Endocrine Abstracts

Disorders of thyroid hormone action are classified broadly, to encompass conditions with defective cellular uptake, metabolism or nuclear action of thyroid hormones. Mutations in SECISBP2 cause a multisystem disorder of defective selenoprotein synthesis, with features due to tissue-specific selenoprotein deficiencies (e.g. male infertility, muscular dystrophy), raised cellular reactive oxygen species due to lack of antioxidant selenoenzymes (e.g. photosensitivity, increased ad...

Professor K ChatterjeeKrishna Chatterjee is Professor of Endocrinology at the University of Cambridge, and a Wellcome Trust Senior Investigator. His research interests in genetic and molecular endocrinology include Disorders of Thyroid Hormone Action. He co-directs a national referral laboratory for unusual and discordant thyroid function tests in Cambridge....