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16th European Congress of Endocrinology

Oral Communications

Neuroendocrinology & Signalling

ea0035oc3.1 | Neuroendocrinology & Signalling | ECE2014

Constant intravenous infusion of kisspeptin-54 restores LH pulsatility in women with hypothalamic amenorrhoea

Jayasena Channa , Abbara Ali , Comninos Alexander , Veldhuis Johannes , Nihjer Gurjinder , Ganiyu-Dada Zainab , Mehta Amrish , Todd Catriona , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Background: Women with hypothalamic amenorrhoea (HA) have reduced LH pulsatility causing amenorrhea and infertility. Estrogen supplementation provides symptomatic relief for women with HA, but does not restore the pulsatile pattern of LH secretion which necessary for fertility. Kisspeptin-54 is a recently identified hormone, which potently stimulates GNRH secretion within the hypothalamus. The effect of exogenous kisspeptin-54 administration on LH pulsatility in women with HA ...

ea0035oc3.2 | Neuroendocrinology & Signalling | ECE2014

Copeptin in the diagnosis and differential diagnosis of diabetes dnsipidus – the ‘CoSIP-study’

Timper Katharina , Fenske Wiebke , Katan Mira , Kuehn Felix , Arici Birsen , Frech Nica , Rutishauser Jonas , Kopp Peter , Allolio Bruno , Stettler Christoph , Mueller Beat , Christ-Crain Mirjam

Introduction: The correct differential diagnosis of the disorders related to polyuria–polydipsia syndrome (PPS) is mandatory since inadequate treatment may lead to serious complications. The diagnostic gold standard is the water deprivation test (WDT) with direct or indirect measurement of plasma vasopressin (AVP). But test interpretation is problematic, and direct measurement of AVP is hampered by methodological difficulties. The aim of this study was to evaluate the dia...

ea0035oc3.3 | Neuroendocrinology & Signalling | ECE2014

Evidence for interaction between the β2-adrenergic and the insulin receptor

Mandic Maja , Drinovec Luka , Glisic Sanja , Veljkovic Nevena , Nohr Jane , Vrecl Milka

Functional interplay between different classes of receptors has emerged as a notable factor of cellular response in health and disease. One of the most prominent examples of cross-talk involves the regulation of glucose metabolism, a major regulatory function under the influence of both insulin receptor (IR) and β2-adrenergic receptor (β2-AR) representing the receptor tyrosine kinases (RTKs) and the seven transmembrane receptors (7TMRs) respecti...

ea0035oc3.4 | Neuroendocrinology & Signalling | ECE2014

Role Of thyroid hormone receptor β expression in lymphangiogenesis in breast carcinoma

Martinez-Iglesias Olaia , Aranda Ana

Lymphangiogenesis is a very important event in breast cancer development and VEGF-C and D factors play an essential role in this process. Tumoral invasion of lymphatic vessels facilitates metastasis formation and is a bad pronostic marker in this pathology. Although the thyroid hormone receptors (TRs) are ubiquitously expressed in normal tissues, inactivation and mutations of the TRβ gene are usual events in breast cancer, suggesting that the native receptors could act as...

ea0035oc3.5 | Neuroendocrinology & Signalling | ECE2014

NTRK3 receptor expression is strictly associated with medullary thyroid cancer RET mutation status

Oczko-Wojciechowska Malgorzata , Swierniak Michal , Kowalska Malgorzata , Pawlaczek Agnieszka , Kowal Monika , Tyszkiewicz Tomasz , Zebracka-Gala Jadwiga , Rusinek Dagmara , Gawlik Tomasz , Krajewska Jolanta

Aim of the study: Medullary thyroid cancer (MTC) occurs as hereditary and sporadic form. Hereditary type is a consequence of RET proto-oncogene germline mutations also somatic RET mutations are detectable in sporadic MTC tumors. There is a significant relation between site of mutation and the cancer phenotype as well as a clinical course of the MEN 2 Syndrome as a consequence of the different transforming potential of the RET gene mutations. The aim ...