Endocrine Abstracts

Introduction: Majority of polycystic ovary syndrome (PCOS) women are anovulatory, overweight/obese and insulin resistant. Kisspeptins are the endogenous ligands for GPR54 highly expressed in pancreas. Some studies showed that kisspeptins may play in the regulation of islet function and they stimulate insulin secretion from mouse and human islets. Adipose tissue acts as an endocrine organ and its function may be regulated by kisspeptins. We designed this study based on that obesity, insulin resistance and reproductive function changes may be a reflection of the disruptions in kiss system.

Methods: Forty women with PCOS recruited from the Endocrinology Clinic of Pamukkale University were studied. The diagnosis of PCOS was based on the revised criteria of the European Society of Human Reproduction an Embryology American Society for Reproductive Medicine in 2003. Anthropometric measurements were performed. A fasting blood sample was obtained in the morning for measurement of glucose, insulin, PRL, LH, FSH, estradiol, total testosterone(T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEA-S), 17-hydroxyprogesterone and TSH. Free androgen index and HOMA-IR values were calculated. Kisspeptin levels were also measured with an ELISA kit.

Results: We searched the relationship between metastin and degree of obesity and insulin resistance. Twenty-six PCOS woman were overweight/obese, the remaining 14 were normal weight. In our study, obese/overweight PCOS woman were more insulin resistant than non-obese. We found no correlation between the kisspeptin and body mass index, HOMA-IR values.

Conclusion: There are no much studies looking this relationship in the literature. In the literature, plasma kisspeptin levels were found lower in obese and insulin-resistant PCOS. This inaccordant result may be due to small sample size or sex steroid effects on kisspeptin levels.