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16th European Congress of Endocrinology

Poster Presentations

Calcium and Vitamin D metabolism

ea0035p101 | Calcium and Vitamin D metabolism | ECE2014

Predictive value of early phosphate measurement in post-thyroidectomy hypocalcemia: a prospective study

Vural Selahattin , Kement Metin , Yegen Fatih , Eser Mehmet , Kaptanoglu Levent

Background: The aim of this study is to compare the value of phosphate measures, which may predict the development of hypocalcemia in the early post operative period following total thyroidectomy, to iPTH and Ca measurements.Metods: In this prospective study, patients who underwent total thyroidectomy in our clinic between March 2012 and April 2013, independent of diagnosis were included in a consecutive manner. Venous blood samples for calcium (Ca2...

ea0035p102 | Calcium and Vitamin D metabolism | ECE2014

The effect of FGF23 on renal phosphorus handling is dependent on PTH secretion

Morrin Michelle , O'Keane Myra , Kilbane Mark , McKenna Malachi

Background: Chronic hypophosphataemia due to renal phosphorus wasting results in bone disease (rickets and osteomalacia). The principal regulators of renal phosphorous handling are parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). X-linked hypophosphatemic (XLH) rickets is the most common genetic disorder of renal phosphorus wasting; acquired disorders include tumour-induced osteomalacia (TIO). The aims of this study were: i) to assess the clinical utility of ...

ea0035p103 | Calcium and Vitamin D metabolism | ECE2014

Screening of genes involved in cAMP-mediated signalling in a large Italian series of patients affected with Albright hereditary osteodystrophy and/or Pseudohypoparathyroidism

Elli Francesca Marta , Bordogna Paolo , de Sanctis Luisa , Spada Anna , Mantovani Giovanna

The term pseudohypoparathyroidism (PHP) defines a heterogeneous group of rare, related and deeply impairing metabolic diseases due to end-organ resistance to the actions of PTH, associated to molecular defects at the GNAS locus. Different subtypes of PHP have been described based on the existence of additional clinical features, such as resistance to other hormones acting via GPCRs and Albright’s hereditary osteodystrophy (AHO). Recently, the detection in a small subset o...

ea0035p104 | Calcium and Vitamin D metabolism | ECE2014

Neurological manifestations of vitamin D deficiency, is there any significant clinical correlation?

Qari Faiza'

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of vitamin D deficiency and the levels of 25(OH)D and bone profile.Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2011 and December 2012. We collected information on demographic data, etiological factors for vitamin D deficiency, clinical pre...

ea0035p105 | Calcium and Vitamin D metabolism | ECE2014

Brown tumor in a patient with ectopic mediastinal parathyroid adenoma: a case report

Qari Faiza , Nasser Tariq

Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism.Case: A 55-year-old Saudi woman was admitted to King Abdulaziz University Hospital (Jeddah) with a complaint of anterior maxilla mass of one month duration. Her medical history was unremarkable.Initial examination revealed a painful mass in the anter...

ea0035p106 | Calcium and Vitamin D metabolism | ECE2014

Biochemical response and imaging changes in 99mtc-mibi in patiens with primary hyperparathyroidism treated with Cinacalcet

Munoz-Garach Araceli , Fernandez-Garcia Diego , Molina-Vega Maria , Sebastian-Ochoa Arantzazu , del Valle-Torres Maria Dolores Martinez , Amrani-Raissouni Tomader , Jimenez-Hoyuela Garcia Jose Manuel , Tinahones-Madueno Francisco Jose

Introduction: Treatment with Cinacalcet results in decreased uptake of radiopharmaceutical (because of decreased secretory activity of parathyroid glands as shown by previous studies in secondary hyperparathyroidism). This effect has not been studied in patients with primary hyperparathyroidism (PHPT).Objective: Evaluate clinical and MIBI scintigraphy uptake changes of adenomas in patients treated with Cinacalcet.Patients and metho...

ea0035p107 | Calcium and Vitamin D metabolism | ECE2014

Reversal heart failure secondary to severe hypocalcaemia

Salam Randa , Saaid Nashwa

Introduction: Clinical manifestations of hypocalcaemia vary from very mild and asymptomatic biochemical abnormality to severe life-threatening disorders. Heart failure due to hypocalcaemia is refractory to conventional treatment. Many clinicians may be unaware of hypocalcaemia associated with heart failure, since it is often ignored. Hypocalcaemia heart failure is a rare and potentially reversible disturbance, The decompensated heart failure is rapidly reversed by aggressive c...

ea0035p108 | Calcium and Vitamin D metabolism | ECE2014

Novel mutation of the AIRE gene in Iranian patients with autoimmune polyglandular syndrome type 1

Vakili Rahim , Manshadi Hossain Dehghan , Abbaszadegan Mohhamad Reza , Ghaemi Nosrat , Ghaemi Marta

Autoimmune pollyendocine type 1 (APS1) is a rare inherited autosomal recessive disorder. Typical symptom appears in within the first decade of life and followed by adrenocortical insufficiency, mucocutaneous candidiasis, Addison’s disease, and hypoparathyroidism. The clinical phenotype of APECEP is depends on mutations in autoimmune regulator gene (AIRE) which mapped to chromosome 21q22.3. We analyzed AIRE gene in subject to identify AIRE gene variants a...

ea0035p109 | Calcium and Vitamin D metabolism | ECE2014

Effect of vitamin D concentration on pregnancy, health of pregnant women, and newborn

Skowronska-Jozwiak Elzbieta , Lebiedzinska Katarzyna , Smyczynska Joanna , Lewandowski Krzysztof , Pniewska-Siark Barbara , Glowacka Ewa , Lewinski Andrzej

