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16th European Congress of Endocrinology

Poster Presentations


ea0035p709 | Neuroendocrinology | ECE2014

Identification of the kisspeptin cells of the arcuate nucleus as ‘pulse generators' for gonadotropin releasing hormone.

Clarke Iain , Ezzat Ahmed , Crawshaw Jessica , Pereira Alda

Evidence from studies in goats1, sheep2 and mice3 suggests that the kisspeptin cells of the arcuate nucleus generate the signal that causes the pulsatile secretion of GnRH. This effect may be due to action of kisspeptin on GnRH terminals in the median eminence3,4. We conducted studies on sheep to test the hypothesis that kisspeptin cells of the arcuate nucleus (ARC) and/or the glutamate cells of the hypothalamus pulses of GnRH secret...

ea0035p710 | Neuroendocrinology | ECE2014

Meal-induced plasma ghrelin suppression in different phases of anorexia nervosa

Polli Nicoletta , Giunta Francesca , Cesari Miriam , Zappulli Daniela , Scacchi Massimo , Persani Luca

Introduction: The ghrelin suppressive effect of food is well established in normal subjects, whereas the effectiveness of meals in decreasing plasma ghrelin in patients with anorexia nervosa (AN) is still debated. Based on the above, we elected to study the ghrelin dynamics after food or placebo in a group of anorectic girls at the moment of diagnosis and after weight recuperation.Study design: Nine anorectic women (age 14–32 years) were studied. Bo...

ea0035p711 | Neuroendocrinology | ECE2014

Acromegaly and pregnancy: A descriptive case series

Orjuela Luis Fernanda , Valenzuela Alex , Abreu Alin

To describe the course of acromegaly in a group of seven women, before, during, and after pregnancy.Methods: Descriptive case series of acromegalic pregnant women attending a reference health center in Cali, Colombia.Results: Mean age at conception was 29±10 years, starting prenatal care at 10±3 weeks of gestation. 6 of 7 patients had a macroadenoma as evidenced by neuroimaging (MRI). 43% (three cases) had GH and prolacti...

ea0035p712 | Neuroendocrinology | ECE2014

Papillary thyroid carcinoma associated with silent paraganglioma: An atypical MEN syndrome?

Tarcin Ozlem , Yazici Dilek , Unal Asli , Demirag Nilgun Guvener

Case: A 51-year-old-woman was referred to endocrinology outpatient clinic due to a thyroid nodule 9 mm in diameter. Fine needle aspiration (FNA) biopsy revealed papillary thyroid carcinoma and she was directed to surgery. The surgeon decided to perform subtotal thyroidectomy due to the small nodule size. Pathologic examination showed the histology to be consistent with tall cell carcinoma. Complementary total thyroidectomy was proposed to the patient but she did not accept the...

ea0035p713 | Neuroendocrinology | ECE2014

Copeptin for the differential diagnosis and therapy management of hyponatremia in hospitalized patients – ‘The Co-MED-Study’

Nigro Nicole , Winzeler Bettina , Suter-Widmer Isabelle , Schuetz Philipp , Arici Birsen , Bally Martina , Blum Claudine , Nickel Christian , Bingisser Roland , Bock Andreas , Huber Andreas , Muller Beat , Christ-Crain Mirjam

Background: Hyponatremia is common in hospitalized patients and its differential diagnosis and management challenging. An important mechanism is suppressed or adequately or inadequately secreted plasma arginine vasopressin (AVP). Therefore, plasma vasopressin levels may help in the differential diagnosis and in therapy management. Copeptin is secreted in an equimolar ratio to AVP and is more reliable to measure.Methods: In this prospective observational ...

ea0035p714 | Neuroendocrinology | ECE2014

Clinical symptoms and characteristics of hospitalized patients with severe hyponatremia

