Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2014

Oral Communications

Young Endocrinologists prize session

ea0034oc1.1 | Young Endocrinologists prize session | SFEBES2014

The Thr92Ala substitution in deiodonase-2 is associated with increased odds of a sub-optimal IQ score in children with low-normal thyroid function

Taylor Peter , Okosieme Onyebuchi , Sayers Adrian , Northstone Kate , Draman Mohd , Stevenson Kirsty , Woltersdorf Wolf , Taylor Andrew , Pearce Elizabeth , Panicker Vijay , Ludgate Marian , Gregory John , Lazarus John , Timpson Nicholas , Channon Sue , Dayan Colin

Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability – free thyroxine in t...

ea0034oc1.2 | Young Endocrinologists prize session | SFEBES2014

Characterisation of adrenocortical progenitor cells: isolation of mesenchymal stem cell-like cell populations from human adrenal cortex

Gan Earn , Robson Wendy , Lennard Thomas , Pearce Simon , Oldershaw Rachel

Background: The plasticity of adrenal cortex suggests the presence of adrenocortical stem cells (ACSC) but the exact in vivo identity of ACSC remains elusive. A few studies have demonstrated the differentiation of adipose or bone marrow-derived mesenchymal stem cells (MSC) into steroid-producing cells. We therefore investigated the direct isolation of MSC from human adrenal cortex.Methods: Adrenals were obtained as discarded surgical material. S...

ea0034oc1.3 | Young Endocrinologists prize session | SFEBES2014

Angiogenic factors sFlt1 and PlGF are novel determinants of newborn thyroid (dys)function: the Generation R Study

Korevaar Tim , Schalekamp-Timmermans Sarah , Visser Theo , de Rijke Yolanda , Visser Edward , Visser Willy , de Muinck Keizer-Schrama Sabine , Hofman Albert , Hooijkaas Herbert , Tiemeier Henning , Bongers-Schokking Jacoba , Jaddoe Vincent , Steegers Eric , Medici Marco , Peeters Robin

Introduction: Adequate thyroid hormone availability during early life is crucial for normal child growth and development. Fetal growth in utero heavily depends on angiogenesis. Placental growth factor (PlGF) is a proangiogenic factor sharing high homology with vascular endothelial growth factor (VEGF) whereas soluble FMS-like tyrosine kinase-1 (sFlt1) is a potent antagonist of VEGF and PlGF signaling. Since the thyroid is a highly vascularized organ, we hypothesized t...

ea0034oc1.4 | Young Endocrinologists prize session | SFEBES2014

Single molecule analysis of GPCR transactivation reveals oligomeric complexes that regulate signal sensitivity

Jonas Kim , Fanelli Francesca , Huhtaniemi Ilpo , Hanyaloglu Aylin

G protein-coupled receptors (GPCRs) are the largest family of mammalian receptors, modulating most aspects of endocrine homeostasis. GPCRs can associate to form dimers and higher order oligomers, acting to diversify receptor functionality. Most studies have explored the functional significance of GPCR dimerization in vitro and we have recently demonstrated the functional relevance of GPCR dimerization in vivo. Using the LH receptor (LHR), we have shown that t...

ea0034oc1.5 | Young Endocrinologists prize session | SFEBES2014

Kisspeptin: a novel physiological trigger for oocyte maturation in IVF treatment

Abbara Ali , Jayasena Channa , Comninos Alexander , Nijher Monica , Christopoulos Georgios , Izzi-Engbeaya Chioma , Sridharan Mathini , Narayanaswamy Shankunthala , Ashby Deborah , Ghatei Mohammad , Bloom Steve , Carby Anna , Trew Geoffrey , Dhillo Waljit

Background: IVF is an effective treatment for infertility, but can cause the ovarian hyper-stimulation syndrome (OHSS), which is associated with serous effusions, cardiac tamponade, circulatory collapse, and even death. Injection of human chorionic gonadotrophin (hCG) stimulates oocyte maturation during IVF, but is also the major cause of OHSS. The hypothalamic neuropeptide kisspeptin, stimulates endogenous LH secretion in a GnRH-dependent manner. A more physiological stimulus...

ea0034oc1.6 | Young Endocrinologists prize session | SFEBES2014

A loss-of-function mutation in the prolactin receptor causes familial hyperprolactinaemia

Gorvin Caroline , Newey Paul , Cleland Stephen , Willberg Christian , Bridge Marcus , Azharuddin Mohammed , Drummond Russell , van der Merwe Anton , Klenerman Paul , Bountra Chas , Thakker Rajesh

The prolactin receptor (PRLR) is a member of the class I cytokine receptor family that signals predominantly through the JAK2–STAT5 pathway. To date, PRLR mutations have not been established to be associated with any disorders. Here, we report a PRLR mutation (His188Arg) that caused familial hyperprolactinaemia in three sisters, two of whom presented with oligomenorrhea and one with infertility. The hyperprolactinaemia was not associated with pituitary tumours, which were...