrim

A 22-year-old man presented to the Endocrinology unit for short stature. His height is 1.53 cm; weight is 38.5 kg. Physical examination revealed short stature, lean body mass, low-set ears and a short fifth finger on the right. His bone age were consistent with 19-year. He had a history of undescended testis operation at 5-year old and history of strabismus surgery at 14-year old. He had a delta f 508 heterozygote mutation with normal sweat test. His biochemical analysis excep...

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ea0032p348 | Diabetes | ECE2013

Long-acting insulin analogs exposure and cancer specific mortality in patients with diabetes mellitus

Ioacara Sorin , Guja Cristian , Ionescu-Tirgoviste Constantin , Fica Simona , Martin Sorina , Roden Michael

Aim: To test the hypothesis that exposure to insulin glargine might be associated with increased risk of cancer mortality compared with human basal insulin preparations.Materials and methods: All consecutive diabetes patients aged over 40 years, residing in a major urban area were screened at their first diabetes outpatient visit between 01/01/2001 and 12/31/2008 (n=79 869). Exclusion criteria were insulin treatment at screening (n=14 7...

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ea0032p349 | Diabetes | ECE2013

Expression of adiponectin gene and adiponectin receptors in placental and adipose tissue in women with gestational diabetes mellitus

Matyjaszek-Matuszek Beata , Kowalczyk Mariusz , Lagowska-Batyra Agnieszka , Gernand Wojciech , Nowakowski Andrzej , Leszczynska-Gorzelak Bozena , Kocki Janusz

Introduction: Adiponectin shows its beneficial insulin-sensitizing properties, however, women with gestational diabetes mellitus (GDM) present hypoadiponectinemia.Aim of the study: To assess the expression of adiponectin gene as well as its AdipoR1 and AdipoR2 receptors in placenta and adipose tissue and to determine potential correlations with chosen metabolic parameters (clinical and biochemical).Patients and methods: Thirty-six ...

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ea0032p350 | Diabetes | ECE2013

Effects of Vaspin on expressions of NF-κB and its target genes in endothelial EA.hy926 cells

Liu Shiwei , Yang Kun , Chen Xiaoqin , Zhao Shujun

Introduction: The visceral adipose tissue-derived serine protease inhibitor (vaspin), a novel adipocytokine, has been widely reported to be associated with obesity and insulin resistance. Obesity induced chronic inflammatory process plays a pivotal role in insulin resistance and is characterized by the activation of NF-κB pathway and its target genes. The present study aims to investigate the effects of vaspin on NF-κB pathway and its target genes in basal and TNF-&#...

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ea0032p351 | Diabetes | ECE2013

Skeletal muscle and adipose tissue glycoprotein 130 expression is associated with insulin resistance in humans

Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Adamska Agnieszka , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

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ea0032p352 | Diabetes | ECE2013

Increased alanine aminotransferase levels and associated characteristics among newly diagnosed type 2 diabetes patients: results from the DD2 study

Thomsen Reimar , Mor Anil , Rungby Jorgen , Ulrichsen Sinna , Nielsen Jens , Stidsen Jacob , Friborg Soren , Brandslund Ivan , Christiansen Jens , Beck-Nielsen Henning , Sorensen Henrik

Objectives: There is limited knowledge of high-sensitivity C-reactive protein (CRP) levels among newly diagnosed T2D patients in the population-based setting, and of factors associated with elevated CRP.Methods: Measurements of CRP were performed in the first 1036 T2D patients in the nationwide DD2 project, enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We examined the number of T2D patients within CRP t...

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ea0032p353 | Diabetes | ECE2013

Autoantibodies to the insulin- and IGF1-receptor in human sera

Welsink Tim , Schwiebert Christian , Minich Waldemar , Schomburg Lutz

Introduction: Autoantibodies (aAB) are characteristic of autoimmune diseases, but may also be found in apparently healthy individuals and precede pathological symptoms. We have recently reported on autoantibodies against the IGF1-receptor (IGF1R-aAB) in control subjects and patients with Graves disease (1). The isolated aAB were able to immunoprecipitate the recombinant autoantigen and antagonized IGF1 signaling in vitro. Given the structural similarities betwee...

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ea0032p354 | Diabetes | ECE2013

Physiological role for Angptl4/fiaf in exercise-induced muscle AMPK activation

Kim Min-Seon , Kim Ghi-Su , Chang Hyuckki , Shin Mi-Seon , Kim Hyun Kyong

Introduction: Angiopoietin-like protein 4 (Angptl4), also known as fast-induced adipose factor (Fiaf), is a glycoprotein which is known as a potent inhibitor of lipoprotein lipase. We have reported that hypothalamic Angptl4 is a novel anorexigenic molecule by inhibiting hypothalamic AMPK activity. In the present study, we investigated a potential role of Angptl4 in exercise-related physiology.Methods: We determined changes in Angptl4 mRNA/protein levels ...

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ea0032p355 | Diabetes | ECE2013

Predictive value of HbA1c and glucose fluctuations in hypoglycemia risk in patients with type 1 diabetes

Guelho Daniela , Barros Luisa , Baptista Carla , Paiva Isabel , Gouveis Sofia , Saraiva Joana , Moreno Carolina , Carrilho Francisco

Introduction: Many patients with diabetes experience high variability in glucose concentrations which is associated with a risk of hypoglycemia. The aim of this was to compare the predictive value of HbA1C, mean interstitial glucose (MIG), and glucose variability (GV) in the risk of hypoglycemia in patients with type 1 diabetes (T1D).Methods: Continuous glucose monitoring, using CGMS system, was performed in 130 T1D patients with diabetes duration of 17....

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ea0032p356 | Diabetes | ECE2013

Risk factors for impaired glucose tolerance and diabetes mellitus after liver transplantation

Martinez Guillermo , Allo Gonzalo , Fernandez Ana , Aramendi Mercedes , Jimenez Carlos , Moreno Enrique , Hawkins Federico

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

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ea0032p357 | Diabetes | ECE2013

Acute exercise leads to increased HbA1c and fructosamine levels in athletes with type 1 diabetes

Forga Luis , Goni Maria Jose , Chinchurreta Laura , Lafita Franciso Javier , Iriarte Ana , Manuel Fernandez- Real Jose

Introduction: In patients with type 1 diabetes, exercise has not consistently been shown to improve glycemic control, as measured using HbA1c levels. Participation in competitive sports may even worsen glycaemic control. Free radicals and oxidative stress markers are known to increase during acute exercise in parallel to decreased circulating antioxidant concentrations. We aimed to analyze the effects of chronic and acute exercise on circulating HbA1c and fructosamine levels.<...

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ea0032p358 | Diabetes | ECE2013

Increased alanine aminotransferase levels and associated characteristics among newly diagnosed type 2 diabetes patients: results from the DD2 study

Mor Anil , Thomsen Reimar , Rungby Jorgen , Ulrichsen Sinna , Nielsen Jens , Stidsen Jacob , Friborg Soren , Brandslund Ivan , Christiansen Jens , Beck-Nielsen Henning , Sorensen Henrik

Objectives: Elevated levels of serum alanine aminotransferase (ALAT) have been linked with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), insulin resistance and the metabolic syndrome in type 2 diabetes (T2D) patients. We examined ALAT levels in newly diagnosed T2D patients, and the factors associated with such elevation.Methods: Measurements of ALAT were performed in 1025 (43% women and 57% men) new T2D patients enrolle...

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ea0032p359 | Diabetes | ECE2013

Reconsidering guidance for postnatal glucose screening in gestational diabetes

Jarvis Sheba , Feben Christine , Roy Stephanie , Sheridan Richard , Boret Tony , Trainor Orla , Clements Michael R

Background: National Institute for Health and Clinical Excellence (NICE) guidelines advise that GDM be diagnosed using a 2-hr 75 g oral glucose tolerance test (OGTT). However there is lack of consensus on the optimal postpartum surveillance. Current postpartum screening guidance suggests a single fasting plasma glucose (FPG) at 6-weeks with annual testing thereafter. As women with GDM are often from mixed ethnic groups and frequently have postprandial hyperglycaemia, ...

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ea0032p360 | Diabetes | ECE2013

TCF7L2 gene polymorphisms may influence insulin sensitivity and leptin levels independently from BMI and body fat content

Kretowski Adam , Adamska Edyta , Wawrusiewicz-Kurylonek Natalia , Citko Anna , Goscik Joanna , Maliszewska Katarzyna , Wilk Juliusz , Waszczeniuk Magdalena , Lipinska Danuta , Pliszka Justyna , Ciborowski Michal , Gorska Maria

Introduction: The genome-wide association studies have recently expanded the number of genetic susceptibility loci for type 2 diabetes and obesity. Transcription factor 7-like 2 (TCF7L2) gene seems to be one of the most predictive identifiable factors promoting T2DM development. It has been suggested that TCF7L2 influences pancreatic β-cell function butthe effect of genetic variants of TCF7L2 on metabolic syndrome development is not well characterized among subje...

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ea0032p361 | Diabetes | ECE2013

Type 2 diabetes and prostate cancer risk in Korean men with low PSA

Kimm Heejin , Jo Jaeseong , Jee Sun Ha

Introduction: Diabetes as a risk factor of cancer should be explored further. The value of PSA is limited because we cannot exclude prostate cancer in lower PSA levels. We analyzed diabetes and the risk of prostate cancer in lower PSA in a large cohort study.Method: A total of 179 456 health examinees (men, aged 3089 years) from 1994 to 2010 were participated. Participants with any cancer or potential prostate diseases were excluded from analysis. ...

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ea0032p362 | Diabetes | ECE2013

The association between severity of impaired glucose tolerance in gestational diabetes with age, BMI, and ethnicity in the UK

Jones Benjamin , Balaji Sathyan , Cotzias Christina

Introduction: Gestational diabetes (GDM) has been shown to cause adverse fetal outcomes including macrosomia, shoulder dystocia and stillbirth. The multinational Hyperglycaemia and Pregnancy Outcome (HAPO) Study has shown there is a linear relationship between OGTT result and fetal growth. Investigating epidemiological risk factors is essential to ensure appropriate high-risk groups are being screened.Methods and materials: A retrospective case note revi...

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ea0032p363 | Diabetes | ECE2013

High prevalence of elevated liver transaminases among 38 727 patients in a diabetes centre in the United Arab Emirates

Hannoun Zara , Lessan Nader , Barakat Maha T

Introduction: Liver transaminases are markers of parenchymal liver disease, most commonly non-alcoholic steatohepatitis (NASH), the inflammatory component of non-alcoholic fatty liver disease (NAFLD). Common causes include obesity and type 2 diabetes mellitus (T2DM), both common conditions in the UAE. The prevalence of NAFLD in this population is not known. We report data from a large diabetes centre including ALT and aspartate transaminase (AST) levels in patients with and wi...

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ea0032p364 | Diabetes | ECE2013

Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet

Beiroa Daniel , Amparo Romero-Pico , Carmen Langa , Carmelo Bernabeu , Miguel Lopez , Lopez-Novoa Jose M , Ruben Nogueiras , Carlos Dieguez

Introduction: Endoglin is a transmembrane auxiliary receptor for transforming growth factor-β (TGF-β) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or insulin sensitivity has been unexplored.Material and methods: Heterozygous deficient mice (HZ) were fed standard chow or high fat diet during 16 weeks. Blood glucose levels were measured after ...

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ea0032p365 | Diabetes | ECE2013

Prediabetes in human immunodeficiency virus-infected patients: prevalence and clinical significance

Garcia-Figueras Carolina , Cayon Manuel , Bancalero Patricia , Terron Alberto

Introduction: Although the importance of disorders in glucose metabolism is well recognized in human immunodeficiency virus (HIV) infected patients; the clinical relevance of prediabetes in this population has been little studied. The aims of this observational study were to determine the prevalence of prediabetes in a cohort of HIV-infected patients on long term highly active antiretroviral therapy (HAART) and to assess whether this condition involves the appearance of partic...