Nigro Nicole , Winzeler Bettina , Suter-Widmer Isabelle , Schuetz Philipp , Arici Birsen , Bally Martina , Blum Claudine , Nickel Christian , Bingisser Roland , Andreas Bock , Andreas Huber , Muller Beat , Christ-Crain Mirjam

Background: Hyponatremia is the most common electrolyte disturbance in hospitalized patients and associated with a substantial morbidity and mortality. Symptoms of severe hyponatremia vary among patients between nonspecific symptoms such as nausea or malaise or acute life threatening brain oedema. Prospective studies to assess symptoms and mortality in patients with severe hyponatremia are lacking.Methods: In this prospective multicentre observational st...

ea0035p715 | Neuroendocrinology | ECE2014

Clinical manifestations of neurofibromatosis type 1

Dabrowska Anna , Zwolak Agnieszka , Kurowska Maria , Tarach Jerzy

Introduction: Neurofibromatosis type 1 (NF1; von Recklinghausen’s disease) is an autosomal disorder with the prevalence 1 in 3,000 births. It is caused by mutation of the tumour-suppressor gene encoding neurofibromin. NF1 may affect various organs and patients are at increased risk of developing many neoplasms.Material and methods: We analysed seven cases of patients with NF1 (four females and three males) aged 19–52 who were treated at Endocri...

ea0035p716 | Neuroendocrinology | ECE2014

Long-term remission and recurrence rates after transsphenoidal surgery for cushing's disease

Moreno Paloma Moreno , Fernandez Julia Silva , Exposito Maria Rosa Alhambra , Moreno Maria angeles Galvez

Objective: Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing’s disease (CD), 95% microadenomas. Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Remission rates in the postoperative vary between 55 and 85%, with a recurrence of up to 25%. The aim of this study was to describe the rate of remission and recurrence of CD in our midst after TSS, and c...

ea0035p717 | Neuroendocrinology | ECE2014

A rare incident of gastric mucinous adenocarcinoma in an acromegalic patient

Molitvoslovova Natalia , Oleynik Olga , Soldatova Tatyana , Leytes Yuriy

Acromegaly is frequently associated with tumor development of various organs, mostly with cancer of colon and thyroid gland while the development of gastric cancer is a very rare condition.We observed a 33-years-old woman with mild clinical signs of acromegaly. The diagnosis was confirmed by laboratory tests (increased levels of IGF1 and growth hormone – 573 ng/ml and 9.8 ng/ml respectively) and MRI (supra-infra-latero-cellary pituitary adenoma, 9&#...

ea0035p718 | Neuroendocrinology | ECE2014

Bilateral ovariectomy and neurodegeneration

Simonyan Karen

Bilateral ovariectomy (OVX) in female rats cause neurodegeneration in the nervous system of rodents and imitates systemic disorders in postmenopausal women’s organism. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. The aim of present work was to determine the action of Sinestrol on rats’ hippocampal synaptic transmission, plasticity and cell survival in condition of bilateral OVX. Electrophysiologi...

ea0035p719 | Neuroendocrinology | ECE2014

Effects of pharmacological blockade of glucocorticoids on energy homeostasis control by liver and pancreas in rats without pineal gland

Rodrigues Sandra Campos , Pantaleao Lucas Carminatti , de Araujo Veras Katherine M. , Amaral Fernanda Gaspar , Anhe Gabriel Forato , Bordin Silvana

In liver, melatonin (Mel) and glucocorticoids (GC) influence the systemic energy homeostasis. Animals without pineal gland present impairment in glycemic control, as in type-2 diabetes. In turn, Mel reduces the GC levels, particularly in nocturnal animals. We aimed to evaluate the influence of Mel, as well as GC receptor blockade by RU486 treatment on hepatic and pancreatic energy metabolism. Male Wistar rats were subjected to surgical removal of pineal and, 25 days after the ...

ea0035p720 | Neuroendocrinology | ECE2014

Copeptin levels measured after pituitary surgery predict later development of diabetes insipidus