Introduction: In pregnant women there is a twofold increase in synthesis of calcitriol, i.e. the active metabolite of vitamin D. Literature data point to adverse effects of vitamin D deficiency during pregnancy both for pregnant woman and foetus. Polish data on the effects of vitamin D deficiency in this group are scarce.Aim of the study: The aim of this study was to evaluate the relationship between vitamin D3 concentrations in pregnant women on health ...

ea0035p110 | Calcium and Vitamin D metabolism | ECE2014

A case of post-operative hypoparathyroidism

Kumar Pranav , Jones M Keston

Case history: A 41-year-old lady had Total Thyroidectomy in 2007 for a large multi-nodular goitre. Post-operatively, she was hypocalcemic with mild inappropriately low Pth levels. She was treated with high dose α-calcidol and calcium supplements but the response was suboptimal. Following introduction of teriparatide, serum calcium has been improving to between 1.90 and 2.06 mmol/l. She continues on high dose α-calcidol.Investigations: Corrected...

ea0035p111 | Calcium and Vitamin D metabolism | ECE2014

Bone and vitamin D status in young male patients with relapsing kidney lithiasis and hypercalciuria

Branisteanu Dumitru , Pricop Catalin , Serban Lacramioara , Serban Dragomir , Gatu Alina , Velicescu Cristian , Ungureanu Didona , Mogos Voichita

Introduction: Idiopathic hypercalciuria is a risk factor for nephrolithiasis. Both renal stones and hypercalciuria are often associated with lower bone mineral density (BMD), but the relationship between these modifications is not completely understood. We aimed to evaluate some metabolic particularities possibly related to relapsing nephrolithiasis in young male patients.Methods: We performed a cross-sectional study including a group of 30 young male pa...

ea0035p112 | Calcium and Vitamin D metabolism | ECE2014

Surgery for primary hyperparathyroidism: a 10 years single-centre experience

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Manzanares Alvaro Garcia , Gomez-Alfonso Francisco , Lopez-Gallardo Gema , Lopez-Iglesias Maria , Gomez-Garcia Ines

Objective: To describe the clinical characteristics and post-surgical outcome of our primary hyperparathyroidism case series.Methods: A retrospective cohort study of primary hyperparathyroidism patients who underwent surgery in the last 10 years in our centre. The medical records were reviewed to extract data. A statistical descriptive analysis was performed using mean and S.D. for continuous variables and percentages for qualitative varia...

ea0035p113 | Calcium and Vitamin D metabolism | ECE2014

Severe hypomagnesemia due to long-term PPI use

Yetkin Demet Ozgil

A 73-year-old woman, admitted to emergency room due to generalized tonic–clonic seizures. She had a previous history of muscle cramps and paresthesia for 4 months. She had a medical history of peptic ulcer and she was taking omeprazole for 7 years. Her laboratory evaluation showed marked hypomagnesemia (<0.4 mg/dl normal ranges: 1.7–2.55 mg/dl) and hypocalcemia (6.83 mg/dl and normal ranges: 8.8–10.2 mg/dl) with extremely low urinary Ca and Mg excretion (&#6...

ea0035p114 | Calcium and Vitamin D metabolism | ECE2014

A novel mutation in GATA3 gene in HDR syndrome

Kim Doo-Man , Yang Seung , Park Juri , Son Ho Young

The combination of hypoparathyroidism, sensorineural deafness and renal dysplasia, named HDR syndrome, is a rare disease. Heterozygous abnormalities of GATA3 gene are associated with this syndrome. Here we report a novel heterozygous mutation, c.255_256ins4 (GTGC), in GATA3 gene. A 41-year-old man was diagnosed as having idiopathic hypoparathyroidism and has been treated with 1α-hydroxyvitamin D3 and calcium carbonate. Three years later, he had a hearing...

ea0035p115 | Calcium and Vitamin D metabolism | ECE2014

Correlations of vitamin D level with hormonal and biochemical parameters in polycystic ovary syndrome

Kucur Suna Kabil , Gozukara Ilay , Yilmaz Havva , Aksoy Aysenur , Uludag Eda Ulku , Uzkeser Hulya , Kaya Yasemin , Ademoglu Esra , Carlioglu Ayse , Durmaz Senay Arikan

Objective: To investigate the level of 25(OH) vitamin D (25(OH)D) and correlation between 25(OH)D level and hormonal-biochemical parameters in polycystic ovary syndrome (PCOS).Materials and methods: Thirty-three patients diagnosed with PCOS and 42 age and BMI matched control group admitted to Erzurumm Regional Training and Research Hospital from May to October were included in the study. Serum total testosterone (TT), free testosterone (fT), 25(OH)D, DHE...

ea0035p116 | Calcium and Vitamin D metabolism | ECE2014

Cardiovascular view and QT interval in primary hyperparathyroidism

Dokupilova Adriana , Payer Juraj

Introduction: Primary hyperparathyroidism (pHPT) is the unregulated overproduction of parathyroid hormone resulting in abnormal calcium homeostasis. The prevalence has been reported to be ~21 cases/100 000 person-years. The mean age at diagnosis has remained between 52 and 56 years with female-to-male ratio 3:1. In ~85% of cases, pHPT is caused by a single adenoma, in 14% of hyperplasia and 1% is caused by malignant diseases. Association between pHPT and cardiovascular manifes...

ea0035p117 | Calcium and Vitamin D metabolism | ECE2014

New vitamin D less-calcemic analog affects human bone cell line and cultured vascular smooth muscle cells similar to other analogs