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ea0032p366 | Diabetes | ECE2013

Clinical experience of a monogenic diabetes unit during 2008–2012 in the Department of Endocrinology and Nutrition (Malaga, Spain)

Dominguez-Lopez Marta , Fernandez-Arias J David , Gonzalez-Molero INmaculada , Valdes Sergio , Miguel Gomez-Zumaquero Juan , Guerrero Mercedes , Colomo Natalia , Omiste Antonio , Palau David , Soledad Ruiz de Adana Maria , Escofet Federico Soriguer

Objectives: MODY diabetes is the most common form of monogenic diabetes, encompassing a heterogeneous group of disorders whose primary defect results from mutations in one of at least seven genes recognized, associated with a primary defect in insulin secretion. It has early onset and autosomal dominant inheritance.Our objective was to evaluate the results of monogenic diabetes clinic of the Endocrinology and Nutrition Department during 20082012.</...

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ea0032p367 | Diabetes | ECE2013

Progression to impaired glucose metabolism in normal glucose tolerant urban population

Piorowska Natalia , Gilis-Januszewska Aleksandra , Piwonska-Solska Beata , Szafraniec Krystyna , Pach Dorota , Hubalewska-Dydejczyk Alicja

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) and risk factors of progression to diabetes in normal glucose tolerant (NGT) people during 8 years follow up study using WHO 1999 criteria and new criteria of IFG (IFG 5.6-fasting glucose 5.66.9 mmol/l).Research design and methods: This is an 8 year prospective observation in a randomly selected urban population aged ...

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ea0032p368 | Diabetes | ECE2013

Impact of the insulin pump therapy on quality of life children and adolescents with diabetes mellitus type 1

Natalyia Nikolaeva , Nina Bolotova , Olga Kompaniets , Natalyia Filina

Objectives: To investigate the changes parameters of quality of life (QoL) in children and adolescents with diabetes mellitus type 1 (T1DM), using different regimes insulin therapy.Research design and methods: Thirty patients with diabetes mellitus type 1, aged 518 years (mean 13.3±3.04 years), with disease duration from 1 to 10 years (mean 5.4±3.4 years) took part in paired study. QoL was assessed with the PedsQLä (Generic Core Scal...

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ea0032p369 | Diabetes | ECE2013

Relation of serum chemerin level with markers of atherosclerosis in diabetes and prediabetes

Aydin Kadriye , Canpolat Ugur , Dural Muhammet , Akin Safak , Karakaya Jale , Aytemir Kudret , Gurlek Alper

Introduction: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism and inflammation, but its role remains to be elucidated in atherosclerosis particularly in diabetes and prediabetes. We aimed to investigate the relation of serum chemerin levels with markers of atherosclerosis as exemplified by pulse wave velocity (PWV), carotid intima media thickness (CIMT), and carotid plaque presence in these groups.Metho...

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ea0032p370 | Diabetes | ECE2013

Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum

Gkiomisi Athina , Makedou Kali , Anastasilakis Athanasios , Polyzos Stergios , Kourtis Anargyros , Gerou Spyridon , Gavana Elpida , Dagklis Themistoklis , Rousso David , Giannoulis Charalambos

Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM (GDM Group 20 managed with diet only (GDM-diet) and 24 with diet plus insulin (GDM-insulin)) and 44 age-matched pregnant women with normal glucose tolerance (control group) were studied. Serum glucose, lip...

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ea0032p371 | Diabetes | ECE2013

Abstract withdrawn....

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ea0032p372 | Diabetes | ECE2013

Association between toll-like receptor 4 polymorphism and type 2 diabetes mellitus

Mesci Banu , Eren Pinar , Kiziltas Safak , Oguz Aytekin , Tuncer Ilyas , Kostek Osman , Colak Yasar

Introduction: Type two diabetes (T2DM), is the most common form of diabetes and known to be associated with low-grade inflammation. Since TLR-4 plays an important role in bacteriel recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways we aimed of to test whether TLR-4 gene polymorphism plays a protective role in the development of T2DM in a pilot Turkish population.Description of methods/design: Blood samples were collected f...

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ea0032p373 | Diabetes | ECE2013

Altered reactivity of pituitary–adrenal axis to stimulation tests and altered tissue metabolism of cortisol in long-standing type 1 Diabetes

Simunkova Katerina , Vondra Karel , Duskova Michaela , Hill Martin , Starka Luboslav

This work aimed to evaluate pituitaryadrenal axis and tissue metabolism of cortisol in patients with long standing type one diabetes.Fifty patients with diabetes type 1 were investigated; age 38±10 years (mean±S.D.), age at diagnosis 25.5±10 years, disease duration 15±8 years, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%. Control group consisted of 40 healthy volunteers.The study...

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ea0032p374 | Diabetes | ECE2013

The effects of gestational diabetes on basal metabolic rate in pregnancy

Ergen Nilay , Bulgurlu Sami Sabri , Dayan Akin , Bozat Ali Erkan , Parildar Hulya , Gebeloglu Nuray , Tarcin Ozlem , Unal Asli Dogruk , Demirtunc Refik

Introduction: The total energy expenditure in pregnancy is increased largely due to elevated basal metabolic rate (BMR) during pregnancy. The aim of this study is to evaluate the effects of gestational diabetes on basal metabolic rate, body weight and HbAlc, by comparing these parameters in gestational diabetic and healthy pregnant women.Method: Fifty-eight gestational diabetic women (GDM) and fourty healthy non diabetic pregnants who had normal thyroid ...

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ea0032p375 | Diabetes | ECE2013

Gene expression of TLR2, TLR4, and TLR9 in human PBMCs with diabetes

Liu Fengjing , Feng Bo , Bao Yuqian

Objective: To investigate the relationship between expression of TLR2, TLR4, and TLR9 in PBMCs and type 2 diabetes and their significance in pathogenesis of diabetes.Methods: Expression of TLR2, TLR4, and TLR9 in PMBCs was measured by flow cytometry in 112 subjects with coronary heart disease (CHD, n=49), type 2 diabetes plus coronary heart disease (DM+CHD, n=34), type 2 diabetes (DM, n=4) and healthy controls (CONTROL, n</...

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ea0032p376 | Diabetes | ECE2013

Prevalence of achievement of HbA1c, blood pressure, and cholesterol (ABC) Goal in Koreans with diabetes

Yu Sung Hoon , Kang Jun Goo , Hwang Yoo-Cheol , Ahn Hong Yup , Park Cheol-Young

Introduction: Diabetes is one of the most challenging health problems in the world. The degree of prevention or control of complications directly affects patients mortality. Therefore, it is crucial to control the risk factors of diabetes. We investigated the prevalence, treatment, and control of diagnosed diabetes in Korean adults from 1998 to 2010.Methods: The Korean Ministry of Health and Welfare conducted the Korean National Health and Nutritio...

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ea0032p377 | Diabetes | ECE2013

Nutritional status assessment in patients with cystic fibrosis

Almanza Matilde Rubio , Prol Agustin Ramos , Malpartida Katherine Garcia , Pla Maria Argente , de Zayas Beatriz Leon , de Solis Soledad Navas , Alborg Vicente Campos , Martin Silvia Sanchis , Ripoll Roser Querol , Torres Juan Francisco Merino

Introduction: Cystic fibrosis (CF) is a chronic disease at risk of malnutrition. The aim of the study is to assess nutritional status of patients with CF.Methods: Descriptive study of CF patients referred for a nutritional evaluation. Data collected included lung function, pancreatic and carbohydrate metabolism (according to ADAs diagnostic criteria), anthropometric and laboratory parameters. Results are shown as mean (S.D.).<p c...

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ea0032p378 | Diabetes | ECE2013

The expression mechanism of lipocalin-2 by co-stimulation with interleukin 1β and interferon γ in RINm5F β-cells

Chang Seo-Yoon , Kim Dong-Bin , Jo Yang-Hyeok , Kim Myung-Jun

Lipocalin-2 (LCN-2) is known to act as an antiinflammatory or a proinflammatory mediator. Recently, LCN-2 has been recognized to play a role in obesity and insulin resistance. However, there is no knowledge about the expression and the role of LCN-2 in pancreatic islet β-cells. Therefore, we examined molecular mechanisms by which proinflammatory cytokines interleukin 1β (IL1β) and interferon γ (IFNγ) induce LCN-2 expression in RINm5F β-cells. IL1&...

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ea0032p379 | Diabetes | ECE2013

The effect of CCR2 G190A gene polymorphism on development of diabetic coronary artery disese

Bagci Gokhan , Koksal Binnur , Cakmakoglu Bedia

Introduction: Inflammatory mechanisms play an important role in the development of cardiovascular diseases and diabetes. Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. Some studies have shown that CCR2 G190A polymorphism might be important for protection of susceptibility to some immunologically-mediated disorders. The aim of our study was to investigate the effec...

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ea0032p380 | Diabetes | ECE2013

High prevalence of the metabolic syndrome among newly diagnosed type 2 diabetes patients in Denmark

Nielsen Jens Steen , Thomsen Reimar W , Ulrichsen Sinna Pilgaard , Mor Anil , Stidsen Jacob Volmer , Rungby Jorgen , Friborg Soren , Brandslund Ivan , Christiansen Jens Sandahl , Toft-Sorensen Henrik , Beck-Nielsen Henning

Few population-based data exist on the prevalence of the metabolic syndrome (MS) its components, and its association with subclinical inflammation and insulin resistance among patients newly diagnosed with type two diabetes (T2D).We examined the MS according to IDF criteria by linkage primary data (waist circumference, fasting blood glucose, and high-sensitivity C-reactive protein (CRP)) with variables from the Danish diabetes database for adults (blood ...

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ea0032p381 | Diabetes | ECE2013

Trans-operative and post-operative medical complications in patients with diabetes mellitus type 2

Abreu Alin , Diaz Johann

Purpose: To determine the association between clinical indicators of metabolic state and cardiovascular, infectious and metabolic complications during or after elective surgery in patients with type 2 diabetes mellitus (T2DM) regardless of their treatment scheme.Methods: Prospective observational study. Patients with T2DM, ages 2080 years, scheduled for elective surgery were evaluated with office BP, BMI, Hb1Ac, fasting glucose, fibrinogen, total c...

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ea0032p382 | Diabetes | ECE2013

Assessment of pre-pregnancy BMI in patients with gestational diabetes

Segura-Galindo Amparo , Fernandez-Alonso Ana Maria , Moreno-Ruiz Inmaculada , Sebastian-Ibanez Virginia , Canizo-Gomez Francisco Javier del

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fishers exact test and Students t-test. A P<0.05 was significant (SPSS 19.0).Re...

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ea0032p383 | Diabetes | ECE2013

Study of the development and validation of the specific “Satiglu” questionnaire to evaluate the satisfaction of diabetic patients with glucometers

Portillo Cristobal Morales , Garcia Clara Garcia , Sanlaureano Florentino Carral , Huerga Juan Carlos , Casares Martin Lopez de la Torre , Hurtado Javier

Objective: To develop a specific questionnaire to evaluate the satisfaction of diabetic patients with the use of glucometers and evaluate their psychometric properties (feasibility, reliability, and validity).Material and methods: Two stages: i) questionnaire development: a set of 53 items was constructed after a bibliographic review. A panel of six experts and 50 patients concluded a 25-item version of the questionnaire (dimensions: satisfaction, inconv...

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ea0032p384 | Diabetes | ECE2013

Inflammatory markers in diabetic foot and impact of vitamin D deficiency

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: i) To evaluate plasma levels of IL6, adiponectin and resistin in subjects with diabetic foot in comparison with subjects without foot complications. ii) To assess the impact of vitamin D status on the levels of above inflammatory markers.Methods: A total 100 diabetic foot cases and 100 diabetic controls were recruited in the study. Serum level of 25OH vitamin D was estimated from the cases and controls by RIA. Serum IL6, adiponectin and resist...

