Endocrine Abstracts

Background: The aim of this study is to compare the value of phosphate measures, which may predict the development of hypocalcemia in the early post operative period following total thyroidectomy, to iPTH and Ca measurements.Metods: In this prospective study, patients who underwent total thyroidectomy in our clinic between March 2012 and April 2013, independent of diagnosis were included in a consecutive manner. Venous blood samples for calcium (Ca2...

Background: Chronic hypophosphataemia due to renal phosphorus wasting results in bone disease (rickets and osteomalacia). The principal regulators of renal phosphorous handling are parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). X-linked hypophosphatemic (XLH) rickets is the most common genetic disorder of renal phosphorus wasting; acquired disorders include tumour-induced osteomalacia (TIO). The aims of this study were: i) to assess the clinical utility of ...

The term pseudohypoparathyroidism (PHP) defines a heterogeneous group of rare, related and deeply impairing metabolic diseases due to end-organ resistance to the actions of PTH, associated to molecular defects at the GNAS locus. Different subtypes of PHP have been described based on the existence of additional clinical features, such as resistance to other hormones acting via GPCRs and Albright’s hereditary osteodystrophy (AHO). Recently, the detection in a small subset o...

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of vitamin D deficiency and the levels of 25(OH)D and bone profile.Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2011 and December 2012. We collected information on demographic data, etiological factors for vitamin D deficiency, clinical pre...

Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism.Case: A 55-year-old Saudi woman was admitted to King Abdulaziz University Hospital (Jeddah) with a complaint of anterior maxilla mass of one month duration. Her medical history was unremarkable.Initial examination revealed a painful mass in the anter...

Introduction: Treatment with Cinacalcet results in decreased uptake of radiopharmaceutical (because of decreased secretory activity of parathyroid glands as shown by previous studies in secondary hyperparathyroidism). This effect has not been studied in patients with primary hyperparathyroidism (PHPT).Objective: Evaluate clinical and MIBI scintigraphy uptake changes of adenomas in patients treated with Cinacalcet.Patients and metho...

Introduction: Clinical manifestations of hypocalcaemia vary from very mild and asymptomatic biochemical abnormality to severe life-threatening disorders. Heart failure due to hypocalcaemia is refractory to conventional treatment. Many clinicians may be unaware of hypocalcaemia associated with heart failure, since it is often ignored. Hypocalcaemia heart failure is a rare and potentially reversible disturbance, The decompensated heart failure is rapidly reversed by aggressive c...

Autoimmune pollyendocine type 1 (APS1) is a rare inherited autosomal recessive disorder. Typical symptom appears in within the first decade of life and followed by adrenocortical insufficiency, mucocutaneous candidiasis, Addison’s disease, and hypoparathyroidism. The clinical phenotype of APECEP is depends on mutations in autoimmune regulator gene (AIRE) which mapped to chromosome 21q22.3. We analyzed AIRE gene in subject to identify AIRE gene variants a...

Introduction: In pregnant women there is a twofold increase in synthesis of calcitriol, i.e. the active metabolite of vitamin D. Literature data point to adverse effects of vitamin D deficiency during pregnancy both for pregnant woman and foetus. Polish data on the effects of vitamin D deficiency in this group are scarce.Aim of the study: The aim of this study was to evaluate the relationship between vitamin D3 concentrations in pregnant women on health ...

Case history: A 41-year-old lady had Total Thyroidectomy in 2007 for a large multi-nodular goitre. Post-operatively, she was hypocalcemic with mild inappropriately low Pth levels. She was treated with high dose α-calcidol and calcium supplements but the response was suboptimal. Following introduction of teriparatide, serum calcium has been improving to between 1.90 and 2.06 mmol/l. She continues on high dose α-calcidol.Investigations: Corrected...

Introduction: Idiopathic hypercalciuria is a risk factor for nephrolithiasis. Both renal stones and hypercalciuria are often associated with lower bone mineral density (BMD), but the relationship between these modifications is not completely understood. We aimed to evaluate some metabolic particularities possibly related to relapsing nephrolithiasis in young male patients.Methods: We performed a cross-sectional study including a group of 30 young male pa...