Somjen Dalia , Kulesza Urszula , Sharon Orli , Knoll Esther , Stern Naftali

Vitamin D receptors (VDRs) are expressed in bone and vascular cells which also respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis and energy metabolism measured by CK specific activity. We have previously observed that vitamin D-related compounds target several genes which affect cell proliferation, including mRNA expression of estrogen receptor (ER)α, ERβ, VDR, 1α hydroxylase of 25OHD3 (1OHase) and 12 and 15 lipoxygenas...

ea0035p118 | Calcium and Vitamin D metabolism | ECE2014

The relationship with plasma calcium levels, metabolic syndrome, and risk parameters in overweight and obese Turkish women

Ipek Emel , Ucer Mehtap , Cikim Ayse , Tanyolac Sinan

Introduction: Obesity prevalance is rapidly increasing all over the world and become a serious health problem. There is a significant correlation between serum calcium levels and body fat mass. It was indicated that when plasma calcium levels increase, BMI decrease however, insulin, total cholesterol, and triglycerides levels increase. In this study, it was investigated the relationship between plasma calcium levels and cardiovascular risk factors and metabolic syndrome parame...

ea0035p119 | Calcium and Vitamin D metabolism | ECE2014

Levels of vitamin D in patients with various endocrine disorders

Pigarova Ekaterina , Dzeranova Larisa , Rozhinskaya Liudmila , Il'in Alexander , Melnichenko Galina

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

ea0035p120 | Calcium and Vitamin D metabolism | ECE2014

Calcium metabolism in a child with type 1 diabetes mellitus and familial Mediterranean fever

Bayburdyan Gayane , Arakelyan Lusine , Akopyan Sergej , Aghajanova Yelena

Introduction: Recent studies demonstrate decrease in vitamin D3 level and bone mineral density in more than 50% of type 1 diabetes (T1DM) patients. It is also suggested that vitamin D deficiency in familial mediterranean fever (FMF) patients may trigger the disease flare. These patients are at high-risk of other autoimmune diseases, as well as described combination of FMF, celiac disease, and autoimmune thyroiditis. However, there are only two case reports on combination of FM...

ea0035p121 | Calcium and Vitamin D metabolism | ECE2014

Retrospective evaluation of patients with primary hyperparathyroidism in Konya Meram Faculty of Medicine

Turan Elif , Kaya Ahmet , Savut Bulent , Gonulalan Gulsum , Kulaksizoglu Mustafa

Introduction: Primary hyperparathyroidism (PHP), is generalized with calcium, phosphate, and bone metabolism disorder due to increased PTH secretion. It’s common in fifth and sixth decades. Nowadays, it’s widely detected by measurement of blood calcium and may be presented with minimal or no symptoms.Design: 102 patients with PHP admitted to Department of Endocrinology, between years of 2008–2013 were analyzed.Result...

ea0035p122 | Calcium and Vitamin D metabolism | ECE2014

Frequency of BsmI polymorphism of vitamin D receptor gene and its association with 25-hydroxyvitamin D levels

Babur Huseyin , Kaya Ahmet , Turan Elif , Polat Ilker , Kulaksizoglu Mustafa , Yildirim Mahmut Selman , Zamani Aysegul

Introduction: Vitamin D deficiency has become a major public health problem. It’s known that the effects of vitamin D are made by its receptors. VDR gene polymorphisms in susceptibility to different diseases demonstrated in many studies. The polymorphisms of VDR are ApaI, TaqI, FokI, and BsmI. BsmI is the most extensively studied polymorphism. In our study, the aim is to show the frequency of VDR BsmI gene polymorphisms and to show the relationship between polymorphisms a...

ea0035p123 | Calcium and Vitamin D metabolism | ECE2014

Correlation between 25-OH vitamin D3 and TSH concentration in population over 65: preliminary report

Przybylska- Just Joanna , Bronczyk-Puzon Anna , Nowak Justyna , Koszowska Aneta , Dittfeld Anna , Jagielski Pawel , Zubelewicz-Szkodzinska Barbara

Introduction: Active metabolites of vitamin D have pleiotropic influence on whole body.Aim: The aim of the study was evaluation of the correlation between vitamin D3 and TSH values in population over 65.Materials and methods: 94 patients admitted to diagnosis on Geriatric Department entered the study. People with age above 65 were included to research and divided on two groups according to sex. The material samples were obtained fr...

ea0035p124 | Calcium and Vitamin D metabolism | ECE2014

Correlation among arm circumference index, 25-OH vitamin d3 concentration and lipid profile in patients over 65 years: preliminary study

Nowak Justyna , Przybylska-Just Joanna , Koszowska Aneta , Bronczyk-Puzon Anna , Dittfeld Anna , Jagielski Pawel , Agata Kulpok , Zubelewicz-Szkodzinska Barbara

Introduction: Anthropometric parameters such as: waist circumference, hips circumference, or arm circumference allow to find a correlation between the obesity and the risk of some metabolic disturbances (for example arm circumference index of upper part indicates the level of protein storage in the body).Aim: The aim of the study was to assess the correlation among the arm circumference index, concentration of 25-OH vitamin D3 and lipid profile parameter...

ea0035p125 | Calcium and Vitamin D metabolism | ECE2014

First seizure presentation in an elderly woman with primary vitamin D deficiency: a case report

Arpaci Dilek , Yilmaz Ulku , Yaylaci Selcuk , Colbay Mehmet , Tamer Ali

Introduction: Vitamin D insufficiency is common in older people and is associated with several disorders related to aging such as osteoporosis, which leads to a significantly increased risk of bone fractures. This deficiency is more common in Mediterranean countries than in Northern European countries. Hypocalcemic seizures resulting from vitamin D deficiency are rare in adults, and fractures caused by seizures without evidence of direct trauma have not yet been reported.<...