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ea0032p385 | Diabetes | ECE2013

Study of the prevalence of subclinical hypothyroidism in type 2 diabetic Egyptian women

Eloraby Hussein , Halawa Mohammed , Abdelsalam Mona , Abdelbaki Rania , Moustafa Bassim

Background: Subclinical hypothyroidism is a common thyroid disorder. Although there is a recognized association between thyroid disease and diabetes mellitus, there is no definite answer as to whether screening for subclinical hypothyroidism is necessary in patients with type 2 diabetes.Objective: To evaluate the prevalence of subclinical hypothyroidism in women with type 2 diabetes in Egypt.Patients and methods: women with type 2 ...

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ea0032p386 | Diabetes | ECE2013

Maternal serum fetuin-A, leptin, and hs-CRP concentrations in gestational diabetes

Calan Mehmet , Yilmaz Ozgur , Altindag Tamer , Solak Ahmet , Kebabcilar Levent , Yuvanc Huseyin Oguz , Dal Tuba

Aim: The aim of this study was to examine serum fetuin-A, leptin and hs-CRP concentrations among pregnant women with gestational diabetes (GDM), and to evaluate the relationship between these parameters and insulin resistance.Materials and methods: In this study, we evaluated 47 pregnant patients with GDM. As the control group, 43 normal pregnant women having similar properties with these GDM patients, but not gestational diabetes were enrolled. Serum fe...

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ea0032p387 | Diabetes | ECE2013

The impact of fasting during Ramadan on the glycemic control of patients with type 2 diabetes mellitus

Sahin Serap Baydur , Ayaz Teslime , Ozyurt Neslihan , Ilkkilic Kadir , Kirvar Abdulkadir , Sezgin Hacer

Background: Millions of Muslims fast from dawn until dusk during the annual Islamic holy month of Ramadan. Most of the studies evaluating biochemical changes in diabetic patients during Ramadan showed little changes in the glycemic control. In this study, our aim was to assess the impact of fasting during Ramadan on glycemic control in patients with type 2 diabetes.Methods and design: We examined 122 patients with type 2 diabetes (82 females, 40 males, a...

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ea0032p388 | Diabetes | ECE2013

Identification of plasma biomarkers in human diabetic retinopathy

Lee Ying-Ray , Lu Chieh-Hsiang , Chan Hong-Lin

Retinopathy has been observed in around 25% of patients with type one and type two diabetes for 35 years. Diabetic retinopathy can cause poor vision and even blindness since high glucose has been evidenced to weaken retinal capillary leading to leakage of blood into the surrounding space. Therefore, the prevention, diagnosis and therapy of diabetes retinopathy are very important in diabetes patients. Here, we adopted a proteomics-based approach using 2D-DIGE and MALDI-TO...

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ea0032p389 | Diabetes | ECE2013

Diabetes awareness in the general population of northern Greece

Somali Maria , Daramilas Christos , Mastorakos Georgios , Mouslech Zadalla

Introduction: The current study was conducted to assess the level of awareness about diabetes in a random population.Methods: A questionnaire was conducted by communication over the telephone in Thessaloniki, Macedonia, and Greece in a random population of 600 persons. Presence of DM1 or DM2 in the person questioned or a family member, knowledge of precipitating factors, duration, curability, choice of phycisian and compliance with medication were assess...

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ea0032p390 | Diabetes | ECE2013

Insulin resistance among adults with type 1 diabetes mellitus

Barrera Jerome , Jimeno Cecilia , Paz-Pacheco Elizabeth

Insulin resistance (IR) has been proven to increase the risks for cardiovascular complications in type 2 diabetes mellitus. Recently, IR has also been shown to play a bigger role in the natural history of type 1 diabetes mellitus (T1DM) disease process than is commonly recognized. The objectives of this study are to determine the prevalence of IR among Filipino adults with T1DM and to describe the clinical features of T1DM with IR.This cross-sectional an...

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ea0032p391 | Diabetes | ECE2013

Atypical early onset Werner's syndrome

Aydogan Berna Imge , Yurumez Seda , Sengul Gozde , Sahin Mustafa , Baskal Nilgun

Introduction: Werners Syndrome (WS) is a rare autosomal recessive adult onset progeroid disorder characterized by the early onset of aged-appearance and age related metabolic disorders. Patients usually develop normally until the 3rd decades of life.Case report: We report a 27 years old female who admitted to our clinic at the age of 15 with hyperglycemia. She was diagnosed as diabetes and type 4 dyslipidemia at the age of 7 years. In her family hi...

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ea0032p392 | Diabetes | ECE2013

Potentialities of skin impedance spectroscopy in vivo in non-invasive monitoring of glucose level

Ivan Turkovskiy , Boris Paramonov , Vitaly Kharin , Monica Gericke , Nicolay Belyaev

Considered are the physiological mechanisms of relationship of the magnitude of blood plasma and interstitial fluid osmolarity conditioned by glycaemia with transmembrane movement of water between intra- and extracellular water compartments of organism. Analysed are the potentialities of impedance spectroscopy in quantitative evaluation of increments of specific volumes of extra- and intracellular fluid of hypoderm tissues occurring due to fluctuations of intercellular fluid g...

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ea0032p393 | Diabetes | ECE2013

Association of plasma testosterone concentration with cardiovascular risk factors in young Chinese men of type 2 diabetes mellitus

Li Xin , Yang Miao , Wu Yuwen , Sun SuXin

Introduction: Type 2 diabetes mellitus (T2DM) has the same risk of cardiovascular event with coronary artery disease (CAD). Men with diabetes are characterized by a decrease in circulating testosterone concentrations, and testosterone deficiency have been associated with increased risk of metabolic syndrome and CAD. With the increased popularity of western life style in China, the morbidity of T2DM increased greatly in young Chinese people. This study aimed to investigate the ...

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ea0032p394 | Diabetes | ECE2013

Leptin and other adipocins in patients with type 2 diabetes

Verbovoy Andrey , Solomonova Elena , Pashenceva Anna

Aim: To evaluate leptin and other adipocins content in the blood with type 2 diabetes.Materials and methods: Eighty six patients with type 2 diabetes were examined (59 women and 27 men) middle-aged 58.6±1.04 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The HOMA-IR, insulin, adiponectin, resistin, leptin, and omentin levels were investigated.Results: In patie...

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ea0032p395 | Diabetes | ECE2013

Leptin, resistin and omentin in patients with the obesity and with impaired glucose tolerance

Verbovoy Andrey , Solomonova Elena

Aim: To evaluate the adipocins content in the blood with IGT.Materials and methods: One hundred and one patients with IGT were examined (86 women and 15 men) middle-aged 62.1±1.2 years old. The control group included 16 patients (eight women and eight men) middle-aged 22.6±0.6 years old. The anthropometric indications (IMB, WC, and WC/TC), HOMA-IR, insulin, CRP, resistin, leptin, and omentin levels were investigated.Resul...

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ea0032p396 | Diabetes | ECE2013

Quality of care in diabetic patients

Marcelino Mafalda , Domingues Andreia , Pereira Armando , Passos Dolores , Raimundo Joaquim , Silva Joao , Lopes Luis , Lopes Maria , Chambel Paula , Santos Valentim , de Castro Joao Jacome

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease, with prevalence increasing worldwide and its complications are major causes of early morbidity and mortality. Recent guidelines suggest the individualisation of glycaemic targets and glucose-lowering therapies.The aim of this study was to determine the quality of care provided to type 2 diabetic patients in our institution, analysing metabolic control, cardiovascular risk factors and pre...

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ea0032p397 | Diabetes | ECE2013

Lipid profile of patients newly diagnosed with type 2 diabetes in Albania

Toti Florian , Shehu Aldi , Hoti Kliti , Carcani Manjola , Lapardhaja Adriana , Bruka Luftime

Background and aims: Diabetic patients are at increased risk for macrovascular complications and lower extremity amputations. Knowing their metabolic control degree, and lipid profile, through an early intervention, we can reduce their risk factors for cardiovascular disease, and diabetes complications. The aim of our study was to determine the lipid profile of patients newly diagnosed with type 2 diabetes.Patients and methods: Hundred patients, selected...

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ea0032p398 | Diabetes | ECE2013

Glycemic and lipid profile in patients with acute pancreatitis

Maric Andreja , Bel Masa , Igrec Miljenka , Kovacic Mihajlo , Marodi Ivana , Kuzat Luka , Poljak Bozidar , Gradiser Marina

Introduction: Early hyperglycemia in acute pancreatitis (AP) is prognostic sign of severe attack. Elevated lipid levels are one of the major risk factors for AP. The objective of this work was to evaluate the glycaemic and lipid profile in patients (pts) with acute pancreatitis, treated in our institution.Methods: A total of sixty nine pts with AP were admitted to a Department of Internal medicine, from January to December 2012.At ...

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ea0032p399 | Diabetes | ECE2013

Practical knowledge about diabetes and the risk of death: 9-year observation

Kostrzewa-Zablocka Ewa , Marczewski Krzysztof

Introduction: Although education is widely regarded as one of the pillars of diabetes treatment, it is relatively little work analysing its effectiveness. Therefore we would like to present our prospective observations.Method: In 20032004, 500 consecutive patients visiting our diabetes education centre put to the test the knowledge of diabetes as 20 questions which focus on practical skills proceedings in diabetes. We did not have a direct affect t...

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ea0032p400 | Diabetes | ECE2013

Blood pressure control in type 2 diabetic patients with overweight or obesity in Guangdong Province: a cross-sectional survey

Cheng Yanzhen , Chen Rongping , Yang Fan , Song Qingqing , Yan Ting , Chen Lishu , Lin Shaoda , Liang Ganxiong , Hu Baochun , Cai Dehong

Objective: To investigate the blood pressure control in type 2 diabetic patients with overweight or obesity in Guangdong Province.Methods: From August 2011 to March 2012, The 2 diabetic patients with overweight or obesity was recruited from 67 hospitals in 20 cities of Guangdong Province, and received a standard questionnaire. The conditions of Demographic data, clinical examinations, the most recent laboratory assessment, and drug therapy were recorded....

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ea0032p401 | Diabetes | ECE2013

The role of a lifestyle modification in preventing type 2 diabetes mellitus and influence it on changes serum leptin levels

Shishko Elena

Aim: The aim of our study is to assess the efficacy of a lifestyle modification including altered diet composition and physical activity in preventing diabetes mellitus type 2 (DM 2) in individuals with impaired glucose tolerance and impaired fasting glucose (IGT/IFG) and influence it on changes serum leptin levelsMaterials and methods: The study included 327 patients with IGT/IFG (68 males and 258 females) 2565 years. Patients were divided into tw...

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ea0032p402 | Diabetes | ECE2013

Signs of accelerated carotid atherosclerosis assessed by MRI in newly diagnosed type 2 diabetes

Hoyem Pernille H , Laugesen Esben , Mikkelsen Anders A F S , Christensen Britt , Opstrup Ulla K , Poulsen Per L , Erlandsen Mogens , Kerwin Bill , Thrysoe Samuel , Christiansen Jens S , Kim Won Y , Hansen Troels K

Introduction: Type 2 diabetes is associated with accelerated atherosclerosis, which causes macro-vascular complications such as cerebral infarctions, myocardial infarctions, and peripheral vascular disease. We aimed to investigate whether there are differences in the morphology of atherosclerosis in the carotid arteries assessed by MRI in newly diagnosed type 2 diabetic patients compared to non-diabetic control subjects.Methods: Hundred type 2 diabetic p...

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ea0032p403 | Diabetes | ECE2013

Cardiovascular risk management in the patients with type 2 diabetes mellitus

Kim Doo-Man , Kim Sin Gon , Cho Donghyouk , Kim Chong Hwa , Kim Chul-Sik , Lee Won-Young , Won Kyu Chang

Current guidelines on cardiovascular (CV) disease prevention recommend targeted management after assessment of CV risks using many of available method even if the patient is asymptomatic. This study was performed to explore how CV high-risk is differently detected between two distinct methods: non-invasive test (NIT) and risk calculation and how the awareness of CV high-risk impacts physician and patient behavior for risk management in diabetes patient.A...

