Searchable abstracts of presentations at key conferences in endocrinology
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15th European Congress of Endocrinology

Poster Presentations

Endocrine disruptors

ea0032p497 | Endocrine disruptors | ECE2013

Reproductive aging in rats is altered by developmental exposure to mixtures of endocrine disrupters

Boberg Julie , Isling Louise Krag , Christiansen Sofie , Axelstad Marta , Jacobsen Pernille , Hass Ulla

Long-lasting and/or delayed reproductive effects of developmental exposure to mixtures of environmental chemicals were investigated in rats. Wistar rats were exposed to mixtures of estrogenic or anti-androgenic endocrine disrupters in pregnancy and lactation, and effects in offspring at 12–18 months of age were studied. The mixture included 13 estrogenic and anti-androgenic chemicals, including phthalates, pesticides, u.v.-filters, bisphenol A, butylparaben and paracetamo...

ea0032p498 | Endocrine disruptors | ECE2013

An investigation about metabolic disruption: organostannic compounds as PPAR gamma agonists

Leao Isabella Gontijo de Sa , Amato Angelica Amorim , Amorim Natacha Thalita Santos , Cortes Leticia Mendes , Neves Francisco Assis Rocha

The parallel increase in the amount of environmental contaminants and in the prevalence of some human diseases has led to a growing interest in understanding how these compounds, so-called endocrine disruptors, may affect human health. In this scenario, the concept that obesity is the result of the interplay of genetic and lifestyle factors has been changing due to the growing evidence that environmental contaminants might alter endocrine function.Organo...

ea0032p499 | Endocrine disruptors | ECE2013

Tributyltin changes the thyroid gland morphology of male rats

Pereira Paula Rodrigues , Mattos Romulo Medina de , Palmero Celia Yelimar , Fortunato Rodrigo , Gracelli Jones Bernardes , Carvalho Denise Pires de , Nasciutti Luiz Eurico , Miranda-Alves Leandro

Triorganotins, such as tributyltin (TBT), are environmental contaminants commonly found in antifouling paints that are used on the ships and other vessels. Unfortunately, these chemical are also suspected to cause endocrine-disrupting effects in mammals, due in part to their possible transfer through marine food chains and to the consumption of contaminated seafood. The importance of triorganotins as environmental endocrine disruptors in different animal models is well known; ...

ea0032p500 | Endocrine disruptors | ECE2013

Sex hormone-induced gender differences in vascular muscle cells motility are susceptible to the environmental disruptors

Pellegrini Marco , Marino Maria

Sex steroid hormone-induced variations of vascular smooth muscle cells (VSMCs) migration are critical in determining the sex/gender-related differences in male and female pathophysiology of cardiovascular system. Although several substances present in the environment, defined endocrine disruptors (EDs), could interfere with androgen and estrogen effects, the sex/gender-related susceptibility of VSMC motility to these substances is completely unknown. Here, naringenin (Nar) and...

ea0032p501 | Endocrine disruptors | ECE2013

Vitamin E protects against methomyl-induced reproductive toxicity in pregnant female rats

Rachid Mosbah , Mokhtar Ibrahim Yousef

Purpose: The aim of this study was to evaluate the effects of methomyl 25%WP (Lannate, carbamate broad spectrum insecticide) on the reproductive parameters in female Wistar rats during pregnancy and the possible protective role of vitamin E against methomyl-induced toxicity.Methods: The animals were randomly divided into four groups, eight of each. Group I served as control; Group II received orally a dose of methomyl (Met, 10 mg/kg per day), Group III w...

ea0032p502 | Endocrine disruptors | ECE2013

Bisphenol-A modulates proliferation of human breast adenocarcinoma cells (MCF-7) by modulating apoptosis and cyclin-A

Havranek Tomas , Macho Ladislav , Fickova Maria

Endocrine disruptors represent exogenous substances that alter hormonal, reproductive, immune and homeostatic systems. Bisphenol-A (BPA) in the form of polymer is a part of polycarbonates used in plastics, food packing and medical devices. Incomplete BPA polymerization and cleavage of weak chemical bonds result in monomer release/leakage to the foods and beverages. Many studies have associated exposure to BPA with higher incidence of hormone-dependent mammary and prostate carc...

ea0032p503 | Endocrine disruptors | ECE2013

Protective potential of 17-beta-estradiol on membrane linked functions in aging female rats: a behavioral, biochemical and ultrastructural study

Kumar Pardeep , Kale R K , Baquer N Z

Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of b-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of estradiol is decreased.Objective: The objective of this study was to investigate neuroprotective potential of 17β estradiol (E2) treatment on the activities of acetyl...

ea0032p504 | Endocrine disruptors | ECE2013

Effects of chlorobenzenes on the histamine (HA) activated arginine-vasopressin (AVP) release – from rat pituitary cells

Valkusz Zsuzsanna , Molnar Zsolt , Hausinger Peter , Radacs Mariann , Galfi Marta , Palfoldi Regina , Jojart Bela

Introduction: The endocrine disruptor compounds (EDC), as persistent organic pollutant (POP) agents, have ability to interfere with endocrine systems. These properties of EDC may modify the homeostasis of biological organisms.Aim: The aim was to investigate the effects of chlorobenzenes (ClB), hexa-chlorobenzenes+2,4,6,trichloro-benzenes, with chronic exposure and extremely low doses on histamine mediated neuroendocrine functions.M...

ea0032p505 | Endocrine disruptors | ECE2013

Rise of obesity incidence in ChNPP accident survivors is related to abnormal secretion of α-melanotropin

Kaminskyi Oleksii , Afanasyev Dmytro , Kovalenko Oleksandr , Derevanko Ludmila , Atamanuk Natalia , Vakoluk Katerina

Introduction: Accident at the Chernobyl NPP (ChNPP) in Ukraine on the 26th of April, 1986 was followed by the intensive release of a wide range of radioactive elements with affinity to many endocrine tissues. The mentioned radioactive fallout resulted in both internal and external radiation exposure, among others, of the central endocrine structures of the human brain.Methods: We have conducted a retrospective analysis (20–25 years upon radiation ex...

ea0032p506 | Endocrine disruptors | ECE2013

Endocrine functions in premenopausal and postmenopausal women

Sarac Fulden , Savas Sumru , Akcicek Fehmi

Introduction: The anabolic hormones, namely GH, testosterone and dehydroepiandrosterone, as well as the reproductive function of women, enter a period of progressive insufficiency which is characteristically designated as somatopause, andropause and adrenopause respectively. The aim of the study was to compare the endocrine functions between premenopausal and postmenopausal women.Subjects and methods: The study was included 40 premenopausal (mean age 34....

ea0032p507 | Endocrine disruptors | ECE2013

Peutz Jegher syndrome with multiple endocrinal failures

Abdo Randa , Sherif Heba , Farag Ali , Nadi Mohamed , Darwoish Inas

Introduction: Peutz-Jeghers syndrome (PJS) is a rare familial disorder with an incidence of one in 12–30,000 live births characterized by mucocutaneous pigmentation, gastrointestinal and extra gastrointestinal hamartomatous polyps and an increased risk of malignancy.Case presentation: We report a 22-year-old female hypothyroid since age of 4, type 1 diabetic since age of 11, who presented with melaena. Pigmentation of the buccal mucosa, multiple lip...