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16th European Congress of Endocrinology


Dilemmas in hormonal replacements

ea0035s21.3 | Dilemmas in hormonal replacements | ECE2014

Dilemmas in hormonal replacements: can we offer GH replacement to patients with a history of malignancy?

Abs Roger

Experimental studies have shown that GH and IGFs stimulate cell mutagenesis and proliferation. Moreover, an association between high-normal serum IGF-I levels and an increased risk of malignancies has been suggested in the general population. Bearing this relationship in mind, the question raises whether patients with GH deficiency (GHD) replaced with GH are at increased risk of developing malignancies and whether some patients, particularly cancer survivors, are more prone to...