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ea0032p404 | Diabetes | ECE2013

Circulating endothelial progenitor cells as a predictor of clinical outcomes in diabetic patients with symptomatic chronic heart failure

Berezin Alexander , Kremzer Alexander

Background: Recent evidence has defined that circulating endothelial progenitor cells (EPCs) might have a pivotal role in the presence of atherosclerosis, chronically diseased vessels or following acute vascular injury. We hypothesized that diabetes mellitus (DM) may be related to worsening of ischemic chronic heart failure thereby suppression of mobilization of bone marrow-derived EPCs.The aim of this study was to evaluate predict value of circulating E...

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ea0032p405 | Diabetes | ECE2013

Correlations between umbilical and maternal adiponectin as well as neonatal birthweight

Matyjaszek-Matuszek Beata , Burska Agata , Gernand Wojciech , Lenart-Lipinska Monika , Nowakowski Andrzej , Paszkowski Tomasz

Introduction: Adiponectin (AdipoQ) is a known insulinsensitizing adipokine which is also present in fetal circulation. It has been postulated to play a role in the regulation of fetal growth and development together with other adipokines. The aim of the study was to determine fetal adiponectin and find its correlations with the neonatal birthweight and maternal AdipoQ.Patients and methods: The study included 36 women with singleton pregnancy (20 diagnose...

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ea0032p406 | Diabetes | ECE2013

The relationship between glycemic control and BNP levels in diabetic patients

Dal Kursad , Ata Naim , Yavuz Bunyamin , Sen Omer , Kizilca Guler , Akoz Zekeriya , Yildirim Aslihan Mete , Uygungelen Bulent , Akin Kadir Okhan , Beyan Esin , Ertugrul Derun Taner

Background: Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess BNP levels in patients with poor control diabetes before specific treatment for hyperthyroidism and after glycemic regulation was achieved. The study was performed in a prospective design.Methods: The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiogr...

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ea0032p407 | Diabetes | ECE2013

Diagnostic and prognostic value of system matrix mettalloproteinases-1 in patients with diabetes mellitus 2 type

Zhuravlyova Larysa , Olga Lavrinenko

Non-alcoholic fatty liver disease (NAFLD) develops in 7590% of patients with diabetes mellitus 2 type (DM2) and obesity (Ob). Collagen degradation is regulated by the activity of interstitial collagenases, especially matrix metalloproteinases 1 type (MMP-1). It is necessary to determine levels of tissue inhibitor of metalloproteinases-1 (TIMP-1), which regulates activity of MMP-1.Aim: Optimisation of diagnosis and specification of prognosis of NAFL...

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ea0032p408 | Diabetes | ECE2013

Fibroblast growth factor 21: a new predictor of cardiovascular events in type 2 diabetes

Lenart-Lipinska Monika , Matyjaszek-Matuszek Beata , Gernand Wojciech , Solski Janusz , Nowakowski Andrzej

Introduction: The course of type 2 diabetes (DM2) is linked with increased fibroblast growth factor 21 (FGF21) concentrations, however little information is available on the prognostic significance of FGF21 in DM2. The aim of the study was to assess whether FGF21 may be a predictor of cardiovascular (CV) events in patients with DM2.Patients and methods: The study comprised 87 patients with DM2, aged 5766 years, with the median duration of diabetes ...

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ea0032p409 | Diabetes | ECE2013

Diabetes and hyperglycemia: relation with clinical outcome in the community acquired pneumonia

Fernandes Vera , Ramalho Julieta , Santos Maria Joana , Oliveira Narciso , Pereira Maria

Background: Community acquired pneumonia (CAP) is a common condition and a major cause of morbidity. Diabetes mellitus (DM) increases the risk and complications of infectious diseases. However, it is necessary to clarify if DM and glycemia at the time of presentation are prognostic factors in patients with CAP.Objectives: To evaluate the relationship between DM/glycemia at the time of presentation and complications, length of stay and mortality in patien...

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ea0032p410 | Diabetes | ECE2013

iNOS, eNOS, and XOR involvement in hyperglycaemia-induced kidney injury in rats with streptozotocin diabetes mellitus

Sokolovska Jelizaveta , Isajevs Sergejs , Sugoka Olga , Baumane Larisa , Isajeva Darja , Sharipova Jelena , Kalvinsh Ivars , Sjakste Nikolajs

Introduction: Diabetic nephropathy is a major complication of diabetes mellitus. Involvement of abnormal nitric oxide (NO) production, both via nitric oxide synthase (NOS) dependent and independent pathways (for example, xantine oxoridoreductase (XOR)) has been discussed. New compounds to treat diabetic nephropathy are searched intensively, some novel dihydropirine class drugs (DHP) have been proposed for this purpose.Aim: To study the changes in NO conc...

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ea0032p411 | Diabetes | ECE2013

Advanced glycation end-products inhibit insulin signaling in human granulosa cells

Piperi Christina , Papageorgiou Efstathia , Kandaraki Eleni , Koutsilieris Michael , Diamanti-Kandarakis Evanthia

Introduction: AGEs have been shown to be accumulated in granulosa cell layer from human ovaries in normal and in women with polycystic ovarian syndrome (PCOS) and insulin resistance. AGEs interfere with insulin signaling pathways of several target tissues and are implicated in insulin resistance mechanisms. There is evidence that within the ovary these pathways are also important for glucose metabolism and normal folliculogenesis. The effect of human glycated albumin (HGA) eit...

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ea0032p412 | Diabetes | ECE2013

Diabetic polyneuropathy course clinical features of patients with various age of diabetes demonstration

Savasteeva Irina , Zekenova Kulash , Malkov Aleksei , Filiptsova Natalia , Tsukanov Anatolii , Jmailik Margarita , Vasuhina Irina

Aim: To single out polineuropathy development risk group.Materials and methods: Four hundred and fifty patients with a more than 5 years diabetes experience were examined.For verification of a diabetic polyneuropathy the electroneuromyography was made. By a method of the immunofermental analysis neurospecific S100 protein level was defined. Data are presented in Me (Q25; Q75) format. The importance of distinctions was estimated by ...

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ea0032p413 | Diabetes | ECE2013

Cardiovascular risk and prevalence of metabolic syndrome in LADA patients depending on thyroid autoimmunity presence

Reghina Aura Diana , Constantin Madalina , Georgescu Olivia , Nistor Madalina , Olaru Ramona , Florea Suzana , Fica Simona

Background: Latent autoimmune diabetes in adults (LADA) is a form of autoimmune diabetes with a slower decline of β cell function and distinct features from type 1 and type 2 diabetes. LADA is also a very heterogenic group. Frequently LADA is associated with other autoimmune diseases especially endocrine diseases.Aim: To evaluate prevalence of thyroid autoimmunity (TA) and its impact on cardiovascular risk and metabolic syndrome in LADA patients.</p...

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ea0032p414 | Diabetes | ECE2013

Endothelial dysfunction in type 2 diabetic patients; its relation with level of albuminuria and frequency of the microvascular complications

Yagmur Murat , Yagmur Julide , Keskin Lezzan , Sahin Ibrahim

Introduction: Both endothelial dysfunction and albuminuria have been shown to be related to cardiovascular risk. We aimed to investigate relations between endothelial dysfunction, albuminuria and frequency of the microvascular complication in type 2 diabetic patients.Method: Forty type 2 diabetic patients (24 microalbuminuria and 16 macroalbuminuria) with a mean age of 57.2±10.8 years and 25 healthy control subjects with a mean age of 54.1±9.6 ...

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ea0032p415 | Diabetes | ECE2013

Association between type 1 diabetes and oral health status

Poplawska-Kita Anna , Siewko Katarzyna , Szpak Piotr , Krol Beata , Telejko Beata , Mysliwiec Janusz , Stokowska Wanda , Gorska Maria , Szelachowska Malgorzata

Aims: We assessed periodontal status in patients with type 1 diabetes and healthy individuals in relation to their glycemic control, smoking, and inflammatory biomarkers.Methods: Periodontal status was examined in 107 patients with type 1 diabetes and 40 controls, using oral hygiene index (OHI), community periodontal index (CPI) and teeth number. CPI values of 02 and 34 were classified as non-periodontitis and periodontitis respectively. Bloo...

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ea0032p416 | Diabetes | ECE2013

Lower incidence of severe hypoglycaemia during pregnancy in a recent cohort of women with type 1 diabetes followed in a routine care setting

Ringholm Lene , Secher Anna Lilja , Pedersen-Bjergaard Ulrik , Thorsteinsson Birger , Andersen Henrik Ullits , Damm Peter , Mathiesen Elisabeth R

Introduction: To investigate whether the incidence of severe hypoglycaemia in pregnant women with type 1 diabetes can be reduced without deteriorating pregnancy outcomes in a routine care setting.Methods/design: A new cohort (20092011) of 59 women receiving intensified education about the risk of severe hypoglycaemia in pregnancy was compared with an old cohort (20042006) of 108 women. The women entered the study at median 8 (range 513)...

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ea0032p417 | Diabetes | ECE2013

Association between periodontal disease and vitamin D status in a type 1 diabetic population

Ramos Laura , Casanova Leticia , Piedra Maria , Munoz Pedro , Teresa Maria , , Garcia-Unzueta , Amado Jose Antonio

Background and aims: Periodontal disease (PD) is a chronic inflammatory condition where the key feature is the alveolar bone loss. Diabetes mellitus is a major risk factor in the occurrence of PD and vitamin D has been found to play a role in the development of diseases such as PD for its immunomoduratory and anti-inflammatory effects. The purpose of this study was to evaluate the relationship between PD and vitamin D levels in type 1 diabetic patients.S...

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ea0032p418 | Diabetes | ECE2013

The role of cardio metabolic markers to predict carotid intima media thickness in type 2 diabetic patients

Mansouri Masoume , Omidfar Kobra , Fakhrzadeh Hossein , Larijani Bagher

Introduction: The aim of this study was to investigate the cardiovascular risk factors which could predict vascular thickness in diabetic patients who did not have clinical symptom of atherosclerotic vascular diseaseMethod: A total of 101 type 2 diabetic patients (48 males and 53 females) with a mean age of (53.6±8.4 years) were recruited in this study. CIMT were measured by B-mode ultrasonography and ankle brachial pressure index (ABI) was measured...

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ea0032p419 | Diabetes | ECE2013

Improvement in sympathetic cardiac autonomic functions after 6 months of comprehensive yogic breathing program in patients with diabetes

Jyotsna V P , Singla R , Ambekar S , Dhawan Anju , Gupta Nandita , Sreenivas V , Deepak K K

Aims and objectives: To assess the effect of Comprehensive Yogic Breathing Program on glycemic control, quality of life, and cardiac autonomic functions in diabetes.Material and methods: This is a prospective randomized controlled intervention trial. 120 diabetes patients who were having HbA1c between 6 and 8% for atleast 6 months were selected. Oral drug dose was adjusted to keep the HbA1c between 6 and 8. Plasma fasting glucose, post prandial plasma gl...

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ea0032p420 | Diabetes | ECE2013

Relationship between metformin treatment and hyperlactacidemia diagnosed at the emergency room

Guelho Daniela , Paiva Isabel , Fonseca Isabel , Gouveia Sofia , Saraiva Joana , Moreno Carolina , Carvalheiro Manuela , Carrilho Francisco

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

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ea0032p421 | Diabetes | ECE2013

Type 1 diabetes and pregnancy: importance of glycemic control in maternal and perinatal outcomes

Moreno Carolina , Ruas Luisa , Paiva Sandra , Marta Elvira , Gouveia Sofia , Saraiva Joana , Guelho Daniela , Moura Paulo , Carvalheiro Manuela , Carrilho Francisco

Introduction: Type one diabetes is estimated to account for 1% of the pregnancies complicated by diabetes, associated with an increased risk of maternal and perinatal morbidity. The multidisciplinary follow up of the diabetic women can contribute to an improvement of the glycemic control, minimizing the obstetric and perinatal complications.Aims: To characterize pregnant women with type one diabetes followed in our Departments Endocrinology/Obstetr...