Objective: To describe the clinical characteristics and post-surgical outcome of our primary hyperparathyroidism case series.Methods: A retrospective cohort study of primary hyperparathyroidism patients who underwent surgery in the last 10 years in our centre. The medical records were reviewed to extract data. A statistical descriptive analysis was performed using mean and S.D. for continuous variables and percentages for qualitative varia...

A 73-year-old woman, admitted to emergency room due to generalized tonic–clonic seizures. She had a previous history of muscle cramps and paresthesia for 4 months. She had a medical history of peptic ulcer and she was taking omeprazole for 7 years. Her laboratory evaluation showed marked hypomagnesemia (<0.4 mg/dl normal ranges: 1.7–2.55 mg/dl) and hypocalcemia (6.83 mg/dl and normal ranges: 8.8–10.2 mg/dl) with extremely low urinary Ca and Mg excretion (&#6...

The combination of hypoparathyroidism, sensorineural deafness and renal dysplasia, named HDR syndrome, is a rare disease. Heterozygous abnormalities of GATA3 gene are associated with this syndrome. Here we report a novel heterozygous mutation, c.255_256ins4 (GTGC), in GATA3 gene. A 41-year-old man was diagnosed as having idiopathic hypoparathyroidism and has been treated with 1α-hydroxyvitamin D3 and calcium carbonate. Three years later, he had a hearing...

Objective: To investigate the level of 25(OH) vitamin D (25(OH)D) and correlation between 25(OH)D level and hormonal-biochemical parameters in polycystic ovary syndrome (PCOS).Materials and methods: Thirty-three patients diagnosed with PCOS and 42 age and BMI matched control group admitted to Erzurumm Regional Training and Research Hospital from May to October were included in the study. Serum total testosterone (TT), free testosterone (fT), 25(OH)D, DHE...

Introduction: Primary hyperparathyroidism (pHPT) is the unregulated overproduction of parathyroid hormone resulting in abnormal calcium homeostasis. The prevalence has been reported to be ~21 cases/100 000 person-years. The mean age at diagnosis has remained between 52 and 56 years with female-to-male ratio 3:1. In ~85% of cases, pHPT is caused by a single adenoma, in 14% of hyperplasia and 1% is caused by malignant diseases. Association between pHPT and cardiovascular manifes...

Vitamin D receptors (VDRs) are expressed in bone and vascular cells which also respond to vitamin D treatment by modulation of cell proliferation measured by DNA synthesis and energy metabolism measured by CK specific activity. We have previously observed that vitamin D-related compounds target several genes which affect cell proliferation, including mRNA expression of estrogen receptor (ER)α, ERβ, VDR, 1α hydroxylase of 25OHD3 (1OHase) and 12 and 15 lipoxygenas...

Introduction: Obesity prevalance is rapidly increasing all over the world and become a serious health problem. There is a significant correlation between serum calcium levels and body fat mass. It was indicated that when plasma calcium levels increase, BMI decrease however, insulin, total cholesterol, and triglycerides levels increase. In this study, it was investigated the relationship between plasma calcium levels and cardiovascular risk factors and metabolic syndrome parame...

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

Introduction: Recent studies demonstrate decrease in vitamin D3 level and bone mineral density in more than 50% of type 1 diabetes (T1DM) patients. It is also suggested that vitamin D deficiency in familial mediterranean fever (FMF) patients may trigger the disease flare. These patients are at high-risk of other autoimmune diseases, as well as described combination of FMF, celiac disease, and autoimmune thyroiditis. However, there are only two case reports on combination of FM...

Introduction: Primary hyperparathyroidism (PHP), is generalized with calcium, phosphate, and bone metabolism disorder due to increased PTH secretion. It’s common in fifth and sixth decades. Nowadays, it’s widely detected by measurement of blood calcium and may be presented with minimal or no symptoms.Design: 102 patients with PHP admitted to Department of Endocrinology, between years of 2008–2013 were analyzed.Result...

