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Endocrine Abstracts (2013) 32 P433 | DOI: 10.1530/endoabs.32.P433


Endothelial dysfunction in diabetes mellitus

Alexander Rozhko, Elena Rodzina, Irina Savasteeva & Maria Rusalenko


Republican Research Center for Radiation Medicine, Gomel, Belarus.

Objective: To identify the frequency of occurrence of endothelial dysfunction dorsalis pedis arteries in diabetes.

Materials and methods: patients with diabetes mellitus, with no complaints of the legs were examined (aged 40.25±3.12, duration of diabetes 12.50±1.25). Endothelial dysfunction was studied with high-resolution ultrasound (9 MHz) and diagnosed in the absence of growth in artery diameter in response to reactive hyperemia >10% or at the appearance of paradoxical vasoconstriction.

Results: Endothelial dysfunction was diagnosed in 39 patients (29.3%), while violation macrocirculation was confirmed in 19 patients (14.3%). Among patients with endothelial dysfunction blood flow disturbance in the arteries of the foot was diagnosed in 48.7%. The result of the discriminant analysis showed that increased levels of HbA1c>7.5%, cholesterol >6.5 mmol/l and triglycerides >1.7 mmol/l increase the risk of endothelial dysfunction. The risk of endothelial dysfunction also significantly increases with disease duration >5 years, and if there is hypertension in a case history. Total accuracy of the discriminant model was 82.5%, at P<0.05.

Conclusion: Endothelial dysfunction is an early indicator of clinical and instrumental form of angiopathy. The presence of hypertension and the lack of compensation of carbohydrate and lipid metabolism increase the risk of endothelial dysfunction.

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