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ea0032p422 | Diabetes | ECE2013

Assessment of glycemic control in patients with T1DM and depression

Navmenova Yana , Mokhort Tatiana

Aim: Is to determine the frequency of hypoglycemic states in patients with T1DM with and without depression.Materials and Methods: patients with T1DM (57 men and 51 women) aged 41.15 years (34.65, 46.66) were examined, with the experience of diabetes about 11.32 years (2.80, 11.90). Depression was determined according to the scale HADS. Assessment of glycemia was carried out with the help of daily monitoring system of glucose in intercellular fluid (CGMS...

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ea0032p423 | Diabetes | ECE2013

The peculiarities of atherosclerotic coronary arteries lesion in patients with coronary artery disease and type 2 diabetes mellitus

Zhuravlyova Larysa , Lopina Nataliia , Demchenko Inna

Purposes: To assess the peculiarities of atherosclerotic coronary arteries (CA) lesion in patients with coronary artery disease (CAD) and type two diabetes mellitus (T2DM).Materials and methods: We provide a retrospective analysis of 90 cases of patients with CAD (54 males, aged 60,5±4,7 years). Baseline characteristics of patients included history of CAD (7,2±2,3 years), T2DM (4,7±0,5 years). All patients were divided into two groups: 1st...

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ea0032p424 | Diabetes | ECE2013

The influence of resistin on liver function in patients with diabetes mellitus type 2 and obesity

Zhuravlyova Larysa , Ogneva Olena

There is a need in study of resistin (R) role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) against the background of metabolic disorders.Aim: To assess the relationship between R and indexes of enzyme and pigment metabolism in patients (pts) with NAFLD combined with diabetes mellitus (DM) type 2 and obesity (Ob).Methods: Fifty pts with NAFLD in combination with subcompensated DM (HbA1c 8.3±1.7%) and Ob (BMI&...

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ea0032p425 | Diabetes | ECE2013

Risk factors and outcomes of periferal artery disease in patients with diabetes mellitus

Zabuliene Lina , Piragyte Simona , Triponiene Dalia , Zabulis Vaidotas , Grigaitis Arunas

Objective: To analyse features of peripheral artery disease (PAD) in patients with diabetes mellitus (DM), to determine the consequences of PAD and the risk factors for amputation.Material and methods: Retrospective study of 925 diabetic patients (58% males, 95.6% with type 2 DM) with PAD treated in Vascular Surgery Centre in Vilnius City University Hospital in 19972011 was performed.Results: Mean age was 67.99±9.47 year...

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ea0032p426 | Diabetes | ECE2013

Early on evaluation of hearing function with transient evoked otoacoustic emissions (TEOAE) and distortion product otoacoustic emissions (DPOAE) in type 2 diabetic patients without hypertension

Dikbas Oguz , Apuhan Tayfun , Altunrende Burcu , Erdurmus Mesut , Tosun Mehmet , Ozturk Serkan

Objective: Altered hearing function in diabetic patients has been found in both pure tone audiometry and otoacoustic emissions (OAEs). We intended to evaluate the cochlear function with both DPOAE and TEOAE in patients with DM without polyneuropathy and hypertension.Patients and methods: Study group consisted of type 2 diabetic patients and healthy control group consisted of healthy age and sex matched volunteers. Detailed ear examination, pure tone audi...

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ea0032p427 | Diabetes | ECE2013

Maternal 75 g OGTT glucose levels as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus

Krstevska Branka , Simeonova Sladjana , Velkovska-Nakova Valentina , Jovanoska Biljana , Ahmeti Irfan , Pemovska Gordana

Objective: Our goal was to investigate the effects of glucose levels from 75-g oral glucose tolerance test (OGTT) on large for gestational age (LGA) newborns in women with gestational diabetes mellitus (GDM).Material and methods: A prospective study was undertaken in Outpatient Department of Clinics for Endocrinology, Diabetes and Metabolic Disorders. One hundred and eighteen pregnant women were prospectively screened for GDM between 24 and 28 weeks of p...

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ea0032p428 | Diabetes | ECE2013

The influence of erythropoietin therapy on renal function and proteinuria level in patients with early diabetic nephropathy

Pchelin Ivan , Shishkin Alexander

Introduction: Anemia is associated with an increased risk of cardiovascular events and death in patients with diabetic nephropathy (DN). However, there are still a lot of contradictions related to the benefits and risks of antianemic treatment in this group of patients due to variety of non-hematopoietic effects of erythropoietin. The aim of this study was to assess the influence of erythropoietin therapy on renal function and proteinuria in patients with early DN.<p class...

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ea0032p429 | Diabetes | ECE2013

The diabetic hand: a forgotten complication?

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Ursavas Ulfet

Aim: To investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus patients.Material and methods: patients (mean age 50±9.01 years, 34 women and 24 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytrens contracture, tinnel sign and tendinitis was assessed. All patients were evaluated also by the Rheumatology Division. Diabetic reti...

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ea0032p430 | Diabetes | ECE2013

Echocardiographic parameters and blood pressure in normoalbuminuric prehypertensive diabetic patients

Themeli Yllka , Bajrami Valbona , Muka Lutfie , Barbullushi Myftar , Idrizi Alma , Teferici Daniela , Shijaku Mahmud , Daka Albana

Introduction: Elevated blood pressure levels are more frequently observed in diabetic patients, than in the general population. Ambulatory blood pressure monitoring (ABPM) is better correlated with target organ damage from hypertension (HT) than clinic blood pressure readings. The correlation between ABPM and urinary albumin excretion rate (UAER) in diabetes mellitus (DM) has been found to be stronger than the correlation between clinic blood pressure (BP) and UAER.<p clas...

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ea0032p431 | Diabetes | ECE2013

Relationship between endothelin-1 levels in diabetics with and without microangiopathy and control subjects

Vicente Maria Rosa Villar , Alameda Carmen , Becerra Antonio , Menacho Miriam , Lopez Gilberto Perez , de Villar Noemi G Perez , Rodriguez Azucena , Cancer Emilia , Canovas Gloria

Aim: To assess ET1 levels in diabetic patients with and without microangiopathy, and compared with normal subjects, nondiabetic, without underlying vascular pathology.Introduction: The pathophysiology of diabetic microangiopathy is complex and many important aspects of it still are not fully understood. Endothelial dysfunction is of major importance in the pathogenesis of atherosclerosis and diabetic angiopathy. ET-1 is one of the most potent vasoconstri...

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ea0032p432 | Diabetes | ECE2013

Diabetic polyneuropathy predictors

Malkov Aleksei , Ponomarev V

Introduction: Diabetic polyneuropathy is detected in 12.514.5% of patients after 5 years of falling ill.Aim: To detect predictors of diabetic polyneuropathy development in prospective parallel open clinical research.Methods: From 2010 to 2012, 189 patients were examined (108 men, 81 women, average age 38±7 years) with DM type 2 (82%) and type 1 (18%), without neurological complaints. We estimated the neurological ...

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ea0032p433 | Diabetes | ECE2013

Endothelial dysfunction in diabetes mellitus

Rozhko Alexander , Rodzina Elena , Savasteeva Irina , Rusalenko Maria

Objective: To identify the frequency of occurrence of endothelial dysfunction dorsalis pedis arteries in diabetes.Materials and methods: patients with diabetes mellitus, with no complaints of the legs were examined (aged 40.25±3.12, duration of diabetes 12.50±1.25). Endothelial dysfunction was studied with high-resolution ultrasound (9 MHz) and diagnosed in the absence of growth in artery diameter in response to reactive hyperemia >10% or a...

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ea0032p434 | Diabetes | ECE2013

Risk factors and diabetic foot wound classification: ten years of follow-up

Nobrega Marta , Colares Victor , Aras Roque , Campelo Priscilla , Nunes Marcos

Objective: To outline the risk factors, the epidemiological profile, and the classification of diabetes type two foot ulcer.Methods: A prospective observational study, including all the people that sought out in a consecutive way, a tertiary diabetic foot service, from February 2002 until September 2012. At admission, the patients were examined and had their ulcers evaluated by only one observer, in accordance with the University of Texas classification....

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ea0032p435 | Diabetes | ECE2013

Smoking and progression of diabetic nephropathy in type 1 diabetes mellitus

Themeli Yllka , Bajrami Valbona , Barbullushi Myftar , Idrizi Alma , Daka Albana

Objective: To investigate the association between cigarette smoking and the progression of diabetic nephropathy in type 1 diabetic patients.Research design and methods: A prospective, follow-up study over 1 year was conducted in a sequential sample of 30 smokers, 30 nonsmokers, and 30 ex-smokers with type 1 diabetes, hypertension, and diabetic nephropathy. Progression of renal disease was defined according to the stage of nephropathy as an increase in pr...

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ea0032p436 | Diabetes | ECE2013

Association of C-reactive protein and nephropathy in type 1 diabetic patients

Vasilkova Volha , Mokhort Tatiana

Aim: To determine the relationship between C-reactive protein (CRP) and nephropathy in type 1 diabetic patients.Methods: A total of 68 patients (24 women and 44 men) with type 1 diabetes aged 46.58±12.23 years were studied. All subjects had BMI<35 kg/m2. The levels of CRP, fasting blood glucose (FBG), triglycerides (TG), HbA1c and renal function tests were assessed. Patients were divided into 2 groups: 1 group patients with nep...

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ea0032p437 | Diabetes | ECE2013

Relation of high sensitive CRP and insulin resistance to retinopathy in type 2 diabetes

Bonakdaran Shokoufeh , Yaghoubi Mohammad Ali

Background: Pathophysiology of Diabetic retinopathy is a complex process. The aim of this study was to evaluate the association between insulin resistance, high sensitive CRP level as inflammation markers and diabetic retinopathy.Methods: In this cross-sectional, 342 patients with type 2 diabetes were selected. The following data were recorded: age, sex, duration of diabetes and type of medical treatment. HbA1c, FBS, HSCRP, lipid profiles and insulin lev...

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ea0032p438 | Diabetes | ECE2013

Assessment of hypoglycemia risk factors in insulin treated patients

Maiza Mouna , Haouat Emna , Turki Zinet , Kandara Hajer , Salem Leila Ben , Slama Claude Ben

Achieving glycemic targets is crucial in the management of diabetes mellitus. Insulin is the most effective hypoglycemic treatment for diabetes but its use can be associated with a risk of hypoglycemia.The aim of this study is to specify risk factors of hypoglycemia in insulin-treated patients.Patients and methods: This transversal study included 69 patients. They were females in 49.4% of cases (n=41). Mean age was 52 year...

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ea0032p439 | Diabetes | ECE2013

Admissions of diabetic patients due to hypoglycemia of external cause in a central hospital from 2006 to 2012

Fonseca Ricardo , Duarte Joao Sequeira

Background: Hypoglycemia is a common complication of Diabetes Mellitus treatment, especially in patients receiving intensive therapy. It can cause severe clinical consequences and is an obstacle to achieve glycemic targets.Methods: Retrospective study of severe hypoglycemia due to insulin or oral drug therapy that lead to hospitalization in a central hospital. We reviewed the medical records in the last 7 years (20062012) for blood glucose levels a...

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ea0032p440 | Diabetes | ECE2013

Ambulatory blood pressure profiles in type 2 diabetic patients

Nelaj E , Sadiku E , Gjata M , Tase M

Introduction: Arterial hypertension is a major risk factor for micro- and macrovascular complications in type 2 diabetes. Several factors are known to influence blood pressure profile in diabetic patients, such as age, sex, body weight, diabetes duration, insulin dosage, metabolic control, and microalbuminuria. Ambulatory blood pressure monitoring (ABPM) permits the observation of blood pressure throughout day and night. ABPM is better related to end organ damage and cardiovas...