ea0035p126 | Calcium and Vitamin D metabolism | ECE2014

Primary hyperparathyroidism presented with peripheral brown tumor in the oral cavity: a case report

Elbuken Gulsah , Ozan Bora , Ozturk Onur , Yazicioglu Bahadir , Kazak Zulay , Aktimur Recep , Kececi Ilsen Semiha , Kolcu-Bulbul Sema , Demirag Mehmet Derya

Brown tumor is a non-neoplastic lesion which resulting from abnormal bone metabolism caused by hyperparathyroidism. We report a rare case of peripheral brown tumor related with primary hyperparathyroidism which simulating a peripheral giant cell granuloma of the jaws.Introduction: PHPT occurs in a setting of excessive parathyroid hormone (PTH) secretion which resulting in hypercalcemia.Case report: A 50-year-old man was admitted to...

ea0035p127 | Calcium and Vitamin D metabolism | ECE2014

VDR gene polymorphisms in Alzheimer's disease: pilot study

Laczmanski Lukasz , Jakubik Marta , Rymaszewska Joanna , Bednarek-Tupikowska Grazyna , Lwow Felicja , Sloka Natalia , Milewicz Andrzej

Aggravation of the symptoms of Alzheimer’s disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimer’s disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expr...

ea0035p128 | Calcium and Vitamin D metabolism | ECE2014

Cinacalcet hydrochloride more efficiently controls serum calcium levels in mild-asymptomatic primary hyperparathyroidism without surgery criteria, as compared with surgical cases

Marotta Vincenzo , di Somma Carolina , Rubino Manila , del Prete Michela , Marciello Francesca , Ramundo Valeria , Sciammarella Concetta , Buonomano Pasqualina , Carratu Annachiara , de Luca di Roseto Chiara , Colao Annamaria , Faggiano Antongiulio

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

ea0035p129 | Calcium and Vitamin D metabolism | ECE2014

Cardio-metabolic phenotyping of patients with familiar hypocalciuric hypercalcemia

Wolf Peter , Krssak Martin , Winhofer Yvonne , Anderwald Christian , Zwettler Elisabeth , Trattnig Siegfried , Luger Anton , Baumgartner-Parzer Sabina , Krebs Michael

Introduction: Heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene cause mild alterations in calcium metabolism (familiar hypocalciuric hypercalcemia (FHH)). However, in addition to the parathyroid gland CaSR expression was recently identified in the myocardium and many other endocrine cells including pancreatic islet cells, entero-endocine cells and adipose tissue. So far, it is unknown whether FHH is associated with cardio-metabolic altera...

ea0035p130 | Calcium and Vitamin D metabolism | ECE2014

The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus microvascular complications and vitamin D deficiency

Usluogullari Celil , Balkan Fevzi , Caner Sedat , Ucler Rifki , Kaya Cafer , Ersoy Reyhan , Cakir Bekir

Aim: Vitamin D deficiency is reported as a risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications.Materials and methods: Retrospectively, medical records of 557 type 2 diabetic patients admitted to the Endocrinology Outpatient Clinic in January–Mar...

ea0035p131 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of biochemical cardiovascular risk factors, carotid intima media thickness, and arterial stiffness before and after surgery in patients with primary hyperparathyroidism

Cansu Guven Baris , Ozdem Sebahat , Suleymanlar Gultekin , Sari Ramazan , BAlcI Mustafa Kemal , Altunbas Hasan Ali

Primary hyperparathyroidism is a condition related with cardiovascular mortality and morbidity. Aim of this study is to investigate whether there is a difference between healthy controls, hypercalcemic patients with surgical decision and normocalcemic primary hyperparathyroidism patients for parameters like metabolic cardiovascular risk factors, carotis intima media thickness and pulse wave velocity and if there is a difference at patients with surgical decision 6 months after...

ea0035p132 | Calcium and Vitamin D metabolism | ECE2014

Genu valgum in primary hyperparathyroidism in children

Jyotsna Viveka P , Ramkumar S , Tripathy Madhavi , Kandasamy Devasenapathy , Vijay M K

Background: Bony deformity due to primary hyperparathyroidism is a rare entity in children.Methods: We describe two children who presented with genu valgum to the Endocrine Department. Ten children with primary hyperparathyroidism presenting with genu valgum have been reported in literature and have been reviewed by us.Results: Biochemical investigations revealed parathyroid hormone dependent hypercalcemia despite a deficiency of v...

ea0035p133 | Calcium and Vitamin D metabolism | ECE2014

Interdisciplinary aspects of primary hyperparathyroidism: symptomatology in a series of 100 cases (single-centre experience)

Jodkowska Anna , Tupikowski Krzysztof , Szymczak Jadwiga , Bohdanowicz-Pawlak Anna , Bolanowski Marek , Bednarek-Tupikowska Grazyna

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...

ea0035p134 | Calcium and Vitamin D metabolism | ECE2014

Serum 25-hydroxyvitamin D deficiency in acute cerebral strokes' patients with and without carbohydrate metabolism disturbances in North-Eastern part of Poland

Adamska Agnieszka , Oleksiewicz Luiza , Maksymowicz Anna , Lipinska Danuta , Drozdowski Wieslaw , Gorska Maria

Introduction: The pleiotropic effects of vitamin D extend to control many physiological and pathophysiological processes in the human body. One of them is involved in the protective process of the nerve cells during stroke as well as pathogenesis of type 2 diabetes. Serum 25-hydroxyvitamin D concentration <20 ng/ml indicating vitamin D deficiency which is common in Poland. The aim of this study was to estimate serum level of 25-hydroxyvitamin D in acute ischemic strokes&#1...