Introduction: Vitamin D deficiency has become a major public health problem. It’s known that the effects of vitamin D are made by its receptors. VDR gene polymorphisms in susceptibility to different diseases demonstrated in many studies. The polymorphisms of VDR are ApaI, TaqI, FokI, and BsmI. BsmI is the most extensively studied polymorphism. In our study, the aim is to show the frequency of VDR BsmI gene polymorphisms and to show the relationship between polymorphisms a...

Introduction: Active metabolites of vitamin D have pleiotropic influence on whole body.Aim: The aim of the study was evaluation of the correlation between vitamin D3 and TSH values in population over 65.Materials and methods: 94 patients admitted to diagnosis on Geriatric Department entered the study. People with age above 65 were included to research and divided on two groups according to sex. The material samples were obtained fr...

Introduction: Anthropometric parameters such as: waist circumference, hips circumference, or arm circumference allow to find a correlation between the obesity and the risk of some metabolic disturbances (for example arm circumference index of upper part indicates the level of protein storage in the body).Aim: The aim of the study was to assess the correlation among the arm circumference index, concentration of 25-OH vitamin D3 and lipid profile parameter...

Introduction: Vitamin D insufficiency is common in older people and is associated with several disorders related to aging such as osteoporosis, which leads to a significantly increased risk of bone fractures. This deficiency is more common in Mediterranean countries than in Northern European countries. Hypocalcemic seizures resulting from vitamin D deficiency are rare in adults, and fractures caused by seizures without evidence of direct trauma have not yet been reported.<...

Brown tumor is a non-neoplastic lesion which resulting from abnormal bone metabolism caused by hyperparathyroidism. We report a rare case of peripheral brown tumor related with primary hyperparathyroidism which simulating a peripheral giant cell granuloma of the jaws.Introduction: PHPT occurs in a setting of excessive parathyroid hormone (PTH) secretion which resulting in hypercalcemia.Case report: A 50-year-old man was admitted to...

Aggravation of the symptoms of Alzheimer’s disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimer’s disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expr...

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

Introduction: Heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene cause mild alterations in calcium metabolism (familiar hypocalciuric hypercalcemia (FHH)). However, in addition to the parathyroid gland CaSR expression was recently identified in the myocardium and many other endocrine cells including pancreatic islet cells, entero-endocine cells and adipose tissue. So far, it is unknown whether FHH is associated with cardio-metabolic altera...

Aim: Vitamin D deficiency is reported as a risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications.Materials and methods: Retrospectively, medical records of 557 type 2 diabetic patients admitted to the Endocrinology Outpatient Clinic in January–Mar...

Primary hyperparathyroidism is a condition related with cardiovascular mortality and morbidity. Aim of this study is to investigate whether there is a difference between healthy controls, hypercalcemic patients with surgical decision and normocalcemic primary hyperparathyroidism patients for parameters like metabolic cardiovascular risk factors, carotis intima media thickness and pulse wave velocity and if there is a difference at patients with surgical decision 6 months after...

Background: Bony deformity due to primary hyperparathyroidism is a rare entity in children.Methods: We describe two children who presented with genu valgum to the Endocrine Department. Ten children with primary hyperparathyroidism presenting with genu valgum have been reported in literature and have been reviewed by us.Results: Biochemical investigations revealed parathyroid hormone dependent hypercalcemia despite a deficiency of v...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...

Introduction: The pleiotropic effects of vitamin D extend to control many physiological and pathophysiological processes in the human body. One of them is involved in the protective process of the nerve cells during stroke as well as pathogenesis of type 2 diabetes. Serum 25-hydroxyvitamin D concentration <20 ng/ml indicating vitamin D deficiency which is common in Poland. The aim of this study was to estimate serum level of 25-hydroxyvitamin D in acute ischemic strokes&#1...