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ea0032p441 | Diabetes | ECE2013

Studying the effect of hypertriglyceridemia and hyperglycemia on the outcome of pregnancy in diabetics and nondiabetics

AL-Deen Ahmad Saad , Ahmad Assmaa , AL-Sagheer Ghada , AL-Gelany Saad , ahmad Lamia

Background: Wide range of biochemical and hematological laboratory values changed during diabetic pregnancy comparable to physiological pregnancies. hyperglycemia is a risk factor for fetal macrosomia. The level of maternal triglycerides have been strongly correlated with excess fetal growth and large for gestational age.Aim of the study: The aim of this study is to evaluate the effect of maternal hyperglycemia and triglycerides on pregnancy outcome in d...

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ea0032p442 | Diabetes | ECE2013

Severe diabetic ketoacidosis in type 2 diabetes mellitus

Rodriguez-Gutierrez Rene , Gonzalez-Moreno Emanuel I , Camara-Lemarroy Carlos R , Quintanilla-Flores Dania L , Gonzalez-Chavez Juan M , Galarza-Delgado Dionicio A , Tamez-Perez Hector E , Gonzalez-Gonzalez Jose G

Introduction: Severe diabetic ketoacidosis (S-DKA) is a life-threatening condition requiring immediate hospitalization and treatment. Although mostly associated with type one diabetic patients, it is also a common condition in type two diabetes mellitus (T2DM). Our objective was to determine the main clinical and metabolic alterations associated with S-DKA in T2DM patients.Methods: We retrospectively analyzed the medical records of 27 consecutive T2DM pa...

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ea0032p443 | Diabetes | ECE2013

Disabilities of the arm, shoulder and hand (DASH) questionnaire and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Ursavas Ulfet

Aim: DASH questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH Questionnaire in 1000 type two diabetes mellitus (DM) patients.Material and methods: Fifty-eight patients (mean age 50±9.01 years, 34 women and 24 men) who had type II DM were included as ...

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ea0032p444 | Diabetes | ECE2013

Impact of a comprehensive management of glycemic profile, arterial hypertension and dislypidemia on the onset of type 2 diabetes mellitus

Portillo Cristobal Morales , Pena Ignacio Fernandez , Jimenez Virginia Hernando , Garcia Clara Garcia , Rodriguez Jose Perez , Zelaya Raquel Venegas , Olmedo Isabel Serrano , Perez Angel Sendon

Objective: To analyze the impact of a specialized management on cardiovascular risk at the onset of type 2 diabetes mellitus.Material and method: Were analyzed 171 patients who visited our diabetes day hospital (DDH) during 20102011, studying the following variables: sex, age, BMI, smoking habit, arterial hypertension (de novo/previously known), antihypertensive therapy, dislypidemia (de novo/previously known), hypolipidemic thera...

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ea0032p445 | Diabetes | ECE2013

Monoballism associated with newly onset ketotic Hyperglycemia

Soysal Dilek Ersil , Gelen Baris , Hizar Sezin , Pekdiker Mete , Tekesin Ebru , Beckmann Yesim , Karakus Volkan

Movement disorders as the initial symptoms of diabetes mellitus are rare. Here, we describe one of these rare manifestations of primary diabetes: a case of newly diagnosed diabetes mellitus in an old age female patient with transient monoballismus during an episode of ketotic hyperglycemia. Ballism can be rapidly controlled by normalization of glycemia. Our patient had monoballism confined to her upper extremity. To our knowledge, this is the first report describing monoballis...

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ea0032p446 | Diabetes | ECE2013

Comparison of Irbesartan and combination with Nigella sativa oil in experimental diabetic nephropathy

Peynirci Hande , Sen Saniye , Kanter Mehmet , Ustundag Sedat , Aktas Cevat , Asker Semra

Introduction: Diabetic nephropathy is the leading cause of chronic renal failure worldwide. Related to the increased glucose and its metabolites, activation of reninangiotensinaldosterone system, and increased oxidative stress are important in renal deterioration. The studies indicate that suppression of reninangiotensinaldosterone system slow down diabetic nephropathy; Nigella sativa decreases blood glucose and oxidative stress. Were viewed th...

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ea0032p447 | Diabetes | ECE2013

Association lipids with albuminuria in patients with type 1 diabetes

Vasilkova Volha , Mokhort Tatiana

Aim: To determine the relationship between serum lipids with albuminuria in patients with type one diabetes.Methods: A total of 150 diabetic patients both sexes aged 41.58±11.33 years were studied. The levels of total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), HbA1c and renal function tests were assessed. Patients were classified as normoalbuminuric (albumin excretion...

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ea0032p448 | Diabetes | ECE2013

Characteristics of the patients treated at the onset of type 2 diabetes mellitus in our Diabetes Day Hospital (DDH) during 2010–2011

Portillo Cristobal Morales , Pena Ignacio Fernandez , Herrero Cristina Hernandez , Garcia Clara Garcia , Rodriguez Jose Perez , Jimenez Virginia Hernando , Zelaya Raquel Venegas , Olmedo Isabel Serrano , Perez Angel Sendon

Objective: To analyze the demographic and clinical characteristics of the patients treated at the onset of type two diabetes mellitus in our DDH.Material and method: During 20102011 were analyzed 171 patients treated in our DDH, studying the following variables: sex, age, BMI, waist circumference, family diabetes history, microvascular and macrovascular long-term complications, smoking habit, rate of associated hypertension (de novo/ previ...

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ea0032p449 | Diabetes | ECE2013

Lipid profile in type 1 diabetic patients in Kragujevac

Mladenovic Violeta , Djukic Aleksandar , Sipetic Sandra

Introduction: The prevalence of hyperlipidemia in type 1 diabetics is 30 to 90%. High total cholesterol, LDL and triglyceride serum level is independent risk factor for cardiovascular disease. High prevalence of malignant atherogenic profile is alarming in type 1 diabetics (high triglyceride, low HDL). It is very often that dislipidemia is associated with diabetes and obesity, as well as hypertension, that pointed to inherited disorders.The aim of this s...

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ea0032p450 | Diabetes | ECE2013

Association of type II diabetes mellitus with hepatocelular carcinoma occurrence. A case control study from Western Nepal

Pandeya Dipendra

Objective: To assess the association of type II DM with hepatocelular carcinoma occurrence.Materials and methodsIt was a case control study carried out using data retrieved from the register maintained in the Department of Biochemistry of Manipal College of Medical Sciences, Pokhara, Nepal between 1st January, 2012 and 31st August, 2012. The variables collected were age, gender, HbA1c. All these biochemical parameters were analyzed...

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ea0032p451 | Diabetes | ECE2013

HbA1c levels did not correlate with SF-36 and DQOL scores in patients with poorly controlled type 2 diabetes

Cander Soner , Gul Ozen Oz , Dizdar Oguzhan Sitki , Akkurt Aysen , Guclu Metin , Tuncel Ercan , Erturk Erdinc , Ersoy Canan

Aim: To evaluate the relationship between glycemic control and quality of life parameters in patients with poorly controlled type 2 diabetes.Methods: Fifty patients with poorly controlled (HbA1c 812%) type 2 diabetes included the study and were answered DQOL and SF-36 questionnaires to an assistant in internal medicine. HbA1c levels, age, gender, duration of diabetes, height, weight and waisthip ratio measurements recorded at the same time.</...

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ea0032p452 | Diabetes | ECE2013

Diabetic ketoacidosis in hospitalized patients with hypertriglyceridemia induced pancreatitis. Case control study

Quintanilla-Flores Dania L. , Rendon-Ramirez Erick J. , Colunga-Pedraza Perla R. , Corral-Benavides Sergio A. , Gallardo-Escamilla Jesus , Galarza-Delgado Dionicio A.

Introduction: Hypertriglyceridemia induced pancreatitis (HIP) is an uncommon condition accounting for 14% of cases of acute pancreatitis, mostly associated with poor glycemic control in diabetic patients. Diabetic ketoacidosis (DKA) may complicate the clinical course of HIP; however, few studies have documented this association. Our objective was to identify clinical and demographic differences between HIP patients with co-existing DKA compared to those without DKA.<...

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ea0032p453 | Diabetes | ECE2013

Deficiency of vitamin D3 in patients with diabetic retinopathy

Antonenko Olena , Skrypnik Rimma , Komissarenko Julia

Diabetic retinopathy (DR), is the cause of population invalidization which is diagnosed in 3090% of patients.Purpose - to examine vitamin D levels in patients with diabetic retinopathy.Materials and methods: Under our supervision, there were 48 patients (93 eyes). Among examined 26 patients had nonproliferative form DR and 19 proliferative DR.Results: Among the patients with type 1 diabetes 23 (5...

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ea0032p454 | Diabetes | ECE2013

A poorly controlled type 2 diabetes complicated by an episode of severe hypertriglyceridemia-induced pancreatitis

Denecker Nathalie , Decochez Katelijn

Introduction: Although it is recognised that diabetic ketoacidosis may present with abdominal pain, it remains important to exclude an underlying acute pancreatitis which may be masked due to ambiguous presentation.Case: A 23-year old woman with a history of type 2 diabetes and non-compliance for her oral antidiabetic medication presented to the emergency department with abdominal epigastric pain and nausea starting a few hours before admission. Laborato...

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ea0032p455 | Diabetes | ECE2013

Self care practice among diabetic patients in Kathmandu

Pandey Radha Acharya , Chapagain Pratikcha

Diabetes is expected to rise from 177 million today to 370 million in 2030. Self care is a crucial to keep the disease under control. Appropriate self care practice can keep the disease under control.The aim of the study was to find out the self care practice among diabetic patients.This is a simple descriptive cross-sectional study was done in Metropolyclinic Kathmandu, Nepal. A total of 50 respondents, who met eligible criteria w...

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ea0032p456 | Diabetes | ECE2013

Newly diagnosed diabetic patient presenting with crural infection

Yilmaz Merve , Gedik Arzu , Havitcioglu Hasan , Demir Tevfik , Gumus Tugba , Tunc Ulku Aybuke , Calan Mehmet , Comlekci Abdurrahman , yener Serkan , Eraslan Sevinc , Bayraktar Firat

Introduction: The incidence of diabetic foot in diabetics is 5-10%. We herein aimed to share a formerly undiagnosed diabetic patient presenting with crural infection.Case: A 48-year-old male patient, without a formerly known disease, presented to a local medical center due to spontaneously progressing ulceration on left leg. The ulcers did not improve with antibiotics in seven days and afterwards he was referred to our hospital. At admission, his plasma ...

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ea0032p457 | Diabetes | ECE2013

Relation between psychiatric symptoms and diabetic complications: preliminary results

Tuzun Dilek , Bozkirli Emine Duygu Ersozlu , Ursavas Ulfet

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (DM) patients.Material and methods: Fifty-eight patients (mean age 50±9.01 years, 34 women and 24 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytrens contracture, tinnel sign and tendinitis was assessed. Diabetic retinopathy was assessed by direct ophthalmoscopy. Urinary albumin excretion ...

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ea0032p458 | Diabetes | ECE2013

Pelvic pain in a type 2 diabetes patient

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: To present a patient with long standing type 2 diabetes complaining of chronic pelvic pain, due to an uncommon cause of bilateral vas calcification.Methods: Clinical, laboratory and radiographic data are reported on a 62-year-old diabetic presenting with chronic pelvic painResults: A 62-year-old man with a history of 17 years of diabetes presented with chronic dull aching, non radiating pain in the pelvis and in the regi...

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ea0032p459 | Diabetes | ECE2013

Marking out group of the increased risk of disorder of the mineralization of the osseous tissue at patients with diabetes

Savasteeva Irina , Romanov George , Moskvicheva Tamara , Chernova Nellie , Vashchenko Elena , Filyustin Andrei , Domantsevich Victor , Korzhich Alexander , Jmailik Margarita , Vasuhina Irina

The aim of this research was foot mineralization level definition by means of the two-absorbing X-ray densitometer and marking out group of the greater risk of a foot mineralization disorder development at patients with diabetes.Materials and methods: Decrease in a foot mineralization at diabetes patients conformed a mineralization of metatarsal bones below 0.50 g/cm2 level and (or) tarsal bones below 0.69 g/cm2 level.<p class="...