ea0035p135 | Calcium and Vitamin D metabolism | ECE2014

Estimation of optimal serum levels of 25-hydroxyvitamin D in a cohort of HIV-infected patients

Garcia-Figueras Mateos Carolina , Blanco Manuel Cayon , Herrera Patricia Bancalero , Pernia Alberto Terron , Cortes Salvador Perez

Introduction: 25-Hydroxyvitamin D (25(OH)D) deficiency is a growing healthcare problem in HIV-infected patients. Evidence suggests that an optimal level of 25(OH)D would avoid secondary hyperparathyroidism but its optimal serum concentration has not been defined in HIV-infection. The aim of our study was to identify the 25(OH)D serum concentration that correlates to i-PTH increase and describe the prevalence of hypovitaminosis D in a cohort of HIV-infected patients.<p clas...

ea0035p136 | Calcium and Vitamin D metabolism | ECE2014

Functional parathyroid cyst: a rare cause of hypercalcemia

Sacikara Muhammed , Dellal Fatma Dilek , Aydin Cevdet , Cetin Huseyin , Aydogdu Koray , Agackiran Yetkin , Ersoy Reyhan , Cakir Bekir

Primary hyperparathyroidism (PHPT) is usually caused by single adenoma. Functional parathyroid cysts are a rare cause of PHPT. Parathyroid cysts can be subdivided into nonfunctional, without biochemical derangement, or functional, with elevated serum calcium accompanying clinical evidence of hyperparathyroidism. Parathyroid cysts are found in the neck and anterior mediastinum. Functional parathyroid cysts are not only secretary but larger cysts can lead to compression symptoms...

ea0035p137 | Calcium and Vitamin D metabolism | ECE2014

Effects of nutritional intervention program on vitamin D serum levels in adolecents

Pastor M Mar Campos , Pardo Ma Dolores Serrano , Soto Ma Luisa Fernandez , de Dios Luna del Castillo Juan , Gomez-Villalba Fernando Escobar , Escobar-Jimenez Fernando

Introduction: Vitamin D deficiency and insufficiency is highly prevalent even in young people. Vitamin D status has been linked to the BMI and insulin resistance.Aim: Determine 25(OH)D concentrations in adolescents before and after nutritional intervention program (NIP) and its relationship to BMI and metabolic syndrome (MS).Methods: We selected 256 secondary school students (127 males) aged between 12 and 16 years from Granada (Sp...

ea0035p138 | Calcium and Vitamin D metabolism | ECE2014

Acute pancreatitis as the presenting feature and metabolic encephalopathy during the course of newly diagnosed primary hyperparathyroidism

Okaygun Pembe , Sav Hasan , Mousa Umut , Esatoglu Varol , Kucuk Turgut , Koseoglulari Osman , Buyuk Sonuc

Primary hyperparathyroidism is the most frequent cause of hypercalcemia in adults. Hypercalcemia due to primary hyperparathyroidism is generally mild-moderate. Severe hypercalcemia in these cases is rare. Coexistence of severe hypercalcemia and hypercalcemic encephalopathy is very unusual with a very limited number of reported cases.A 50-year-old female presented to the Emergency Department with symptoms of nausea and severe abdominal pain. Her serum cal...

ea0035p139 | Calcium and Vitamin D metabolism | ECE2014

Ghrelin may have a role in obesity pathogenesis in patients with vitamin D deficiency

Arslan Muyesser Sayki , Topaloglu Oya , Karakose Melia , Ucan Bekir , Tutal Esra , Karbek Basak , Unsal Ilknur Ozturk , Gungunes Askin , Demirci Taner , Caliskan Mustafa , Ginis Zeynep , Sahin Mustafa , Cakal Erman , Ozbek Mustafa , Delibasi Tuncay

Aim: Several studies suggest a link between vitamin D and obesity. Vitamin D may play a role in obesity. Ghrelin is an orexigenic peptide which induces obesity by central and peripheral mechanisms. Administration of ghrelin promotes food intake and decreased fat utilisation in rodents. Ghrelin levels are decreased in obese individuals.The aim of this study was to evaluate the relationship between vitamin D status and ghrelin levels.Methods: All subjects ...

ea0035p140 | Calcium and Vitamin D metabolism | ECE2014

Prospective evaluation of endocrine complications in adults with X-linked hypophosphatemic rickets

Kamenicky Peter , Boros Emese , Rothenbuhler Anya , Brailly Sylvie , Silve Caroline , Souberbielle Jean-Claude , Chanson Philippe , Linglart Agnes

Objectives: X-linked hypophosphatemic Rickets (XLHR) is characterized by phosphate wasting and decreased production of 1,25OH-vitamin D, due, in most patients, to elevated FGF23 and PHEX mutation. In children, the disease has been extensively studied because of the devastating presentation of rickets, teeth abcesses, and growth retardation. In adults, however, metabolic complications, such as hyperparathyroidism or consequences on glucose and lipid metabolism of FGF23 excess, ...

ea0035p141 | Calcium and Vitamin D metabolism | ECE2014

Vitamin D deficiency prevalence before and after sleeve or bypass in morbid obesity

Gonzalez-Molero Inmaculada , Gonzalo-Marin Monserrat , Garcia-Arnes Juan Antonio , Maldonado Cristina , Valdes Sergio , Tinahones Francisco

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study vitamin D deficiency prevalence in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 88 morbidly obese patients befor...

ea0035p142 | Calcium and Vitamin D metabolism | ECE2014

Vitamin D deficiency in Russian pregnant women and risk for gestational diabetes

Popova Polina , Dronova Alexandra , Sadikova Elza , Parkkinen Mary , Bolshakova Maria , Grineva Elena