Introduction: 25-Hydroxyvitamin D (25(OH)D) deficiency is a growing healthcare problem in HIV-infected patients. Evidence suggests that an optimal level of 25(OH)D would avoid secondary hyperparathyroidism but its optimal serum concentration has not been defined in HIV-infection. The aim of our study was to identify the 25(OH)D serum concentration that correlates to i-PTH increase and describe the prevalence of hypovitaminosis D in a cohort of HIV-infected patients.<p clas...

Primary hyperparathyroidism (PHPT) is usually caused by single adenoma. Functional parathyroid cysts are a rare cause of PHPT. Parathyroid cysts can be subdivided into nonfunctional, without biochemical derangement, or functional, with elevated serum calcium accompanying clinical evidence of hyperparathyroidism. Parathyroid cysts are found in the neck and anterior mediastinum. Functional parathyroid cysts are not only secretary but larger cysts can lead to compression symptoms...

Introduction: Vitamin D deficiency and insufficiency is highly prevalent even in young people. Vitamin D status has been linked to the BMI and insulin resistance.Aim: Determine 25(OH)D concentrations in adolescents before and after nutritional intervention program (NIP) and its relationship to BMI and metabolic syndrome (MS).Methods: We selected 256 secondary school students (127 males) aged between 12 and 16 years from Granada (Sp...

Primary hyperparathyroidism is the most frequent cause of hypercalcemia in adults. Hypercalcemia due to primary hyperparathyroidism is generally mild-moderate. Severe hypercalcemia in these cases is rare. Coexistence of severe hypercalcemia and hypercalcemic encephalopathy is very unusual with a very limited number of reported cases.A 50-year-old female presented to the Emergency Department with symptoms of nausea and severe abdominal pain. Her serum cal...

Aim: Several studies suggest a link between vitamin D and obesity. Vitamin D may play a role in obesity. Ghrelin is an orexigenic peptide which induces obesity by central and peripheral mechanisms. Administration of ghrelin promotes food intake and decreased fat utilisation in rodents. Ghrelin levels are decreased in obese individuals.The aim of this study was to evaluate the relationship between vitamin D status and ghrelin levels.Methods: All subjects ...

Objectives: X-linked hypophosphatemic Rickets (XLHR) is characterized by phosphate wasting and decreased production of 1,25OH-vitamin D, due, in most patients, to elevated FGF23 and PHEX mutation. In children, the disease has been extensively studied because of the devastating presentation of rickets, teeth abcesses, and growth retardation. In adults, however, metabolic complications, such as hyperparathyroidism or consequences on glucose and lipid metabolism of FGF23 excess, ...

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study vitamin D deficiency prevalence in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 88 morbidly obese patients befor...

Introduction: Some, but not all, previously published studies suggest that low vitamin D status maybe associated with increased risk of gestational diabetes (GDM). We examined the association of plasma plasma 25-hydroxyvitamin D (25(OH)D) concentration with GDM risk and neonatal macrosomia.Methods: 143 women were recruited before 15 weeks of gestation and were followed-up until delivery. Maternal plasma 25(OH)D concentrations were measured at 8–14 w...

Currently relationship between the decrease in vitamin D (VD) levels and the formation of bone pathology has established. The presence of certain VD receptor (VDR) polymorphisms has been suggested to be associated with the serum VD. Therefore, the aim of study was to assess the association between VDR single nucleotide polymorphisms (SNPs) in type 1 diabetic patients and serum VD.Materials and methods: We studied 66 type 1 diabetic (T1D) patients (28 men...

CYP24A1 gene encodes 24-hydroxylase that inactivates 1-25-OHvitaminD. Mutations induce infantile hypercalcemia, with high 1-25-OHvitaminD, contrasting with low PTH levels. Adult phenotypes are not well known yet. We report two cases of post-surgical persistent hypercalcemia, related to CYP24A1 mutations. Two unrelated patients, a 40-year-old female (#1) and 54-year old male (#2), were referred for nephrolithiasis, enthesis and hypertension in both, associated...