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ea0032p460 | Diabetes | ECE2013

Postprandial hypotension is attenuable with Acarbose treatment in older adults with diabetes mellitus type 2: a randomized controlled crossover cohort study

Harris David , Lockhart Chris , Meneilly Graydon , Madden Kenneth

Postprandial hypotension (PPH) is common for older adults and may lead to syncope and falls. Adults with autonomic dysfunction, commonly those with diabetes mellitus (DM), are also at risk for PPH. Reported prevalence rates are 40% for PPH in DM patients. To date there are no reliable treatments for this condition in DM patients. It was our objective to demonstrate Acarbose, an α-glucosidase inhibitor, decreases the degree of PPH in an elderly DM cohort.<p class="abst...

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ea0032p461 | Diabetes | ECE2013

Effect of bariatric surgery on serum glucagon like peptide-1 concentration and metabolic parameters among obese type 2 diabetics

Shelbaya Salah El Din , Mostafa Alaa Abbas , Seddik Salwa , Shady Manal M. Abu , Bekhet Meram M. , Ibraheem Nesma Ali

Objective: Assess the effect of bariatric surgery on serum glucagon like peptide-1 (GLP-1) concentration and metabolic and biochemical parameters pre and postoperatively.Methods: This prospective study comprised 50 subjects divided into 3 groups. Group 1: 20 obese subjects with T2DM (BMI >35) that underwent Roux-en-y gastric bypass surgery; Group 2: 20 lean subjects with T2DM and Group 3: 10 lean subjects as healthy controls.Bo...

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ea0032p462 | Diabetes | ECE2013

Ileal interposition with diverted sleeve gastrectomy for treatment of type 2 diabetes

Kota Sunil Kumar , Ugale Surendra , Gupta Neeraj , Modi Kirtikumar D

Objective: To prospectively evaluate the results of laparoscopic ileal interposition (II) with diverted sleeve gastrectomy (DSG) for control of type 2 diabetes mellitus (T2DM) and related metabolic abnormalities.Methods: All patients underwent II +DSG. They had T2DM ≥5 years with poor glycemic control despite adequate dosage of oral hypoglycemic agents (OHAs) and/ or insulin. The primary outcome was remission of diabetes (HbA1c <6.5% without OH...

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ea0032p463 | Diabetes | ECE2013

Clinical usefulness of a bolus calculator in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion (CSII)

Dominguez-Lopez Marta , Gonzalez-Molero Mercedes Inmaculaca , Guerrero Inmaculaca , Gonzalez Stella , Adana MSoledad Ruiz de , Soriguer Federico

Objective: One of the major problems related to the use of CSII, or intensive insulin regimens in general, is the calculation of accurate insulin boluses. Abolus calculator incorporated into the insulin pump, estimates the dose of insulin to be administered at the meal on the basis of the following parameters: current blood glucose, grams of carbohydrate in the meal, carbohydrate to-insulin ratio (CIR), insulin sensitivity factors (ISF), target blood glucose and quantity of in...

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ea0032p464 | Diabetes | ECE2013

Effects of human insulin and insulin aspart preparations on levels of IGFI, IGFBPs and IGFI bioactivity in patients with type 1 diabetes

Ma Zhulin , Christiansen Jens Sandahl , Lauritzen Torsten , Parkner Tina , Laursen Torben , Frystyk Jan

Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GHIGFIGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...

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ea0032p465 | Diabetes | ECE2013

Vitamin B₁₂ deficiency in type 2 diabetic patients on metformin

Niafar Mitra , Jamali Behrad , Alikhah Hosseyn , Bahrami Amir

Introduction: Metformin is the only biguanide that is currently in use as an oral hypoglycemic agent in type 2 diabetes mellitus (DM). There are reports about the vitamin B12 deficiency in metformin users. This study was aimed to evaluate the vitamin B12 deficiency in patients with type 2 DM using metformin or other hypoglycemic agents.Methods: A descriptive-comparative study was performed on 400 patients with type 2 DM presenting t...

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ea0032p466 | Diabetes | ECE2013

Medical staff experience and acceptance of an ICU insulin infusion protocol in a tertiary hospital in the Philippines

Ngalob Queenie , Jimeno Cecilia , Isip-Tan Iris Thiele

Introduction: The recommended strategy for glycemic control among critically ill is i.v. insulin adjusted via a standardized insulin protocol. Critical to its success is acceptance of the implementing staff. In our hospital, we adapted and modified the Yale insulin infusion protocol (IIP). Evaluation of medical staff experience has not yet been done.Objectives: To evaluate medical staff experience and acceptance of the IIP through a survey and focused gr...

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ea0032p467 | Diabetes | ECE2013

Efficacy and safety of 1 year treatment with Liraglutide in subjects with type 2 diabetes

Prodam Flavia , Zavattaro Marco , Ponziani Chantal , Pagano Loredana , Caputo Marina , Allochis Gabriele , Teresa Sama Maria , Busti Arianna , Aimaretti Gianluca

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

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ea0032p468 | Diabetes | ECE2013

Metabolic surgery assessment score (MSAS): a tool to predict diabetes remission after modified bariatric surgery

Kota Sunil Kumar , Meher Lalit Kumar , Jammula Sruti , Modi Kirtikumar D

Objective: Laparoscopic ileal interposition (II) with sleeve gastrectomy (SG)/diverted sleeve gastrectomy (DSG) are types of modified bariatric surgery for treatment of type 2 diabetes (T2DM). DSG is preferred over SG in patients with less favourable metabolic profile. Owing to variable remission response in our patients, retrospectively we devised a novel score metabolic surgery assessment score (MSAS). It helps to select the type of procedure and to predict the diabetes remi...

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ea0032p469 | Diabetes | ECE2013

No benefit for mortality but advanced risk of hypoglycemia with intensive glucose control in critical care unit brain injured patients: a meta-analysis of RCTs

Chantziara Klio , Maniotis Christos , Kokkoris Panagiotis , Toloumis Georgios

Background: Acute stroke, traumatic brain injury, and subarachnoid hemorrhage are common diagnoses of patients in Critical Care Units, which often lead to increased morbidity and mortality. Patients with brain damage experience wide glucose fluctuation, with episodes of hyperglycemia. Hyperglycemia has traditionally been associated with poor clinical outcomes after brain injury.Objectives: To evaluate the effects of intensive versus conventional glucose ...

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ea0032p470 | Diabetes | ECE2013

Monitoring and control of blood glucose levels in patients with inefficiently controlled insulin-treated diabetes mellitus through the utilization of an on-line telemonitoring system

Fountoulakis Stelios , Papanastasiou Labrini , Marakaki Chrisanthi , Anastasakou Marina , Piaditis George

Introduction: Our goal was to monitor and control the blood glucose levels in inefficiently controlled insulin-treated patients with diabetes mellitus (DM). The target was to achieve an early detection of DM deregulation, to maintain accepted HbA1c levels through active intervention and to minimize the outpatient department visits.Description of methods/design: Twenty-six insulin-treated type 1 and 2 DM patients were enrolled (mean age 61.42±14.5 ye...

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ea0032p471 | Diabetes | ECE2013

Insulin detemir has similar effect when using single daily dose with same dose twice daily as basal insulin therapy with oral antidiabetics.

Cander Soner , Dizdar Oguzhan Sitki , Gul Ozen Oz , Akkurt Aysen , Guclu Metin , Unal Oguz Kaan , Tuncel Ercan , Erturk Erdinc , Imamoglu Sazi , Ersoy Canan

Aim: To compare the effectiveness of insulin detemir when added to oral antidiabetic drug therapy as a single daily dose or twice daily.Method: Fifty patients with a diagnosis of type 2 diabetes receiving oral antidiabetic drug therapy and glycemic control did not provided were included the study. Insulin detemir was begun 0.10.2 U/kg daily dose, half of the patients started with a single daily dose and the other half with same dose twice daily. At...

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ea0032p472 | Diabetes | ECE2013

Factors related to nonadherence with diabetes treatment among Brazilian type 2 diabetes mellitus patients

Arrelias Clarissa , Faria Heloisa , Zanetti Maria Lucia , Rodrigues Flavia , Teixeira Carla Regina

Introduction: The patients nonadherence to treatment is a universal problem and has several related factors. Knowing these factors can provide information for planning of health actions. The aim of this study was to relate the prevalence of nonadherence to treatment for diabetes with sex, age, years of education, duration of diabetes and metabolic control.Description of methods/design: This is cross-sectional study. The data were derived from the d...

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ea0032p473 | Diabetes | ECE2013

Cardiovascular effects of treatment with Liraglutide in a population with type 2 diabetes

Zavattaro Marco , Prodam Flavia , Grazia Mauri Maria , Pagano Loredana , Caputo Marina , Belcastro Sara , Allochis Gabriele , Aimaretti Gianluca

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

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ea0032p474 | Diabetes | ECE2013

Therapeutic swicht at discharge improves medium term metabolic control in patients with type 2 diabetes and high vascular risk

Javier Vilchez-Lopez Francisco , Belen Ojeda-Schuldt Maria , Mateo Gavira Isabel , Lopez-Tinoco Cristina , Roldan-Caballero Pilar , Aguilar-Diosdado Manuel

Objective: To evaluate the characteristics and glycemic control in admitted patients with type 2 diabetes and high vascular risk. To analyze therapeutic switch effect at hospital discharge on medium term metabolic control.Methods: Cross-sectional study including patients with type 2 diabetes and high vascular risk. Demographic and clinical characteristics, laboratory parameters, and diabetes treatment at baseline and discharge were analized. We used a sp...

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ea0032p475 | Diabetes | ECE2013

Abstract withdrawn....

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ea0032p476 | Diabetes | ECE2013

Impact on weight and glycemic control in patients with type 2 diabetes and obesity treated with liraglutide

Hernando Virginia , Morales Cristobal , Garcia Clara , Fernandez Ignacio , Serrano Isabel , Sendon Angel

Background and objectives: Evaluate the impact of therapy with GLP-1 analogues (liraglutide) on glycemic control and weight in patients with type 2 diabetes and poor metabolic control.Material and methods: We conducted a retrospective observational study analyzing 67 patients with type 2 diabetes mellitus and BMI >30 kg/m2, over 6 months of treatment. We evaluated HbA1c and weight at 3 and 6 months, performing statistical analysis with SPS...

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ea0032p477 | Diabetes | ECE2013

Short-term, temporary insulin degludec, an ultra-long-acting basal insulin, as compared with glargine on the glycemic control in Japanese patients with type 2 diabetes

Kaneko Shizuka , Tahara Yumiko , Sato Yuichi , Tashima Masao

Introduction: Insulin degludec (IDeg) is a new-generation insulin that forms soluble multi-hexamers after s.c. injection, resulting in ultra-long duration of action.Objective: We investigated the efficacy of glycemic control and safety on Japanese patients with type 2 diabetes who treated temporarily with IDeg or glargine and achieved target glucose level.Research design and methods: Ten Japanese subjects with type 2 diabetes (male...

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ea0032p478 | Diabetes | ECE2013

Perioperative liraglutide therapy for orthopedic patients with T2DM

Kaneko Shizuka , Katagiri Naoko , Tahara Yumiko , Sato Yuichi , Tashima Masao , Hamano Kumiko

Introduction: Diabetic patients with limited exercise during orthopedic perioperative period tend to gain weight, and their glycemic control frequently deteriorates. However, temporary insulin therapy has a risk of hypoglycemia. To investigate the efficacy and safety of perioperative liraglutide therapy, we performed a retrospective case analysis.Research design and methods: Twenty one Japanese patients with T2DM (male/female; 9/12, Age; 68.2±14.7 y...