Winzeler Bettina , Nigro Nicole , Zweifel Christian , Arici Birsen , Bally Martina , Blum Claudine , Kelly Christopher , Mariani Luigi , Landolt Hans , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Introduction: Postoperative diabetes insipidus (DI) remains a common complication after pituitary surgery. AVP measurement might contribute to a straightforward diagnosis, though, its measurement is cumbersome. Copeptin, the stable C-terminal glycopeptide of the AVP prohormone, is a reliable surrogate of AVP.We aimed to elucidate whether copeptin is a helpful marker in the diagnostic approach of postoperative DI.Methods/design: Pro...

ea0035p721 | Neuroendocrinology | ECE2014

Multiple endocrine neoplasia presenting with a novel mutation on menin gene

Yalcin Mehmet Muhittin , Cerit Ethem Turgay , Ozkan Cigdem , Sare Mustafa , Yesilyurt Ahmet , Toruner Fusun Balos , Yetkin Ilhan

Introduction: Mutations on menin gene are associated with multiple endocrine neoplasia type 1.Case report: Thirty-five year-old male patient was admitted to our hospital with history of recurrent syncope episodes for 5 years which were attributed to hypoglycemia. In physical examination, he had obesity and multiple papillamatous skin lesions on his abdominal region. He had no family history of similar symptoms. His laboratory eveluation was consistent wi...

ea0035p722 | Neuroendocrinology | ECE2014

Long-term remission and recurrence rate in a cohort of Cushing's disease: The need for long-term follow-up

Velazquez Gloria B. Aranda , Hanzu Felicia A. , Porta Mireia Mora , Ensenat Joaquin , Puig-Domingo Manel , Osaba Maria Jesus Martinez de , Casals Gregori , Verger Eugenia , Ribalta Maria Teresa , Patrascioiu Ioana , Halperin Irene

Introduction: Transsphenoidal surgery (TSS) is the procedure of choice in Cushing disease (CD), with immediate post-operative remission rates ranging between 59 and 94% and recurrence rates between 3 and 46%, both depending upon the definition criteria and the duration of the follow-up. Our aim was to assess the rate of remission, recurrence and persistence of the disease after the first treatment and to identify predictors of remission in the CD population of our center durin...

ea0035p723 | Neuroendocrinology | ECE2014

Cinacalcet hydrochloride more efficiently controls serum calcium levels in mild-asymptomatic primary hyperparathyroidism without surgery criteria, as compared with surgical cases

Hernandez Irene Crespo , Gracia Teresa Ruiz , Hoyos Emilia Gomez , Buigues Ana Ortola , Hernandez Martin Cuesta , Capel Francisco Fernandez , Novoa Paz de Miguel , Perez Maria Concepcion Sanabria , Pascual Alfonso Calle , Vega Isabelle Runkle de la

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

ea0035p724 | Neuroendocrinology | ECE2014

Treatment of SIADH in a patient with fatal familial insomnia (FFI) and hypersomnia

Hoyos Emilia Gomez , Gracia Teresa Ruiz , Azorin David Garcia , Hernandez Martin Cuesta , Buigues Ana Ortola , Hernandez Irene Crespo , Orozco Francisco Martinez , Pascual Alfonso Luis Calle , Dolado Alberto Marco , Vega Isabelle Runkle de la

Introduction: Fatal insomnia is a neurodegenerative spongiform prion disease. Presentation can be sporadic or hereditary (autonomal dominant). The latter, FFI, is caused by a mutation in the human prion protein gene on chromosome 20. Affected individuals present a disorderd sleep-wake cycle, dysautonomia and motor signs, with a predominance of lesions in the thalamus. SIADH has been described in two affected patients.Case Study: A 70-year-old woman was r...

ea0035p725 | Neuroendocrinology | ECE2014

If there are differences in postoperative pituitary dysfunction in patients with micro and macroadenomas.