Introduction: Some, but not all, previously published studies suggest that low vitamin D status maybe associated with increased risk of gestational diabetes (GDM). We examined the association of plasma plasma 25-hydroxyvitamin D (25(OH)D) concentration with GDM risk and neonatal macrosomia.Methods: 143 women were recruited before 15 weeks of gestation and were followed-up until delivery. Maternal plasma 25(OH)D concentrations were measured at 8–14 w...

ea0035p143 | Calcium and Vitamin D metabolism | ECE2014

Variety of vitamin D receptor gene polymorphisms and serum levels of vitamin D in patients with type 1 diabetes

Shepelkevich Alla , Dydyshko Yulia , Kholodova Helena , Vasilieva Natalia

Currently relationship between the decrease in vitamin D (VD) levels and the formation of bone pathology has established. The presence of certain VD receptor (VDR) polymorphisms has been suggested to be associated with the serum VD. Therefore, the aim of study was to assess the association between VDR single nucleotide polymorphisms (SNPs) in type 1 diabetic patients and serum VD.Materials and methods: We studied 66 type 1 diabetic (T1D) patients (28 men...

ea0035p144 | Calcium and Vitamin D metabolism | ECE2014

Recurrent post-surgical hyperparathyroidism: think of CYP 24A1 mutations!

Loyer Camille , Leroy Clara , Huglo Damien , Boury Samuel , Molin Arnaud , Kottler Marie-Laure , Pattou Francois , Vantyghem Marie-Christine

CYP24A1 gene encodes 24-hydroxylase that inactivates 1-25-OHvitaminD. Mutations induce infantile hypercalcemia, with high 1-25-OHvitaminD, contrasting with low PTH levels. Adult phenotypes are not well known yet. We report two cases of post-surgical persistent hypercalcemia, related to CYP24A1 mutations. Two unrelated patients, a 40-year-old female (#1) and 54-year old male (#2), were referred for nephrolithiasis, enthesis and hypertension in both, associated...

ea0035p145 | Calcium and Vitamin D metabolism | ECE2014

The association between vitamin D deficiency and metabolic parameters in pediatric obesity is influenced by what surrogate index of sunlight exposure is used

Prodam Flavia , Zanetta Sara , Bellone Simonetta , Ricotti Roberta , Giglione Enza , Marolda Agostina , Petri Antonella , Zavattaro Marco , Aimaretti Gianluca , Bona Gianni

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

ea0035p146 | Calcium and Vitamin D metabolism | ECE2014

Three patients with idiopathic hypoparatiroidism presented with different clinical manifestations

Gul Kamile , Sahin Murat , Oguz Ayten , Cabioglu Eren , Erhan Cigdem , Kesici Fatma , Ozkaya Mesut

Aim: Patients with hypoparatiroidism may admit to hospitals with different symptoms.In this report we presented 3 case of hypoparatiroidism with congestive heart failure,epilepsy and muscle pain.Case 1: 31-year-old male admitted to hospital with dyspnea on lying down and evaluation revealed pericardial and pleural effusion. The patient was hospitalized to cardiology clinic with a prediagnosis of decompansated heart failure. In echocardiography ejection f...

ea0035p147 | Calcium and Vitamin D metabolism | ECE2014

Hypoparathyroidism and celiac disease a rare autoimmune disease combination

Ogmen Berna , Cuhaci Neslihan , Polat Burcak , Aydin Cevdet , Ersoy Reyhan , Cakir Bekir

Case: A 30-year-old man with hypoparathyroidism has been treated with calcitriol and calcium for 2 years, admitted hospital with persisting diarrhea. An endoscopic operation is planned. But when he was waiting for this examination as outpatient condition, he had a convulsion and had been taken in hospital by parents. Initial laboratory analyses revealed that he was hypocalcemic (total calcium of 6 mg/dl) and parathormone (PTH) 8 pg/ml, phosphorus 5.7 mg/dl, and magnesium 2 mg/...

ea0035p148 | Calcium and Vitamin D metabolism | ECE2014

Paternal isodisomy is a frequent cause of pseudohypoparathyroidism 1-b

Colson Cindy , Richard Nicolas , Decamp Mathieu , Abeguile Genevieve , Gruchy Nicolas , Kottler Marie-Laure

Patients affected by pseudohypoparathyroidism type 1b (PHP-1b) develop resistance to PTH leading to hypocalcemia and hyperphosphoremia, which is often associated with resistance to TSH. PHP-Ib is associated with methylation changes at one or several differentially methylated regions (DMRs) within the GNAS complex locus, located at 20q13.2–13.3. This locus gives rise to several different transcripts (NESP55, XL, A/B), with varying patterns of expression depending on the pa...

ea0035p149 | Calcium and Vitamin D metabolism | ECE2014

Frequency of vitamin D deficiency in pregnant diabetics

Tuzun Dilek

Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy resulting from pregnancy associated insulin resistance and impaired insulin secretion. We aimed to investigate the frequency of vitamin D deficiency and its relation with glucose parameters and the incidence of gestational diabetes.Materials and methods: Gestational diabetes was diagnosed with 75 g oral glucose tolerance test. 32 preg...

ea0035p150 | Calcium and Vitamin D metabolism | ECE2014

Vitamin D seasonal variation of elderly people in Konya Residantal Care

Kaya Ahmet , Turan Elif

Introduction: Many factors influence intensity and duration of exposure to ultraviolet, including geographic location, season, dietary intake, atmospheric conditions and the daily sunlight exposure. Study was performed to determine prevelance of hypovitaminosis in housebound elderly.Design: 41 people (22 men and 19 women) living in Konya Residantal Care (RC) were taken. Serum 25-OH vitamin D (VD) measured in winter and in summer. Results were evaluated b...