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ea0032p479 | Diabetes | ECE2013

Insulinator: a computer program to help in the insulin therapy

Rodriguez Jose Perez , Portillo Cristobal Morales , Jimenez Virginia Hernando , Cobos Manuel Malagon , Olmedo Isabel Serrano , Perez Angel Sendon

Introduction and objectives: In clinical practice many professionals are involved in the diabetes treatment. To facilitate this work, we present a computer program, based in recommended guidelines, to improve the management of insulin therapy, called insulinator. We evaluated the correlation between these and clinical practice.Materials and methods: Insulinator has been made so that using a number of variables (weight, HbA1c and glycemic control) offer a...

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ea0032p480 | Diabetes | ECE2013

The long term effect of metformin plus DPP-4 inhibitor switching from metformin plus pioglitazone combination therapy in type 2 diabetes

Kim Yonghyun , Shin Donghyun

Two years ago, we presented the short term 6 month results of metformin plus DPP-4 inhibitor combination therapy when we cant reach the target below 7% of HgA1c with metformin plus pioglitazone combination that is best in terms of relieving insulin resistance in early diabetes.Switching the pioglitazone to the DPP-4 inhibitor that improves insulin secretory dysfunction can be the next useful step to attain glucose control goal and DPP-4 inhibitors ...

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ea0032p481 | Diabetes | ECE2013

Protective effects of Swietenia macrophylla King (seed & endocarp) aqueous-methanolic extract on pancreatic islet histology in streptozotocin-induced diabetic rats

Gopalan Hanan Kumar , Marican Nur Hayati Jafaar , Noah Rahim Mhd , Jais Rohani Mat

The oral antidiabetic drug, glibenclamide, stimulates the insulin producing β-cells constantly through a harsh mechanism which eventually may permanently reverse its endocrinofunction. The study investigates the protective effects from Swietenia seed and endocarp aqueous-methanol extract on pancreatic islets histology in rats of type 2 DM model. Phytochemical analyses were performed prior to the in vivo study to screen the aqueous-methanolic extract of the combin...

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ea0032p482 | Diabetes | ECE2013

Are there gender differences in liraglutide response in adults with type 2 diabetes?

Sastre Julia , Vicente Almudena , Maqueda Esther , Luque Ines , Castro Enrique , Marco Amparo , Pena Virginia , Lopez Jose

Background: Recent reports suggest that female sex could be an indicator of better response to liraglutide in patients included in clinical trials.Aim: To compare efficacy of liraglutide in women and men with type 2 diabetes mellitus (T2DM), in real clinical practice.Patients and methods: Our study included 116 patients with T2DM and obesity (BMI >30) attending outpatient clinic, which initiated with liraglutide (0.6 mg/daily f...

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ea0032p483 | Diabetes | ECE2013

Degree of glycemic control in treated type 2 diabetic patients who live in a district of Madrid, Spain

Canizo-Gomez Francisco Javier del , Silveira-Rodriguez Manuela Belen , Perez-Jauregui Carlos de Gorospe , Moreno-Ruiz Inmaculada , Gonzalez-Losada Tomas , Segura-Galindo Amparo

There is a direct relation between the degree of glycemic control and the incidence and progression of diabetic complications. In addition improving glycemic control improves diabetic complications.Aim: To assess the degree of glycemic control, according to published guidelines, in treated type 2 diabetes mellitus patients who live in a district of Madrid, Spain.Methods: Cross-sectional study in 501 consecutive patients with T2DM w...

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ea0032p484 | Diabetes | ECE2013

Copeptin: may it be a novel biomarker for insulin theraphy in subjects with diabetes?

Harman Ece , Dodurga Yavuz , Gundogdu Gulsah , Ayada Ceylan , Erken Gulten , Kucukatay Vural , Avci Cigir Biray , Genc Osman

Background and aim: As a prognostic marker, copeptin levels were independent predictors of survival in critically ill patients suffering from hemorrhagic and septic shock. Copeptin levels also have prognostic implications in chronic diseases other than acute illness. The stress-mediated activation of the HPA axis may be have role in the pathogenesis of the insulin resistance, metabolic syndrome, and diabetes. Furthermore, AVP action has been linked to liver glycogenolysis and ...

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ea0032p485 | Diabetes | ECE2013

Efficacy and safety of liraglutide in morbid obese patients in first year of commercialization in Spain

Molero Inmaculada Gonzalez- , Vallejo Rosario , Dominguez Marta , Garcia-Arnes Juan

Aim: To evaluate the efficacy and safety for first patients treated in our clinic with liraglutide.Methods: Retrospective study of patients who started treatment with liraglutide in the last year in our department. We collected data on age, years of evolution, chronic complications, previous treatment, physical examination, analytical parameters and side effects.Results: Fifty-four patients. Follow-up: 412 months. Mean age: 5...

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ea0032p486 | Diabetes | ECE2013

Evaluation of adolescents with type 1 diabetes after transition from paediatric to adult care

Dominguez-Lopez Marta , Gonzalez-Molero Inmaculada , Lopez-Siguero Juan Pedro , Navas MSoledad Ruiz de Adana , Escofet Federico Soriguer

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

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ea0032p487 | Diabetes | ECE2013

Insulin pump therapy as an obligatory treatment modality in a type 2 diabetic patient

Yilmaz Merve , Gedik Arzu , Demir Tevfik , Calan Mehmet , Gumus Tugba , Tunc Ulku Aybuke , Comlekci Abdurrahman , Yener Serkan , Eraslan Sevinc , Bayraktar Firat

Introduction: Continuous s.c. insulin infusion (CSII) therapy is a well documented treatment modality in type 1 diabetes mellitus (DM), but its usage in type 2 DM has not become prevalent so far. It may be a treatment alternative in severely insulin resistant type 2 diabetics recieving high doses of insulin. We present a type 2 diabetic patient that we had to shift from multiple dosage insulin (MDI) injection to CSII therapy due to the widespread echimosis at the insulin injec...

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ea0032p488 | Diabetes | ECE2013

Absence od metformin therapy and inadequate insulin doses are the basic features of diabetic patients with unregulated diabetes

Tesic Dragan , Mitrovic Milena , Benc Damir , Popovic Djordje

Introduction and objectives: The aim of our study was to determine which characteristics of the uncontrolled diabetes are among randomly selected patients with type 1 (T1DM) and type 2 (T2DM) diabetes.Material and methods: A total of 194 diabetic patients were observed, 142 with T2DM and 52 with T1DM, recruted in outpatient clinic. Patients were divided into three groups according to HbA1c values: <7% (G1), 78% (G2) and >8% (G3). Statistica...

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ea0032p489 | Diabetes | ECE2013

Analysis of the newly diagnosed diabetic patients, one year and five years of evolution, C-peptide, autoinmunity, treatment and metabolic control

Dominguez-Lopez Marta , Fernandez-Arias David , Gonzalez-Molero Inmaculada , Colomo Natalia , Adana Marisol Ruiz de , Soriguer Federico

Objective: We retrospectively analyzed patients with type 1 diabetes onset, attended during the years 2005 and 2006 on the specific query of type 1 DM debut of a tertiary hospital, with initial treatment assessment, at 1 and 5 years evolution.Results: Patients were treated for newly diagnosed DM 1, 25 patients (72% male, 28% female) mean age 23.2 years (1436), mean BMI: 23.18 (1833.8%).The clinical presentation included: 88.24% presented with...

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ea0032p490 | Diabetes | ECE2013

Assesment of diabetes knowledge evaluation in type 2 diabetic patients

Gonzalez-Molero Inmaculada , Dominguez Marta , Adana MArisol Ruiz de , Soriguer FEderico

Introduction: Research has demonstrated that knowledge about medications, diet, exercise, home glucose monitoring, foot care, and treatment modifications is necessary to effectively self-manage diabetes, and the assessment of diabetes-related knowledge is an important first step from which to individualize diabetes education programs and make evaluations of their effectiveness.Purpose: To assess the knowledge of diabetes mellitus (about the disease, its ...

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ea0032p491 | Diabetes | ECE2013

Advantages of using DPP-4 inhibitors in patients with type 2 diabetes mellitus and overweight

Rodriguez Jose Perez , Portillo Cristobal Morales , Pena Ignacio Fernandez , Olmedo Isabel Serrano , Mayor Maria del Carmen De la Cuesta , Perez Angel Sendon

Objective: Analyze the use of DPP-4 inhibitors (iDPP4) in a specialized consultation as well as metabolic impact, weight and safety in patients with diabetes mellitus type 2 (DM2).Material and methods: We analyzed 100 patients with DM2, derivative to Diabetes hospital with debut or poor glycemic control. We initiated them sitagliptin 100 mg/day and reinforced Diabetes education. We studied the HbA1c, weight and severe hypoglycemia. Statistical analysis w...

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ea0032p492 | Diabetes | ECE2013

Hypoglycemic evaluation of Swietenia macrophylla King combined seed and endocarp extracts: a comparative study between hot water extraction and aqueous-methanol extraction

Noah Rahim Mhd , Jaafar Nur Hayati Marican , Gopalan Hanan Kumar , Jais Mohamad Rohani

Solvent and process variables were critical to optimize the extractions of potential hypoglycemic compounds within medicinal plants. Hence, the undertaken study was designed to evaluate the hypoglycemic effectiveness exhibited by extraction performed in decoction manner using water as solvent and compares it with an aqueous-methanol solvent extraction. To evaluate the extractions prepared, phytochemical assays and in vivo study in induced-diabetic rats were carried ou...

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ea0032p493 | Diabetes | ECE2013

Evaluation of BICI therapy in pregestational type 1 diabetes

Roldan Pilar , Mateo Isabel , Ortego Jose , Baena Gloria , Larran Laura , Gavilan Inmaculada , Ojeda Belen , Tamayo Julian , Aguilar-Diosdado Manuel

Objective: To evaluate in our area BICI therapy efficacy in pregestational type 1 diabetes.Methods: We conducted a descriptive retrospective analysis studying metabolic control and obstetrics results in patients with pregestational type 1 diabetes, treated with BICI between 2004 and 2012 in our hospital.Results: We evaluated 28 patients with type 1 diabetes and diabetes duration of 17.3±6.6 years. In 27.3% of patients the trea...

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ea0032p494 | Diabetes | ECE2013

Quality indicator of glycemic status in patients with diabetes mellitus in primary health care in the Kyrgyz Republic

Omorova Elmirgul

Introduction: Basic medical care to patients with diabetes mellitus (DM) in Kyrgyzstan is on the primary care level, in family medicine centers.Methods: We have analyzed, in a random order histories of diseases of 928 outpatients observed and registered patients with diabetes in primary health care clinics, in Bishkek.Results: The basic amount of patients were women 656 (70.7%), and men 272 (29.3%) respectively. The mean age was 63...

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ea0032p495 | Diabetes | ECE2013

Pre-diabetes study in Libya: delay and prevention T2DM

Eltobgi Abduladim

T2DM is expected to rise to 552 million by 2030. DM is associated with complications which result in reduced quality of life and premature mortality.T2DM has a long asymptomatic pre-clinical phase (~510 years) which frequently goes undetected. Benefits of early diagnosis on outcomes in screen-detected DM remain unclear. Some indirect evidence suggesting that early detection and intervention may be beneficial.Screening for DM ...

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ea0032p496 | Diabetes | ECE2013

Molecular docking research analysis of novel natural and synthetic PTP 1B inhibitors as potential therapeutic target for diabetes mellitus

Ahmed Danish , Sharma Manju , Kumar Vikas , Subhashchandra Pankaj Yadav

Augmented pervasiveness of type 2 diabetes mellitus and obesity has amplified the medical necessitate for new agents to treat these disease states. Both type 2 diabetes and obesity are connected to the resistance to the hormones insulin and leptin. Protein tyrosine phosphatase 1B (PTP1B) has been shown to function as negative regulator of insulin signalling as well as leptin signal transduction. At present there are copious compounds synthesized as PTP1B inhibitors. The develo...

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