Nasybullina Farida , Vagapova Gulnar , Pashaev Bakhtiyar

Aim: To estimate pituitary disfunction development in patients with micro and macroadenonas before and after transnasal adenomectomy.Methods: A total of 222 patients at the age from 17 to 71 with pituitary adenomas were operated from 2007 to 2013. According to size the pituitary adenomas were classified as microadenomas (diameter less than 10 mm) and macroadenomas (more than 10 mm). Dynamic observation and redetermination of all hormones were performed w...

ea0035p726 | Neuroendocrinology | ECE2014

Radiotherapy or surgical treatment, may affect response of cabergoline in the giant prolactinomas? Report of two cases

Cander Soner , Gul Ozen Oz , Erturk Erdinc

Dopamine agonists are the treatment of choice for prolactinomas and surgery is warranted only when the response to medical therapy is poor, not tolerated, or in those with compromised vision or with extensive invasion. We describe the two cases of a giant prolactinoma treated with cabergoline alone and next to surgery and gamma-knife.Case 1: A 30-year-old man admitted with headache and visual defect, cranial magnetic resonance imaging (MRI) revealed a in...

ea0035p727 | Neuroendocrinology | ECE2014

Hyperprolactinemia in women and men

Ilovayskaya Irena , Dreval Alexander , Chikh Irina , Kubanova Asiyat , Stashuk Galina , Tishenina Raisa

We analyzed data of 148 patients (125 female, 23 male) with hyperprolactinemia who had been investigated in our Department during 2008–2012: Nontumor hyperprolactinemia (NT, n=46, 31%), microadenomas (MI, n=56, 38%), MAcroadenomas (MA, n=46, 31%). Patients’ age was 36 (24; 46), 37 (26; 44) and 49 (33; 60) years respectively. Men were younger than women (P=0.002). Portion of men was higher in MA than in NT and MI: 19% vs 10...

ea0035p728 | Neuroendocrinology | ECE2014

Changes of metabolic status in children with acquired and congenital multiple pituitary insufficiency

Mikhno Hanna , Solntsava Anzhalika , Zagrebaeva Olga

Aim: To assess changes of metabolic status in children with pituitary insufficiency.Methods: We examined retrospectively 28 children with pituitary insufficiency in the Endocrinological department of University hospital (Minsk) over 2001–2013 years. Group 1 (G1) - children with multiple acquired pituitary insufficiency (MAPI) after brain tumors treatment (11 children (73.3%) underwent surgical, 4 (26.7%) - combined treatment: surgical and radiation ...

ea0035p729 | Neuroendocrinology | ECE2014

Poorly differentiated rectal neuroendocrine carcinoma leading to ectopic ACTH syndrome

Anaforoglu Inan , Ersoy Kerem , Kose Mustafa , Ayhan Semiha

Introduction: We present a case investigated due to hypokalemia and diagnosed as rectal neuroendocrine tumor-related EAS.Case: A 67-year-old woman with weight loss and symptoms of lethargy, abdominal pain was referred due to low serum K+ levels. Elevated blood pressure and a rectal mass were detected at physical examination. Low serum K+, elevated ALT levels, lymphopenia, neutrophilia and metabolic alkalosis were present. Computed t...

ea0035p730 | Neuroendocrinology | ECE2014

The role of intraoperative hormone levels as predictors of Cushing's disease remission

Nadezhdina Elena , Grigoriev Andrey , Azizjan Vilen , Ivashenko Oksana , Rozhinskaya Ludmila , Ilyin Alexander

Abstract: Transsphenoidal surgery is the treatment of choice for Cushing’s disease. Despite the 70–90% remission rates relapses after successful transnasal adenectomy are frequently observed.Aim: To evaluate the dynamics of intra- and early postoperative levels of adrenocorticotrophic hormone (ACTH) and cortizol and their role as predictors or Cushing’s disease remission.Materials/methods: Fifty patients with Cushing...