ea0035p151 | Calcium and Vitamin D metabolism | ECE2014

Oncogenic osteomalasia: a rare case due to lipoma

Ozkan Cigdem , Altinova Alev Eroglu , Cerit Ethem Turgay , Yalcin Mehmet Muhittin , Iyidir Ozlem Turhan , Akturk Mujde , Toruner Fusun Balos , Cakir Nuri , Arslan Metin

Introduction: Oncogenic osteomalasia is a rare paraneoplastic syndrome in which a tumor produces fibroblast growth factor 23 which leads to increased urinary phosphate excretion resulting in hypophosphatemia. It is frequently associated with mesenchymal tumors of bone and soft tissues. We report a case of oncogenic osteomalasia due to lipoma.Case report: A 38-year-old female patient with a 6-year history of left hip pain which progressively worsened over...

ea0035p152 | Calcium and Vitamin D metabolism | ECE2014

The effect of VDR polymorphisms on serum testosterone level in aging men population

Laczmanski Lukasz , Lwow Felicja , Kolackov Katarzyna , Milewicz Andrzej

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

ea0035p153 | Calcium and Vitamin D metabolism | ECE2014

The change in paratyroid hormone level by posture in primary hyperparathyroidism

Aydin Cevdet , Polat Sefika Burcak , Dirikoc Ahmet , Evranos Berna , Cuhaci Neslihan , Ersoy Reyhan , Cakir Bekir

Introduction: Major factor that modulates the PTH secretion is serum Ca level. Paratyhyroid gland also receives direct autonomic innervation. To date, measurement of several hormones such as cortisol,prolactin, renin and aldosteron were found to be affected by changing the posture from recumbent to the upright position. In the present study, we aimed to investigate postural change of PTH in normal individuals and patients with primary hyperparathyroidism (PHPT).<p class="a...

ea0035p154 | Calcium and Vitamin D metabolism | ECE2014

Postprandial blood glucose and fetuin-A are independently linked to the coronary calcification progression in patients with type 2 diabetes

Cokolic Miro , Krajnc Mitja , Balon Breda Pecovnik

Introduction: Coronary calcification (quantified as Agatston’s calcium score (CS) and measured with a CT-based method) has been shown to predict coronary atherosclerotic burden and mortality in type 2 diabetics (T2D). Compared to a single measurement, the progression of CS in time better reflects the effects of cardiovascular risk factors that have not yet been fully elucidated.Methods: We measured calcium score (CS) (Agatston’s method, 64-slic...

ea0035p155 | Calcium and Vitamin D metabolism | ECE2014

Denosumab increases bone mineral density in primary hyperparathyroidism treated with Cinacalcet

Gomez Jose Manuel Quesada , Jimenez Concepcion Munoz

Cinacalcet decreases and normalizes serum calcium levels across a broad severity range of primary hyperparathyroidism (PHPT), slightly reduces parathyroid hormone levels which generally remains elevated, whereas it has no effect on bone mineral density (BMD). Therefore, when administering Cinacalcet to a patient with PHPT, concomitant treatment with an anti-catabolic drug should be considered.An open-labeled, prospective trial was conducted in 30 patient...

ea0035p156 | Calcium and Vitamin D metabolism | ECE2014

Vitamin D in men with metabolic syndrome with low or normal testosterone levels

Angelova Petya , Kamenov Zdravko

Introduction: The classical role on calcium homeostasis played by vitamin D is well documented. Lately vitamin D is linked to a variety of chronic diseases related to ageing, diabetes, and cardiovascular diseases. However, the pathophysiological roles of vitamin D in such cases are unclear.Aim: To clarify the relation of metabolic syndrome (MS), testosterone levels, and vitamin D status in men.Patients and methods: 99 male patients...

ea0035p157 | Calcium and Vitamin D metabolism | ECE2014

Is parathyroid hormone venous sampling useful? Correlation of parathyroid hormone selective venous sampling and histopathological results in patients who underwent parathyroidectomy between 2006 and 2013

Rys Andrzej , Dyer Robert , Cunliffe David , Hickey Simon , Seymour Richard

Patients with primary hyperparathyroidism (PHPT) undergo parathyroid ultrasound, Tc-99m sestamibi scan or MRI to localize hyperfunctioning parathyroid gland(s). When scans are negative or discordant we perform parathyroid hormone selective venous sampling (PTHSVS).We report the results of 18 patients (four males, 14 females, average age 58.7) with PHPT, who underwent PTHSVS followed by either focused parathyroidectomy (FP) or bilateral neck exploration (...

ea0035p158 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of the relationship between vitamin D concentration and selected clinical and biochemical features in women with polycystic ovary syndrome

Szymonek Monika , Kowalska Aldona

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

ea0035p159 | Calcium and Vitamin D metabolism | ECE2014

Hypercalcaemia presenting as hyperemesis gravidarum in a pregnant patient

Mlawa Gideon , Silveira Maria

Background: Primary hyperparathyroidism during pregnancy is rare, and may present with symptoms non-specific to hypercalcaemia.Case: A 35 years old 12/40 weeks pregnant lady presented to accident and emergency department with 6 weeks history of nausea and vomiting. On admission she felt anxious with ongoing nausea and numbness all over the body. She was a mother 2-year-old with no significant past medical history. Her medication on admission were; folic ...

ea0035p160 | Calcium and Vitamin D metabolism | ECE2014

PARADIGHM: a natural history registry for patients with chronic hypoparathyroidism

