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16th European Congress of Endocrinology

Oral Communications

Adrenal & Thyroid

ea0035oc5.1 | Adrenal & Thyroid | ECE2014

Diagnostic and therapeutic outcome in ERCUSYN: Preliminary report in over 1000 patients

Valassi Elena , Santos Alicia , Brue Thierry , Netea-Maier Romana T. , Feelders Richard A. , Yaneva Maria , Tsagarakis Stylianos , Pfeifer Marija , Chanson Philippe , Chabre Olivier , Zopf Kathrin , Toke Judit , Wass John AH , Droste Michael , Maiter Dominique , Dusek Tina , Komerdus Irina , Franz Holger , Lamberts Steven W.J. , Strasburger Christian J.

The European Registry on CushingÂ’s Syndrome (ERCUSYN) is designed to collect prospective and follow-up data on patients with CushingÂ’s syndrome (CS) and currently (Sep 2013) includes 1006 patients (804 F, 202 M; mean age (+S.D.) 44.7±13.3 years) from 57 centers in 28 countries.Six hundred and sixty one (66%) had pituitary-dependent CS (PIT-CS), 242 (24%) adrenal-dependent CS (ADR-CS), and 103 (10%) CS from other etiologies, ...

ea0035oc5.2 | Adrenal & Thyroid | ECE2014

Relationship between final height and cardiometabolic risk and quality of life in adults with congenital adrenal hyperplasia: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

Han Thang S , Conway Gerard S , Krone Nils , Aled Rees D , Stimson Roland H , Arlt Wiebke , Walker Brian R , Ross Richard J

Background: Treatment of CAH in childhood focuses on growth and development; however the impact of final height (FH) on adult health is not known. We examined the relationship between FH, adiposity, cardiometabolic risk and quality of life (QoL) in a cohort of adult patients.Methods: Cross-sectional analysis of 199 adults with CAH. FH, waist circumference (WC) and QoL were expressed as z-scores adjusted for mid-parental target height (FHTH<...

ea0035oc5.3 | Adrenal &amp; Thyroid | ECE2014

Mitotane induces endoplasmic reticulum stress triggering apoptosis and decrease of steroid hormone synthesis

Sbiera Silviu , Wiemer Laura , Leich Ellen , Gehl Annemarie , Gardill Felix , Ronchi Cristina L. , Bala Margarita , Schirbel Andreas , Rosenwald Andreas , Allolio Bruno , Fassnacht Martin , Kroisz Matthias

Background: Mitotane is the only drug approved for treatment of adrenocortical carcinoma (ACC). Molecular events leading to cell death in adrenocortical cells are unknown preventing the development of drugs with improved efficacy-toxicity ratio.Methods: We employed the ACC model cell line NCI-H295 to investigate the effects of mitotane on genome-wide mRNA expression using microarray analysis. Several algorithms were used to delineate signaling pathways t...

ea0035oc5.4 | Adrenal &amp; Thyroid | ECE2014

MUC-1 – a novel preclinical model for adrenocortical carcinoma

Hantel Constanze , Jung Sara , Chiapponi Costanza , Mussack Thomas , Reincke Martin , Beuschlein Felix

Only two human cell lines are available for adrenocortical carcinoma (ACC) which do not reflect the functional heterogeneity of individual patient tumors and metastases. To overcome the lack of preclinical models for testing of novel therapeutic options in recent years we aimed at the development of patient-individual tumor models for endocrine tumors. Therefore, pieces of surgically excised patient tumors were implanted subcutaneously in the neck of athymic nude mice. To inve...

ea0035oc5.5 | Adrenal &amp; Thyroid | ECE2014

Validation of follicular thyroid cancer molecular classifier in fine-needle aspiration biopsy samples

Pfeifer Aleksandra , Bartosz Wojtas , Malgorzata Oczko-Wojciechowska , Aleksandra Kukulska , Agnieszka Czarniecka , Markus Eszlinger , Thomas Musholt , Tomasz Stokowy , Ewa Stobiecka , Jolanta Krajewska , Dagmara Rusinek , Tomasz Tyszkiewicz , Monika Kowal , Michal Jarzab , Steffen Hauptmann , Dariusz Lange , Ralf Paschke , Barbara Jarzab

Introduction: Follicular adenomas (FTA) and carcinomas (FTC) are thyroid tumours that are indistinguishable in the fine needle aspiration biopsy (FNAB). In our previous research we concentrated on post-operative material and developed the classifier, which discriminates the FTC and FTA, based on formalin-fixed paraffin-embedded (FFPE) material. The classifier was based on expression of five genes and gave the promising sensitivity of 71% and specificity of 72%. The aim of the ...