ea0035p731 | Neuroendocrinology | ECE2014

Influence of the exon 3 deletion of GH receptor and IGF1 level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

Andujar-Plata Paula , Fernandez-Rodriguez Eva , Quinteiro Celsa , Casanueva Felipe , Bernabeu Ignacio

Introduction: Human recombinant growth hormone (hrGH) treatment in adult patients with GH deficiency (GHD) has an important interindividual variability and several factors can influence it. The aims of the study were: i)- to analyze the genotype of GHR regarding exon 3 deletion (d3-GHR) in a serie of adult patients with GHD; ii)- to assess the effect of d3-GHR on initial IGF1 levels; iii)- to evaluate if d3-GHR and/or initial IGF1 levels were associated with adverse effects an...

ea0035p732 | Neuroendocrinology | ECE2014

Hyponatremia in the emergency room of a general teaching hospital: room for improvement

Buigues Ana Ortola , Hernandez Martin Cuesta , Gracia Teresa Ruiz , Hoyos Emlia Gomez , Hernandez Irene Crespo , Capel Francisco Elias Fernandez , de Miguel Novoa Paz , Perez Jose Angel Diaz , Pascual Alfonso Calle , de la Vega Isabelle Runkle

Introduction: Hyponatremia(HN) is frequent in the emergency room(ER), yet often ignored, or poorly studied/managed. Our objective was to determine the characteristics of patients presenting HN at the ER of a general hospital.Methods: Retrospective analysis of all 347 patients(AllP) presenting/developing non-translocational HN (serum sodium (SNa)<135 mmol/l) the first 48 h at the Hospital Clinico San Carlos ER in August 2012. Volemia was determined by...

ea0035p733 | Neuroendocrinology | ECE2014

Prolactinemia and clinical outcome following second generation antipsychotics in early onset schizophrenia

Dobrescu Iuliana , Trutescu Carmen , Kobylinska Liana , Rad Florina , Petrescu-Ghenea Cristina , Anghel Gianina Cristina , Mihailescu Ilinca

Introduction: As antipsychotic drugs specifically block the D2 receptors, they induce a certain level of prolactin increase, dependent on the time it takes to dissociate from receptors. A recent review (Besnard et al, 2013) mentions that 18% of men and 47% of women treated with antipsychotics for severe mental illness had an increased prolactin level. Even if the long term effects of hyperprolactinemia can be severe, including low bone density, amenorrhea, breast and ...

ea0035p734 | Neuroendocrinology | ECE2014

Efficacy of early postoperative radiotherapy for nonfunctioning null cell or silent pituitary macroadenomas

Stancu Cristina , Gheorghiu Monica Livia , Galoiu Simona , Anghel Rodica , Badiu Corin , Coculescu Mihail

Background: Suitable postoperative radiotherapy (RT) of nonfunctioning pituitary macroadenomas (NFMAs) is still controversial, subjected to rapid technical and medical progress.Patients and methods.: We studied 87 patients with NFMA to identify factors affecting tumor control such as the time of RT and tumor pathology. Partial pituitary surgery was performed either by transfrontal (30 patients) or transsphenoidal (57 patients) approach. An immunoperoxida...

ea0035p735 | Neuroendocrinology | ECE2014

Changes in pituitary comorbidities of adult-onset craniopharyngioma depending on date of diagnosis

Stormann Sylvere , Rimpau Julius , Dimopoulou Christina , Schopohl Jochen , Roemmler-Zehrer Josefine

Introduction: Craniopharyngioma is an insidious disease that leads to profound comorbidities. Outcomes of the disease have been studied in depth, but there is little data comparing pituitary comorbidities of cases diagnosed in recent years opposed to before. We hypothesized that advances in endocrinologic diagnostics and neurosurgery have led to a lower degree of comorbidities.Methods: We investigated 54 patients with adult-onset craniopharyngioma (28 ma...