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

Aim: Patients with hypoparatiroidism may admit to hospitals with different symptoms.In this report we presented 3 case of hypoparatiroidism with congestive heart failure,epilepsy and muscle pain.Case 1: 31-year-old male admitted to hospital with dyspnea on lying down and evaluation revealed pericardial and pleural effusion. The patient was hospitalized to cardiology clinic with a prediagnosis of decompansated heart failure. In echocardiography ejection f...

Case: A 30-year-old man with hypoparathyroidism has been treated with calcitriol and calcium for 2 years, admitted hospital with persisting diarrhea. An endoscopic operation is planned. But when he was waiting for this examination as outpatient condition, he had a convulsion and had been taken in hospital by parents. Initial laboratory analyses revealed that he was hypocalcemic (total calcium of 6 mg/dl) and parathormone (PTH) 8 pg/ml, phosphorus 5.7 mg/dl, and magnesium 2 mg/...

Patients affected by pseudohypoparathyroidism type 1b (PHP-1b) develop resistance to PTH leading to hypocalcemia and hyperphosphoremia, which is often associated with resistance to TSH. PHP-Ib is associated with methylation changes at one or several differentially methylated regions (DMRs) within the GNAS complex locus, located at 20q13.2–13.3. This locus gives rise to several different transcripts (NESP55, XL, A/B), with varying patterns of expression depending on the pa...

Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy resulting from pregnancy associated insulin resistance and impaired insulin secretion. We aimed to investigate the frequency of vitamin D deficiency and its relation with glucose parameters and the incidence of gestational diabetes.Materials and methods: Gestational diabetes was diagnosed with 75 g oral glucose tolerance test. 32 preg...

Introduction: Many factors influence intensity and duration of exposure to ultraviolet, including geographic location, season, dietary intake, atmospheric conditions and the daily sunlight exposure. Study was performed to determine prevelance of hypovitaminosis in housebound elderly.Design: 41 people (22 men and 19 women) living in Konya Residantal Care (RC) were taken. Serum 25-OH vitamin D (VD) measured in winter and in summer. Results were evaluated b...

Introduction: Oncogenic osteomalasia is a rare paraneoplastic syndrome in which a tumor produces fibroblast growth factor 23 which leads to increased urinary phosphate excretion resulting in hypophosphatemia. It is frequently associated with mesenchymal tumors of bone and soft tissues. We report a case of oncogenic osteomalasia due to lipoma.Case report: A 38-year-old female patient with a 6-year history of left hip pain which progressively worsened over...

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

Introduction: Major factor that modulates the PTH secretion is serum Ca level. Paratyhyroid gland also receives direct autonomic innervation. To date, measurement of several hormones such as cortisol,prolactin, renin and aldosteron were found to be affected by changing the posture from recumbent to the upright position. In the present study, we aimed to investigate postural change of PTH in normal individuals and patients with primary hyperparathyroidism (PHPT).<p class="a...

Introduction: Coronary calcification (quantified as Agatston’s calcium score (CS) and measured with a CT-based method) has been shown to predict coronary atherosclerotic burden and mortality in type 2 diabetics (T2D). Compared to a single measurement, the progression of CS in time better reflects the effects of cardiovascular risk factors that have not yet been fully elucidated.Methods: We measured calcium score (CS) (Agatston’s method, 64-slic...

Cinacalcet decreases and normalizes serum calcium levels across a broad severity range of primary hyperparathyroidism (PHPT), slightly reduces parathyroid hormone levels which generally remains elevated, whereas it has no effect on bone mineral density (BMD). Therefore, when administering Cinacalcet to a patient with PHPT, concomitant treatment with an anti-catabolic drug should be considered.An open-labeled, prospective trial was conducted in 30 patient...

Introduction: The classical role on calcium homeostasis played by vitamin D is well documented. Lately vitamin D is linked to a variety of chronic diseases related to ageing, diabetes, and cardiovascular diseases. However, the pathophysiological roles of vitamin D in such cases are unclear.Aim: To clarify the relation of metabolic syndrome (MS), testosterone levels, and vitamin D status in men.Patients and methods: 99 male patients...