Bowlin Steven , Sadowski Tara , Vokes Tamara , Bilezikian John , Clarke Bart , Mannstadt Michael , Shoback Dolores , Lagast Hjalmar

Chronic hypoparathyroidism affects ~2.5/10 000 individuals in the European Union and is classified as a rare disorder. There is limited knowledge of the natural history and epidemiology of this disease. Publications frequently represent a single center’s experience and information across the population of patients with hypoparathyroidism is lacking and needed. To fill the gap, a voluntary global hypoparathyroidism patient registry (PARADIGHM) was initiated by NPS Pharmace...

ea0035p161 | Calcium and Vitamin D metabolism | ECE2014

Cinacalcet in the treatment of primary hyperparathyroidism

Kostoglou-Athanassiou Ifigenia , Xanthakou Eleni , Athanassiou Panagiotis , Gkountouvas Anastasios , Kaldrymides Philippos

Primary hyperparathyroidism is currently recognized with increasing frequency by routine calcium measurement in biochemical examinations. Primary hyperparathyroidism may be due to a parathyroid adenoma, parathyroid hyperplasia and, rarely, parathyroid carcinoma. Cinacalcet is used in the medical management of primary hyperparathyroidism.The aim was to assess the role of cinacalcet in the treatment of primary hyperparathyroidism.Pat...

ea0035p162 | Calcium and Vitamin D metabolism | ECE2014

Hypocalcemia caused by type 1b pseudohypoparathyroidism

Oliveira Joana , Freitas Paula , Carvalho Davide

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

ea0035p163 | Calcium and Vitamin D metabolism | ECE2014

Persistant hypercalcemia due to an atypically localised parathyroid adenoma in a patient operated from parathyroid carcinoma: a report of case

Topaloglu Oya , Ucan Bekir , Arslan Muyesser Sayki , Kilic Mehmet , Karakose Melia , Saylam Guleser , Ozdemir Elif , Cakal Erman , Delibasi Tuncay

Introduction: Patients with parathyroid carcinoma (PCA) and synchronous disease in other parathyroid glands have been reported in the literature. Here, we report a patient who had persistant hypercalcemia after operated from parathyroid carcinoma and improvement of hypercalcemia after the subsequent operation from atypically localised parathyroid adenoma.Case report: A 62-year-old man presented with a history of headache, fatigue, and nervousness. Labora...

ea0035p164 | Calcium and Vitamin D metabolism | ECE2014

The child with Di George syndrome born to a mother with primary hypothyroidism diagnosed during pregnancy

Orlowska-Florek Renata , Dudek Adam , Swider Grzegorz

Di George syndrome is, in 93% of cases, the result of spontaneous mutations within the chromosome 22. Environmental factors may affect its occurrence. Phenotypic characteristics of Di George syndrome in children of alcohol-abusing or treated with izotretionin mothers were described. The case of a baby with Di George sndrome born to a woman with symptomatic hyperparathyroidism during her pregnancy is presented.Case report: A 30-year-old woman at 27 weeks ...

ea0035p165 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of vitamin D concentration in a population of young, healthy women: effects of vitamin D supplementation

Sewerynek Ewa , Cieslak Karol , Janik Malgorzata , Stuss Michal

Vitamin D and calcium are necessary for proper modelling and remodelling of osseous tissue and optimal bone mass depends on their appropriate supplementation.Aim of study, materials and methods: The goal of the study was an evaluation of serum vitamin D concentrations (vit. D) in 106 healthy women, aged 20–30 years plus a monthly evaluation – for 3 months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women wit...

ea0035p166 | Calcium and Vitamin D metabolism | ECE2014

Do Lithuanian military conscripts suffer from hypovitaminosis D?

Preiksa Romualdas Tomas , Gailyte Ieva , Lasaite Lina , Verkauskiene Rasa

The aim of the study was to evaluate vitamin D levels in Lithuanian male military conscripts and its association with PTH, osteocalcin and testosterone, body muscles and LBM percentage, as well as depression–sadness, tension–anxiety and psychological and physical quality of life.Methods: A total of 262 healthy Lithuanian male military conscripts were tested for vitamin D, PTH, osteocalcin and testosterone concentration and 155 (59.2%) of them w...

ea0035p167 | Calcium and Vitamin D metabolism | ECE2014

Unusual case of intrathyroid parathyroid hyperplasia revealed by parathyroid hormone determination in fine-needle aspirate, co-existing with multifocal papillary thyroid carcinoma

Anagnostis Panagiotis , Karras Spyridon , Adamidou Fotini , Christoforidou Varvara , Cox Jeremy

Introduction: Ectopic parathyroid tissue is a rare cause of primary hyperparathyroidism (PHPT). Intrathyroid location has been reported in 18–33% of cases.Case report: A 67-year-old Caucasian female was admitted for evaluation of multi-nodular goiter and normocalcaemic PHPT. The patient was asymptomatic; her medical history was remarkable for hypertension, dyslipidaemia, and albuminuria. Her family history has positive for albuminuria.<p class="...

ea0035p168 | Calcium and Vitamin D metabolism | ECE2014

Vitamin D deficiency and tuberculin skin test reaction in old age home residents in Romania

Mocanu Veronica , Zugun-Eloae Florin , Azoicai Doina , Galesanu Corina

Introduction: We studied the relationship between vitamin D deficiency and tuberculin skin test (TST) to assess the delayed cellular immunity in older age home residents.Design: This was a case–control study.Methods: We evaluated TST in 50 nursing home residents (35 women and 15 men, aged 58–89 years) with 25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol. A one-stage TST was performed using 0.1 ml of PPD RT23. An...