Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2014

Poster Presentations

Cytokines and growth factors

ea0034p155 | Cytokines and growth factors | SFEBES2014

Modelling hepatic encephalopathy in vitro: molecular and functional consequences of hyperammonaemia in C6 glioma cells

Mirczuk Samantha , Robson Camille , Stacey Emily , Fowkes Robert , Lipscomb Victoria

Hepatic encephalopathy (HE), a syndrome of neurological abnormalities caused by impaired liver function, is induced by many chronic liver diseases, such as liver failure or hepatic portosystemic shunts. Whilst multiple substances reach toxic levels in the systemic circulation of HE patients, hyperammonemia (excessive ammonia) is known to be a major contributing factor to the neurological disturbances. Astrocytes utilise ammonia in generating glutamine leading to brain oedema a...

ea0034p156 | Cytokines and growth factors | SFEBES2014

Spatial expression profiling reveals tissue-specific sexual dimorphism of the natriuretic peptide system in mice

Mirczuk Samantha , Robson Camille , Robinson Benjamin , Lessey Andrew , Lipscomb Victoria , McGonnell Imelda , Fowkes Robert

The mammalian natriuretic peptide family consists of three members, Atrial-, B-type, and C-type natriuretic peptides (ANP, BNP, and CNP respectively), and exert their effects on blood pressure, sodium homeostasis, growth and reproduction, via their selective guanylyl cyclase receptors, GC-A or GC-B. Previous attempts to map spatial expression profiling have generated conflicting results, due predominantly to the range of techniques employed, and the relative paucity of tools t...

ea0034p157 | Cytokines and growth factors | SFEBES2014

The remote organ effects of acute kidney injury in a porcine model

Dunford Louise , Gardner David , Duckworth Benjamin , O'Sullivan Saoirse , Devonald Mark

Background: Acute kidney injury (AKI) is common and serious, with no specific treatment. AKI may increase the risk of dysfunction in organs other than the kidney, further increasing the morbidity associated with AKI. The mechanisms of organ cross-talk after AKI are unclear. Small animal models have suggested that infiltration of inflammatory cytokines into extra-renal organs leads to cellular extravasation, oedema and further injury. In this study we used a large animal model ...