Patients with primary hyperparathyroidism (PHPT) undergo parathyroid ultrasound, Tc-99m sestamibi scan or MRI to localize hyperfunctioning parathyroid gland(s). When scans are negative or discordant we perform parathyroid hormone selective venous sampling (PTHSVS).We report the results of 18 patients (four males, 14 females, average age 58.7) with PHPT, who underwent PTHSVS followed by either focused parathyroidectomy (FP) or bilateral neck exploration (...

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

Background: Primary hyperparathyroidism during pregnancy is rare, and may present with symptoms non-specific to hypercalcaemia.Case: A 35 years old 12/40 weeks pregnant lady presented to accident and emergency department with 6 weeks history of nausea and vomiting. On admission she felt anxious with ongoing nausea and numbness all over the body. She was a mother 2-year-old with no significant past medical history. Her medication on admission were; folic ...

Chronic hypoparathyroidism affects ~2.5/10 000 individuals in the European Union and is classified as a rare disorder. There is limited knowledge of the natural history and epidemiology of this disease. Publications frequently represent a single center’s experience and information across the population of patients with hypoparathyroidism is lacking and needed. To fill the gap, a voluntary global hypoparathyroidism patient registry (PARADIGHM) was initiated by NPS Pharmace...

Primary hyperparathyroidism is currently recognized with increasing frequency by routine calcium measurement in biochemical examinations. Primary hyperparathyroidism may be due to a parathyroid adenoma, parathyroid hyperplasia and, rarely, parathyroid carcinoma. Cinacalcet is used in the medical management of primary hyperparathyroidism.The aim was to assess the role of cinacalcet in the treatment of primary hyperparathyroidism.Pat...

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

Introduction: Patients with parathyroid carcinoma (PCA) and synchronous disease in other parathyroid glands have been reported in the literature. Here, we report a patient who had persistant hypercalcemia after operated from parathyroid carcinoma and improvement of hypercalcemia after the subsequent operation from atypically localised parathyroid adenoma.Case report: A 62-year-old man presented with a history of headache, fatigue, and nervousness. Labora...

Di George syndrome is, in 93% of cases, the result of spontaneous mutations within the chromosome 22. Environmental factors may affect its occurrence. Phenotypic characteristics of Di George syndrome in children of alcohol-abusing or treated with izotretionin mothers were described. The case of a baby with Di George sndrome born to a woman with symptomatic hyperparathyroidism during her pregnancy is presented.Case report: A 30-year-old woman at 27 weeks ...

Vitamin D and calcium are necessary for proper modelling and remodelling of osseous tissue and optimal bone mass depends on their appropriate supplementation.Aim of study, materials and methods: The goal of the study was an evaluation of serum vitamin D concentrations (vit. D) in 106 healthy women, aged 20–30 years plus a monthly evaluation – for 3 months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women wit...

The aim of the study was to evaluate vitamin D levels in Lithuanian male military conscripts and its association with PTH, osteocalcin and testosterone, body muscles and LBM percentage, as well as depression–sadness, tension–anxiety and psychological and physical quality of life.Methods: A total of 262 healthy Lithuanian male military conscripts were tested for vitamin D, PTH, osteocalcin and testosterone concentration and 155 (59.2%) of them w...

Introduction: Ectopic parathyroid tissue is a rare cause of primary hyperparathyroidism (PHPT). Intrathyroid location has been reported in 18–33% of cases.Case report: A 67-year-old Caucasian female was admitted for evaluation of multi-nodular goiter and normocalcaemic PHPT. The patient was asymptomatic; her medical history was remarkable for hypertension, dyslipidaemia, and albuminuria. Her family history has positive for albuminuria.<p class="...

Introduction: We studied the relationship between vitamin D deficiency and tuberculin skin test (TST) to assess the delayed cellular immunity in older age home residents.Design: This was a case–control study.Methods: We evaluated TST in 50 nursing home residents (35 women and 15 men, aged 58–89 years) with 25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol. A one-stage TST was performed using 0.1 ml of PPD RT23. An...