ECE2014 Oral Communications Pituitary clinical (5 abstracts)
Assessment of atrial electromechanical delay in patients with acromegaly
Oya Topaloglu 1 , Muyesser Sayki Arslan 1 , Osman Turak 2 , Bekir Ucan 1 , Evrim Cakir 1 , Muhammet Cebeci 2 , Mustafa Sahin 3 , Nujen Colak 1 , Taner Demirci 1 , Ilknur Oztürk Unsal 1 , Melia Karakose 1 , Mustafa Ozbek 1 & Tuncay Delibasi 1
1Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; 2Department of Cardiology, Türkiye Yuksek Ihtisas Hospital, Ankara, Turkey; 3Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey.
Aim: Cardiac rhythm abnormalities have been documented in acromegalic patients. Our aim is to evaluate atrial electromechanical delay (EMD) with tissue doppler imaging (TDI) in patients with acromegaly.
Material and methods: Fourty patients with acromegaly (13 patients with remission disease and 27 patients with active disease; 22 women and 18 men; mean aged 46.1±10.3 years), and 37 age- and sex-matched healthy controls were enrolled in the study. Atrial conduction times of right atrium, left atrium and interatrial septum were measured by 2- dimensional TDI using a 3.5- MHz transducer (GE-Vingmed Ultrasound AS, Horten, Norway). Statistical analysis was performed on the basis of three groups; controls, active acromegaly (AA) and remission acromegaly (RA).
Results: Left atrial conduction time was found as 61.54±13.13 ms in RA patients, 63.44±13.69 ms in AA patients, and 43.94±10.29 ms in controls (P=0.0001). Right atrial conduction time was not found as statistically significant (P>0.05) (RA patients; 11.92±3.84 ms, AA patients; 12.61±4.49 ms and controls 12.12±3.96 ms). Interatrial conduction time was found as 31.53±8.0 ms for RA, 35.65±8.96 ms for AA patients, and 22.79±6.89 ms for controls (P=0.0001). There was not statistically significant difference in left atrial, right atrial and interatrial conduction times between RA and AA groups (P>0.05). However, there was significant delay in left atrial and interatrial septum conduction time between both patients group and controls (RA vs controls, P=0.0001 and AA vs controls, P=0.0001 for left atrial conduction time; RA vs controls, P=0.003 and AA vs controls, P=0.0001, for interatrial septum conduction time)
Conclusion: This study suggests that atrial conduction time is delayed in patients with acromegaly both in remission and active state. Atrial electromechanical delay can be a predisposition factor for increased arrhythmia in acromegalic patients. This must be evaluated with further studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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